Adam Campbell Smith

Atualmente Dr. Smith é Director do laborotorio da citogenetica na Laboratory Medicine Program no University Health Network / University of Toronto. Possui treinamento (Fellowship) em Citogenética Clínica e Genetica Molecular pelo Canadian College of Medical Geneticists (CCMG) que foi sedeado no Hospital for Sick Children (Toronto, Canada). Ele é um Fellow e membro do CCMG e American College of Medical Genetics and Genomics (ACMGG). Possui Mestrado e Doutorado em Patologia e Medicina Laboratorial e Genética, ambos pela University of Toronto. Possui graduação em Biologia pela University of Western Ontario (London, Canada). Dr. Smith tem experiência na área de Genética, com ênfase em Genética Humana e Médica.

Informações coletadas do Lattes em 04/11/2022

Acadêmico

Formação acadêmica

Doutorado

2001 - 2009

University of Toronto
Título: Disruption of Epigenetic Regulatory Elements and Chromosomal Alterations in Patients with Beckwith-Wiedemann Syndrome
Orientador: Rosanna Weksberg
Grande área: Ciências Biológicas

Mestrado em Pathology and Laboratory Medicine

1998 - 2000

University of Toronto
Título: Functional Deficiency of the 67-kDa Elastin Binding Protein is Related to the Pathomechanism of Costello Syndrome, Ano de Obtenção: 2000
Orientador: Aleksander Hinek
Palavras-chave: Elastin; Costello Syndrome.Grande área: Ciências Biológicas

Graduação em Honours Biology

1993 - 1997

The University of Western Ontario

Pós-doutorado

2016 - 2018

Pós-Doutorado. , Canadian College of Medical Geneticists, CCMG, Canadá. , Grande área: Ciências Biológicas, Grande Área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular.

2008 - 2010

Pós-Doutorado. , Canadian College of Medical Geneticists, CCMG, Canadá. , Bolsista do(a): Ontario Ministry of Health and Long-Term Care, OMHLTC, Canadá. , Grande área: Ciências da Saúde

Formação complementar

2001 - 2001

Perinatal and Developmental Biology. (Carga horária: 40h). , Karolinska Institutet, KI, Suécia.

Idiomas

Bandeira representando o idioma Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Bandeira representando o idioma Português

Compreende Razoavelmente, Fala Razoavelmente, Lê Razoavelmente, Escreve Razoavelmente.

Bandeira representando o idioma Francês

Compreende Pouco, Fala Pouco, Lê Pouco, Escreve Pouco.

Áreas de atuação

Grande área: Ciências Biológicas / Área: Genética / Subárea: Genética Humana e Médica.

Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular.

Organização de eventos

FIGUIEREDO, B. C. ; SMITH, A. C. ; Custidio, G . II International Symposium on Nanobiotechnology. 2013. (Congresso).

Participação em eventos

3rd Reunião Brasileira de Citogenética. Next Generation Cytogenetics: Clinical Applications of Array and NGS. 2013. (Congresso).

Congresso Brasileiro de Psiquiatria. Fundementals of Genetics and Pharmacogenetics in Psychiatry? and ?Cytogenetic and Molecular Genetics Diagnostics for Psychiatry?.. 2013. (Congresso).

III International Symposium on Translational Oncology.Using Affymetrix Oncoscan in a Clinical Cytogenetics Setting. 2013. (Simpósio).

II International Symposium on Nanobiotechnology.Microarray Technologies. 2013. (Simpósio).

II International Symposium on Nanobiotechnology.Use of DNA Methylation Microarrays to Detect Regional DNA Hypermethylation in Chromosome region 11p15.5. 2013. (Simpósio).

ll Simposio de oncologia molecular e medicina personalizada.Using Microarrays with Methanol:Acetic Acid Fixed Pellets in Routine Cancer Cytogenomics. 2013. (Simpósio).

Scientific Writing and Editing Course.Investment, Incentives and Growth in Scientific Publishing in Canada - a round table discussion. 2013. (Simpósio).

Scientific Writing and Editing Course.Writing Style, Images and Table, Barriers to Writing. 2013. (Simpósio).

Vlll Jornada de Farmacologia.O Que É Plágio?. 2013. (Simpósio).

XVlll Congresso Brasileiro de oncologia Clinica. Microarray Cromossomico em Oncologia - aplicações clinicas em tumores. 2013. (Congresso).

Affymetrix Oncoscan Seminar.Using Microarrays with Methanol:Acetic Acid Fixed Pellets in Routine Cancer Cytogenomics. 2012. (Seminário).

American Society of Hematology Annual Meeting. Comprehensive Assessment of Clinical Outcomes for CLL Patients with Trisomy 12 (+12): Results of a Population-Based Analysis of 822 CLL Patients in British Columbia (BC), Canada. 2012. (Congresso).

British Columbia CLL Day.Clinical Microarray: Applicationss and Utility. 2012. (Simpósio).

Congresso de Genética Medica - Sociedade Brasileira Genetica Medica.Using Microarrays with Methanol:Acetic Acid Fixed Pellets in Routine Cancer Cytogenomics. 2012. (Seminário).

São Paulo Advanced School of Science ? ?Comparative Oncology?.Using Microarrays with Methanol:Acetic Acid Fixed Pellets in Routine Cancer Cytogenomics. 2012. (Seminário).

Great Lakes Chromosome Conference. Parental Detection of a t(4;11) causing WHS and RSS. 2009. (Congresso).

International Symposium on Psychiatric Genetics.Epigenetics and Psychiatry. 2008. (Simpósio).

Participação em bancas

Aluno: Reginaldo Justino Ferreira

CARVALHO, K. A. T.; ROSATI, R.;Smith, A.C.; BELTRAME, M. P.. Estabelecimento de protocolo de screening de células-tronco mesenquimais cultivadas, derivadas do tecido adiposo. Estudo préclínico. 2014. Tese (Doutorado em Engenharia de Bioprocessos e Biotecnologia) - Universidade Federal do Paraná.

Aluno: Graziele Moraes Losso

BONARDI, R. A.; YOSHI, S.;SMITH, ADAM C. ANÁLISE MOLECULAR DA INSTABILIDADE DE MICROSSATÉLITE ? MSI E DOS GENES KRAS E BRAF EM PACIENTES PORTADORES DE NEOPLASIAS DE RETO SUBMETIDOS A MICROCIRURGIA ENDOSCÓPICA TRANSANAL ? TEM. 2014. Tese (Doutorado em Medicina Interna) - Universidade Federal do Paraná.

Orientou

Maria Rita Drula do Nascimento

Expressão de Genes do Complexo WAVE em Pacientes com Microdeleções 15q11; 2: Sua Relação com o Autismo; 2016; Dissertação (Mestrado em Biotecnologia Aplicada a Saúde da Criança e do Adolescente) - Hospital Infantil Pequeno Príncipe,; Orientador: Adam Campbell Smith;

Daniele Kazue Sugioka

Analise da Função de CYFIP1 no Contexto de Complexos Contendo WAVE e FMRP em Linhagens Linfoblastoide de Pacientes com a Deleção 15q11; 2 e Modelos Animais; 2016; Tese (Doutorado em Biotecnologia Aplicada a Saúde da Criança e do Adolescente) - Hospital Infantil Pequeno Príncipe, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Orientador: Adam Campbell Smith;

Produções bibliográficas

  • DAHER-REYES, GEORGINA KIM, TAEHYUNG NOVITZKY-BASSO, IGOR KIM, KYUOUNG HA Smith, Adam STOCKLEY, TRACY CAPOCHICHI, JOSE-MARIO AL-SHAIBANI, ZEYAD PASIC, IVAN LAW, ARJUN LAM, WILSON MICHELIS, FOTIOS V. GERBITZ, ARMIN VISWABANDYA, AURO LIPTON, JEFFREY KUMAR, RAJAT MATTSSON, JONAS SCHIMMER, AARON MCNAMARA, CAROLINE MURPHY, TRACY MAZE, DAWN GUPTA, VIKAS SIBAI, HASSAN CHAN, STEVEN YEE, KAREN , et al. MINDEN, MARK ZHANG, ZHAOLEI SCHUH, ANDRE KIM, DENNIS D. H. ; Prognostic impact of the adverse molecular-genetic profile on long-term outcomes following allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia. BONE MARROW TRANSPLANTATION , v. 56, p. 1908-1918, 2021.

  • MAKAREM, MAISAM ; EZEIFE, DOREEN A. ; Smith, Adam C. ; LI, JANICE J. N. ; LAW, JENNIFER H. ; TSAO, MING-SOUND ; LEIGHL, NATASHA B. . Reflex ROS1 IHC Screening with FISH Confirmation for Advanced Non-Small Cell Lung Cancer-A Cost-Efficient Strategy in a Public Healthcare System. Current Oncology , v. 28, p. 3268-3279, 2021.

  • CHEUNG, CAROL C. Smith, Adam C. ALBADINE, ROULA BIGRAS, GILBERT BOJARSKI, ANNA COUTURE, CHRISTIAN CUTZ, JEAN-CLAUDE HUANG, WEEI-YUAN IONESCU, DIANA ITANI, DOHA IZEVBAYE, IYARE KARSAN, ALY KELLY, MARGARET M. KNOLL, JOAN KWAN, KEITH NASR, MICHEL R. QING, GEFEI RASHID-KOLVEAR, FARIBOZ SEKHON, HARMANJATINDER S. SPATZ, ALAN STOCKLEY, TRACY TRAN-THANH, DANH TUCKER, TRACY WAGHRAY, RANJIT WANG, HANGJUN , et al. XU, ZHAOLIN YATABE, YASUSHI TORLAKOVIC, EMINA E. TSAO, MING-SOUND ; Canadian ROS proto-oncogene 1 study (CROS) for multi-institutional implementation of ROS1 testing in non-small cell lung cancer. LUNG CANCER , v. 160, p. 127-135, 2021.

  • KIM, JAESEUNG C. ; ZUZARTE, PHILIP C. ; MURPHY, TRACY ; CHAN-SENG-YUE, MICHELLE ; BROWN, ANDREW M. K. ; KRZYZANOWSKI, PAUL M. ; Smith, Adam C. ; NOTTA, FAIYAZ ; MINDEN, MARK D. ; MCPHERSON, JOHN D. . Cryptic genomic lesions in adverse-risk acute myeloid leukemia identified by integrated whole genome and transcriptome sequencing. LEUKEMIA , v. 34, p. 306-311, 2020.

  • QUEVEDO, RENE ; SPREAFICO, ANNA ; BRUCE, JEFF ; DANESH, ARNAVAZ ; EL GHAMRASNI, SAMAH ; GIESLER, AMANDA ; HANNA, YOUSTINA ; HAVE, CHERRY ; LI, TIANTIAN ; YANG, S. Y. CINDY ; ZHANG, TONG ; ASA, SYLVIA L. ; HAIBE-KAINS, BENJAMIN ; KRZYZANOWSKA, MONIKA ; Smith, Adam C. ; SINGH, SIMRON ; SIU, LILLIAN L. ; PUGH, TREVOR J. . Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor. Genome Medicine , v. 12, p. 38, 2020.

  • GARG, SWATI ; NAGARIA, TEDDY S. ; CLARKE, BLAISE ; FREEDMAN, ORIT ; KHAN, ZANOBIA ; SCHWOCK, JOERG ; BERNARDINI, MARCUS Q. ; OZA, AMIT M. ; HAN, KATHY ; Smith, Adam C. ; STOCKLEY, TRACY L. ; ROUZBAHMAN, MARJAN . Molecular characterization of gastric-type endocervical adenocarcinoma using next-generation sequencing. MODERN PATHOLOGY , v. 32, p. 1823-1833, 2019.

  • FISET, PIERRE O. ; LABBÉ, CATHERINE ; YOUNG, KELVIN ; CRADDOCK, KENNETH J. ; Smith, Adam C. ; TANGUAY, JEFFREY ; PINTILIE, MELANIA ; WANG, RI ; TORLAKOVIC, EMINA ; CHEUNG, CAROL ; SANTOS, GILDA ; KO, HYANG'MI ; BOERNER, SCOTT L. ; HWANG, DAVID M. ; LEIGHL, NATASHA B. ; TSAO, MING'SOUND . Anaplastic lymphoma kinase 5A4 immunohistochemistry as a diagnostic assay in lung cancer: A Canadian reference testing center's results in population-based reflex testing. CANCER , v. 125, p. 4043-4051, 2019.

  • WASSERMAN, JASON K. ; DICKSON, BRENDAN C. ; Smith, Adam ; SWANSON, DAVID ; PURGINA, BIBIANNA M. ; WEINREB, ILAN . Metastasizing Pleomorphic Adenoma. AMERICAN JOURNAL OF SURGICAL PATHOLOGY , v. 43, p. 1145-1151, 2019.

  • BEBB, D. G. ; AGULNIK, J. ; ALBADINE, R. ; BANERJI, S. ; BIGRAS, G. ; BUTTS, C. ; COUTURE, C. ; CUTZ, J. C. ; DESMEULES, P. ; IONESCU, D. N. ; LEIGHL, N. B. ; MELOSKY, B. ; MORZYCKI, W. ; RASHID-KOLVEAR, F. ; SEKHON, H. S. ; SMITH, A. C. ; STOCKLEY, T. L. ; TORLAKOVIC, E. ; XU, Z. ; TSAO, M. S. . Crizotinib inhibition of ROS1-positive tumours in advanced non-small-cell lung cancer: a Canadian perspective. Current Oncology , v. 26, p. e551-e557, 2019.

  • BARGHOUT, SAMIR H. ; PATEL, PARASVI S. ; WANG, XIAOMING ; XU, G. WEI ; KAVANAGH, SIMON ; HALGAS, ONDREJ ; ZARABI, SARA F. ; GRONDA, MARCELA ; HURREN, ROSE ; JEYARAJU, DANNY V. ; MACLEAN, NEIL ; BRENNAN, SHAWN ; HYER, MARC L. ; BERGER, ALLISON ; TRAORE, TARY ; MILHOLLEN, MICHAEL ; Smith, Adam C. ; MINDEN, MARK D. ; PAI, EMIL F. ; HAKEM, RAZQ ; SCHIMMER, AARON D. . Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia. LEUKEMIA , v. June, p. 10.1038/s41375-, 2018.

  • HUANG, STEVEN J. ; LEE, LAUREN J. ; GERRIE, ALINA S. ; GILLAN, TANYA L. ; BRUYERE, HELENE ; HRYNCHAK, MONICA ; Smith, Adam C. ; KARSAN, ALY ; RAMADAN, KHALED M. ; JAYASUNDARA, KAVISHA S. ; TOZE, CYNTHIA L. . Characterization of treatment and outcomes in a population-based cohort of patients with chronic lymphocytic leukemia referred for cytogenetic testing in British Columbia, Canada. Leukemia Research , v. 55, p. 79-90, 2017.

  • ABEKHOUKH, SABIHA ; SAHIN, H BAHAR ; GROSSI, MAURO ; ZONGARO, SAMANTHA ; MAURIN, THOMAS ; MADRIGAL, IRENE ; KAZUE-SUGIOKA, DANIELE ; RAAS-ROTHSCHILD, ANNICK ; DOULAZMI, MOHAMED ; CARRERA, PILAR ; STACHON, ANDREA ; SCHERER, STEVEN ; NASCIMENTO, MARIA RITA DRULA DO ; TREMBLEAU, ALAIN ; ARROYO, IGNACIO ; PETER, SZATMARI ; SMITH, ISABEL M. ; MILÀ, MONTSERRAT ; Smith, Adam C. ; GIANGRANDE, ANGELA ; CAILLÉ, ISABELLE ; BARDONI, BARBARA . New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes. DISEASE MODELS & MECHANISMS , v. 10, p. dmm.025809-474, 2017.

  • KAO, K R ; HASAN, T ; BAPTISTA, A ; TRUONG, T ; GAI, L ; SMITH, A C ; LI, S ; GONZALES, P ; VOISEY, K ; ERIWVO, P ; POWER, J ; DENIC, N . Effect of fixation time on breast biomarker expression: a controlled study using cell line-derived xenografted (CDX) tumours. JOURNAL OF CLINICAL PATHOLOGY , v. 1, p. jclinpath-2017-204381, 2017.

  • HUANG, STEVEN J. ; BERGIN, KRYSTAL ; Smith, Adam C. ; GERRIE, ALINA S. ; BRUYERE, HELENE ; DALAL, CHINMAY B. ; SUGIOKA, DANIELE K. ; HRYNCHAK, MONICA ; RAMADAN, KHALED M. ; KARSAN, ALY ; GILLAN, TANYA L. ; TOZE, CYNTHIA L. . Clonal evolution as detected by interphase fluorescence in situ hybridization is associated with worse overall survival in a population-based analysis of patients with chronic lymphocytic leukemia in British Columbia, Canada. CANCER GENETICS , v. 210, p. 1-8, 2017.

  • HUANG, STEVEN J. T. ; GILLAN, TANYA L. ; GERRIE, ALINA S. ; HRYNCHAK, MONICA ; KARSAN, ALY ; RAMADAN, KHALED ; Smith, Adam C. ; TOZE, CYNTHIA L. ; BRUYERE, HELENE . Influence of clone and deletion size on outcome in chronic lymphocytic leukemia patients with an isolated deletion 13q in a population-based analysis in British Columbia, Canada. Genes Chromosomes & Cancer (Print) , v. 55, p. 16-24, 2016.

  • GERRIE, ALINA S. ; HUANG, STEVEN J.T. ; BRUYERE, HELENE ; DALAL, CHINMAY ; HRYNCHAK, MONICA ; KARSAN, ALY ; RAMADAN, KHALED M. ; Smith, Adam C. ; TYSON, CHRISTINE ; TOZE, CYNTHIA L. ; GILLAN, TANYA L. . Population-based characterization of the genetic landscape of chronic lymphocytic leukemia patients referred for cytogenetic testing in British Columbia, Canada: the role of provincial laboratory standardization. Cancer Genetics , v. 1, p. 1, 2014.

  • Lee, Anna F. ; Yip, Stephen ; Smith, Adam C. ; Hayes, Malcolm M. ; Nielsen, Torsten O. ; O'Connell, John X. . Low-grade fibromyxoid sarcoma of the perineum with heterotopic ossification: case report and review of the literature. Human Pathology (Print) , p. epub, 2011.

  • Smith, Adam C. ; Suzuki, Masako ; Thompson, Reid ; Choufani, Sanaa ; Higgins, Michael J. ; Chiu, Idy W. ; Squire, Jeremy A. ; Greally, John M. ; Weksberg, Rosanna . Maternal gametic transmission of translocations or inversions of human chromosome 11p15.5 results in regional DNA hypermethylation and downregulation of CDKN1C expression. Genomics (San Diego, Calif.) , v. Nov3, p. 1, 2011.

  • Horike, Shin-Ichi ; Ferreira, Jose Carlos P. ; Meguro-Horike, Makiko ; Choufani, Sanaa ; Smith, Adam C. ; Shuman, Cheryl ; Meschino, Wendy ; Chitayat, David ; Zackai, Elaine ; Scherer, Stephen W. ; Weksberg, Rosanna . Screening of DNA methylation at the H19 promoter or the distal region of its ICR1 ensures efficient detection of chromosome 11p15 epimutations in Russell-Silver syndrome. American Journal of Medical Genetics. Part A , v. 149A, p. 2415-2423, 2009.

  • GUO, L ; CHOUFANI, S ; FERREIRA, J ; SMITH, A. C. ; CHITAYAT, D ; SHUMAN, C ; UXA, R ; KEATING, S ; KINGDOM, J ; WEKSBERG, R . Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae. Developmental Biology (Print) , v. 320, p. 79-91, 2008.

  • Stachon, Andrea C. ; Baskin, Berivan ; Smith, Adam C. ; Shugar, Andrea ; Cytrynbaum, Cheryl ; Fishman, Leona ; Mendoza-Londono, Roberto ; Klatt, Regan ; Teebi, Ahmed ; Ray, Peter N. ; Weksberg, Rosanna . Molecular diagnosis of 22q11.2 deletion and duplication by multiplex ligation dependent probe amplification. American Journal of Medical Genetics. Part A , v. 143A, p. 2924-2930, 2007.

  • Smith, Adam C. ; Shuman, Cheryl ; Chitayat, David ; Steele, Leslie ; Ray, Peter N. ; Bourgeois, Jaqueline ; Weksberg, Rosanna . Severe presentation of BeckwithWiedemann syndrome associated with high levels of constitutional paternal uniparental disomy for chromosome 11p15. American Journal of Medical Genetics. Part A , v. 143A, p. 3010-3015, 2007.

  • Smith, Adam C. ; Choufani, Sanaa ; FERREIRA, JOSE C. ; Weksberg, Rosanna . Growth Regulation, Imprinted Genes, and Chromosome 11p15.5. Pediatric Research , v. 61, p. 43R-47R, 2007.

  • Shuman, Cheryl ; Smith, Adam C. ; Steele, Leslie ; Ray, Peter N. ; Clericuzio, Carol ; Zackai, Elaine ; Parisi, Melissa A. ; Meadows, Anna T. ; Kelly, Thaddeus ; Tichauer, David ; Squire, Jeremy A. ; Sadowski, Paul ; Weksberg, Rosanna . Constitutional UPD for chromosome 11p15 in individuals with isolated hemihyperplasia is associated with high tumor risk and occurs following assisted reproductive technologies. American Journal of Medical Genetics. Part A , v. 140A, p. 1497-1503, 2006.

  • Smith, A.C. ; Rubin, T. ; Shuman, C. ; Estabrooks, L. ; Aylsworth, A.S. ; McDonald, M.T. ; Steele, L. ; Ray, P.N. ; Weksberg, R. . New chromosome 11p15 epigenotypes identified in male monozygotic twins with Beckwith-Wiedemann syndrome. Cytogenetic and Genome Research (Online) , v. 113, p. 313-317, 2006.

  • McMinn, J. ; Wei, M. ; Schupf, N. ; Cusmai, J. ; Johnson, E.B. ; Smith, A.C. ; Weksberg, R. ; Thaker, H.M. ; Tycko, B. . Unbalanced Placental Expression of Imprinted Genes in Human Intrauterine Growth Restriction. Placenta (Eastbourne) , v. 27, p. 540-549, 2006.

  • Weksberg, Rosanna ; Shuman, Cheryl ; Smith, Adam C. . Beckwith-Wiedemann syndrome. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics , v. 137C, p. 12-23, 2005.

  • CYTRYNBAUM, CHERYL S ; SMITH, ADAM C ; RUBIN, TAMAR ; Weksberg, Rosanna . Advances in overgrowth syndromes: clinical classification to molecular delineation in Sotos syndrome and Beckwith-Wiedemann syndrome. Current Opinion in Pediatrics , v. 17, p. 740-746, 2005.

  • WEKSBERG, R ; Smith, A.C. ; Squire, Jeremy A. ; Sadowski, Paul . Beckwith-Wiedemann Syndrome Demonstrates a Role for Epigenetic Control of Normal Development.. Human Molecular Genetics (Print) , v. 12, p. R61-R68, 2003.

  • Weksberg, R. ; Shuman, C. ; Caluseriu, O ; Smith, A.C. ; Fei, YL ; Nishikawa, J. ; Stockley, T ; Best, L ; CHITAYAT, D ; Olney, A ; Ives, E ; Schneider, A ; Bestor, TL ; Li, M ; Sadowski, Paul ; Squire, Jeremy A. . Discordant KCNQ1OT1 imprinting in sets of monozygotic twins discordant for Beckwith-Wiedemann syndrome.. Human Molecular Genetics (Print) , v. 11, p. 1317-1325, 2002.

  • GOLDMAN, M. ; SMITH, A. ; Shuman, C. ; CALUSERIU, O. ; WEI, C. ; Steele, L. ; RAY, P. ; SADOWSKI, P. ; SQUIRE, J. ; Weksberg, R. ; ROSENBLUM, N. D. . Renal Abnormalities in Beckwith-Wiedemann Syndrome Are Associated with 11p15.5 Uniparental Disomy. Journal of the American Society of Nephrology , v. 13, p. 2077-2084, 2002.

  • Li, M ; Squire, Jeremy A. ; SHUMAN, C ; Fei, YL ; Atkin, J ; Pauli, R ; SMITH, A ; CHITAYAT, D ; Weksberg, R. . Imprinting Status of 11p15 Genes in BeckwithWiedemann Syndrome Patients with CDKN1C Mutations. Genomics (San Diego, Calif.) , v. 74, p. 370-376, 2001.

  • WEKSBERG, R ; Nishikawa, J. ; Caluseriu, O ; Fei, YL ; Shuman, C. ; Wei, C ; Steele, L. ; Cameron, J ; SMITH, A ; Ambus, I ; Li, M ; Ray, P.N. ; Sadowski, Paul ; Squire, Jeremy A. . Tumor development in the Beckwith-Wiedemann syndrome is associated with a variety of constitutional molecular 11p15 alterations including imprinting defects of KCNQ1OT1.. Human Molecular Genetics (Print) , v. 10, p. 2989-3000, 2001.

  • SMITH, A. C. ; Squire, Jeremy A. ; Thorner, P ; Zielenska, M ; Shuman, C. ; Grant, R ; Chitayat, David ; Nishikawa, J. ; Weksberg, R. . Association of Alveolar Rhabdomyosarcoma with the Beckwith-Wiedemann Syndrome. Pediatric and Developmental Pathology (Print) , v. 4, p. 550-558, 2001.

  • HINEK, A ; SMITH, A ; CUTIONGCO, E ; CALLAHAN, J ; GRIPP, K ; WEKSBERG, R . Decreased Elastin Deposition and High Proliferation of Fibroblasts from Costello Syndrome Are Related to Functional Deficiency in the 67-kD Elastin-Binding Protein. American Journal of Human Genetics , v. 66, p. 859-872, 2000.

  • HINEK, A ; Zhang, S ; Smith, A.C. ; CALLAHAN, J . Impaired Elastic-Fiber Assembly by Fibroblasts from Patients with Either Morquio B Disease or Infantile GM1-Gangliosidosis Is Linked to Deficiency in the 67-kD Spliced Variant of Î-Galactosidase. American Journal of Human Genetics , v. 67, p. 23-36, 2000.

  • Weksberg, Rosanna ; Sadowski, Paul ; Smith, Adam C. ; Tycko, B. . Epigenetics. In: Alan E.H. Emery, David L. Rimoin. (Org.). Emery and Rimoin's Principles and Practice of Medical Genetics. 5thed.Philadelphia: Elsevier, 2006, v. 1, p. 81-100.

  • Krystal Bergin ; GERRIE, A. S. ; HUANG, S. J. T. ; RAMADAN, K. M. ; Aly Karsan ; HRYNCHAK, M. A. ; DALAL, C. B. ; BRUYERE, H. ; Smith, A.C. ; TOZE, C. L. ; Gillan, T. . Clonal Evolution Predicts Poor Prognosis in Chronic Lymphocytic Leukaemia and Is Possibly a Worse Prognostic Factor Than 17p Deletion: A Population Based Cohort study of FISH Testing in British Columbia, Canada. In: American Society of Hematology Annual Meeting, 2012, Altanta, GA, USA. 2012 ASH Annual Meeting Abstract Book, 2012.

  • GERRIE, A. S. ; HUANG, S. J. T. ; BRUYERE, H. ; DALAL, C. B. ; HRYNCHAK, M. A. ; Aly Karsan ; RAMADAN, K. M. ; SMITH, A. C. ; Gillan, T. ; TOZE, C. L. . Comprehensive Assessment of Clinical Outcomes for CLL Patients with Trisomy 12 (+12): Results of a Population-Based Analysis of 822 CLL Patients in British Columbia (BC), Canada. In: American Society of Hematology Annual Meeting, 2012, Atlanta, GA, USA. 2012 ASH Annual Meeting Abstract Book, 2012.

  • Horike, Shin-Ichi ; Meguro-Horike, Makiko ; FERREIRA, JOSE C. ; Smith, A.C. ; SHUMAN, C ; Meschino, Wendy ; Scherer, Stephen W. ; Zackai, Elaine ; WEKSBERG, R . Complex epigenetic abnormalities are not detected by targeted methylation analysis.. In: American Society of Human Genetics Annual Meeting, 2008, Philadelphia, USA. American Society of Human Genetics Abstract Book, 2008.

  • SMITH, A ; C. Shuman ; Steele, Leslie ; Ray, Peter N. ; WEKSBERG, R . Severe phenotypic expression of Beckwith-Wiedemann syndrome associated with high levels of paternal uniparental disomy for chromosome 11p15.. In: American Society of Human Genetics Annual Meeting, 2006, New Orleans, USA. American Society of Human Genetics Abstract Book, 2006.

  • SHUMAN, C ; Steele, L. ; SMITH, A ; Ray, Peter N. ; Zackai, Elaine ; Parisi, Melissa A. ; Clericuzio, Carol ; Meadows, Anna T. ; Kelly, Thaddeus ; Tichauer, David ; Squire, Jeremy A. ; WEKSBERG, R . Increased Tumor Frequency in Individuals with Isolated Hemihyperplasia and Molecular Alterations at 11p15.. In: American Society of Human Genetics Annual Meeting, 2005, Salt Lake City, USA. American Society of Human Genetics Abstract Book, 2005.

  • SMITH, A. C. ; Squire, Jeremy A. ; SHUMAN, C ; WEKSBERG, R . Disruption of epigenetic regulatory elements and chromosomal aberrations in patients with Beckwith-Wiedemann syndrome.. In: American Society of Human Genetics Annual Meeting, 2004, Toronto, Canada. American Society of Human Genetics Abstract Book, 2004.

  • Nakabayashi, K. ; Minagawa, S ; Bentley, L ; He, L ; Kapur, R ; SMITH, A. C. ; Bamforth, JS ; Oshimura, M ; WEKSBERG, R ; Moore, GE ; Scherer, Stephen W. . Chromosome-wide discovery of imprinted and differentially expressed genes for disease study.. In: American Society of Human Genetics Annual Meeting, 2002, Baltimore, USA. American Society of Human Genetics Abstract Book, 2002.

  • Goy, J ; Gillan, T. ; HUANG, S. J. T. ; BRUYERE, H. ; HRYNCHAK, MONICA ; KARSAN, ALY ; RAMADAN, KHALED M. ; SMITH, ADAM C ; TOZE, CYNTHIA L. ; GERRIE, ALINA S. . Clinical outcomes for Chronic Lymphocytic Leukemia (CLL) patients with 11q deletion in British Columbia (BC), Canada: Results of an observational population-based cohort. 2014. (Apresentação de Trabalho/Simpósio).

  • Smith, Adam C. . ICF Syndrome. 2010. (Apresentação de Trabalho/Conferência ou palestra).

  • SMITH, A. C. . Genomic Rearrangements in Beckwith-Wiedemann Syndrome: The Genetic and Epigenetic Consequences. 2009. (Apresentação de Trabalho/Comunicação).

  • SMITH, A. C. . Genomic Rearrangements in Beckwith-Wiedemann Syndrome: The Genetic and Epigenetic Consequences. 2009. (Apresentação de Trabalho/Comunicação).

  • SMITH, A. C. . Prenatal diagnosis of a maternally derived unbalanced der(4)t(4;11) leading to an overlapping phenotype of Wolf-Hirschhorn and Russell-Silver syndromes in two siblings: novel recurrent translocation, aCGH and molecular cytogenetic analyses.. 2009. (Apresentação de Trabalho/Comunicação).

  • SMITH, A. C. . Genomic Rearrangements in Beckwith-Wiedemann Syndrome: The Genetic and Epigenetic Consequences. 2009. (Apresentação de Trabalho/Comunicação).

  • Smith, Adam C. . Mosaic Variegated Aneuploidy. 2009. (Apresentação de Trabalho/Comunicação).

  • Smith, Adam C. . Introduction to the Cytogenetic Diagnostic Lab for Medical Residents. 2009. (Apresentação de Trabalho/Conferência ou palestra).

  • Smith, Adam C. . Cancer Epigenetics. 2009. (Apresentação de Trabalho/Conferência ou palestra).

  • Smith, Adam C. . Syndromes with Defects in Chromosome Cohesion. 2009. (Apresentação de Trabalho/Comunicação).

  • Smith, Adam C. . Marker Chromosomes - Emanuel Syndrome. 2009. (Apresentação de Trabalho/Comunicação).

  • Smith, Adam C. . Sex Chromosome Mosaicism. 2009. (Apresentação de Trabalho/Conferência ou palestra).

  • Smith, Adam C. . Uniparental Disomy and Diagnostic Testing. 2009. (Apresentação de Trabalho/Conferência ou palestra).

  • SMITH, A. C. . Epigenetics and Psychiatry. 2008. (Apresentação de Trabalho/Simpósio).

  • Smith, Adam C. . A Primer on Epigenetics. 2008. (Apresentação de Trabalho/Conferência ou palestra).

  • Smith, Adam C. . Array Complete Genomic Hybridization for the Detection of Complex Chromosome Abnormalties. 2008. (Apresentação de Trabalho/Comunicação).

  • Smith, A.C. ; Weksberg, Rosanna ; Shuman, Cheryl . Severe Uniparental Disomy in Beckwith-Wiedemann Syndrome. 2006. (Apresentação de Trabalho/Conferência ou palestra).

  • Smith, A.C. ; Weksberg, Rosanna ; Ray, Peter N. ; Squire, Jeremy A. ; Shuman, Cheryl . Epigenetic Alterations in Patient with Tranlocations and Inversions with the Beckwith-Wiedemann Syndrome. 2005. (Apresentação de Trabalho/Conferência ou palestra).

  • Smith, Adam C. ; Squire, Jeremy A. ; Shuman, Cheryl ; Weksberg, Rosanna . Disruption of epigenetic regulatory elements and chromosomal aberrations in patients with Beckwith-Wiedemann syndrome.. 2004. (Apresentação de Trabalho/Conferência ou palestra).

  • Smith, Adam C. ; Squire, Jeremy A. ; Weksberg, Rosanna ; Shuman, Cheryl ; Ray, Peter N. . Methylation Abnormalties of the H19 DMR in Patients with the Beckwith-Wiedemann Syndrome. 2003. (Apresentação de Trabalho/Conferência ou palestra).

  • Smith, Adam C. ; Squire, Jeremy A. ; Shuman, Cheryl ; Ray, Peter N. ; Weksberg, Rosanna . Methylation Abnormalities in Patients with the Beckwith-Wiedemann Syndrome. 2002. (Apresentação de Trabalho/Conferência ou palestra).

  • Smith, Adam C. ; HINEK, A ; Weksberg, Rosanna . Elastin Deficiency in the Costello Syndrome. 2001. (Apresentação de Trabalho/Congresso).

  • Shuman, Cheryl ; J. Bruce Beckwith ; Smith, Adam C. ; Weksberg, Rosanna . Beckwith-Wiedemann Syndrome. Seattle, Washington, USA: Edited by Roberta A Pagon, Editor-in-chief, Thomas D Bird, Cynthia R Dolan, Karen Stephens, and Marg, 2010 (Capitulo no Livro Online).

Outras produções

Smith, Adam C. ; BOSDET, I. . Molecular Genetic Techniques for Pathology Residents. 2011. (Curso de curta duração ministrado/Outra).

Smith, Adam C. . How to write a scientific paper in English...or any other language for that matter!. 2010. (Desenvolvimento de material didático ou instrucional - Educational Seminar for Graduate Students in Brazil).

Projetos de pesquisa

  • 2014 - 2018

    Role of Genomic Alterations in Intellectual Disability and Autism., Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (1) Doutorado: (1) . , Integrantes: Adam Campbell Smith - Coordenador / Stachon, Andrea C. - Integrante / Barbara Bardoni - Integrante., Financiador(es): Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Auxílio financeiro.

  • 2011 - 2013

    Determination of the Prognostic Significance of IGH Translocations in CLL patients in BC, Descrição: Using a samples of almost 800 patients from British Columbia involving three cytogenetic laboratories the retrospective analysis of the prognostic significance of IGH translocations and other genetic abnormalities involving IGH will be examined.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) . , Integrantes: Adam Campbell Smith - Integrante / Gillan, Tanya - Coordenador., Financiador(es): Vancouver Coastal Health Research Foundation - Auxílio financeiro.

Prêmios

2011

Fellow, American College of Medical Genetics.

2010

Fellow, Canadian College of Medical Geneticists.

2008

Cytogenetic Fellowship Scholarship, Ontario Ministry of Health and Long-Term Care.

2005

Molecular Medicine Scholarship, Hospital for Sick Children Molecular Medince Program funded by CIHR.

2003

Research Training Competition Scholarship, Hospital for Sick Children, Research Institutue.

2001

Graduate Scholarship (PGS-B), Natural Sciences and Engineering Council of Canada.

1999

Margaret and Howard Gamble Research Award, Ontario Student Opportunity Trust Fund.

1999

Open Scholarship, University of Toronto.

Histórico profissional

Endereço profissional

  • Hospital Infantil Pequeno Príncipe, Instituto de Pesquisa Pelé Pequeno Príncipe. , Av. Silva Jardim, 1632, Agua Verde, 80250200 - Curitiba, PR - Brasil, Telefone: (41) 33221446, URL da Homepage:

Experiência profissional

2011 - 2011

Vancouver Island Health Authority

Vínculo: Formal labor contract, Enquadramento Funcional: Locum Cytogeneticist, Carga horária: 8

Outras informações:
Provided short term support running the cytogenetics laboratory and signing out cases at the Victoria General Hospital (part of the Vancouver Island Health Authority).

2010 - Atual

University of British Columbia

Vínculo: Employee, Enquadramento Funcional: Clinical Assistant Professor

2008 - 2010

Hospital for Sick Children

Vínculo: Scholarship, Enquadramento Funcional: Fellow, Clinical Cytogenetics, Carga horária: 40, Regime: Dedicação exclusiva.

2011 - Atual

Hospital Infantil Pequeno Príncipe

Vínculo: Formal labor contract, Enquadramento Funcional: Pesquisador, Carga horária: 40, Regime: Dedicação exclusiva.

Atividades

  • 01/2013

    Pesquisa e desenvolvimento, Instituto de Pesquisa Pelé Pequeno Príncipe.,Linhas de pesquisa

2010 - 2012

British Columbia Cancer Agency

Vínculo: Formal labor contract, Enquadramento Funcional: Clinical Cytogeneticist, Carga horária: 35