Guilherme Fonseca Dal Poggetto

Pós-doutorado

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Produções bibliográficas

• WOOD, JARED S. ; DAL POGGETTO, GUILHERME ; WANG, XIAO ; REIBARKH, MIKHAIL ; WILLIAMSON, R. THOMAS ; COHEN, RYAN D. . Quantitative nuclear magnetic resonance of chloride by an accurate internal standard approach. MAGNETIC RESONANCE IN CHEMISTRY , v. 61, p. 22-31, 2023.

• WANG, YUNYI ; FAN, AILI ; COHEN, RYAN D. ; DAL POGGETTO, GUILHERME ; HUANG, ZHENG ; YANG, HAIFENG ; MARTIN, GARY E. ; SHERER, EDWARD C. ; REIBARKH, MIKHAIL ; WANG, XIAO . Unequivocal identification of two-bond heteronuclear correlations in natural products at nanomole scale by i-HMBC. Nature Communications , v. 14, p. 1842, 2023.

• KUETHE, JEFFREY T. ; LEE, JOSHUA ; THAISRIVONGS, DAVID ; YASUDA, NOBUYOSHI ; POLLACK, SCOTT R. ; LEONE, JOSEPH ; DASILVA, JIMMY ; BIBA, MIRLINDA ; TSAY, FUH-RONG ; REGALADO, ERIK L. ; QI, JI ; LI, HONGMING ; Poggetto, Guilherme Dal ; COHEN, RYAN . Synthesis of a Complex and Highly Potent PCSK9 Inhibitor. ORGANIC LETTERS , v. 25, p. 5001-5005, 2023.

• SOARES, JOÃO VITOR ; Dal Poggetto, G. ; VIESSER, RENAN V. ; COUTO, UENIFER R. ; TORMENA, C. F. . Stereoelectronic interactions: A booster for 4 J HF transmission. MAGNETIC RESONANCE IN CHEMISTRY , v. 60, p. 481-488, 2022.

• Dal Poggetto, G. ; SOARES, JOÃO VITOR ; TORMENA, C. F. . Selective Nuclear Magnetic Resonance Experiments for Sign-Sensitive Determination of Heteronuclear Couplings: Expanding the Analysis of Crude Reaction Mixtures. ANALYTICAL CHEMISTRY , v. 92, p. 14047-14053, 2020.

• DAL POGGETTO, GUILHERME ; CASTAÑAR, LAURA ; ADAMS, RALPH W. ; MORRIS, GARETH A. ; NILSSON, MATHIAS . Dissect and Divide: Putting NMR Spectra of Mixtures under the Knife. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , v. 141, p. 5766-5771, 2019.

• EVANS, ROBERT ; DAL POGGETTO, GUILHERME ; Nilsson, Mathias ; Morris, Gareth A. . Improving the Interpretation of Small Molecule Diffusion Coefficients. Analytical Chemistry , v. 90, p. 3987-3994, 2018.

• CASTAÑAR, LAURA ; Poggetto, Guilherme Dal ; COLBOURNE, ADAM A. ; Morris, Gareth A. ; Nilsson, Mathias . The GNAT: A new tool for processing NMR data. MAGNETIC RESONANCE IN CHEMISTRY , v. 56, p. 546-558, 2018.

• DAL POGGETTO, GUILHERME ; CASTAÑAR, LAURA ; FOROOZANDEH, MOHAMMADALI ; KIRALY, PETER ; ADAMS, RALPH W. ; Morris, Gareth A. ; Nilsson, Mathias . Unexploited Dimension: New Software for Mixture Analysis by 3D Diffusion-Ordered NMR Spectroscopy. ANALYTICAL CHEMISTRY , v. 90, p. 13695-13701, 2018.

• EVANS, ROBERT ; HERNANDEZ-CID, AARON ; DAL POGGETTO, GUILHERME ; VESTY, ASHLEY ; HAIBER, STEPHAN ; MORRIS, GARETH A. ; NILSSON, MATHIAS . Matrix-assisted diffusion-ordered NMR spectroscopy with an invisible matrix: a vanishing surfactant. RSC Advances , v. 7, p. 449-452, 2017.

• Dal Poggetto, G. ; ANTUNES, VICTOR U. ; Nilsson, Mathias ; Morris, Gareth A. ; TORMENA, C. F. . 19 F NMR matrix-assisted DOSY: a versatile tool for differentiating fluorinated species in mixtures. MAGNETIC RESONANCE IN CHEMISTRY , v. 55, p. 323-328, 2017.

• Dal Poggetto, G. ; CASTAÑAR, L. ; ADAMS, R. W. ; MORRIS, G. A. ; NILSSON, M. . Relaxation-encoded NMR experiments for mixture analysis: REST and beer. CHEMICAL COMMUNICATIONS , v. 53, p. 7461-7464, 2017.

• DAL POGGETTO, GUILHERME ; CASTAÑAR, LAURA ; MORRIS, GARETH A ; NILSSON, MATHIAS . A new tool for NMR analysis of complex systems: selective pure shift TOCSY. RSC Advances , v. 6, p. 100063-100066, 2016.

• FOROOZANDEH, M. ; CASTAÑAR, LAURA ; MARTINS, L. G. ; SINNAEVE, D. ; DAL POGGETTO, GUILHERME ; TORMENA, CLÁUDIO F. ; MORRIS, GARETH A. ; NILSSON, MATHIAS . Ultrahigh-Resolution Diffusion-Ordered Spectroscopy. Angewandte Chemie (International ed. Print) , v. 128, p. 15808-15811, 2016.

• DAL POGGETTO, GUILHERME ; FAVARO, DENIZE C. ; NILSSON, MATHIAS ; MORRIS, GARETH A. ; TORMENA, CLÁUDIO F. . 19F DOSY NMR analysis for spin systems with nJFF couplings. MAGNETIC RESONANCE IN CHEMISTRY , v. 52, p. 172-177, 2014.

• DAL POGGETTO, GUILHERME . Multidimensional NMR experiments for mixture analysis. 2019. (Apresentação de Trabalho/Seminário).

Outras produções

Projetos de pesquisa

• 2019 - Atual

  NEW PULSE SEQUENCES AND PROCESSIING TOOLS FOR MULTIIDIIMENSIIONAL NMR EXPERIIMENTS APPLIIED TO NATURAL PRODUCTS MIIXTURE ANALYSIIS, Descrição: The analysis of natural products, often as part of complex mixtures, is very challenging, but identifying the structure of their components is essential for drug discovery and development. In the context of molecular structure assignment of mixture components, Nuclear Magnetic Resonance (NMR) is one of the most suitable non-destructive analytical methods. Its advances in the last decade have not yet reached end-users to a full extent, not taking the full advantage of the state-of-art spectrometer capabilities. This is partially a reflection of the small number of researchers working in NMR development, even though the technique is of large importance for both Academia and industry. In the present project we propose new and improved tools for spectroscopists to tackle challenges existing in natural products samples, by developing and introducing new methodologies in the NMR centre at UNICAMP`s Institute of Chemistry. This will be achieved by a series of sub-projects, involving development of NMR pulse sequences and processing tools for multidimensional experiments, such as 3D TOCSY-DOSY and HSQC-DOSY, which are currently being underused due to the lack of processing capabilities. The most modern NMR methods (such as pure shift NMR) are also going to be implemented for the analysis of natural product mixtures.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Guilherme Fonseca Dal Poggetto - Integrante / Cláudio Francisco Tormena - Coordenador / NILSSON, MATHIAS - Integrante / MORRIS, GARETH A. - Integrante.

• 2015 - 2019

  New NMR methods for the analysis of complex mixtures, Descrição: Nuclear magnetic ressonance (NMR) often fails in cases where the sample of interest is a complex mixture. Diffusion Ordered Spectroscopy (DOSY) have alleviated those problems, but it is still limited in resolution in both frequency and diffusion coefficient dimensions, and therefore new NMR methods have to be developed to tackle those issues. In this project new acquisition methods and processing tools are going to be developed and tested in real mixtures (such as beer or natural oils) to illustrate the proposed concepts.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (2) Doutorado: (1) . , Integrantes: Guilherme Fonseca Dal Poggetto - Integrante / NILSSON, MATHIAS - Coordenador / MORRIS, GARETH A. - Integrante.

• 2013 - 2015

  Aplicação na técnica de RMN 19F DOSY no estudo de misturas complexas, Descrição: Resolução de misturas complexas a partir de suas respectivas difusões determinadas pela técnica de RMN 19F DOSY (diffusion-ordered spectroscopy), com o intuito de aplicação para fármacos comercialmente disponíveis.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (1) . , Integrantes: Guilherme Fonseca Dal Poggetto - Integrante / Cláudio Francisco Tormena - Coordenador.

• 2010 - 2012

  ESTUDOS DA HIDROGENÓLISE DE 2-ARILPIRROLIDINAS QUIRAIS PARA A SÍNTESE DE AMINOÁLCOOIS, Descrição: Aminoálcoois constituem um importante fragmento em compostos orgânicos, visto estarem presentes em substâncias naturais com pronunciada atividade biológica. Dentre estas, encontram-se as esfingosinas, compostos lineares associados com a interrupção do crescimento celular, sendo importante reguladora do processo de apoptose (morte celular programada). A síntese de esfingosinas constitui uma importante contribuição para o estudo destes processos biológicos e, permitindo assim, um melhor entendimento de mecanismos celulares, para conseqüente possível desenvolvimento de novos agentes quimioterápicos. Uma vez que compostos com o fragmento aminoálcool lineares, podem ser formados a partir da hidrogenólise de anéis pirrolidínicos hidroxilados, objetivou-se o estudo sistemático desta reação, com diferentes catalisadores, como PdCl2, Pd(OH)2 e Pd/C. De forma a obter anéis pirrolidínicos de estereoquímica controlada, enecarbamatos endocíclicos, preparados a partir do ácido L-piroglutâmico, sofreram arilação com sais de diazônio (Reação de Heck-Matsuda).. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Guilherme Fonseca Dal Poggetto - Coordenador.

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