Sebastiaan Frans Teunissen

Bas Teunissen, PhD in bio-analytical chemistry (University of Utrecht). Master of science in analytical chemistry (Free University, Amsterdam). During my bachelor and master study I studied high resolution fluorescence and Raman spectroscopy as well as on-line sample pretreatment of biological material. During my PhD I specialized in identification and quantification of drugs and their metabolites in biological material using liquid chromatography and various types of mass spectrometry. In collaboration with the Antoni van Leeuwenhoek Hospital / Dutch Cancer Institute in Amsterdam, analytical methods were developed to facilitate so-called personalized medicine for cancer patients. As a forensic scientist at the Toxicology laboratory of the Netherlands Forensic Institute I was responsible for the quality control and assurance of all methods within the laboratory. I performed method development and data processing of non-regular case work and data interpretation of toxicological screening in biological matrices. As a study director of research projects for the development of quantitative methods in whole blood and dried blood spots of illicit drugs I have been working together with prof. Graham Cooks at Purdue University which included a 3 week work visit at Purdue University where I worked on ambient mass spectrometry such as Paper spray mass spectrometry. Currently I am a post doctoral research fellow at Thomson Mass Spectrometry Laboratory at Unicamp in Campinas, Brazil under the supervision of prof. Marcos Eberlin. Here, I focus on the development of ambient mass spectrometry methods in forensic settings.

Informações coletadas do Lattes em 09/11/2022

Acadêmico

Formação acadêmica

Doutorado em Bioanalytical Chemistry

2007 - 2011

Utrecht University
Título: Bioanalysis and metabolism of tamoxifen and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine - Applications in pharmacology
Orientador: prof. J.H. Beijnen and prof. J.H.M. Schellens

Mestrado em Analytical Chemistry

2004 - 2007

Free University Of Amsterdam
Título: Development and evaluation of a down-scaled SPE-LC system for direct injection and fully automated on-line UV analysis of antifungal drugs in human plasma,Ano de Obtenção: 2007
Orientador: prof. dr. dr. K-S Boos

Graduação em Analytical Chemistry

2000 - 2004

Inholland University of Applied Sciences
Título: Raman spectroscopy as a detection method for capillary electrophoresis; enhancing the Raman signal using silver surfaces
Orientador: dr. Freek Ariese and dr. Evtim Efremov

Pós-doutorado

2015

Pós-Doutorado. , Universidade Estadual de Campinas, UNICAMP, Brasil. , Bolsista do(a): Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. , Grande área: Ciências Exatas e da Terra / Área: Química / Subárea: Química Analítica.

Idiomas

Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Espanhol

Compreende Razoavelmente, Fala Pouco, Lê Razoavelmente, Escreve Pouco.

Português

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Alemão

Compreende Bem, Fala Razoavelmente, Lê Razoavelmente, Escreve Razoavelmente.

Holandês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Áreas de atuação

Grande área: Ciências Exatas e da Terra / Área: Química.

Participação em eventos

International Mass Spectrometry School. 2015. (Seminário).

Produções bibliográficas

VLAMING, M. L. H. ; TEUNISSEN, S. F. ; VAN DE STEEG, E. ; VAN ESCH, A. ; WAGENAAR, E. ; BRUNSVELD, L. ; DE GREEF, T. F. A. ; ROSING, H. ; SCHELLENS, J. H. M. ; BEIJNEN, J. H. ; SCHINKEL, A. H. . Bcrp1;Mdr1a/b;Mrp2 Combination Knockout Mice: Altered Disposition of the Dietary Carcinogen PhIP (2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine) and Its Genotoxic Metabolites. Molecular Pharmacology , v. 85, p. 520-530, 2014.
ESPY, RYAN D. ; TEUNISSEN, SEBASTIAAN FRANS ; MANICKE, NICHOLAS E. ; REN, YUE ; OUYANG, ZHENG ; VAN ASTEN, ARIAN ; COOKS, R. GRAHAM . Paper Spray and Extraction Spray Mass Spectrometry for the Direct and Simultaneous Quantification of Eight Drugs of Abuse in Whole Blood. Analytical Chemistry (Washington) , v. 86, p. 7712-7718, 2014.
TEUNISSEN, S. F. ; ROSING, H. ; BRUNSVELD, L. ; DE GREEF, T. F. A. ; DURMUS, S. ; SCHELLENS, J. H. M. ; SCHINKEL, A. H. ; BEIJNEN, J. H. . Analysis of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and Its Phase I and Phase II Metabolites in Mouse Urine Using LC-UV-MS-MS. Chromatographia (Wiesbaden) , v. 74, p. 215-226, 2011.
TEUNISSEN, S.F. ; ROSING, H. ; SEOANE, M. DOMINGUEZ ; BRUNSVELD, L. ; SCHELLENS, J.H.M. ; SCHINKEL, A.H. ; BEIJNEN, J.H. . Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques. Journal of Pharmaceutical and Biomedical Analysis (Print) , v. 55, p. 518-526, 2011.
TEUNISSEN, S.F. ; JAGER, N.G.L. ; ROSING, H. ; SCHINKEL, A.H. ; SCHELLENS, J.H.M. ; BEIJNEN, J.H. . Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry. Journal of Chromatography. B (Print) , v. 879, p. 1677-1685, 2011.
IUSUF, D. ; TEUNISSEN, S. F. ; WAGENAAR, E. ; ROSING, H. ; BEIJNEN, J. H. ; SCHINKEL, A. H. . P-Glycoprotein (ABCB1) Transports the Primary Active Tamoxifen Metabolites Endoxifen and 4-Hydroxytamoxifen and Restricts Their Brain Penetration. The Journal of Pharmacology and Experimental Therapeutics (Print) , v. 337, p. 710-717, 2011.
DE GRAAN, A.-J. M. ; TEUNISSEN, S. F. ; DE VOS, F. Y. F. L. ; LOOS, W. J. ; VAN SCHAIK, R. H. N. ; DE JONGH, F. E. ; DE VOS, A. I. ; VAN ALPHEN, R. J. ; VAN DER HOLT, B. ; VERWEIJ, J. ; SEYNAEVE, C. ; BEIJNEN, J. H. ; MATHIJSSEN, R. H. J. . Dextromethorphan As a Phenotyping Test to Predict Endoxifen Exposure in Patients on Tamoxifen Treatment. Journal of Clinical Oncology , v. 29, p. 3240-3246, 2011.
TEUNISSEN, S.F. ; VLAMING, M.L.H. ; ROSING, H. ; SCHELLENS, J.H.M. ; SCHINKEL, A.H. ; BEIJNEN, J.H. . Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in plasma, urine, bile, intestinal contents, faeces and eight selected tissues from mice. Journal of Chromatography. B (Print) , v. 878, p. 2353-2362, 2010.
TEUNISSEN, S.F. ; ROSING, H. ; SCHINKEL, A.H. ; SCHELLENS, J.H.M. ; BEIJNEN, J.H. . Review on the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its phase I and phase II metabolites in biological matrices, foodstuff and beverages. Journal of Chromatography. B (Print) , v. 878, p. 3199-3216, 2010.
TEUNISSEN, S.F. ; ROSING, H. ; SCHINKEL, A.H. ; SCHELLENS, J.H.M. ; BEIJNEN, J.H. . Bioanalytical methods for determination of tamoxifen and its phase I metabolites: A review. Analytica Chimica Acta (Print) , v. 683, p. 21-37, 2010.
TEUNISSEN, S.F. ; KOORNSTRA, R.H.T. ; LINN, S.C. ; SCHELLENS, J.H.M. ; SCHINKEL, A.H. ; BEIJNEN, J.H. . Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry. Journal of Chromatography. B (Print) , v. 877, p. 2519-2529, 2009.

Projetos de pesquisa

2015 - Atual

EDITAL PROGRAMA CIÊNCIAS FORENSES nº 25/2014 PRÓ-FORENSES, Descrição: O Pró-Forenses tem por objetivo estimular no País a realização de projetos conjuntos de pesquisa utilizando-se de recursos humanos e de infraestrutura disponíveis em diferentes IES e/ou demais instituições enquadráveis nos termos deste Edital, possibilitando a produção de pesquisas científicas e a formação de recursos humanos pós-graduados aplicados em Ciências Forenses, contribuindo, assim, para desenvolver e consolidar o pensamento brasileiro na área.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (4) . , Integrantes: Sebastiaan Frans Teunissen - Integrante / Marcos Nogueria Eberlin - Coordenador / Rodrigo Borges de Oliveira - Integrante / Rodrigo Soares de Moura Neto - Integrante / Jorge Jardim Zacca - Integrante / Deleon Nascimento Correa - Integrante / Damila Rodrigues de Morais - Integrante / Ana Carolina de Aguiar - Integrante / Vinicius Veri Hernandes - Integrante., Financiador(es): CAPES - Centro Anhanguera de Promoção e Educação Social - Auxílio financeiro.

Prêmios

2004

Innovation stimulating award, Small and medium-sized enterprises in The Netherlands.

2004

Honorable mention for 'Gouden Spatel' for best written Bachelor Thesis, Royal Dutch Chemistry Society.

Histórico profissional

Endereço profissional

Universidade Estadual de Campinas, Instituto de Química, Thomson Mass Spectrometry Laboratory. , AC Unicamp, Cidade Universitária, 13083970 - Campinas, SP - Brasil, Telefone: (19) 983418110

Experiência profissional

2015 - Atual

Universidade Estadual de Campinas

Vínculo: Visitor Professor, Enquadramento Funcional: Professor Visitante do Exterior, Carga horária: 40

Outras informações:
- Development of ambient mass spectrometry methods in forensic settings. - Analysis of lipid profiles in fish using ambient mass spectrometry. - Writing feature articles and assisting colleagues with writing scientific articles in English

2011 - 2014

Netherlands Forensic Institute

Vínculo: , Enquadramento Funcional: Senior Scientist - toxicology laboratory, Carga horária: 36, Regime: Dedicação exclusiva.

Outras informações:
- Responsible for quality control and assurance of all analytical methods within the toxicology laboratory including ISO17025 certified methods. - Method development and data processing of non-regular case work / research concerning the qualitative and quantitative analyses of prescribed and illicit drugs in various biological matrices. - Data interpretation of toxicological screening in biological matrices using GC-MSn, LC-MSn, LC-UV. - Study director of research projects for the development of both a paperspray method and an LC-MS/MS method for the quantification in whole blood and dried blood spots of 10 illicit drugs within the Dutch Road Traffic Act, and its application in forensic case work in collaboration with prof. R.G. (Graham) Cooks including a work visit to Purdue University of 3 weeks. - Set-up an international collaboration between Purdue University, Thermo Fisher Scientific, Prosolia and The Netherlands Forensic Institute on paper spray research and development.