Fernando Pitossi

Possui doutorado em DOCTORADO pela Albert-Ludwigs-Universitaet Freiburg(1993). Atualmente é PRINCIPAL INVESTIGATOR do Instituto Leloir. Tem experiência na área de Medicina.

Informações coletadas do Lattes em 11/05/2023

Acadêmico

Formação acadêmica

Doutorado em DOCTORADO

1989 - 1993

Albert-Ludwigs-Universitaet Freiburg
Título: MECHANSIM OF THE ANTIVIRAL EFFECT OF MX PROTEINS
Orientador: PETER STAEHELI

Idiomas

Bandeira representando o idioma Inglês

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Bandeira representando o idioma Espanhol

Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.

Áreas de atuação

Grande área: Ciências da Saúde / Área: Medicina.

Produções bibliográficas

  • 2018 LEAL, MARÍA C. ; FERRARI, CARINA C. ; DALMASSO, MARÍA C. ; MARTINO ADAMI, PAMELA V. ; FARÍAS, MARÍA I. ; CASABONA, JUAN C. ; PUNTEL, MARIANA ; DO CARMO, SONIA ; SMAL, CLARA ; ARÁN, MARTÍN ; CASTAÑO, EDUARDO M. ; PITOSSI, FERNANDO J. ; CUELLO, A. CLAUDIO ; MORELLI, LAURA . Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer. MOLECULAR NEUROBIOLOGY , v. 55, p. 8637-8650, 2018.

  • SILVA, BERENICE ANABEL ; LEAL, MARÍA CELESTE ; FARÍAS, MARÍA ISABEL ; AVALOS, JUAN CARLOS ; BESADA, CRISTINA HILDA ; PITOSSI, FERNANDO JUAN ; FERRARI, CARINA CINTIA . A new focal model resembling features of cortical pathology of the progressive forms of multiple sclerosis: Influence of innate immunity. BRAIN BEHAVIOR AND IMMUNITY , v. 69, p. 515-531, 2018.

  • ROSATO-SIRI, MARIA VICTORIA ; MARZIALI, LEANDRO ; GUITART, MARÍA EUGENIA ; BADARACCO, MARIA ELVIRA ; PUNTEL, MARIANA ; PITOSSI, FERNANDO ; CORREALE, JORGE ; PASQUINI, JUANA MARIA . Iron Availability Compromises Not Only Oligodendrocytes But Also Astrocytes and Microglial Cells. MOLECULAR NEUROBIOLOGY , v. 55, p. 1068-1081, 2018.

  • MIRAGLIA, M. C. ; COSTA FRANCO, M. M. ; RODRIGUEZ, A. M. ; BELLOZI, P. M. Q. ; FERRARI, C. C. ; FARIAS, M. I. ; DENNIS, V. A. ; BARRIONUEVO, P. ; DE OLIVEIRA, A. C. P. ; PITOSSI, F. ; KIM, K. S. ; DELPINO, M. V. ; OLIVEIRA, S. C. ; GIAMBARTOLOMEI, G. H. . Glial Cell-Elicited Activation of Brain Microvasculature in Response to Brucella abortus Infection Requires ASC Inflammasome-Dependent IL-1  Production. JOURNAL OF IMMUNOLOGY , v. 196, p. 3794-3805, 2016.

  • WENKER, SHIRLEY D. ; LEAL, MARÍA CELESTE ; FARÍAS, MARÍA ISABEL ; ZENG, XIANMIN ; PITOSSI, FERNANDO J. . Cell therapy for Parkinson-s disease: Functional role of the host immune response on survival and differentiation of dopaminergic neuroblasts. BRAIN RESEARCH , v. 1638, p. 15-29, 2016.

  • WENKER, SHIRLEY D. ; CASALÍA, MARIANA ; CANDEDO, VERÓNICA CAVALIERE ; CASABONA, JUAN CRUZ ; PITOSSI, FERNANDO J. . Cell reprogramming and neuronal differentiation applied to neurodegenerative diseases: Focus on Parkinson's disease. FEBS LETTERS , v. 589, p. 3396-3406, 2015.

  • RADICE, PABLO DANIEL ; MATHIEU, PATRICIA ; LEAL, MARÍA CELESTE ; FARÍAS, MARÍA ISABEL ; FERRARI, CARINA ; PUNTEL, MARIANA ; SALIBE, MARIANO ; CHERNOMORETZ, ARIEL ; PITOSSI, FERNANDO JUAN . Fibulin-2 is a key mediator of the pro-neurogenic effect of TGF-beta1 on adult neural stem cells. MOLECULAR AND CELLULAR NEUROSCIENCE , v. 67, p. 75-83, 2015.

  • MURTA, VERÓNICA ; FARÍAS, MARÍA ISABEL ; PITOSSI, FERNANDO JUAN ; FERRARI, CARINA CINTIA . Chronic systemic IL-1β exacerbates central neuroinflammation independently of the blood-brain barrier integrity. JOURNAL OF NEUROIMMUNOLOGY , v. 278, p. 30-43, 2015.

  • SOLOMON, SUSAN ; PITOSSI, FERNANDO ; RAO, MAHENDRA S. . Banking on iPSC- Is it Doable and is it Worthwhile. Stem Cell Reviews and Reports , v. 11, p. 1-10, 2015.

  • SEVLEVER, GUSTAVO ; MIRIUKA, SANTIAGO ; PITOSSI, FERNANDO . Differentiation of Mesenchymal Stem Cells into Retinal Progenitor Cells. OPHTHALMIC RESEARCH , v. 53, p. 28-29, 2015.

  • PITOSSI, FERNANDO J. ; PODHAJCER, OSVALDO L. . Current Status of Stem Cells and Regenerative Medicine Research in Argentina. STEM CELLS AND DEVELOPMENT , v. 23, p. 17-19, 2014.

  • GRACIARENA, MARIANA ; ROCA, VALERIA ; MATHIEU, PATRICIA ; DEPINO, AMAICHA M. ; PITOSSI, FERNANDO J. . Differential vulnerability of adult neurogenesis by adult and prenatal inflammation: Role of TGF-β1. BRAIN BEHAVIOR AND IMMUNITY , v. 34, p. 17-28, 2013.

  • LEAL, MARÍA C. ; CASABONA, JUAN C. ; PUNTEL, MARIANA ; PITOSSI, FERNANDO J. . Interleukin-1β and tumor necrosis factor-α: reliable targets for protective therapies in Parkinson?s Disease?. Frontiers in Cellular Neuroscience , v. 7, p. 53, 2013.

  • ANTHONY, DANIEL C. ; PITOSSI, FERNANDO J. . Special issue commentary: The changing face of inflammation in the brain. MOLECULAR AND CELLULAR NEUROSCIENCE , v. 53, p. 1-5, 2013.

  • MURTA, VERONICA ; PITOSSI, FERNANDO J. ; FERRARI, CARINA C. . CNS response to a second pro-inflammatory event depends on whether the primary demyelinating lesion is active or resolved. BRAIN BEHAVIOR AND IMMUNITY , v. 26, p. 1102-1115, 2012.

  • MATHIEU, PATRICIA ; ROCA, VALERIA ; GAMBA, CECILIA ; DEL POZO, ANA ; PITOSSI, FERNANDO . Neuroprotective effects of human umbilical cord mesenchymal stromal cells in an immunocompetent animal model of Parkinson's disease. JOURNAL OF NEUROIMMUNOLOGY , v. 246, p. 43-50, 2012.

  • LEAL, MARÍA C. ; SURACE, EZEQUIEL I. ; HOLGADO, MARÍA P. ; FERRARI, CARINA C. ; TARELLI, RODOLFO ; PITOSSI, FERNANDO ; WISNIEWSKI, THOMAS ; CASTAÑO, EDUARDO M. ; MORELLI, LAURA . Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: Implications for cellular Aβ metabolism. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH , v. 1823, p. 227-235, 2012.

  • BARCIA, CARLOS ; HUNOT, STÉPHANE ; GUILLEMIN, GILLES J. ; PITOSSI, FERNANDO . Inflammation and Parkinson's Disease. Parkinson's Disease , v. 2011, p. 1-2, 2011.

  • ROCA, VALERIA ; CASABONA, JUAN CRUZ ; RADICE, PABLO ; MURTA, VERÓNICA ; JUAN PITOSSI, FERNANDO . The Degenerating Substantia Nigra as a Susceptible Region for Gene Transfer-Mediated Inflammation. Parkinson's Disease , v. 2011, p. 1-8, 2011.

  • TARAVINI, IRENE RE ; CHERTOFF, MARIELA ; CAFFERATA, EDUARDO G ; COURTY, JOSÉ ; MURER, MARIO G ; PITOSSI, FERNANDO J ; GERSHANIK, OSCAR S . Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats. Molecular Neurodegeneration , v. 6, p. 40, 2011.

  • DEPINO, AMAICHA MARA ; LUCCHINA, LUCIANA ; PITOSSI, FERNANDO . Early and adult hippocampal TGF-β1 overexpression have opposite effects on behavior. BRAIN BEHAVIOR AND IMMUNITY , v. 25, p. 1582-1591, 2011.

  • CHERTOFF, M. ; DI PAOLO, N. ; SCHOENEBERG, A. ; DEPINO, A. ; FERRARI, C. ; WURST, W. ; PFIZENMAIER, K. ; EISEL, U. ; PITOSSI, F. . Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor α in the nigrostriatal dopaminergic circuit of adult mice. EXPERIMENTAL NEUROLOGY , v. 227, p. 237-251, 2011.

  • TAYLOR, PATRICK L. ; BARKER, ROGER A. ; BLUME, KARL G. ; CATTANEO, ELENA ; COLMAN, ALAN ; DENG, HONGKUI ; EDGAR, HAROLD ; FOX, IRA J. ; GERSTLE, CLAUDE ; GOLDSTEIN, LAWRENCE S.B. ; HIGH, KATHERINE A. ; LYALL, ANDREW ; PARKMAN, ROBERTSON ; PITOSSI, FERNANDO J. ; PRENTICE, ERNEST D. ; ROOKE, HEATHER M. ; SIPP, DOUGLAS A. ; SRIVASTAVA, ALOK ; STAYN, SUSAN ; STEINBERG, GARY K. ; WAGERS, AMY J. ; WEISSMAN, IRVING L. . Patients Beware: Commercialized Stem Cell Treatments on the Web. Cell Stem Cell , v. 7, p. 43-49, 2010.

  • GRACIARENA, MARIANA ; DEPINO, AMAICHA M. ; PITOSSI, FERNANDO J. . Prenatal inflammation impairs adult neurogenesis and memory related behavior through persistent hippocampal TGFβ1 downregulation. BRAIN BEHAVIOR AND IMMUNITY , v. 24, p. 1301-1309, 2010.

  • POTT GODOY, MARÍA CLARA ; FERRARI, CARINA CINTIA ; PITOSSI, FERNANDO JUAN . Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression. JOURNAL OF NEUROIMMUNOLOGY , v. 222, p. 29-39, 2010.

  • MATHIEU, PATRICIA ; PIANTANIDA, ANA PAULA ; PITOSSI, FERNANDO . Chronic Expression of Transforming Growth Factor-Beta Enhances Adult Neurogenesis. NEUROIMMUNOMODULATION , v. 17, p. 200-201, 2010.

  • GARCÍA SAMARTINO, CLARA ; DELPINO, M. VICTORIA ; POTT GODOY, CLARA ; DI GENARO, MARÍA SILVIA ; PASQUEVICH, KARINA A. ; ZWERDLING, ASTRID ; BARRIONUEVO, PAULA ; MATHIEU, PATRICIA ; CASSATARO, JULIANA ; PITOSSI, FERNANDO ; GIAMBARTOLOMEI, GUILLERMO H. . Brucella abortus Induces the Secretion of Proinflammatory Mediators from Glial Cells Leading to Astrocyte Apoptosis. AMERICAN JOURNAL OF PATHOLOGY , v. 176, p. 1323-1338, 2010.

  • MATHIEU, PATRICIA ; BATTISTA, DANIELA ; DEPINO, AMAICHA ; ROCA, VALERIA ; GRACIARENA, MARIANA ; PITOSSI, FERNANDO . The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain. JOURNAL OF NEUROCHEMISTRY , v. 112, p. 1368-1385, 2010.

  • DE LELLA EZCURRA, ANA LAURA ; CHERTOFF, MARIELA ; FERRARI, CARINA ; GRACIARENA, MARIANA ; PITOSSI, FERNANDO . Chronic expression of low levels of tumor necrosis factor-α in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation. NEUROBIOLOGY OF DISEASE , v. 37, p. 630-640, 2010.

  • LUCCHINA, LUCIANA ; CAROLA, VALERIA ; PITOSSI, FERNANDO ; DEPINO, AMAICHA MARA . Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors. BEHAVIOURAL BRAIN RESEARCH , v. 213, p. 56-65, 2010.

  • POTT GODOY, M. C. ; TARELLI, R. ; FERRARI, C. C. ; SARCHI, M. I. ; PITOSSI, F. J. . Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. BRAIN , v. 131, p. 1880-1894, 2008.

  • CAMPBELL, SANDRA J. ; DEACON, ROB M.J. ; JIANG, YANYAN ; FERRARI, CARINA ; PITOSSI, FERNANDO J. ; ANTHONY, DANIEL C. . Overexpression of IL-1β by adenoviral-mediated gene transfer in the rat brain causes a prolonged hepatic chemokine response, axonal injury and the suppression of spontaneous behaviour. NEUROBIOLOGY OF DISEASE , v. 27, p. 151-163, 2007.

Histórico profissional

Endereço profissional

  • CONICET. , Patricias Argentinas 435, CABALLITO, Argentina - ciudad de buenos aires, - Argentina, Telefone: (54) 1951209958

Experiência profissional

1997 - Atual

Instituto Leloir

Vínculo: Servidor Público, Enquadramento Funcional: PRINCIPAL INVESTIGATOR