Thatiane de Oliveira Sergio

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Produções bibliográficas

• STARSKI, PHILLIP ; MORNINGSTAR, MITCH D. ; KATNER, SIMON N. ; FRASIER, RAIZEL M. ; DE OLIVEIRA SERGIO, THATIANE ; WEAN, SARAH ; LAPISH, CHRISTOPHER C. ; HOPF, F WOODWARD . Neural activity in anterior insula at drinking onset and licking relates to compulsion-like alcohol consumption. JOURNAL OF NEUROSCIENCE , v. 1, p. e1490232023, 2024.

• FRASIER, RAIZEL M. ; STARSKI, PHILLIP A. ; DE OLIVEIRA SERGIO, THATIANE ; GRIPPO, ANGELA J. ; HOPF, F. WOODWARD . Sex differences in heart rate variability measures that predict alcohol drinking in rats. ADDICTION BIOLOGY , v. 29, p. 3, 2024.

• DE OLIVEIRA SERGIO, THATIANE ; DAREVSKY, DAVID ; KELLNER, JACOB ; DE PAULA SOARES, VANESSA ; DE CASSIA ALBINO, MARYELLE ; MAULUCCI, DANIELLE ; WEAN, SARAH ; HOPF, FREDERIC W. . Sex- and estrous-related response patterns for alcohol depend critically on the level of compulsion-like challenge. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY , v. 133, p. 111008, 2024.

• DE OLIVEIRA SERGIO, THATIANE ; JANE SMITH, REBECCA ; WEAN, SARAH E. ; ENGLEMAN, ERIC A. ; HOPF, FREDERIC W. . Greater inhibition of female rat binge alcohol intake by adrenergic receptor blockers using a novel Two-Shot rat binge drinking model. Scientific Reports , v. 14, p. 14029, 2024.

• RAIZEL, M. FRASIER ; DE OLIVEIRA SERGIO, THATIANE ; STARSKI, PHILLIP A. ; HOPF, F. WOODWARD . Heart rate variability: A primer for alcohol researchers. ALCOHOL , v. 5, p. 6, 2024.

• DE OLIVEIRA SERGIO, THATIANE ; WEAN, SARAH ; KATNER, SIMON N. ; HOPF, FREDERIC W. . The role of beta- and alpha-adrenergic receptors on alcohol drinking. NEUROPHARMACOLOGY , v. 234, p. 109545, 2023.

• DE OLIVEIRA SERGIO, THATIANE ; FRASIER, RAIZEL M. ; HOPF, FREDERIC W. . Animal models of compulsion alcohol drinking: Why we love quinine-resistant intake and what we learned from it. Frontiers in Psychiatry , v. 14, p. 1116901, 2023.

• STARSKI, PHILLIP A. ; Sergio, Thatiane De Oliveira ; HOPF, FREDERIC W. . Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking. Addiction Neuroscience , v. 7, p. 100102, 2023.

• FRASIER, RAIZEL M. ; DE OLIVEIRA SERGIO, THATIANE ; STARSKI, PHILLIP A. ; GRIPPO, ANGELA J. ; HOPF, F. WOODWARD . Heart rate variability measures indicating sex differences in autonomic regulation during anxiety-like behavior in rats. Frontiers in Psychiatry , v. 14, p. 1244389, 2023.

• DE OLIVEIRA SERGIO, THATIANE ; LEI, KELLY ; KWOK, CLAUDINA ; GHOTRA, SHAHBAJ ; WEGNER, SCOTT A. ; WALSH, MARGARET ; WAAL, JACLYN ; DAREVSKY, DAVID ; HOPF, FREDERIC W. . The role of anterior insula-brainstem projections and alpha-1 noradrenergic receptors for compulsion-like and alcohol-only drinking. NEUROPSYCHOPHARMACOLOGY , v. 46, p. 1918-1926, 2021.

• DE OLIVEIRA SERGIO, THATIANE ; WETHERILL, LEAH ; KWOK, CLAUDINA ; KHOYLOO, FARRAH ; HOPF, FREDERIC W. . Sex differences in specific aspects of two animal tests of anxiety-like behavior. PSYCHOPHARMACOLOGY , v. 238, p. 2775-2787, 2021.

• DE OLIVEIRA SERGIO, THATIANE ; FRIAS, ALANA TERCINO ; VILELA-COSTA, HELOISA HELENA ; DE OLIVEIRA, DANIELLE CG ; ZUARDI, ANTÔNIO W ; ZANGROSSI, HÉLIO . Serotonin mediates the panicolytic-like effect of oxytocin in the dorsal periaqueductal gray. JOURNAL OF PSYCHOPHARMACOLOGY (OXFORD. ONLINE) , v. 34, p. 383-390, 2020.

• WEGNER, SCOTT ANDREW ; HU, BING ; DE OLIVEIRA SERGIO, THATIANE ; DAREVSKY, DAVID ; KWOK, CLAUDINA CHOI-YAN ; LEI, KELLY ; HOPF, FREDERIC WOODWARD . A novel NMDA receptor-based intervention to suppress compulsion-like alcohol drinking. NEUROPHARMACOLOGY , v. 157, p. 107681, 2019.

• FELTMANN, KRISTIN ; BORROTO'ESCUELA, DASIEL OSCAR ; RÜEGG, JOËLLE ; PINTON, LUCA ; DE OLIVEIRA SERGIO, THATIANE ; NARVÁEZ, MANUEL ; JIMENEZ'BERISTAIN, ANTONIO ; EKSTRÖM, TOMAS J. ; FUXE, KJELL ; STEENSLAND, PIA . Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH , v. 42, p. 338-351, 2018.

• SANT?ANA, ANA BEATRIZ ; WEFFORT, LUIZ FERNANDO ; DE OLIVEIRA SERGIO, THATIANE ; GOMES, RAFAEL CALSONI ; FRIAS, ALANA TERCINO ; MATTHIESEN, MELINA ; VILELA-COSTA, HELOISA HELENA ; YAMASHITA, PAULA SHIMENE DE MELO ; VASCONCELOS, ALEX TELES ; DE BORTOLI, VALQUIRIA ; DEL-BEN, CRISTINA MARTA ; Zangrossi, Helio . Panic-modulating effects of alprazolam, moclobemide and sumatriptan in the rat elevated T-maze. BEHAVIOURAL BRAIN RESEARCH , v. 315, p. 115-122, 2016.

• SPIACCI, A. ; DE OLIVEIRA SERGIO, T. ; DA SILVA, G.S.F. ; GLASS, M.L. ; SCHENBERG, L.C. ; GARCIA-CAIRASCO, N. ; ZANGROSSI, H. . Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia. NEUROSCIENCE , v. 32, p. 8, 2015.

• DE OLIVEIRA SERGIO, THATIANE ; SPIACCI, AILTON ; ZANGROSSI, HÉLIO . Effects of dorsal periaqueductal gray CRF1- and CRF2-receptor stimulation in animal models of panic. Psychoneuroendocrinology , v. 49, p. 321-330, 2014.

• SERGIO, T. O. ; Bortoli, Valquiria Camin ; Zangrossi, Helio . Serotonin-2A receptor regulation of panic-like behavior in the rat dorsal periaqueductal gray matter: the role of GABA. Psychopharmacologia (Heidelberg) , v. 218, p. 725-732, 2011.

• SERGIO, T. O. ; STARSKI, P. ; HOPF, F. . LIckometry to Circuitry: How Compulsion-Like Alcohol Drinking Microstructure Helped Discover Functional Differences in Salience Network Regions. ickometry to Circuitry: How Compulsion-Like Alcohol Drinking Microstructure Helped Discover Functional Differences in Salience Network Regions.. 1ed.: , 2023, v. , p. 77-.

• DE OLIVEIRA SERGIO, THATIANE ; HOPF, F. . Researchers study anxiety differences between females and males.. Indiana University School of Medicine Newsroom.

• DE OLIVEIRA SERGIO, THATIANE ; HOPF, FREDERIC W. . Anxiety Differences Between Females and Males.. Neuroscience News.

• Oliveira Sergio, Thatiane ; ZANGROSSI JUNIOR, H. . Repeated dorsal periaqueductal gray injection of corticotrophin-releasing fator facilitates the expression of a panic response.. In: 25th ECNP Congress, 2012, 2012, Viena. European Neuropsychopharmacology,, 2012.

• Oliveira Sergio, Thatiane ; ZANGROSSI Jr H . Facilitation of panic-related defensive behaviors after corticotrophin-releasing factor (CRF) injection in the rat dorsal periaqueductal gray.. In: In 21th IBNS Meeting, 2012, Kona-Hawai. In 21th IBNS Meeting, 2012.

• Oliveira Sergio, Thatiane ; ZANGROSSI JUNIOR, H. . Facilitation of panic-related defensive behaviors after corticotrophin-releasing factor (CRF) injection in the rat dorsolateral periaqueductal gray.. In: I Simpósio Internacional sobre Modelos Translacionais do Transtorno do Pânico, 2012. I Simpósio Internacional sobre Modelos Translacionais do Transtorno do Pânico, 2012.

• Gomes RC ; Oliveira Sergio, Thatiane ; ZANGROSSI Jr H . Efeito da administração aguda e crônica da moclobemida em ratos submetidos ao teste do conflito de Vogel.. In: 19˚ Congresso Internacional de Iniciação Cientifica., 2011, Ribeirão Preto. 19˚ Congresso Internacional de Iniciação Cientifica., 2011.

• SERGIO, T. O. ; de BORTOLI VC ; Zangrossi, Helio . Papel da neurotransmissão Gabaérgica sobre o efeito panicolítico de agonista de receptores 5HT2 na substância cinzenta periaquedutal dorsal.. In: Reunião Anual do Instituto de Neuropsicologia e Comportamento do Fórum em Neurobiologia do Estresse,, 2010, Rio de Janeiro. Reunião Anual do Instituto de Neuropsicologia e Comportamento do Fórum em Neurobiologia do Estresse,, 2010.

• SERGIO, T. O. ; de BORTOLI VC ; ZANGROSSI Jr H . Activation of 5-HT2A receptors in the dorsal periaqueductal gray causes antiaversive effect by facilitating gaba neurotransmission. In: XXIV Reunião anual da Federação de Sociedades de Biologia Experimental, 2009, águas de lindóis. XXIV Reunião anual da Federação de Sociedades de Biologia Experimental, 2009.

• ANDRADE TGCS ; SERGIO, T. O. ; BROIZ, A. C. G. ; AVANZI, V . The effect of oestradiol banzoate in the median raphe nucleus on the exploratory behaviour in forced swimming test.. In: 4th International Meeting Steroids and Nervous System, 2007, Madrid. 4th International Meeting Steroids and Nervous System, 2007.

• SERGIO, T. O. ; ANDRADE TGCS . Efeito da microinjeção direta de Benzoato de Estradiol no Núcleo Mediano da Rafe sobre o comportamento exploratório no Teste do Nado Forçado.. In: Encontro Anual de Etologia, 2005, Assis. XXIII Encontro Anual de Etologia, 2005.

• DE OLIVEIRA SERGIO, THATIANE ; HOPF, FREDERIC W. . Do female and male rats use anterior insula differently to drive alcohol-only and compulsionlike drinking?. 2023. (Apresentação de Trabalho/Conferência ou palestra).

• DE OLIVEIRA SERGIO, THATIANE . ?Papel dos circuitos noradrenérgicos no consumo e compulsão ao álcool em roedores?. 2023. (Apresentação de Trabalho/Conferência ou palestra).

• DE OLIVEIRA SERGIO, THATIANE . Differential regulation of compulsion-like alcohol drinking across the estrus cycle -. 2020. (Apresentação de Trabalho/Conferência ou palestra).

• DE OLIVEIRA SERGIO, THATIANE . Anterior Insula to Locus Coeruleus inputs on compulsive alcohol drinking: role α1 adrenergic signaling. 2019. (Apresentação de Trabalho/Seminário).

• DE OLIVEIRA SERGIO, THATIANE . Effects of dorsal periaqueductal gray CRF1- and CRF2-receptor stimulation in animal models of panic. 2014. (Apresentação de Trabalho/Conferência ou palestra).

• COSTA, H. H. V. ; SERGIO, T. O. ; Oliveira DCG ; ZUARDI, A. ; ZANGROSSI JUNIOR, H. . EFFECTS OF OXYTOCIN INJECTION INTO THE DORSAL PERIAQUEDUCTAL GRAY OF RATS TESTED IN THE ELEVATED T-MAZE. 2014. (Apresentação de Trabalho/Simpósio).

• STARSKI, P. ; MORNINGSTAR, M. ; KATNER, S. ; FRASIER, R. ; DE OLIVEIRA SERGIO, THATIANE ; WEAN, S. ; HOPF, FREDERIC WOODWARD . Anterior insular cortex firing links initial and sustained encoding during aversion-resistant alcohol consumption 2022 (Preprint).

• DE OLIVEIRA SERGIO, THATIANE ; WEAN, SARAH ; KATNER, S. ; HOPF, F. WOODWARD . [PDF] de biorxiv.org THE ROLE OF ALPHA-AND BETA-ADRENERGIC RECEPTORS ON COMPULSION-LIKE ALCOHOL DRINKING 2022 (Preprint).

• SERGIO, T. O. ; Darevsky D ; SOARES, V. P. ; ALBINO, M. C. ; MAULUCCI, D. ; WEAN, S. ; HOPF, F. W. . Evidence for different greater-persistence strategies under lower and higher challenge for alcohol in female rats 2022 (Preprint).

Projetos de pesquisa

• 2023 - Atual

  Anterior Insula Projections for Alcohol Drinking/Anxiety Interactions in Female and Male Rats, Descrição: Abstract Alcohol Use Disorder (AUD) extracts substantial medical, social, and economic costs, and compulsion-like alcohol drinking (CLAD), where intake persists despite negative consequences, can be a particular obstacle to treatment. Also concerning is that problem drinking in women has risen dramatically, and women can have greater alcohol problems. However, mechanisms underlying sex differences remain poorly understood, although anxiety-like states can strongly contribute to alcohol drinking, and women have greater prevalence of mood disorders and AUD/anxiety comorbidity. Also, our rat studies suggest that females have greater persistence in responding for alcohol, as well as greater anxiety-like responding. Thus, to help develop better, personalized therapies, it is essential to understand sex differences and similarities in mechanisms underlying excessive drinking and comorbidity with anxiety. Alcohol intake is likely driven by its salient motivational properties, and anterior insula (aINS) is a critical regulator of responding to important situations and regulating accompanying emotional states. We find that specific aINS projections (including aINS-Nucleus Accumbens, NAcb) promote male CLAD, with little impact on alcohol-only drinking (AOD); in agreement, compulsion-like responding for alcohol in women and men with AUD activates a similar aINS circuit. However, very little is known about specific aINS mechanisms for alcohol drinking in females, or overcoming higher challenge more generally. Also, global aINS inhibition reduces AOD, but the underlying aINS projection(s) remain completely undiscovered. Here, we address the overarching hypothesis that different aINS circuits drive CLAD vs AOD, and, especially, that particular aINS circuits mediate both CLAD and anxiety-like behavior (ALB) in higher-anxiety individuals, which is especially cogent in females. Aim 1 uses projection-specific optogenetic inhibition to examine particular aINS projections for AOD and CLAD: aINS-NAcb and aINS- amygdala for CLAD, and aINS-posterior insula (pINS) for AOD. aINS-pINS projection is large, and pINS inhibition decreases drinking, but aINS-pINS is nearly unstudied in rodent. Also, to best understand how aINS outputs regulate behavior, it is critical to identify actual activity patterns within specific aINS projections. Thus, Aim 2 uses cutting edge in vivo electrophysiology recording methods with opto-tagging to identify firing patterns within specific aINS projections, especially predicted higher activity in females that underlies greater persistence for alcohol. Finally, Aim 3 examines potential sex differences in the relation between ALB and alcohol drinking, aINS encoding of these behaviors, and the impact of optogenetic inhibition of specific aINS projections on both ALB and drinking. We predict that higher ALB rats will have greater aINS encoding of both ALB and drinking, and greater optogenetic inhibition of ALB and intake, particularly in females. If successful, we will discover key aINS projection mechanisms that drive AOD, CLAD, ALB, and their interrelations, including important sex differences, which may open novel, sex-specific AUD treatments.NIH 1R01AA030710-01. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Thatiane de Oliveira Sergio - Integrante / HOPF, FREDERIC W. - Coordenador.

• 2018 - 2020

  Encoding and regulation of compulsion-like alcohol drinking by subtypes of nucleus accumbens core neurons, Descrição: This proposal is aimed at studying mechanisms that drive compulsion-like alcohol drinking (CLAD). Compulsive alcohol intake is characterized by drinking that persists even when alcohol is paired with adverse social, legal and physical consequences, and this consequence-resistant intake is a major obstacle to treating alcohol use disorder (AUD). Thus, we have pioneered the use of rat models to identify brain circuits that underlie CLAD, where drinking continues even when alcohol is paired with aversive stimuli. However, little is known about brain circuits that promote CLAD, especially brain areas that process aversion and allow alcohol drinking to continue in the face of adverse consequences. We previously discovered that the nucleus accumbens core (Core) is a critical region that drives CLAD. The Core has two main types of neurons, which have differential dopamine receptor expression that helps define them as D1-cells versus D2-cells. Although Core D1-cells promote while D2-cells inhibit many addiction-related behaviors, including compulsive cocaine intake, nothing is known about Core D1- and D2-cell activity during alcohol drinking, with or without negative consequences, or the importance of Core D1- or D2-cells for driving CLAD. Since D1-cells promote many behaviors, we predict that increased D1-cell activity will support CLAD. In contrast, D2-cells often promote avoidance of aversive states. Thus, we propose that Core D2-cell activity will be reduced during CLAD, which may be crucial for allowing intake in the face of aversion to persist. Also, we find that CLAD has particular focus on initiation of alcohol-drinking bouts, and we propose that D1-cell activity will be important at the onset of CLAD bouts. To test these possibilities, we use novel genetically-modified rat lines to specifically target Core D1- and D2-cells.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Thatiane de Oliveira Sergio - Integrante / HOPF, FREDERIC W. - Coordenador / Josh Berke - Integrante.

• 2017 - 2021

  Insula Circuitry and Compulsive Alcohol Drinking, Descrição: The proposal aimed at studying mechanisms that drive compulsion-like alcohol drinking. Compulsive alcohol intake is characterized by drinking that persists even when alcohol is paired with adverse social, legal and physical consequences, and this aversion-resistant intake is a major obstacle to treating alcohol use disorders (AUDs). Thus, we have pioneered the use of rat models to identify brain circuits that underlie compulsion-like intake, where drinking continues even when alcohol is paired with aversive stimuli. However, little is known about brain circuits that promote compulsive addiction, especially the role of brain areas that control responding to aversion. Human and animal studies implicate anterior insula (aINS) and connected brain regions in abuse of drugs and alcohol. In humans, alcohol-cues activate aINS circuitry, and the level of activity can predict future intake, suggesting a causal role in driving addictive behaviors. The few animal studies support these human data, and our recent work found that the aINS, through inputs to nucleus accumbens, promotes compulsion-like drinking. Given the importance of aversion-resistant responding during compulsion-like intake, it is interesting that the aINS also regulates aversion-related behavior, and projects to powerful regulators of stress and aversion, the central amygdala (CeA) and locus coeruleus/parabrachial areas (LCPB). The CeA mediates conditioned and unconditioned responses to aversive stimuli, as well as excessive alcohol intake. The LCPB mediates stress responses through activation of noradrenaline receptors (NAdrRs), and NAdrRs promote excessive drinking in rodents and humans. Given the importance of these pathways for responding to aversion, we hypothesize that aINS activation of CeA and LCPB, and subsequent activation of NAdRs, promote compulsion-like drinking. In addition, aINS glutamate receptors are likely to be essential for activating these aINS projections, and, based on our preliminary results, we further hypothesize that calcium-permeable AMPA-type glutamate receptors (CP- AMPARs) within the aINS mediate compulsion-like drinking. We will test these hypotheses using powerful opto- and chemo-genetics techniques to functionally isolate and define the role of aINS-CeA and aINS- LCPB inputs during alcohol drinking, in combination with receptor pharmacology, projection tracing methods and ex vivo electrophysiology.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Thatiane de Oliveira Sergio - Integrante / LEI, KELLY - Integrante / Frederic Hopf - Coordenador.