Carlo de Oliveira Martins

Pós-doutorado

Formação complementar

Idiomas

Áreas de atuação

Organização de eventos

Participação em eventos

Produções bibliográficas

• VAN WONDEREN, JESSICA H. ; CRACK, JASON C. ; EDWARDS, MARCUS J. ; CLARKE, THOMAS A. ; SAALBACH, GERHARD ; Martins, Carlo ; BUTT, JULEA N. . Liquid-chromatography mass spectrometry describes post-translational modification of Shewanella outer membrane proteins. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES , v. 1866, p. 184221, 2024.

• BRIDGE, THOMAS ; WEGMANN, UDO ; CRACK, JASON C. ; ORMAN, KATE ; SHAIKH, SAHER A. ; FARNDON, WILLIAM ; Martins, Carlo ; SAALBACH, GERHARD ; SACHDEVA, AMIT . Site-specific encoding of photoactivity and photoreactivity into antibody fragments. Nature Chemical Biology , v. 01, p. 1, 2023.

• THOMPSON, CATRIONA M. A. ; HALL, JAMES P. J. ; CHANDRA, GOVIND ; Martins, Carlo ; SAALBACH, GERHARD ; PANTURAT, SUPAKAN ; BIRD, SUSANNAH M. ; FORD, SAMUEL ; LITTLE, RICHARD H. ; PIAZZA, AINELEN ; HARRISON, ELLIE ; JACKSON, ROBERT W. ; BROCKHURST, MICHAEL A. ; MALONE, JACOB G. . Plasmids manipulate bacterial behaviour through translational regulatory crosstalk. PLOS BIOLOGY , v. 21, p. e3001988, 2023.

• MCLEAN, THOMAS C. ; BEATON, AINSLEY D. M. ; Martins, Carlo ; SAALBACH, GERHARD ; CHANDRA, GOVIND ; WILKINSON, BARRIE ; HUTCHINGS, MATTHEW I. . Evidence of a role for CutRS and actinorhodin in the secretion stress response in Streptomyces coelicolor M145. MICROBIOLOGY-SGM , v. 169, p. 001358, 2023.

• KAMBLE, NITIN UTTAM ; MAKHAMADJONOV, FARRUKH ; FAHY, BRENDAN ; Martins, Carlo ; SAALBACH, GERHARD ; SEUNG, DAVID . Initiation of B-type starch granules in wheat endosperm requires the plastidial α-glucan phosphorylase PHS1. PLANT CELL , v. 35, p. 4091-4110, 2023.

• POLTURAK, GUY ; MISRA, RAJESH CHANDRA ; EL-DEMERDASH, AMR ; OWEN, CHARLOTTE ; STEED, ANDREW ; MCDONALD, HANNAH P. ; WANG, JIAOJIAO ; SAALBACH, GERHARD ; Martins, Carlo ; CHARTRAIN, LAETITIA ; WILKINSON, BARRIE ; NICHOLSON, PAUL ; OSBOURN, ANNE . Discovery of isoflavone phytoalexins in wheat reveals an alternative route to isoflavonoid biosynthesis. Nature Communications , v. 14, p. 6977, 2023.

• APPIA'AYME, CORINNE ; LITTLE, RICHARD ; CHANDRA, GOVIND ; de Oliveira Martins, Carlo ; BUENO BATISTA, MARCELO ; DIXON, RAY . Interactions between paralogous bacterial enhancer binding proteins enable metal-dependent regulation of alternative nitrogenases in. MOLECULAR MICROBIOLOGY , v. X, p. XX, 2022.

• LI, JIE ; SCARANO, AURELIA ; GONZALEZ, NESTOR MORA ; D?ORSO, FABIO ; YUE, YAJUAN ; NEMETH, KRISZTIAN ; SAALBACH, GERHARD ; HILL, LIONEL ; de Oliveira Martins, Carlo ; MORAN, ROLANDO ; SANTINO, ANGELO ; MARTIN, CATHIE . Biofortified tomatoes provide a new route to vitamin D sufficiency. NATURE PLANTS , v. XX, p. XX, 2022.

• MIKULSKI, PAWEL ; WOLFF, PHILIP ; LU, TIANCONG ; NIELSEN, MATHIAS ; ECHEVARRIA, ELSA FRANCO ; ZHU, DANLING ; QUESTA, JULIA I. ; SAALBACH, GERHARD ; Martins, Carlo ; DEAN, CAROLINE . VAL1 acts as an assembly platform co-ordinating co-transcriptional repression and chromatin regulation at Arabidopsis FLC. Nature Communications , v. 13, p. 5542, 2022.

• PERROTTA, ALLISON R. ; BORRELLI, GIULIANO M. ; Martins, Carlo O. ; KALLAS, ESPER G. ; SANABANI, SABRI S. ; GRIFFITH, LINDA G. ; ALM, ERIC J. ; ABRAO, MAURICIO S. . The Vaginal Microbiome as a Tool to Predict rASRM Stage of Disease in Endometriosis: a Pilot Study. Reproductive Sciences (Thousand Oaks. Online) , v. 1, p. xxx, 2020.

• Martins, Carlo O. ; HUET, SARAH ; YI, SAN S. ; RITORTO, MARIA S. ; LANDGREN, OLA ; DOGAN, AHMET ; CHAPMAN, JESSICA R. . Mass Spectrometry-Based Method Targeting Ig Variable Regions for Assessment of Minimal Residual Disease in Multiple Myeloma. JOURNAL OF MOLECULAR DIAGNOSTICS , v. 22, p. 901-911, 2020.

• DANELLA FIGO, DANIELE ; DE AMICIS, KARINE ; NEIVA SANTOS DE AQUINO, DENISE ; POMIECINSKI, FABIANE ; Gadermaier, Gabriele ; BRIZA, PETER ; EDUARDO SANTOS GALVÃO, CLOVIS ; BUSSADOR DO AMARAL, JÔNATAS ; de Oliveira Martins, Carlo ; FERNANDES MORATO CASTRO, FABIO ; Kalil, Jorge ; SOUZA SANTOS, KEITY . Cashew Tree Pollen: An Unknown Source of IgE-Reactive Molecules. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 20, p. 2397, 2019.

• Martins, Carlo O. ; LEZCANO, CECILLIA ; YI, SAN S. ; LANDAU, HEATHER J. ; CHAPMAN, JESSICA R. ; DOGAN, AHMET . Novel iatrogenic amyloidosis caused by peptide drug liraglutide: a clinical mimic of AL amyloidosis. HAEMATOLOGICA , v. 103, p. haematol.2018.203000, 2018.

• MARTINS, C. O. ; DEMARCHI, LEA ; FERREIRA, FREDERICO MORAES ; POMERANTZEFF, PABLO MARIA ALBERTO ; BRANDAO, CARLOS ; SAMPAIO, RONEY ORISMAR ; SPINA, GUILHERME SOBREIRA ; KALIL, J. ; Cunha-Neto, Edecio ; Guilherme, Luiza . Rheumatic Heart Disease and Myxomatous Degeneration: Differences and Similarities of Valve Damage Resulting from Autoimmune Reactions and Matrix Disorganization. PLoS One , v. 12, p. e0170191, 2017.

• Cunha-Neto, Edecio ; MARTINS, C. O. ; SOUZA SANTOS, KEITY ; MORAES FERREIRA, FREDERICO ; CAMILLO TEIXEIRA, PRISCILA ; MARIA ALBERTO POMERANTZEFF, PABLO ; M. A. BRANDÃO, CARLOS ; ORISMAR SAMPAIO, RONEY ; S. SPINA, GUILHERME ; KALIL, J. ; Guilherme, Luiza . Distinct Mitral Valve Proteomic Profiles in Rheumatic Heart Disease and Myxomatous Degeneration. Clinical Medicine Insights: Cardiology , v. 27, p. 79-86, 2014.

• DE AMICIS, KARINE M. ; DE BARROS, SAMAR FRESCHI ; ALENCAR, RAQUEL E. ; POSTÓL, EDILBERTO ; MARTINS, CARLO DE OLIVEIRA ; ARCURI, HELEN ANDRADE ; GOULART, CIBELLY ; Kalil, Jorge ; Guilherme, Luiza . Analysis of the coverage capacity of the StreptInCor candidate vaccine against Streptococcus pyogenes. Vaccine (Guildford) , v. xxxx, p. xxxxx, 2013.

• Santos, Keity Souza ; Gadermaier, Gabriele ; VEJVAR, EVA ; ARCURI, HELEN ANDRADE ; GALVÃO, CLOVIS EDUARDO ; Yang, Ariana Campos ; RESENDE, VIRGÍNIA MARIA FERREIRA ; MARTINS, C. O. ; HIMLY, MARTIN ; MARI, ADRIANO ; LISO, MARINA ; POMPONI, DEBORA ; BREITENEDER, HEIMO ; WAGNER, STEFAN ; KALIL, J. ; FERREIRA, FÁTIMA ; Castro, Fábio Fernandes Morato . Novel allergens from ancient foods: Man e 5 from manioc ( Manihot esculenta Crantz) cross reacts with Hev b 5 from latex. MOLECULAR NUTRITION & FOOD RESEARCH , v. 57, p. n/a-1109, 2013.

• Santos, Keity Souza ; MARTINS, C. O. ; Kalil, Jorge ; Castro, Fabio Fernandes Morato ; de Oliveira Martins, Carlo ; Gadermaier, Gabriele ; Yang, Ariana Campos ; PALMA, M. S. ; Palma, Mario Sergio ; Ferreira, Fatima ; Galvao, Clovis Eduardo ; Misumi, Denise Shimbo . Allergic reactions to manioc (Manihot esculenta Crantz): Identification of novel allergens with potential involvement in latex-fruit syndrome. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY , v. 128, p. 1367-1369, 2011.

• Guerino, Milton T. ; Postol, Edilberto ; Demarchi, Lea M.F. ; MARTINS, C. O. ; Mundel, Luiz R. ; Kalil, Jorge ; Guilherme, L . HLA class II transgenic mice develop a safe and long lasting immune response against StreptInCor, an anti-group A streptococcus vaccine candidate. VACCINE , v. 29, p. 8250-8256, 2011.

• SANTOS SOUZA, KEITY ; GALVAO, CLOVIS ; FERREIRA, RESENDE ; VIRGINIA, MARIA ; Martins, Carlo ; VEVJAR, EVA ; Gadermaier, Gabriele ; Ferreira, Fatima ; Kalil, Jorge ; FERNANDES MORATO-CASTRO, FABIO . Identification of new Brazilian allergens from manioc (Manihot esculenta). Clinical and Translational Allergy , v. 1, p. O7, 2011.

• MARTINS, C. O. ; Ritorto, M. S. ; HUET, S. ; Pichardo, J ; YI, S. S. ; LANDGREN, O. ; DOGAN, A. . Use of a MS-based Targeted Approach for Detection of Minimal Residual Disease (MRD) in Multiple Myeloma. 2018. (Apresentação de Trabalho/Congresso).

• MARTINS, C. O. ; DOGAN, A. ; Ritorto, M. S. . Targeted Analysis of clonotypic peptides in plasma cell dyscrasias. 2017. (Apresentação de Trabalho/Seminário).

• MELLO, D. ; STANTON, M. ; Martins, Carlo . Trabalhando em Redes Globais de Conhecimento. 2015. (Apresentação de Trabalho/Conferência ou palestra).

• MARTINS, C. O. ; Freitas, O. J. . Gestão da qualidade em análises clínicas: fundamentos e aplicação de ferramentas. 2008. (Apresentação de Trabalho/Conferência ou palestra).

• MARTINS, C. O. . A qualidade no laboratório clínico: o que esperar dos resultados?. 2005. (Apresentação de Trabalho/Conferência ou palestra).

Projetos de pesquisa

• 2016 - 2018

  Proteomica direcionada aplicada `a deteccao de doenca residual minima em mieloma multiplo, Descrição: Utilizo sequenciamento por RACE-PCR e DeNovo no estudo das porcoes variaveis de anticorpos produzidos por portadoes de mieloma multiplo. A deteccao deste peptideos derivados deste anticorpo - dito clonotipico - e' feita no momento do diagnostico e apos o tratamento, para detectar a presenca de doenca residual minima. Para este deteccao, utilizamos abordagem proteomica direcionada por espectrometria de massas (PRM) apos enriquecimento da amostra para cadeias kappa ou lambda, de acordo com o clonotipo expandido em cada paciente.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Carlo de Oliveira Martins - Integrante / Ahmet Dogan - Coordenador / Maria Stella Ritorto - Integrante.

• 2015 - 2016

  Analise do secretoma em celulas de mamiferos produtoras de anticorpos, Descrição: Secreted proteins such as chemokines, cytokines and hormones are mediators of important biological processes, including cell-cell communication, proliferation and differentiation and are often involved in the pathophysiology of inflammation, autoimmunity, cancer, and other diseases. For this reason, the discovery of secreted proteins to target for the treatment of disease is very important for multiple therapeutic areas. However, due technical limitations which make the detection of very low abundance proteins within biological samples very difficult due to masking, such as in serum or in situations where non-secreted proteins are released from cells after lysis or death, these proteins can be difficult to discover and characterize. For this reason, we will develop a mass spec (MS) based proteomics technique to characterize secreted proteins, also referred to as the secretome, and compare the secretome of two or more cell populations with the goal of discovering differentially secreted proteins. The method that will be used combines two metabolic labelling systems, AHA (azidohomoalanine) and SILAC (stable isotope labeling with amino acids in cell culture), which will be coupled to MS-based proteomics techniques to quantify newly secreted proteins. This will allow us to distinguish between newly synthesized proteins and the high abundant or interfering non-secreted proteins that are often released in cell cultures. As a first effort, we will utilize CHO as a model secretion system because it is easy to work with and we have much experience in handling them as expression hosts for our biologic drugs. More specifically, CAT-S CHO cell lines that express high or low levels of bispecific Abs will be used to establish AHA and SILAC labeling and MS coupled techniques. In the second phase of the project, these newly developed capabilities will be applied to compare CD4 and CD8 T cells from normal individuals and patients suffering from systemic lupus erythematosus (SLE) to characterize the repertoire of secreted proteins from these two cell types, which will aid in the study of the biology of these cells in disease, biomarker discovery, and hopefully new target discovery.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Carlo de Oliveira Martins - Integrante / Michael Bowen - Coordenador / Deniz Baycin-Hizal - Integrante.

• 2013 - 2014

  Caracterização da microbiota em mulheres com endometriose pélvica, Descrição: O objetivo do projeto é caracterizar as diferenças da microbiota oral, vaginal e retal em mulheres com e sem endometriose pélvica, e correlacionar os resultados com o local e estadiamento das lesões. , Situação: Desativado; Natureza: Pesquisa. , Integrantes: Carlo de Oliveira Martins - Integrante / Maurício Simões Abrão - Coordenador.

• 2009 - 2013

  Análise proteômica diferencial na doença reumática cardíaca, Descrição: Proteínas de fragmentos de biópsias de válvulas mitrais acometidas por doença reumática cardíaca, e por degeneração mixomatosa, foram separadas por 2DE-DIGE. As proteínas com expressão diferencial, em relação a tecido sadio, foram identificadas por ESI-MS/MS. Através de análise computacional de interações proteína-proteína, importantes redes metabólicas envolvidas no desenvolvimento/manutenção da lesão reumática foram encontradas.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Carlo de Oliveira Martins - Coordenador / Luiza Guilherme - Integrante / Edecio Cunha-Neto - Integrante / Jorge Kalil - Integrante.