Michael Huber

Pós-doutorado

Idiomas

Áreas de atuação

Produções bibliográficas

• HABIB, PARDES ; STAMM, ANN-SOPHIE ; ZEYEN, THOMAS ; NORISTANI, ROZINA ; SLOWIK, ALEXANDER ; BEYER, CORDIAN ; WILHELM, THOMAS ; HUBER, MICHAEL ; KOMNIG, DANIEL ; SCHULZ, JÖRG B. ; REICH, ARNO . EPO regulates neuroprotective Transmembrane BAX Inhibitor-1 Motif-containing (TMBIM) family members GRINA and FAIM2 after cerebral ischemia-reperfusion injury. EXPERIMENTAL NEUROLOGY , v. 320, p. 112978, 2019.

• WILHELM, THOMAS ; BICK, FABIAN ; PETERS, KERSTIN ; MOHTA, VRINDA ; TIROSH, BOAZ ; PATTERSON, JOHN B. ; KHARABI-MASOULEH, BEHZAD ; HUBER, MICHAEL . Infliction of proteotoxic stresses by impairment of the unfolded protein response or proteasomal inhibition as a therapeutic strategy for mast cell leukemia. Oncotarget , v. 9, p. 29423023, 2018.

• ZORN, CAROLIN N. ; SIMONOWSKI, ANNE ; HUBER, MICHAEL . Stimulus strength determines the BTK-dependence of the SHIP1-deficient phenotype in IgE/antigen-triggered mast cells. Scientific Reports , v. 8, p. 15467, 2018.

• GAST, MATHIAS ; PREISINGER, CHRISTIAN ; NIMMERJAHN, FALK ; HUBER, MICHAEL . IgG-Independent Co-aggregation of FcεRI and FcγRIIB Results in LYN- and SHIP1-Dependent Tyrosine Phosphorylation of FcγRIIB in Murine Bone Marrow-Derived Mast Cells. Frontiers in Immunology , v. 9, p. 30210494, 2018.

• KLASEN, CHRISTINA ; ZIEHM, TAMAR ; HUBER, MICHAEL ; ASARE, YAW ; KAPURNIOTU, APHRODITE ; SHACHAR, IDIT ; BERNHAGEN, JÜRGEN ; EL BOUNKARI, OMAR . LPS-mediated cell surface expression of CD74 promotes the proliferation of B cells in response to MIF. CELLULAR SIGNALLING , v. 46, p. 32-42, 2018.

• POPLUTZ, MAGDALENA ; LEVIKOVA, MARYNA ; LÜSCHER-FIRZLAFF, JULIANE ; LESINA, MARINA ; ALGÜL, HANA ; LÜSCHER, BERNHARD ; HUBER, MICHAEL . Endotoxin tolerance in mast cells, its consequences for IgE-mediated signalling, and the effects of BCL3 deficiency. Scientific Reports , v. 7, p. 4534, 2017.

• MALER, MAREIKE D. ; NIELSEN, PETER J. ; STICHLING, NICOLE ; COHEN, IDAN ; RUZSICS, ZSOLT ; WOOD, CONNOR ; ENGELHARD, PEGGY ; SUOMALAINEN, MAARIT ; GYORY, ILDIKO ; HUBER, MICHAEL ; MÜLLER-QUERNHEIM, JOACHIM ; SCHAMEL, WOLFGANG W. A. ; GORDON, SIAMON ; JAKOB, THILO ; MARTIN, STEFAN F. ; JAHNEN-DECHENT, WILLI ; GREBER, URS F. ; FREUDENBERG, MARINA A. ; FEJER, GYÖRGY . Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages. mBio , v. 8, p. 28765216, 2017.

• ZOTZ, JULIA S. ; WÖLBING, FLORIAN ; LASSNIG, CAROLINE ; KAUFFMANN, MARLIES ; SCHULTE, UWE ; KOLB, ANDREAS ; WHITELAW, BRUCE ; MÜLLER, MATHIAS ; BIEDERMANN, TILO ; HUBER, MICHAEL . CD13/aminopeptidase N is a negative regulator of mast cell activation. FASEB JOURNAL , v. 30, p. 2225-2235, 2016.

• MEURER, STEFFEN K. ; NEß, MELANIE ; WEISKIRCHEN, SABINE ; KIM, PHILIPP ; TAG, CARMEN G. ; KAUFFMANN, MARLIES ; HUBER, MICHAEL ; WEISKIRCHEN, RALF . Isolation of Mature (Peritoneum-Derived) Mast Cells and Immature (Bone Marrow-Derived) Mast Cell Precursors from Mice. PLoS One , v. 11, p. e0158104, 2016.

• NUNES DE MIRANDA, SUSANA M. ; WILHELM, THOMAS ; HUBER, MICHAEL ; ZORN, CAROLIN N. . Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype. Cell Communication and Signaling , v. 14, p. 12, 2016.

• KUHNY, MARCEL ; HOCHDÖRFER, THOMAS ; AYATA, CEMIL KORCAN ; IDZKO, MARCO ; HUBER, MICHAEL . CD39 is a negative regulator of P2X7-mediated inflammatory cell death in mast cells. Cell Communication and Signaling , v. 12, p. 40, 2014.

• PLUM, LAURA MARIE ; BRIEGER, ANNE ; ENGELHARDT, GABRIELA ; HEBEL, SILKE ; NESSEL, ANDREAS ; ARLT, MARCUS ; KALTENBERG, JENNIFER ; SCHWANEBERG, ULRICH ; HUBER, MICHAEL ; RINK, LOTHAR ; HAASE, HAJO . PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation. Metallomics , v. 6, p. 1277, 2014.

• ZORN, CAROLIN N. ; PARDO, JULIAN ; MARTIN, PRAXEDIS ; KUHNY, MARCEL ; SIMON, MARKUS M. ; HUBER, MICHAEL . Secretory lysosomes of mouse mast cells store and exocytose active caspase-3 in a strictly granzyme B dependent manner. EUROPEAN JOURNAL OF IMMUNOLOGY , v. 43, p. 3209-3218, 2013.

• FEJER, G. ; WEGNER, M. D. ; GYORY, I. ; COHEN, I. ; ENGELHARD, P. ; VORONOV, E. ; MANKE, T. ; RUZSICS, Z. ; DOLKEN, L. ; PRAZERES DA COSTA, O. ; BRANZK, N. ; HUBER, M. ; PRASSE, A. ; SCHNEIDER, R. ; APTE, R. N. ; GALANOS, C. ; FREUDENBERG, M. A. . Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , v. 110, p. E2191-E2198, 2013.

• KUNDU, KOUSIK ; COSTA, FABRIZIO ; HUBER, MICHAEL ; RETH, MICHAEL ; BACKOFEN, ROLF . Semi-Supervised Prediction of SH2-Peptide Interactions from Imbalanced High-Throughput Data. PLoS One , v. 8, p. e62732, 2013.

• HOCHDÖRFER, THOMAS ; TIEDJE, CHRISTOPHER ; STUMPO, DEBORAH J. ; BLACKSHEAR, PERRY J. ; GAESTEL, MATTHIAS ; HUBER, MICHAEL . LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP. CELLULAR SIGNALLING , v. 25, p. 1339-1347, 2013.

• YOUSEFI, OMID SASCHA ; WILHELM, THOMAS ; MASCHKE-NEUß, KARIN ; KUHNY, MARCEL ; MARTIN, CHRISTIAN ; MOLDERINGS, GERHARD J ; KRATZ, FELIX ; HILDENBRAND, BERND ; HUBER, MICHAEL . The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions. Cell Communication and Signaling , v. 11, p. 13, 2013.

• HAENISCH, BRITTA ; HUBER, MICHAEL ; WILHELM, THOMAS ; STEFFENS, MICHAEL ; MOLDERINGS, GERHARD J. . Investigation into mechanisms mediating the inhibitory effect of 1,4-benzodiazepines on mast cells by gene expression profiling. LIFE SCIENCES , v. 92, p. 345-351, 2013.

• MARSCHALL, J.S. ; WILHELM, T. ; SCHUH, W. ; HUBER, M. . MEK/Erk-based negative feedback mechanism involved in control of Steel Factor-triggered production of Krüppel-like factor 2 in mast cells. CELLULAR SIGNALLING , v. 24, p. 879-888, 2012.

• MUKHERJEE, OINDRILLA ; WEINGARTEN, LARS ; PADBERG, INKEN ; PRACHT, CATRIN ; SINHA, RILEEN ; HOCHDÖRFER, THOMAS ; KUPPIG, STEPHAN ; BACKOFEN, ROLF ; RETH, MICHAEL ; HUBER, MICHAEL . The SH2-domain of SHIP1 interacts with the SHIP1 C-terminus: Impact on SHIP1/Ig-α interaction. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH , v. 1823, p. 206-214, 2012.

• KECK, SIMONE ; MÜLLER, INES ; FEJER, GYÖRGY ; SAVIC, IVA ; TCHAPTCHET, SANDRINE ; NIELSEN, PETER J. ; GALANOS, CHRIS ; HUBER, MICHAEL ; FREUDENBERG, MARINA A. . Absence of TRIF Signaling in Lipopolysaccharide-Stimulated Murine Mast Cells. JOURNAL OF IMMUNOLOGY , v. 186, p. 5478-5488, 2011.

• HOCHDÖRFER, THOMAS ; KUHNY, MARCEL ; ZORN, CAROLIN N. ; HENDRIKS, RUDI W. ; VANHAESEBROECK, BART ; BOHNACKER, THOMAS ; KRYSTAL, GERALD ; HUBER, MICHAEL . Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells. CELLULAR SIGNALLING , v. 23, p. 866-875, 2011.

• BARTSCH, INGRID ; BLÄSER, SUSANNE ; RÖSELER, SABRINA ; SANDROCK, KIRSTIN ; BUSSE, ANJA ; HUBER, MICHAEL ; REMPP, HANSJÖRG ; LIEBER, MAREIKE ; HORN, JULIA ; BRENDLE, CORNELIA ; ZIEGER, BARBARA . Human endothelial and platelet septin SEPT11: Cloning of novel variants and characterisation of interaction partners. THROMBOSIS AND HAEMOSTASIS , v. 104, p. 1201-1210, 2010.

• ORINSKA, Z. ; FOGER, N. ; HUBER, M. ; MARSCHALL, J. ; MIRGHOMIZADEH, F. ; DU, X. ; SCHELLER, M. ; ROSENSTIEL, P. ; GOLDMANN, T. ; BOLLINGER, A. ; BEUTLER, B. A. ; BULFONE-PAUS, S. . I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development. BLOOD , v. 116, p. 2665-2675, 2010.

• KECK, SIMONE ; FREUDENBERG, MARINA ; HUBER, MICHAEL . Activation of Murine Macrophages via TLR2 and TLR4 Is Negatively Regulated by a Lyn/PI3K Module and Promoted by SHIP1. JOURNAL OF IMMUNOLOGY , v. 184, p. 5809-5818, 2010.

• GROCHOWY, GORDON ; HERMISTON, MICHELLE L. ; KUHNY, MARCEL ; WEISS, ARTHUR ; HUBER, MICHAEL . Requirement for CD45 in fine-tuning mast cell responses mediated by different ligand-receptor systems. CELLULAR SIGNALLING , v. 21, p. 1277-1286, 2009.

• FEHRENBACH, KERSTIN ; LESSMANN, EVA ; ZORN, CAROLIN N. ; KUHNY, MARCEL ; GROCHOWY, GORDON ; KRYSTAL, GERALD ; LEITGES, MICHAEL ; HUBER, MICHAEL . Steel Factor Enhances Supraoptimal Antigen-Induced IL-6 Production from Mast Cells via Activation of Protein Kinase C-β. JOURNAL OF IMMUNOLOGY , v. 182, p. 7897-7905, 2009.

• ZORN, C ; KECK, S ; HENDRIKS, R ; LEITGES, M ; FREUDENBERG, M ; HUBER, M . Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells. CELLULAR SIGNALLING , v. 21, p. 79-86, 2009.

• MINGUET, SUSANA ; DOPFER, ELAINE P. ; POLLMER, CAREEN ; FREUDENBERG, MARINA A. ; GALANOS, CHRIS ; RETH, MICHAEL ; HUBER, MICHAEL ; SCHAMEL, WOLFGANG W. . Enhanced B-cell activation mediated by TLR4 and BCR crosstalk. EUROPEAN JOURNAL OF IMMUNOLOGY , v. 38, p. 2475-2487, 2008.

• MOLENDIJK, ARTHUR J. ; RUPERTI, BENEDETTO ; SINGH, MANOJ K. ; DOVZHENKO, ALEXANDER ; DITENGOU, FRANCK A. ; MILIA, MATTIA ; WESTPHAL, LORE ; ROSAHL, SABINE ; SOELLICK, TIM-ROBERT ; UHRIG, JOACHIM ; WEINGARTEN, LARS ; HUBER, MICHAEL ; PALME, KLAUS . A cysteine-rich receptor-like kinase NCRK and a pathogen-induced protein kinase RBK1 are Rop GTPase interactors. PLANT JOURNAL , v. 53, p. 909-923, 2008.

• ALI, S. ; HUBER, M. ; KOLLEWE, C. ; BISCHOFF, S. C. ; FALK, W. ; MARTIN, M. U. . IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , v. 104, p. 18660-18665, 2007.

• GROSSE, JOHANNES ; BRAUN, ATTILA ; VARGA-SZABO, DAVID ; BEYERSDORF, NIKLAS ; SCHNEIDER, BORIS ; ZEITLMANN, LUTZ ; HANKE, PETRA ; SCHROPP, PATRICIA ; MÜHLSTEDT, SILKE ; ZORN, CAROLIN ; HUBER, MICHAEL ; SCHMITTWOLF, CAROLIN ; JAGLA, WOLFGANG ; YU, PHILIPP ; KERKAU, THOMAS ; SCHULZE, HARALD ; NEHLS, MICHAEL ; NIESWANDT, BERNHARD . An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. JOURNAL OF CLINICAL INVESTIGATION , v. 117, p. 3540-3550, 2007.

• PARDO, J ; WALLICH, R ; EBNET, K ; IDEN, S ; ZENTGRAF, H ; MARTIN, P ; EKICILER, A ; PRINS, A ; MÜLLBACHER, A ; HUBER, M ; SIMON, M M . Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin. CELL DEATH AND DIFFERENTIATION , v. 14, p. 1768-1779, 2007.

• FEHRENBACH, KERSTIN ; PORT, FILLIP ; GROCHOWY, GORDON ; KALIS, CHRISTOPH ; BESSLER, WOLFGANG ; GALANOS, CHRIS ; KRYSTAL, GERALD ; FREUDENBERG, MARINA ; HUBER, MICHAEL . Stimulation of mast cells via Fc-R1 and TLR2: The type of ligand determines the outcome. MOLECULAR IMMUNOLOGY , v. 44, p. 2087-2094, 2007.

• PRACHT, CATRIN ; MINGUET, SUSANA ; LEITGES, MICHAEL ; RETH, MICHAEL ; HUBER, MICHAEL . Association of protein kinase C-δ with the B cell antigen receptor complex. CELLULAR SIGNALLING , v. 19, p. 715-722, 2007.

• ABRAHAM, D ; OSTER, H ; HUBER, M ; LEITGES, M . The expression pattern of three mast cell specific proteases during mouse development. MOLECULAR IMMUNOLOGY , v. 44, p. 732-740, 2007.

• LESSMANN, EVA ; NGO, MIKE ; LEITGES, MICHAEL ; MINGUET, SUSANA ; RIDGWAY, NEALE D. ; HUBER, MICHAEL . Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation. CELLULAR SIGNALLING , v. 19, p. 384-392, 2007.

• HUBER, MICHAEL ; KALIS, CHRISTOPH ; KECK, SIMONE ; JIANG, ZHENGFAN ; GEORGEL, PHILIPPE ; DU, XIN ; SHAMEL, LOUIS ; SOVATH, SOSATHYA ; MUDD, SUZANNE ; BEUTLER, BRUCE ; GALANOS, CHRIS ; FREUDENBERG, MARINA'A. . R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells. EUROPEAN JOURNAL OF IMMUNOLOGY , v. 36, p. 701-711, 2006.

• ELIS, WINFRIED ; LESSMANN, EVA ; OELGESCHLAGER, MICHAEL ; HUBER, MICHAEL . Mutations in the inter-SH2 domain of the regulatory subunit of phosphoinositide 3-kinase: effects on catalytic subunit binding and holoenzyme function. BIOLOGICAL CHEMISTRY , v. 387, p. 14374315, 2006.

• GIBBS, B ; RATHLING, A ; ZILLIKENS, D ; HUBER, M ; HAAS, H . Initial Fc-RI-mediated signal strength plays a key role in regulating basophil signaling and deactivation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY , v. 118, p. 1060-1067, 2006.

• LESSMANN, EVA ; GROCHOWY, GORDON ; WEINGARTEN, LARS ; GIESEMANN, TORSTEN ; AKTORIES, KLAUS ; LEITGES, MICHAEL ; KRYSTAL, GERALD ; HUBER, MICHAEL . Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway. EXPERIMENTAL HEMATOLOGY , v. 34, p. 1532-1541, 2006.

• BLÄSER, S ; RÖSELER, S ; REMPP, H ; BARTSCH, I ; BAUER, H ; LIEBER, M ; LESSMANN, E ; WEINGARTEN, L ; BUSSE, A ; HUBER, M ; ZIEGER, B . Human endothelial cell septins: SEPT11 is an interaction partner of SEPT5. JOURNAL OF PATHOLOGY , v. 210, p. 103-110, 2006.

• LESSMANN, EVA ; LEITGES, MICHAEL ; HUBER, MICHAEL . A redundant role for PKC-- in mast cell signaling and effector function. INTERNATIONAL IMMUNOLOGY , v. 18, p. 767-773, 2006.

• GIMBORN, KERSTIN ; LESSMANN, EVA ; KUPPIG, STEPHAN ; KRYSTAL, GERALD ; HUBER, MICHAEL . SHIP Down-Regulates FcεR1-Induced Degranulation at Supraoptimal IgE or Antigen Levels. JOURNAL OF IMMUNOLOGY , v. 174, p. 507-516, 2005.

• JIANG, ZHENGFAN ; GEORGEL, PHILIPPE ; DU, XIN ; SHAMEL, LOUIS ; SOVATH, SOSATHYA ; MUDD, SUZANNE ; HUBER, MICHAEL ; KALIS, CHRISTOPH ; KECK, SIMONE ; GALANOS, CHRIS ; FREUDENBERG, MARINA ; BEUTLER, BRUCE . CD14 is required for MyD88-independent LPS signaling. NATURE IMMUNOLOGY , v. 6, p. 565-570, 2005.

• MINGUET, SUSANA ; HUBER, MICHAEL ; ROSENKRANZ, LISA ; SCHAMEL, WOLFGANG?W.?A. ; RETH, MICHAEL ; BRUMMER, TILMAN . Adenosine and cAMP are potent inhibitors of the NF-?B pathway downstream of immunoreceptors. EUROPEAN JOURNAL OF IMMUNOLOGY , v. 35, p. 31-41, 2005.

• ELIS, WINFRIED ; RETH, MICHAEL ; HUBER, MICHAEL . Functional folding of a cytoplasmic single-chain variable fragment and its use as elutable protein purification tag. IMMUNOLOGY LETTERS , v. 92, p. 185-192, 2004.

• LEITGES, M. ; GIMBORN, K. ; ELIS, W. ; KALESNIKOFF, J. ; HUGHES, M. R. ; KRYSTAL, G. ; HUBER, M. . Protein Kinase C-  Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation. MOLECULAR AND CELLULAR BIOLOGY , v. 22, p. 3970-3980, 2002.

• KALESNIKOFF, JANET ; BAUR, NICOLE ; LEITGES, MICHAEL ; HUGHES, MICHAEL R. ; DAMEN, JACQUELINE E. ; HUBER, MICHAEL ; KRYSTAL, GERALD . SHIP Negatively Regulates IgE + Antigen-Induced IL-6 Production in Mast Cells by Inhibiting NF-κB Activity. JOURNAL OF IMMUNOLOGY , v. 168, p. 4737-4746, 2002.

• PRACHT, CATRIN ; GIMBORN, KERSTIN ; RETH, MICHAEL ; HUBER, MICHAEL . BCR mutants deficient in ligand-independent and more sensitive for ligand-dependent signaling. EUROPEAN JOURNAL OF IMMUNOLOGY , v. 32, p. 1614, 2002.

• SCHEID, MICHAEL P. ; HUBER, MICHAEL ; DAMEN, JACQUELINE E. ; HUGHES, MICHAEL ; KANG, VERONICA ; NEILSEN, PAUL ; PRESTWICH, GLENN D. ; KRYSTAL, GERALD ; DURONIO, VINCENT . Phosphatidylinositol (3,4,5)P Is Essential but Not Sufficient for Protein Kinase B (PKB) Activation; Phosphatidylinositol (3,4)P Is Required for PKB Phosphorylation at Ser-473. JOURNAL OF BIOLOGICAL CHEMISTRY , v. 277, p. 9027-9035, 2002.

• HUBER, MICHAEL ; HUGHES, MICHAEL R. ; KRYSTAL, GERALD . Thapsigargin-Induced Degranulation of Mast Cells Is Dependent on Transient Activation of Phosphatidylinositol-3 Kinase. JOURNAL OF IMMUNOLOGY , v. 165, p. 124-133, 2000.

• RABKIN, S.W. ; HUBER, M. ; KRYSTAL, G. . Modulation of palmitate-induced cardiomyocyte cell death by interventions that alter intracellular calcium. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS , v. 61, p. 195-201, 1999.

• HUBER, M. ; DAMEN, J. E. ; LIU, L. ; HUMPHRIES, R. K. ; KRYSTAL, G. . The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , v. 95, p. 11330-11335, 1998.

• HUBER, M. . Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells. The EMBO Journal , v. 17, p. 7311-7319, 1998.

• KRAMER, BORIS ; HUBER, MICHAEL ; KERN, CHRISTOPHER ; KLINGEL, KARIN ; KANDOLF, REINHARD ; SELINKA, HANS-CHRISTOPH . Chinese hamster ovary cells are non-permissive towards infection with coxsackievirus B3 despite functional virus-receptor interactions. VIRUS RESEARCH , v. 48, p. 149-156, 1997.