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possui graduação em Ciências Biológicas Modalidade Médica (Biomedicina) pelo Centro Universitário Barão de Mauá (1999), mestrado em Genética e Evolução pela Universidade Federal de São Carlos (2003), Doutorado em Ciências - Genética (2007) pela Universidade de São Paulo e Pós-Doutorado pela Faculdade de Medicina de Ribeirão Preto (FMRP-USP). Realizou estágio como pesquisador visitante na Oklahoma State University. Também realizou pós-doutorado pela Faculdade de Medicina de São Paulo (FM-USP) junto ao Departamento de Patologia, sob a supervisão do Prof. Paulo Saldiva. Foi pesquisador visitante na Harvard School of Public Health no Dept. Environmental Health. É pesquisador do Centro de Oncologia Molecular do Hospital de Câncer de Barretos e docente da Pós-Graduação em Oncologia do Instituto de Ensino e Pesquisa da Fundação Pio XII - Hospital de Câncer de Barretos. Também é docente da Pós-Graduação em Ambiente e Saúde da Universidade de Cuiabá. Tem experiência em Genética e Biologia Molecular e Prevenção de Câncer, atuando principalmente nos seguintes temas: populações expostas ocupacionalmente, câncer ocupacional, interações genes e ambiente: sua influência na carcinogênese, resposta ao estresse ambiental e saúde ambiental.
Informações coletadas do Lattes em 30/04/2022
Acadêmico
Formação acadêmica
Doutorado em Ciências Biológicas (Genética)
2003 - 2007
Universidade de São Paulo
Título: A Capacidade de Infecção do dermatófito Trichophyton rubrum está correlacionada com a sinalização do pH extracelular
Nilce M Martinez Rossi. Bolsista do(a): Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES, Brasil. Palavras-chave: pH regulation; Trichophyton rubrum; expressão gênica.
Mestrado em GENÉTICA EVOLUTIVA E BIOLOGIA MOLECULAR
2000 - 2003
Universidade Federal de São Carlos
Título: Estudo das proteínas ligantes a DCRA (Envolvida com a Síndrome de Down), utilizando a metodologia do Duplo- Híbrido,Ano de Obtenção: 2003
Flávio Henrique Silva.Bolsista do(a): Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Brasil. Palavras-chave: Síndrome de Down; Duplo-Híbrido; interação proteína- proteína; DCRA.Grande área: Ciências BiológicasSetores de atividade: Outro.
Pós-doutorado
2010 - 2011
Pós-Doutorado. , Faculdade de Medicina (FM-USP), FM-USP, Brasil. , Bolsista do(a): Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP, Brasil. , Grande área: Ciências Biológicas, Grande Área: Ciências Biológicas / Área: Fisiologia / Subárea: Fisiologia de Órgãos e Sistemas. , Grande Área: Ciências da Saúde / Área: Medicina / Subárea: Anatomia Patológica e Patologia Clínica / Especialidade: Saude Ambiental.
2009 - 2010
Pós-Doutorado. , Faculdade de Medicina de Ribeirão Preto, FMRP-USP, Brasil. , Bolsista do(a): Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Brasil. , Grande área: Ciências Biológicas, Grande Área: Ciências Biológicas / Área: Genética / Subárea: Genética Molecular e de Microorganismos. , Grande Área: Ciências Biológicas / Área: Genética / Subárea: Genômica Funcional de Fungos.
2007 - 2009
Pós-Doutorado. , Faculdade de Medicina de Ribeirão Preto, FMRP-USP, Brasil. , Bolsista do(a): Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP, Brasil. , Grande área: Ciências Biológicas, Grande Área: Ciências Biológicas / Área: Genética / Subárea: Genética e Bioinformática. , Grande Área: Ciências Biológicas / Área: Genética / Subárea: Genômica Funcional de Fungos.
Formação complementar
2019 - 2019
Leadership and Management in Health.. (Carga horária: 900h). , Universidade de Washington, WASHINGTON, Estados Unidos.
2018 - 2018
Curso de Atualização: Estimativa de Exposição para Matriz de Exposição Ocup. (Carga horária: 36h). , Instituto Nacional de Câncer, INCA, Brasil.
2015 - 2015
Metodologia de Pirosequenciamento. (Carga horária: 40h). , Qiagen, QIAGEN, Brasil.
2013 - 2013
Treinamento em construção de bibliotecas para NGS. (Carga horária: 80h). , Centro de Pesquisa Rene Rachou - FIOCRUZ Minas, CPQRR - FIOCRUZ, Brasil.
2010 - 2010
Curso de Referências Bibliográficas. (Carga horária: 3h). , Fundação Pio XII - Hospital de Câncer de Barretos, HCB, HCB, Brasil.
2004 - 2004
Extensão universitária em Curso de Extensão Universitária em Bioinformática. (Carga horária: 90h). , Laboratório Nacional de Computação Científica, LNCC, Brasil.
2004 - 2004
Extensão universitária em III Curso de Radioproteção. (Carga horária: 40h). , Faculdade de Medicina deRibeirão Preto, FMRP, Brasil.
2004 - 2004
I Seminário de Empreendedorismo Tecnológico Potenc. (Carga horária: 16h). , Faculdade de Economia Administração e Contabilidade de Ribeirão Preto, FEARP, Brasil.
2003 - 2003
Extensão universitária em Workshop 'Expressão Gênica em Câncer". (Carga horária: 30h). , Fundação Hemocentro de Ribeirão Preto, FUNDHERP, Brasil.
2001 - 2001
Extensão universitária em Tecnologia em Microarrays. , Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Brasil.
1997 - 1997
Procedimentos Básicos em Quimica Clínica. , Sociedade Brasileira de Patologia Clinica, SBPC, Brasil.
1997 - 1997
Biossegurança no Laboratório de Patologia Clínica. , Sociedade Brasileira de Patologia Clinica, SBPC, Brasil.
Idiomas
Inglês
Compreende Bem, Fala Razoavelmente, Lê Bem, Escreve Bem.
Espanhol
Compreende Bem, Fala Razoavelmente, Lê Bem, Escreve Razoavelmente.
Português
Compreende Bem, Fala Bem, Lê Bem, Escreve Bem.
Áreas de atuação
Grande área: Ciências Biológicas / Área: Bioquímica / Subárea: Biologia Molecular.
Grande área: Ciências Biológicas / Área: Genética / Subárea: Genética Molecular e de Microorganismos.
Grande área: Ciências Biológicas / Área: Genética / Subárea: Genomica Funcional.
Grande área: Ciências da Saúde / Área: Saúde Coletiva / Subárea: Meio Ambiente e Saúde.
Organização de eventos
Marques, M. M. C. M. ; Silveira, H.C.S. ; REIS, RUI MANUEL . Latin American Symposium and Training in Biobanking of the Barretos Cancer Hospital. 2019. (Congresso).
Marques, M. M. C. M. ; PALMERO, E. ; MELENDEZ, M. ; REIS, RUI M. ; SILVEIRA, H. C. S. . VI Simpósio Internacional de Oncologia Translacional e Pesquisa Clinica. 2017. (Outro).
SILVEIRA, H. C. S. ; Marques, M. M. C. M. ; VIDAL, D. O. ; PALMERO, E. ; SCAPULATEMPO, C. ; REIS, RUI MANUEL . V Simpósio Internacional de Oncologia Translacional. 2015. (Congresso).
SILVEIRA, H. C. S. . Meus Filhos Meu Trabalho (Estação Ciencia). 2015. (Outro).
SILVEIRA, H. C. S. . II Concurso de Redação do Hospital de Câncer de Barretos. 2014. (Concurso).
Silveira, H.C.S. ; VIDAL, D. O. ; PALMERO, E. ; Marques, M. M. C. M. ; CARVALHO, A. L. ; REIS, R. M. . IV International Symposium on Translational Oncology. 2014. (Congresso).
CARVALHO, A. L. ; REIS, R. M. ; SCAPULATEMPO, C. ; VIDAL, D. O. ; Silveira, H.C.S. ; Marques, MMC ; PALMERO, E. . III International Symposium on Translacional Oncology. 2013. (Congresso).
Silveira, H.C.S. . I Concurso de Redação do Centro de Pesquisa em Oncologia Molecular do Hospital de Câncer de Barretos. 2013. (Concurso).
SILVEIRA, H. C. S. ; CARVALHO, A. L. ; CATANEO, C. . 2* Workshop de Meio Ambiente do Hospital de Câncer de Barretos. 2012. (Outro).
SILVEIRA, H. C. S. ; CATANEO, C. . 1* Workshop de Meio-Ambiente do Hospital de Câncer de Barretos. 2011. (Outro).
SILVEIRA, H. C. S. ; CAMPINA, N. ; VILLEGAS, C. . Curso de Educação Ambiental: Rede Ambiência (INAIRA) EAD, ministrado em Barretos.. 2011. (Outro).
SILVEIRA, H. C. S. ; CATANEO, C. . 1 Workshop de Meio Ambiente do Hospital de Câncer de Barretos. 2011. (Outro).
SILVEIRA, H. C. S. ; CAMPINA, N. ; SALDIVA, P.H. ; CARVALHO, A. L. . Curso de Educação Ambiental RedeAmbiência EAD e presencial em Barretos. 2011. (Outro).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Centro Brasileiro-Argentino de Biotecnologia (CBAB) - Curso Expressão Diferencial de Genes em Fungos: Interação Patógeno-hospedeiro. 2004. (Outro).
Participação em eventos
5 Broccoli Comsuption Conference. Brócolis: Mecanismos, Alvos celulares e ação antitumoral. 2017. (Congresso).
I Encontro Científico em Ambiente e Saúde.Meio Ambiente e Estudos Moleculares. 2017. (Encontro).
INCA 80 Anos. Contribuição da biologia molecular na investigação da exposição a agentes cancerígenos ocupacionais e ambientais. 2017. (Congresso).
25th Annual Meeting Expousure in an Evolving Environment. pôster. 2015. (Congresso).
BiG SUGAR SUMMIT.Emissions generated with sugarcane burning promote genotoxicity in rural workers. 2015. (Encontro).
V Simpósio Internacional de Oncologia Translacional.Environmental Factors and Cancer. 2015. (Simpósio).
9 th International Cancer Genome Consortium.9 th International Cancer Genome Consortium. 2014. (Encontro).
Environmental Mutagenesis and Genomics Society 45th Annual Meeting. Assessment of micronuclei in construction workers exposed to occupational and environmental agents. 2014. (Congresso).
8 International Cancer Genome Consortium. 2013. (Outra).
58 Congresso Brasileiro de Genética. Evaluation of Genotoxic effects of sugarcane workers using micronucleus assay. 2012. (Congresso).
27* REGEM - Reunião de Genética de Microrganismos. Análise das interações transcricionais no dermatófito Trichophyton rubrum em resposta ao pH ambiente durante o processo de degradação de queratina. 2010. (Congresso).
56* Congresso Brasileiro de Genética. Analise das interações transcricionais no dermatófito Trichophyton rubrum em resposta ao pH ambiente durante o processo de degradação de queratina. 2010. (Congresso).
Joint Symposium on Cancer Research. 2010. (Simpósio).
25th Fungal Genetics Conference at Asilomar. Trichophyton rubrum gene expression profile during the process of keratin degradation. 2009. (Congresso).
55* Congresso Brasileiro de Genética. Genomica Funcional em Fungos. 2009. (Congresso).
26 REGEM - Reunião de Genética de Microrganismos.Análise do perfil de expressão gênica do dermatófito Trichophyton rubrum em resposta ao pH ambiente durante o processo de degradação de queratina. 2008. (Outra).
54 Congresso Brasileiro de Genética. Análise do Perfil de Expressão Gênica do dermatófito trichophyton rubrum em resposta ao pH ambiente durante o processo de degradação de queratina. 2008. (Congresso).
9th European Conference on Fungal Genetics. Transcription factor PacC also has metabolic functions specific to acid pH sensing by the dermatophyte Trichophyton rubrum. 2008. (Congresso).
53 Congresso Brasileiro de Genética. Identificação de genes possivelmente expressos nos passos iniciais da infecção do dermatófito Trichophyton rubrum e suas relações com a via de sinalização do pH extracelular. 2007. (Congresso).
52 Congresso Brasileiro de Genética. Apresentação de trabalho poster. 2006. (Congresso).
8th Conference on Fungal Genetics. 8th Conference on Fungal Genetics. 2006. (Congresso).
13* SIICUSP - Simpósio Internacional de Iniciação Cientifica da USP..x. 2005. (Simpósio).
51 Congresso Brasileiro de Genética. 51 Congresso Brasileiro de Genética. 2005. (Congresso).
49 Congresso Nacional de Genética da Sociedade Brasileira de Genética. 49 Congresso Nacional de Genética da Sociedade Brasileira de Genética. 2003. (Congresso).
XXXII Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq. XXXII Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq. 2003. (Congresso).
III Simpósio Nacional de Biologia Molecular Aplicada à Medicina.III Simpósio Nacional de Biologia Molecular Aplicada à Medicina. 2002. (Simpósio).
XXXI Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular. XXXI Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular. 2002. (Congresso).
1° Encontro: As Universidades e a Difusão das Ciências Moleculares - Centro de Biologia Molecular e Estrutural..1° Encontro: As Universidades e a Difusão das Ciências Moleculares - Centro de Biologia Molecular e Estrutural. 2001. (Encontro).
Brazilian Genome Conference. Brazilian International Genome Conference. 2001. (Congresso).
XXX Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular. XXX Reunião Anual da Sociedad Brasileira de Bioquímica e Biologia Molecular. 2001. (Congresso).
I Encontro Internacional de Biomédicos.I Encontro Internacional de Biomédicos. 1998. (Encontro).
XXXI Congresso Brasileiro de Patologia Clínica. XXXI Congresso Brasileiro de Patologia Clínica. 1997. (Congresso).
II Simpósio Regional de Biomedicina.II Simpósio Regional de Biomedicina. 1996. (Simpósio).
Simpósio de Microbiologia Clínica.Simpósio de Microbiologia Clínica. 1996. (Simpósio).
Participação em bancas
Silveira, H.C.S.; QUEIROZ, C.; FIGUEREDO, S. E. F. M. R.. Associação entre a exposição a agrotóxicos e câncer do colo do útero. 2020. Dissertação (Mestrado em Ambiente e Saúde) - Universidade de Cuiabá.
Silveira, H.C.S.; OLIVEIRA, M. S. P.; PAUMGARTTEN, F. J. R.; COELHO, S.. Análise de alterações epigenéticas em trabalhadores de postos de combustíveis expostos ao benzeno no município do Rio de Janeiro. 2020. Dissertação (Mestrado em ONCOLOGIA) - Instituto Nacional de Câncer.
SILVEIRA, H. C. S.; FERREIRA, S. M. B.; PALACIOS, R. S.. Avaliação da instabilidade cromossômica e o potencial risco associado a câncer em trabalhadores rurais expostos a agrotóxicos. 2019. Dissertação (Mestrado em Ambiente e Saúde) - Universidade de Cuiabá.
Silveira, H.C.S.; SANTOS, E. L.; CRISPIM, B. A.; GRISOLIA, A. B.. Efeitos toxicogenéticos de contaminantes químicos detectados em águas subterrâneas utilizando ensaios in vitro.. 2019. Dissertação (Mestrado em Ciência e Tecnologia Ambiental) - Universidade Federal da Grande Dourados.
Silveira, H.C.S.; IGNACIO, A. R. A.; OLIVEIRA JUNIOR, E. S.; LAZARO, W. L.. Relação entre vendas de agrotóxicos e intoxicações humanas em Estados com altos índices de produção agrícola. 2019. Dissertação (Mestrado em Ciências Ambientais) - Universidade do Estado de Mato Grosso.
Silveira, H.C.S.; CURADO, M. P.; FREGNANI, J. H. T. G.. Avaliação dos Benefícios previdenciários concedidos e dos procedimentos realizados na área de oncologia e os respectivos gastos para os Ministérios da Previdência Social a da Saúde. 2018. Dissertação (Mestrado em Pós-graduação em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB.
BARBOSA JR, F.; SALVADORI, D. M. F.;SILVEIRA, H. C. S.. Avaliação da citotoxicidade, genototoxicidade e o efeito da exposição no perfil de metilação em linhagem celular de pulmão.. 2018. Dissertação (Mestrado em Pós-graduação em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB.
SILVEIRA, H. C. S.; SANTOS, D. A. S.; SILVA, A. M. C.. Exposições Ambientais aos agrotóxicos e câncer de mama em região de intensa produção agrícola.. 2018. Dissertação (Mestrado em Ambiente e Saúde) - Universidade de Cuiabá.
SILVA, A. M. C.; HOFFMAN, H.;SILVEIRA, H. C. S.. Perfil sócio demográfico, ambiental e alguns fatores de associação ao uso de agrotóxicos em trabalhadores rurais da região de Barretos, SP.. 2018. Dissertação (Mestrado em Ambiente e Saúde) - Universidade de Cuiabá.
SILVEIRA, H. C. S.; FREDERICO, R. C. P.; GOMES, M. V. M.. Efeitos do estresse e da prática de exercício físico sobre o mecanismo de metilação do DNA em células do pulmão de ratos. 2016. Dissertação (Mestrado em Pos-Graduação em Ciências da Reabilitação) - Universidade Norte do Paraná.
BRAIT, M.; HOJO, E. T. S.;SILVEIRA, H. C. S.. Avaliação do perfil de metilaçao do DNA em genes supressores tumorais e seqüências repetitivas em trabalhadores da construção civil expostas a agentes carcinogênicos ambientais e ocupacionais. 2016. Dissertação (Mestrado em Pós-graduação em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB.
SILVA, A. E.;SILVEIRA, H. C. S.; SOUZA, D. R. S.; ZUCCARI, D. A. P. C.; CURY, P. M.. Avalaiação da Anexina A1, FPR1, FPR2 e miRNAs em adenocarcinoma gástrico. 2016. Tese (Doutorado em Biociências) - Universidade Estadual Paulista Júlio de Mesquita Filho.
Silveira, H.C.S.; PAZZINI, J. M.; COSTA, M. T.. Expression profile of acetylated histones 3 and 4 histones desacetylase enzimes 1,2 and their association in cutaneous T- cell Lymphoma in dogs.. 2019. Exame de qualificação (Doutorando em Programa de Pós-Graduação em Medicina Veterinária) - FCAV - UNESP Jaboticabal.
SILVEIRA, H. C. S.; LEVI, J. E.. careHPVTM- Teste de Captura Híbrida em Unidade Móvel para Melhoria do Programa de Rasteio do Câncer Cervical em Áreas Rurais e Remotas Brasileiras. 2015. Exame de qualificação (Doutorando em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB.
SILVEIRA, H. C. S.; MARIN, A. L. A.; PREIRA, A. M. S.. Plant Venon: Database of anti-venom medicinal plants. 2010 - Universidade de São Paulo.
SILVEIRA, H. C. S.; BITONDI, M. M. G.; NUNES, F. M. F.. Effects of stingless bee and honey bee própolis on four species of bacteria. 2010. Exame de qualificação (Doutorando em Doutorado) - Faculdade de Medicina de Ribeirão Preto.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C.; Santos JRC; SOARES, A. E. E.. In vitro antifungal drug susceptibilities of dermatophytes microconidia and arthroconidia. 2008. Exame de qualificação (Doutorando em Doutorado) - Faculdade de Medicina de Ribeirão Preto.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C.. Development and characterization of 15 microsatelite loci for Cariniana estrellensis and transferability to Cariniana legalis, two endangered tropical tree species. 2008 - Faculdade de Medicina deRibeirão Preto.
SILVEIRA, H. C. S.; FREDERICO, R. C. P.. Efeitos do estresse e da prática de exercício físico sobre o mecanismo de metilação do DNA em células do pulmão de ratos. 2015. Exame de qualificação (Mestrando em Pos-Graduação em Ciências da Reabilitação) - Universidade Norte do Paraná.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C.Sanches PR; GIULUATTI, S.. Analise de possiveis agentes como fontes para obtencao de sistema moleculares complexos.. 2006. Trabalho de Conclusão de Curso (Graduação em Informática Biomédica) - Universidade de São Paulo.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C.; LEMOS, M. V. F.. Bioinformática e Ferramentas Aplicadas à Análise de Seqüências de Nucleotídeos. 2003. Trabalho de Conclusão de Curso (Graduação em Ciências da Computação) - Centro Universitário de Araraquara.
SILVEIRA, H. C. S.. Banca na etapa de processo seletivo de mestrado Universidade de Cuiabá. 2016. Universidade de Cuiabá.
SILVEIRA, H. C. S.. EPTV na Escola (Rede Globo) julgamento das melhores redações.. 2013.
SILVEIRA, H. C. S.; GARCIA, L.. I Concurso de Redação do Centro de Pesquisa em Oncologia Molecular do Hospital de Câncer de Barretos. 2013. Fundação Pio XII - Hospital de Câncer de Barretos, HCB.
SILVEIRA, H. C. S.; Cursino-Santos, Jeny R; MOLFETTA, G. A.. Are aurora kinases gene overexpression associated to more agressive atages in children with adrenocortical tumors ? - qualificação de mestrado.. 2009. Faculdade de Medicina de Ribeirão Preto.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C.; MACEDO, C.; Santos JRC. Computer-Aided Diagnosis to Rheumatoid Arthritis via Artificial Intelligence-Qualificação de Mestrado. 2008. Faculdade de Medicina de Ribeirão Preto.
Comissão julgadora das bancas
FUNGARO, M. H. P.;MAFFEI, C. M. L.; BERTOLINI, M. C.; GIANNINI, M. J. S. M.. A capacidade de infecção do dermatófilo Trichophyton rubrum está correlacionada com a sinalização do pH extracelular. 2007 - Faculdade de Medicina de Ribeirão Preto-USP.
MARTINEZ-ROSSI, N. M.. A capacidade de infecção do dermatófito Trichophyton rubrum está correlacionada com a sinalização do pH extracelular. 2007. Tese (Doutorado em Genética) - Faculdade de Medicina de Ribeirão Preto-USP.
BERTOLINI, M. C.; MAFFEI, Claudia Maria Leite;MENDES-GIANNINI, Maria José Soares; Fungaro, Maria Helena Pelegrinelli; ROSSI, Nilce Maria Martinez. A capacidade de infecção do dermatófito Trichophyton rubrum está correlacionada com a sinalização do pH extracelular. 2007. Tese (Doutorado em Genética USP-RP) - Universidade de São Paulo.
Henrique-Silva, F.; GALETTI JUNIOR, Pedro Manoel;POLIKARPOV, Igor. Estudos das proteínas ligantes à DCRA e DSCR1 (Envolvidas com a Síndrome de Down) utilizando a metodologiado duplo-híbrido.. 2003. Dissertação (Mestrado em GENÉTICA EVOLUTIVA E BIOLOGIA MOLECULAR) - Universidade Federal de São Carlos.
SILVEIRA, H. C. S.;SELISTRE-de-ARAUJO, H. S.. DSCR1, a calcineurin interacting protein, also interacts with ubiquitously expressed transcript (UXT). 2002. Outra participação, Universidade Federal de São Carlos.
SIMÕES, A. L.. Identification of genes displayng differential expression in the nuc-2 mutant strain of the mold Neurospora crassal grown under phosphate starvation. 2006. Exame de qualificação (Doutorando em Ciências Biológicas (Genética) [Ribeirão Preto]) - Faculdade de Medicina de Ribeirão Preto.
MANFRIN, M. H.. Identification of genes displaying differential expression in the nuc-2 mutant strain of the mold Neurospora crassa I grown under phosphate starvation. 2006. Exame de qualificação (Doutorando em Ciências Biológicas (Genética)) - Universidade de São Paulo.
Del Lama, M. A.; ALENCAR, M. M.; ARAUJO, H. S. S.. DSCR1, a calcineurin interacting protein, also interacts with ubiquitously expressed transcript (UXT). 2002. Exame de qualificação (Doutorando em GENÉTICA EVOLUTIVA E BIOLOGIA MOLECULAR) - Universidade Federal de São Carlos.
ROSSI, Nilce Maria Martinez; MAFFEI, Cláudia Maria Leite; BERTOLINI, Maria Célia; Maria Helena Pelegrinelli Fungaro; Aline Maria da Silva;Roselino. [Membro suplente] A capacidade de infecção do dermatófito Trichophyton rubrum está correlacionada com a sinalização do pH extracelular. 2007. Tese (Doutorado em Genética) - Faculdade de Medicina de Ribeirão Preto.
MENDES-GIANNINI, M.J.S.; ROSSI, N.M.M.; MAFFEI, C.M.L.; FUNGARO, M. H. P;BERTOLINI, M.C.. A capacitação de infecção do dermatófito Trichophyton rubrum está correlacionada com a sinalização do pH extracelular. 2007. Tese (Doutorado em Genética USP-RP) - Universidade de São Paulo.
Orientou
AVALIAÇÃO DE GENES E PROTEÍNAS RELACIONADAS A RESPOSTA INFLAMATÓRIA EM UMA POPULAÇÃO EXPOSTA OCUPACIONALMENTE AOS AGROTÓXICOS; Início: 2021; Dissertação (Mestrado em Pós-graduação em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; (Orientador);
Implementação de protocolo para adesão e aplicação da agenda global dos hospitais verdes e saudáveis na rede hospital de amor; Início: 2020; Dissertação (Mestrado profissional em Pós-graduação em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB; (Orientador);
Predição computacional de indivíduos de alto e baixo risco de câncer baseado em marcadores de instabilidade genômica; Início: 2020; Tese (Doutorado em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; (Orientador);
Avaliação da expressão de biomarcadores em indivíduos expostos a agrotóxicos: uma abordagem exposômica; Início: 2019; Tese (Doutorado em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Fundação de Amparo à Pesquisa do Estado de São Paulo; (Orientador);
Início: 2021; Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Ministério da Saúde;
Início: 2021; Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Ministério da Saúde;
Cancer e trabalhadores rurais: um estudo de coorte; Início: 2021; Orientação de outra natureza; Fundação Pio XII - Hospital de Câncer de Barretos, HCB; Ministério da Saúde; (Orientador);
Cancer e trabalhadores rurais: um estudo de coorte; Início: 2021; Orientação de outra natureza; Fundação Pio XII - Hospital de Câncer de Barretos, HCB; Ministério da Saúde; (Orientador);
Cancer e trabalhadores rurais: um estudo de coorte; Início: 2021; Orientação de outra natureza; Fundação Pio XII - Hospital de Câncer de Barretos, HCB; Ministério da Saúde; (Orientador);
Análise da instabilidade genômica pela avaliação do comprimento dos telêmetros e o potencial risco ao câncer em individuos expostos a agrotóxicos; 2021; Dissertação (Mestrado em Pós-graduação em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Orientador: Henrique César Santejo Silveira;
AVALIAÇÃO DOS FATORES AMBIENTAIS E OCUPACIONAIS ENVOLVIDOS NA MAIOR INCIDÊNCIA DE LINFOMA NÃO HODGKIN: UMA REVISÃO SISTEMÁTICA; 2021; Dissertação (Mestrado em Ambiente e Saúde) - Universidade de Cuiabá,; Orientador: Henrique César Santejo Silveira;
Avaliação da instabilidade cromossômica e o potencial risco ao câncer em trabalhadores rurais expostos a agrotóxicos; 2019; Dissertação (Mestrado em Ambiente e Saúde) - Universidade de Cuiabá, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Orientador: Henrique César Santejo Silveira;
Perfil sócio-demográfico, ambiental e alguns fatores de associação ao uso dos agrotóxicos em trabalhadores rurais da região de Barretos, SP; ; 2018; Dissertação (Mestrado em Ambiente e Saúde) - Universidade de Cuiabá,; Orientador: Henrique César Santejo Silveira;
Avaliação da citoxicidade, genotoxicidade de herbicidas e o efeito da exposição no perfil epigenético em linhagem celular de pulmão; ; 2018; Dissertação (Mestrado em Pós-graduação em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Fundação de Amparo à Pesquisa do Estado de São Paulo; Orientador: Henrique César Santejo Silveira;
Avaliação do perfil de metilação global do DNA e em genes supressores tumorais de trabalhadores da construção civil expostos a agentes carcinogênicos ambientais e ocupacionais; 2016; Dissertação (Mestrado em Pós-graduação em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Fundação Pio XII- Hospital de Câncer de Barretos; Orientador: Henrique César Santejo Silveira;
Perfil de Metilação de genes em lesões precursoras do câncer do coloco útero; 2016; Dissertação (Mestrado em Pós-graduação em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Coorientador: Henrique César Santejo Silveira;
AVALIAÇÃO DA PRESENÇA DE ANTINEOPLÁSICOS E SEUS METABÓLITOS EM EFLUENTES NO MUNICÍPIO DE BARRETOS, SP, E SUAS INTERAÇÕES ECOLÓGICAS E GENOTÓXICAS; 2021; Tese (Doutorado em Oncologia) - Fundação Pio XII - Hospital de Câncer de Barretos, HCB,; Orientador: Henrique César Santejo Silveira;
2021; Fundação Pio XII - Hospital de Câncer de Barretos, HCB,; Henrique César Santejo Silveira;
Analise de possiveis agentes como fontes para obtencao de sistema moleculares complexos (Co-orientação); ; 2006; Trabalho de Conclusão de Curso; (Graduação em Informática Biomédica) - Universidade de São Paulo; Orientador: Henrique César Santejo Silveira;
Análise do perfil de metilação de supressores tumorais de células brônquio alveolares do pulmão em resposta a exposição ao Glifosato; 2021; Iniciação Científica - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Conselho Nacional de Desenvolvimento Científico e Tecnológico; Orientador: Henrique César Santejo Silveira;
Avaliação do status de metilação do DNA em linhagens celulares de pulmão expostas aos principais agrotóxicos utilizados na região de Barretos; 2016; Iniciação Científica - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Hospital de Cancer de Barretos; Orientador: Henrique César Santejo Silveira;
Avaliação do câncer ocupacional e do potencial risco em trabalhadores rurais expostos a agentes carcinogênicos ambientais e ocupacionais na região de Barretos; 2014; Iniciação Científica - Fundação Pio XII - Hospital de Câncer de Barretos, HCB; Orientador: Henrique César Santejo Silveira;
Análise do potencial risco de câncer na exposição dos trabalhadores da construção civil a agentes carcinogênicos; 2013; Iniciação Científica - Fundação Pio XII, Conselho Nacional de Desenvolvimento Científico e Tecnológico; Orientador: Henrique César Santejo Silveira;
Avaliação de micronúcleos em populações de risco ao câncer; 2013; Iniciação Científica - Fundação Pio XII - Hospital de Câncer de Barretos, HCB; Orientador: Henrique César Santejo Silveira;
Avaliação de biomarcadores moleculares frente a agentes genotoxicos em trabalhadores da agroindustria; ; 2011; Iniciação Científica - Fundação Pio XII - Hospital de Câncer de Barretos, HCB; Orientador: Henrique César Santejo Silveira;
Análise da Expressão Diferencial de Genes do Mutante AtrD de T; rubrum Em Resposta ao Antifúngico Terbinafina; 2005; Iniciação Científica; (Graduando em Medicina) - Faculdade de Medicina deRibeirão Preto, Conselho Nacional de Desenvolvimento Científico e Tecnológico; Orientador: Henrique César Santejo Silveira;
Avaliação de risco e conscientização do câncer ocupacional em trabalhadores rurais na região de Barretos; 2015; Orientação de outra natureza - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Organizacão Pan-Americana da Saude/Organizacão Mundial da Saude; Orientador: Henrique César Santejo Silveira;
Avaliação de risco e conscientização do câncer ocupacional em trabalhadores rurais na região de Barretos; 2015; Orientação de outra natureza - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Organizacão Pan-Americana da Saude/Organizacão Mundial da Saude; Orientador: Henrique César Santejo Silveira;
Avaliação da genetoxicidade em linhagens celulares expostas aos agrotóxicos; 2015; Orientação de outra natureza - Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Organizacão Pan-Americana da Saude/Organizacão Mundial da Saude; Orientador: Henrique César Santejo Silveira;
Avaliação de danos genotóxicos em trabalhadores da construção civil expostos a agentes carcinogênicos ambientais e ocupacionais; 2012; Orientação de outra natureza - Fundação Pio XII - Hospital de Câncer de Barretos, HCB; Orientador: Henrique César Santejo Silveira;
Avaliação do potencial genotóxico causado pela queima da palha da cana-de-açúcar e suas relações com a mutagênese humana; 2011; Orientação de outra natureza - Fundação Pio XII - Hospital de Câncer de Barretos, HCB; Orientador: Henrique César Santejo Silveira;
Educação Ambiental e prevenção de Câncer; 2011; Orientação de outra natureza - Fundação Pio XII - Hospital de Câncer de Barretos, HCB; Orientador: Henrique César Santejo Silveira;
Foi orientado por
2011; Faculdade de Medicina da Universidade de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo; Paulo Hilario Nascimento Saldiva;
A capacidade de infecção do dermatófito Trichophyton rubrum está correlacionada com a sinalização do pH extracelular; 2007; Tese (Doutorado em Genética) - Faculdade de Medicina de Ribeirão Preto-USP, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Orientador: Nilce Maria Martinez-Rossi;
Introdução à Bioinformática (Programa PAE); 2006; 0 f; Orientação de outra natureza; (Informática Biomédica) - Faculdade de Medicina de Ribeirão Preto - USP; Orientador: Silvana Giuliatti;
Avaliação do câncer ocupacional e do potencial risco em trabalhadores rurais expostos a agentes carcinogênicos ambientais e ocupacionais na região de Barretos; 2014; Iniciação Científica - Instituto Social Hospital de Câncer de Barretos; Orientador: Isabella Alves Brunetti;
Estudos das proteinas ligantes a DCRA e DSCR1 (envolvidas com a Síndrome de Down) utilizando a metodologia do Duplo-Hibrido; 2003; 95 f; Dissertação (Mestrado em GENÉTICA EVOLUTIVA E BIOLOGIA MOLECULAR) - Universidade Federal de São Carlos, Conselho Nacional de Desenvolvimento Científico e Tecnológico; Orientador: Flavio Henrique da Silva;
A capacidade de infecção do dermatófito Trichophyton rubrum está correlacionada com a sinalização do pH extracelular; 2007; Tese (Doutorado em Programa de Genética) - Faculdade de Medicina de Ribeirão Preto, USP, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Coorientador: Antonio Rossi Filho;
Produções bibliográficas
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ROHR, PAULA ; CAMPANELLI DOS SANTOS, ISABELA ; VAN HELVOORT LENGERT, ANDRÉ ; ALVES DE LIMA, MARCOS ; MANUEL REIS, RUI ; BARBOSA, FERNANDO ; CESAR SANTEJO SILVEIRA, HENRIQUE . Absolute telomere length in peripheral blood lymphocytes of workers exposed to construction environment. INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH , v. 1, p. 1-9, 2022.
DE OLIVEIRA KLEIN, MARIANA ; SERRANO, SERGIO V. ; SANTOS-NETO, ÁLVARO ; DA CRUZ, CLAUDINEI ; BRUNETTI, ISABELLA ALVES ; LEBRE, DANIEL ; GIMENEZ, MAÍSE PASTORE ; REIS, RUI M. ; Silveira, Henrique C.S. . Detection of anti-cancer drugs and metabolites in the effluents from a large Brazilian cancer hospital and an evaluation of ecotoxicology. ENVIRONMENTAL POLLUTION , v. 268, p. 115857, 2021.
FERNANDES, FLÁVIA GONÇALVES ; SILVEIRA, HENRIQUE CESAR SANTEJO ; JÚNIOR, JOÃO NEIF ANTONIO ; DA SILVEIRA, ROSANA ANTUNES ; ZUCCA, LUIS EDUARDO ; CÁRCANO, FLAVIO MAVIGNIER ; SANCHES, ANDRÉ OCTAVIO NICOLAU ; NEDER, LUCIANO ; SCAPULATEMPO-NETO, CRISTOVAM ; SERRANO, SERGIO VICENTE ; JONASCH, ERIC ; REIS, RUI MANUEL ; EVANGELISTA, ADRIANE FEIJÓ . Somatic Copy Number Alterations and Associated Genes in Clear-Cell Renal-Cell Carcinoma in Brazilian Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES , v. 22, p. 2265, 2021.
CAMPANELLA, NATHÁLIAC. ; SILVA, EDUARDOCAETANO ; DIX, GUSTAVO ; DELIMAVAZQUEZ, FABIANA ; ESCREMIMDEPAULA, FLÁVIA ; BERARDINELLI, GUSTAVON. ; BALANCIN, MARCELO ; CHAMMAS, ROGER ; MENDOZALOPEZ, ROSSANAV. ; SILVEIRA, HENRIQUECÉSARS. ; CAPELOZZI, VERALUIZA ; REIS, RUIMANUEL . Mutational Profiling of Driver Tumor Suppressor and Oncogenic Genes in Brazilian Malignant Pleural Mesotheliomas. PATHOBIOLOGY , v. 5, p. 1-8, 2020.
SILVA, ISANA RODRIGUES ; FRANCISCO, LUIZA FLAVIA VEIGA ; BERNARDO, CASSIA ; OLIVEIRA, MARCO ANTÔNIO ; BARBOSA, FERNANDO ; SILVEIRA, HENRIQUE CÉSAR SANTEJO . DNA methylation changes in promoter region of gene in workers exposed in construction environment. BIOMARKERS , v. xx, p. 1-28, 2020.
SILVA, ISANA ; RAMOS, MANOELA ; ARANTES, LÍDIA ; LENGERT, ANDRÉ ; OLIVEIRA, MARCO ; CURY, FERNANDA ; MARTINS PEREIRA, GUILHERME ; SANTOS, ALDENOR ; BARBOSA, FERNANDO ; VASCONCELLOS, PÉROLA ; CUENIN, CYRILLE ; HERCEG, ZDENKO ; Silveira, Henrique . Evaluation of DNA Methylation Changes and Micronuclei in Workers Exposed to a Construction Environment. International Journal of Environmental Research and Public Health , v. 16, p. 902, 2019.
RADOVICH, MILAN PICKERING, CURTIS R. FELAU, INA HA, GAVIN ZHANG, HAILEI JO, HEEJOON HOADLEY, KATHERINE A. ANUR, PAVANA ZHANG, JIEXIN MCLELLAN, MIKE BOWLBY, REANNE MATTHEW, THOMAS DANILOVA, LUDMILA HEGDE, APURVA M. LEISERSON, MARK D.M. SETHI, GEETIKA LU, CHARLES RYAN, MICHAEL SU, XIAOPING CHERNIACK, ANDREW D. ROBERTSON, GORDON AKBANI, REHAN SPELLMAN, PAUL WEINSTEIN, JOHN N. HAYES, D. NEIL , et al. RAPHAEL, BEN LICHTENBERG, TARA LERAAS, KRISTEN ZENKLUSEN, JEAN CLAUDE FUJIMOTO, JUNYA SCAPULATEMPO-NETO, CRISTOVAM MOREIRA, ANDRE L. HWANG, DAVID HUANG, JAMES MARINO, MIRELLA KORST, ROBERT GIACCONE, GIUSEPPE GOKMEN-POLAR, YESIM BADVE, SUNIL RAJAN, ARUN STRÖBEL, PHILIPP GIRARD, NICOLAS TSAO, MING S. MARX, ALEXANDER TSAO, ANNE S. LOEHRER, PATRICK J. ALLY, ADRIAN APPELBAUM, ELIZABETH L. AUMAN, J. TODD BALASUNDARAM, MIRUNA BALU, SAIANAND BEHERA, MADHUSMITA BEROUKHIM, RAMEEN BERRIOS, MARIO BLANDINO, GIOVANNI BODENHEIMER, TOM BOOTWALLA, MOIZ S. BOWEN, JAY BROOKS, DENISE CARCANO, FLAVIO M. CARLSEN, REBECCA CARVALHO, ANDRE L. CASTRO, PATRICIA CHALABREYSSE, LARA CHIN, LYNDA CHO, JUOK CHOE, GINA CHUAH, ERIC CHUDAMANI, SUDHA CIBULSKIS, CARRIE COPE, LESLIE CORDES, MATTHEW G. CRAIN, DANIEL CURLEY, ERIN DEFREITAS, TIMOTHY DEMCHOK, JOHN A. DETTERBECK, FRANK DHALLA, NOREEN DIENEMANN, HENDRIK EDENFIELD, W. JEFF FACCIOLO, FRANCESCO FERGUSON, MARTIN L. FRAZER, SCOTT FRONICK, CATRINA C. FULTON, LUCINDA A. FULTON, ROBERT S. GABRIEL, STACEY B. GARDNER, JOHANNA GASTIER-FOSTER, JULIE M. GEHLENBORG, NILS GERKEN, MARK GETZ, GAD HEIMAN, DAVID I. HOBENSACK, SHITAL HOLBROOK, ANDREA HOLT, ROBERT A. HOYLE, ALAN P. HUTTER, CAROLYN M. ITTMANN, MICHAEL JEFFERYS, STUART R. JONES, CORBIN D. JONES, STEVEN J.M. KASAIAN, KATAYOON KIM, JAEGIL KIMES, PATRICK K. LAI, PHILLIP H. LAIRD, PETER W. LAWRENCE, MICHAEL S. LIN, PEI LIU, JIA LOLLA, LAXMI LU, YILING MA, YUSSANNE MAGLINTE, DENNIS T. MALLERY, DAVID MARDIS, ELAINE R. MARRA, MARCO A. MARTIN, JULIE MAYO, MICHAEL MEIER, SAM MEISTER, MICHAEL MENG, SHAOWU MEYERSON, MATTHEW MIECZKOWSKI, PIOTR A. MILLER, CHRISTOPHER A. MILLS, GORDON B. MOORE, RICHARD A. MORRIS, SCOTT MOSE, LISLE E. MULEY, THOMAS MUNGALL, ANDREW J. MUNGALL, KAREN NARESH, RASHI NEWTON, YULIA NOBLE, MICHAEL S. OWONIKOKO, TAOFEEK PARKER, JOEL S. PAULASKIS, JOSEPH PENNY, ROBERT PEROU, CHARLES M. PERRIN, CORINNE PIHL, TODD RADENBAUGH, AMIE RAMALINGAM, SURESH RAMIREZ, NILSA RIEKER, RALF ROACH, JEFFREY SADEGHI, SARA SAKSENA, GORDON SCHEIN, JACQUELINE E. SCHMIDT, HEATHER K. SCHUMACHER, STEVEN E. SHELTON, CANDACE SHELTON, TROY SHI, YAN SHIH, JULIANN SICA, GABRIEL Silveira, Henrique C.S. SIMONS, JANAE V. SIPAHIMALANI, PAYAL SKELLY, TARA SOFIA, HEIDI J. SOLOWAY, MATTHEW G. STUART, JOSHUA SUN, QIANG TAM, ANGELA TAN, DONGHUI TARNUZZER, ROY THIESSEN, NINA VAN DEN BERG, DAVID J. VASEF, MOHAMMAD A. VELUVOLU, UMADEVI VOET, DOUG WALTER, VONN WAN, YUNHU WANG, ZHINING WARTH, ARNE WEIS, CLEO-ARON WEISENBERGER, DANIEL J. WILKERSON, MATTHEW D. WISE, LISA WONG, TINA WU, HSIN-TA WU, YE YANG, LIMING ZHANG, JIASHAN ZMUDA, ERIK ; The Integrated Genomic Landscape of Thymic Epithelial Tumors. CANCER CELL , v. 33, p. 244-258.e10, 2018.
SCHAUB, FRANZ X. DHANKANI, VARSHA TRIVEDI, MIHIR RICHARDSON, ANNE B. SHAW, REID ZHAO, WEI ZHANG, XIAOYANG VENTURA, ANDREA LIU, YUEXIN AYER, DONALD E. HURLIN, PETER J. CHERNIACK, ANDREW D. EISENMAN, ROBERT N. BERNARD, BRADY GRANDORI, CARLA CAESAR-JOHNSON, SAMANTHA J. DEMCHOK, JOHN A. FELAU, INA KASAPI, MELPOMENI FERGUSON, MARTIN L. HUTTER, CAROLYN M. SOFIA, HEIDI J. TARNUZZER, ROY WANG, ZHINING YANG, LIMING , et al. ZENKLUSEN, JEAN C. ZHANG, JIASHAN (JULIA) CHUDAMANI, SUDHA LIU, JIA LOLLA, LAXMI NARESH, RASHI PIHL, TODD SUN, QIANG WAN, YUNHU WU, YE CHO, JUOK DEFREITAS, TIMOTHY FRAZER, SCOTT GEHLENBORG, NILS GETZ, GAD HEIMAN, DAVID I. KIM, JAEGIL LAWRENCE, MICHAEL S. LIN, PEI MEIER, SAM NOBLE, MICHAEL S. SAKSENA, GORDON VOET, DOUG ZHANG, HAILEI CHAMBWE, NYASHA KNIJNENBURG, THEO KRAMER, ROGER LEINONEN, KALLE MILLER, MICHAEL REYNOLDS, SHEILA SHMULEVICH, ILYA THORSSON, VESTEINN ZHANG, WEI AKBANI, REHAN BROOM, BRADLEY M. HEGDE, APURVA M. JU, ZHENLIN KANCHI, RUPA S. KORKUT, ANIL LI, JUN LIANG, HAN LING, SHIYUN LIU, WENBIN LU, YILING MILLS, GORDON B. NG, KWOK-SHING RAO, ARVIND RYAN, MICHAEL WANG, JING WEINSTEIN, JOHN N. ZHANG, JIEXIN ABESHOUSE, ADAM ARMENIA, JOSHUA CHAKRAVARTY, DEBYANI CHATILA, WALID K. DE BRUIJN, INO GAO, JIANJIONG GROSS, BENJAMIN E. HEINS, ZACHARY J. KUNDRA, RITIKA LA, KONNOR LADANYI, MARC LUNA, AUGUSTIN NISSAN, MORIAH G. OCHOA, ANGELICA PHILLIPS, SARAH M. REZNIK, ED SANCHEZ-VEGA, FRANCISCO SANDER, CHRIS SCHULTZ, NIKOLAUS SHERIDAN, ROBERT SUMER, S. ONUR SUN, YICHAO TAYLOR, BARRY S. WANG, JIOAJIAO ZHANG, HONGXIN ANUR, PAVANA PETO, MYRON SPELLMAN, PAUL BENZ, CHRISTOPHER STUART, JOSHUA M. WONG, CHRISTOPHER K. YAU, CHRISTINA HAYES, D. NEIL PARKER, JOEL S. WILKERSON, MATTHEW D. ALLY, ADRIAN BALASUNDARAM, MIRUNA BOWLBY, REANNE BROOKS, DENISE CARLSEN, REBECCA CHUAH, ERIC DHALLA, NOREEN HOLT, ROBERT JONES, STEVEN J.M. KASAIAN, KATAYOON LEE, DARLENE MA, YUSSANNE MARRA, MARCO A. MAYO, MICHAEL MOORE, RICHARD A. MUNGALL, ANDREW J. 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DINH, HUYEN DODDAPANENI, HARSHAVARDHAN DONEHOWER, LAWRENCE A. DRUMMOND, JENNIFER GIBBS, RICHARD A. GLENN, ROBERT HALE, WALKER HAN, YI HU, JIANHONG KORCHINA, VIKTORIYA LEE, SANDRA LEWIS, LORA LI, WEI LIU, XIUPING MORGAN, MARGARET MORTON, DONNA MUZNY, DONNA SANTIBANEZ, JIREH SHETH, MARGI SHINBROT, EVE WANG, LINGHUA WANG, MIN WHEELER, DAVID A. XI, LIU ZHAO, FENGMEI HESS, JULIAN APPELBAUM, ELIZABETH L. BAILEY, MATTHEW CORDES, MATTHEW G. DING, LI FRONICK, CATRINA C. FULTON, LUCINDA A. FULTON, ROBERT S. KANDOTH, CYRIAC MARDIS, ELAINE R. MCLELLAN, MICHAEL D. MILLER, CHRISTOPHER A. SCHMIDT, HEATHER K. WILSON, RICHARD K. CRAIN, DANIEL CURLEY, ERIN GARDNER, JOHANNA LAU, KEVIN MALLERY, DAVID MORRIS, SCOTT PAULAUSKIS, JOSEPH PENNY, ROBERT SHELTON, CANDACE SHELTON, TROY SHERMAN, MARK THOMPSON, ERIC YENA, PEGGY BOWEN, JAY GASTIER-FOSTER, JULIE M. GERKEN, MARK LERAAS, KRISTEN M. LICHTENBERG, TARA M. RAMIREZ, NILSA C. 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NOUSHMEHR, HOUTAN CARLOTTI, CARLOS GILBERTO DA CUNHA TIRAPELLI, DANIELA PRETTI WEISENBERGER, DANIEL J. VAN DEN BERG, DAVID J. MAGLINTE, DENNIS T. BOOTWALLA, MOIZ S. LAI, PHILLIP H. TRICHE, TIMOTHY SWISHER, ELIZABETH M. AGNEW, KATHY J. SHELLEY, CARL SIMON LAIRD, PETER W. SCHWARZ, JULIE GRIGSBY, PERRY MUTCH, DAVID ; Integrated genomic and molecular characterization of cervical cancer. Nature (London) , v. 11, p. 1465-1467, 2017.
BORDINHAO, A. L. ; EVANGELISTA, A. F. ; OLIVEIRA, R. J. S. ; MACEDO, T. ; SILVEIRA, H. C. S. ; REIS, R. M. ; Marques, M. M. C. M. . MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib. Oncology Reports , v. x, p. 1, 2016.
RAMOS, M. C. ; CURY, F. P. ; SCAPULATEMPO, C. ; Marques, M. M. C. M. ; SILVEIRA, H. C. S. . Micronucleus Evaluation of Exfoliated Buccal Epithelial Cells Using Liquid-Based Cytology Preparation. Acta Cytologica , v. 58, p. 582-588, 2014.
MARINO, AUGUSTO LF ; EVANGELISTA, ADRIANE F ; VIEIRA, RENÉ AC ; MACEDO, TACIANE ; KERR, LIGIA M ; ABRAHÃO-MACHADO, LUCAS FARIA ; LONGATTO-FILHO, ADHEMAR ; Silveira, Henrique CS ; MARQUES, MARCIA MC . MicroRNA expression as risk biomarker of breast cancer metastasis: a pilot retrospective case-cohort study. BMC Cancer (Online) , v. 14, p. 739, 2014.
Silveira, Henrique César ; SCHMIDT-CARRIJO, MARINA ; SEIDEL, ERVALD HENRIQUE ; SCAPULATEMPO-NETO, CRISTOVAM ; LONGATTO-FILHO, ADHEMAR ; CARVALHO, ANDRE LOPES ; REIS, RUI MANUEL ; SALDIVA, PAULO HILÁRIO . Emissions generated by sugarcane burning promote genotoxicity in rural workers: a case study in Barretos, Brazil. Environmental Health (London. 2002. Online) , v. 12, p. 87, 2013.
MaranhÃo, Fernanda C.A. ; Silveira, Henrique C.S. ; ROSSI, Antonio ; Martinez-Rossi, Nilce M. . Isolation of transcripts overexpressed in the human pathogen. Canadian Journal of Microbiology (Print) , v. 57, p. 333-338, 2011.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras D ; R, C. ; Sanches PR ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Transcriptional profiling reveals genes in the human pathogen Trichophyton rubrum that are expressed in response to pH signaling. Microbial Pathogenesis , v. 48, p. 91-96, 2010.
Peres, Nalu TA ; Sanches, Pablo R ; Falcão, Juliana P ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Paião, Fernanda G ; Maranhão, Fernanda CA ; Gras, Diana E ; Segato, Fernando ; Cazzaniga, Rodrigo A ; Mazucato, Mendelson ; Cursino-Santos, Jeny R ; Aquino-Ferreira, Roseli ; ROSSI, Antonio ; Martinez-Rossi, Nilce M . Transcriptional profiling reveals the expression of novel genes in response to various stimuli in the human dermatophyte Trichophyton rubrum. BMC Microbiology (Online) , v. 10, p. 39, 2010.
Gras, Diana E. ; Silveira, Henrique C.S. ; Peres, Nalu T.A. ; Sanches, Pablo R. ; Martinez-Rossi, Nilce M. ; ROSSI, Antonio . Transcriptional changes in the nuc-2A mutant strain of Neurospora crassa cultivated under conditions of phosphate shortage. Microbiological Research , v. 164, p. 658-664, 2009.
Silva, Emiliana M. ; Freitas, Janaína S. ; Gras, Diana E. ; Squina, Fábio M. ; Leal, Juliana ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Martinez-Rossi, Nilce M. ; ROSSI, Antonio . Identification of genes differentially expressed in a strain of the mold Aspergillus nidulans carrying a loss-of-function mutation in the palA gene. Canadian Journal of Microbiology (Online) , v. 54, p. 803-811, 2008.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras, Diana E. ; Martinez-Rossi, Nilce M. ; ROSSI, Antonio . Identification of genes displaying differential expression in the nuc-2 mutant strain of the mold Neurospora crassa grown under phosphate starvation. FEMS Microbiology Letters , v. 269, p. 196-200, 2007.
Ferreira-Nozawa, Monica ; Silveira, Henrique ; Ono, Carlos ; Fachin, Ana ; ROSSI, Antonio ; Martinez-Rossi, Nilce . The pH signaling transcription factor PacC mediates the growth of Trichophyton rubrum on human nail in vitro. Medical Mycology (Oxford) , v. 44, p. 641-645, 2006.
Malago, W. ; Sommer, C. A. ; Andrade CD ; Soares-Costa, A ; Possik P ; Cassago, A ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; HENRIQUE-SILVA, F. . Gene Expression Profile of Human Down Syndrome. Croation Medical Journal C M J, v. 46, n.4, p. 647-656, 2005.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Sommer, C.A. ; Soares-Costa, A. ; HENRIQUE-SILVA, F. . A calcineurin inhibitory protein overexpressed in Down's syndrome interacts with the product of a ubiquitously expressed transcript. Brazilian Journal of Medical and Biological Research (Impresso) , v. 37, n.6, p. 785-789, 2004.
VETTORE, A. L. DA SILVA, F. R. KEMPER, E. L. SOUZA, G. M. DA SILVA, A. M. FERRO, M. I. T. HENRIQUE-SILVA, F. GIGLIOTI, E. A. LEMOS, M. V. F. COUTINHO, L. L. NOBREGA, M. P. CARRER, H. FRANCA, S. C. BACCI, M. GOLDMAN, M. H. S. GOMES, S. L. NUNES, L. R. CAMARGO, L. E. A. SIQUEIRA, W. J. VAN SLUYS, M. A. THIEMANN, O. H. KURAMAE, E. E. SANTELLI, R. V. MARINO, C. L. TARGON, M. L. P. N. , et al. FERRO, J. A. SILVEIRA, H. C. S. MARINI, D. C. LEMOS, E. G. M. MONTEIRO-VITORELLO, C. B. TAMBOR, J. H. M. CARRARO, D. M. ROBERTO, P. G. MARTINS, V. G. GOLDMAN, G. H. DE OLIVEIRA, R. C. TRUFFI, D. COLOMBO, C. A. ROSSI, M. DE ARAUJO, P. G. SCULACCIO, S. A. ANGELLA, A. LIMA, M. M. A. DE ROSA, V. E. SIVIERO, F. COSCRATO, V. E. MACHADO, M. A. GRIVET, L. DI MAURO, S. M. Z. NOBREGA, F. G. MENCK, C. F. M. BRAGA, M. D. V. TELLES, G. P. CARA, F. A. A. PEDROSA, G. MEIDANIS, J. ARRUDA, P. ; Analysis and Functional Annotation of an Expressed Sequence Tag Collection for Tropical Crop Sugarcane. Genome Research , v. 13, p. 2725-2735, 2003.
SANTOS, I. C. ; VICENTE, J. T. S. ; DAMASCENO, L. S. P. ; FRANSCISCO, L. V. ; SILVEIRA, H. C. S. . Agrotóxicos e biomarcadores de instabilidade genômica. In: Silva, Cristhiane Almeida Leite da, et al.. (Org.). Uma Visão Interdisciplinar Sobre os Impactos dos Fatores Ambientais na Saúde Humana. 1ed.Londrina: Editora Cientifica Kroton, 2020, v. 1, p. 5-11.
GOES, R. F. ; CAPELETO, S. M. ; FREITAS, D. M. ; SILVA, C. A. L. ; SILVEIRA, H. C. S. ; BITTENCOURT, W. S. . Relação da saúde e exposição ambiental aos agrotóxicos na agricultura familiar. In: Silva, Cristhiane Almeida Leite da, et al.. (Org.). Uma Visão Interdisciplinar Sobre os Impactos dos Fatores Ambientais na Saúde Humana. 1ed.Londrina: Editora Cientifica Kroton, 2020, v. 1, p. 21-28.
FREITAS, D. M. ; CAPELETO, S. M. ; GOES, R. F. ; SILVA, C. A. L. ; SILVEIRA, H. C. S. ; BITTENCOUR, W. S. . Exposição à poluição atmosférica por material particulado e doenças cardíacas. In: Silva, Cristhiane Almeida Leite da, et al.. (Org.). Uma Visão Interdisciplinar Sobre os Impactos dos Fatores Ambientais na Saúde Humana. 1ed.Londrina: Editora Cientifica Kroton, 2020, v. 1, p. 138-145.
FRANSCISCO, L. V. ; SILVA, R. N. ; SANTOS, I. C. ; SILVEIRA, H. C. S. . Exposição aos Agrotóxicos e sua influência no Linfoma não Hodgkin. In: Silva, Cristhiane Almeida Leite da, et al.. (Org.). Uma Visão Interdisciplinar Sobre os Impactos dos Fatores Ambientais na Saúde Humana. 1ed.Londrina: Editora Científica Kroton, 2020, v. 1, p. 77-87.
SILVEIRA, H. C. S. ; VAZQUEZ, F. ; COSTA, A. M. ; MUZI, C. D. ; SILVEIRA, M. L. F. G. . Registro de Câncer. In: Departamento de Saúde Ambiental e Saúde do Trabalhador - DASAT (Ministério da Saúde). (Org.). Atlas do Câncer relacionado ao trabalho. 1ed.Brasilia-DF: Ministério da Saúde, 2018, v. 1, p. 32-35.
Silveira, H.C.S. . Vida Longa ao Brócolis. Revista Abril, 01 out. 2017.
Silveira, H.C.S. . Brócolis contém substâncias que previnem câncer e ajudam pacientes em quimioterapia. Revista Globo Rural, 11 ago. 2017.
Silveira, H.C.S. . Vídeo ensina o correto manuseio de defensivos agrícolas. Diario Oficial do Estado de São Paulo, Estado de São Paulo, p. número 73, 19 abr. 2017.
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Silveira, H.C.S. . Hospital do Câncer de Barretos lança vídeo para orientar agricultores. Globo Rural, 01 mar. 2017.
Silveira, H.C.S. ; GARCIA, L. ; LOPES, L. F. . Alunos acompanham luta contra o câncer em Hospital de Barretos. Portal G1, Barretos, 15 jul. 2013.
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Silveira, H.C.S. . Alunos acompanham o dia a dia e as pesquisas do Hospital de Câncer. Diario de Barretos, 07 jul. 2013.
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SILVEIRA, H. C. S. . Fumaça gerada pela queima do diesel causa câncer, alerta OMS. Gazeta do Povo, Curitiba, 16 jul. 2012.
SILVEIRA, H. C. S. . Câncer e Meio Ambiente. EComunicação, Barretos, 08 set. 2011.
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Silveira, H.C.S. ; BERNARDO, C. ; SARAIVA, J. M. D. ; CAUSIN, R. ; SALOMAO, R. . Governo de SP e Hospital de Câncer de Barretos orientarão aplicação correta de defensivos agricolas. Secretária de Abastecimento e Agricultura do Estado de São Paulo. Secretaria de Agricultura e Abastecimento do Estado de São Paulo, São Paulo.
Silveira, H.C.S. . Vídeo alerta sobre os riscos dos agrotóxicos. OncoNews.
CAZZANIGA, R. ; SILVEIRA, H. C. S. ; Marques, MMC ; Sanches PR ; PASSOS, GAS ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Avaliação da expressão gênica do dermatófito Trichophyton rubrum durante o cultivo em queratina como única fonte de nutriente. In: 25* Congresso Brasileiro de Micribiologia, 2009, Porto de Galinhas. Revista da SBM, 2009. p. 73-73.
DAMASCENO, L. S. P. ; SHIMOYA-BITTENCOURT, W. ; SILVEIRA, H. C. S. . EXPOSIÇÃO OCUPACIONAL E A OCORRÊNCIA DE CÂNCER DE BEXIGA: UMA REVISÃO SISTEMÁTICA. In: 23 Encontro de Atividades Cientificas, 2020, Cuiabá. 23 Encontro de Atividades Cientificas. Londrina: Kroton, 2020. v. 1. p. 1.
SILVA, R. N. ; SILVA, C. A. L. ; SILVEIRA, H. C. S. . AVALIAÇÃO DE FATORES AMBIENTAIS E OCUPACIONAIS ENVOLVIDOS NO LINFOMA NÃO HODGKIN: UMA REVISÃO SISTEMÁTICA. In: 23 Encontro de Atividades Científicas, 2020, Cuiabá. 23 Encontro de Atividades Cientificas. Londrina: Editora Kroton, 2020. v. 1. p. 1.
VICENTE, J. T. S. ; SANTOS, I. C. ; SILVEIRA, H. C. S. . Exposição ocupacional no contexto agricultura familiar através do ensaio de micronúcleos em células bucais. In: 22 Encontro de Atividades Cientificas, 2019, Cuiabá. 22 Encontro de Atividades Cientificas, 2019. v. x. p. x-x.
SILVA, R. N. ; VICENTE, J. T. S. ; SILVEIRA, H. C. S. . Avaliação dos Fatores Ambientais causadores do Linfoma não Hodgkin: uma revisão sistemática. In: 22 Encontro de Atividades Cientificas, 2019, Cuiabá. 22 Encontro de Atividades Cientificas, 2019. v. x.
SANTOS, I. C. ; VICENTE, J. T. S. ; BERNARDO, C. R. ; SARAIVA, J. M. D. ; CAUSIN, R. ; CANGANI, T. M. ; Silveira, H.C.S. . Utilização da ferramenta RedCap na conscientização e prevenção de câncer em trabalhadores rurais expostos a pesticidas na região de Barretos. In: I Simpósio de REDCap, 2019, Barretos. I Simpósio de REDCap. Barretos: Hospital de Câncer de Barretos, 2019. v. 1. p. 1.
TENESSE, J. ; CANGANI, T. ; SILVEIRA, H. C. S. . AVALIAÇÃO DOS DANOS NO DNA EM TRABALHADORES RURAIS EXPOSTOS A AGROTÓXICOS NA REGIÃO DE BARRETOS-SP. In: 21 Encontro de Atividades Cientificas, 2018, Cuiabá. 21 Encontro de Atividades Cientificas, 2018.
CANGANI, T. M. ; VICENTE, J. T. S. ; SILVEIRA, H. C. S. . AVALIAÇÃO DOS AGROTÓXICOS MAIS UTILIZADOS NO INTERIOR DO ESTADO DE SÃO PAULO. In: 21 Encontro de Atividades Cientificas, 2018, Cuiaba. 21 Encontro de Atividades Cientificas, 2018.
KLEIN, M. O. ; SERRANO, S. V. ; REIS, R. M. ; Silveira, H.C.S. . AVALIAÇÃO DA PRESENÇA DE ANTINEOPLÁSICOS E METABÓLITOS EM EFLUENTE HOSPITALAR E MUNICIPAL de BARRETOS, SP, POR MEIO DE CROMATROGRAFIA LÍQUIDA ACOPLADA A ESPECTROMETRIA DE MASSAS (CLAE-EM/EM). In: 10° Seminário Hospitais Saudáveis e 3ª Conferência Latino-Americana da Rede Global de Hospitais Verdes e Saudáveis, 2017, São Paulo. 10° Seminário Hospitais Saudáveis e 3ª Conferência Latino-Americana da Rede Global de Hospitais Verdes e Saudáveis, 2017.
SARAIVA, J. M. D. ; CAMARGO, R. C. ; BRUNETTI, I. ; OLIVEIRA, R. J. S. ; REIS, R. M. ; Silveira, H.C.S. . Cytotoxicity effects the active principle of herbicide 2,4-D in lung cell line. In: VI Simpósio Internacional em Oncologia Translacional e Pesquisa Clinica, 2017, Barretos. VI Simpósio Internacional em Oncologia Translacional e Pesquisa Clinica, 2017.
CAMARGO, R. C. ; SARAIVA, J. M. D. ; SOLERA, A. ; OLIVEIRA, R. J. S. ; LENGERT, A. ; REIS, R. M. ; Silveira, H.C.S. . Evaluation of citoxicity of 2,4-Dichlorophenoxyacetic acid (2,4-D) in human cell line. In: VI Simposio Internacional em Oncologia Molecular e Pesquisa Clinica, 2017, Barretos. VI Simposio Internacional em Oncologia Molecular e Pesquisa Clinica, 2017.
SANTOS, I. C. ; BERNARDO, C. R. ; SARAIVA, J. M. D. ; CAUSIN, R. ; CANGANI, T. M. ; VICENTE, J. T. S. ; Silveira, H.C.S. . Utilização de mídia digital para conscientização e prevenção de câncer em trabalhadores rurais expostos a pesticidas na região de Barretos. In: II Encontro Cientifico de Educação em Saúde, 2017, Barretos. II Encontro Cientifico de Educação em Saúde, 2017.
ROGERI, C. D. ; CAUSIN, R. ; CARVALHO, A. ; ARANTES, L. M. ; STEIN, M. ; POSSATI, J. ; SCAPULATEMPO, C. ; REIS, R. M. ; VILLA, L. ; LONGHATO, A. ; Silveira, H.C.S. ; FREGNANI, J. H. T. G. . Methylation profile of tumor supressor genes as biomarker of cervical high-grade lesions. In: VI Simpósio Internacional em Oncologia Translacional e Pesquisa Clínica, 2017, Barretos. VI Simpósio Internacional em Oncologia Translacional e Pesquisa Clínica, 2017.
SILVA, I. R. ; RAMOS, M. C. ; CURY, F. P. ; ARANTES, L. M. ; LENGERT, A. V. ; BARBOSA JR, F. ; CUENIN, C. ; HERCEG, Z. ; SILVEIRA, H. C. S. . Evaluation of global and gene-specific promoter methylation changes and micronuclei levels in construction workers exposed to environmental carcinogens. In: Epigenetics and Environmental origins of cancer, 2016, Lyon. Epigenetics and Environmental origins of cancer, 2016. v. 1. p. 37.
SARAIVA, J. M. D. ; BERNARDO, C. R. ; CAUSIN, R. ; BRUNETTI, I. ; CRUZ, C. ; SILVEIRA, H. C. S. . Cytotoxicity effects of herbicides 2,4-D, atrazine and glyphosate in lung cell lines. In: 1st International Meeting of Environmental Health and Toxicology, 2016, Ribeirão Preto. IMEHTOX, 2016. v. 1.
SILVA, I. R. ; BERNARDO, C. ; DUARTE, J. ; CAUSIN, R. ; Silveira, H.C.S. . Rapid DNA methylation changes in cosntruction workers. In: 1st International Meeting of Environmental Health and Toxicology, 2016, Ribeirão Preto. IMEHTOX, 2016. v. 1.
TORRIERI, R. ; KITAGIMA, J. P. ; SILVEIRA, H. C. S. ; SCAPULATEMPO, C. ; OLIVEIRA, G. ; VAZQUEZ, V. L. ; REIS, R. M. ; CARVALHO, A. L. . ICGC MELANOMA BRAZIL: A PRELIMINARY REPORT. In: ICGC, 2015, Verona. ICGC, 2015.
EVANGELISTA, A. F. ; SILVEIRA, H. C. S. ; SILVEIRA, R. A. ; ZUCCA, E. ; SCAPULATEMPO, C. ; JONASCH, E. ; SERRANO, S. V. ; REIS, R. M. . Genome-wide analysis of copy number aberrations (CNA) in renal cell carcinomas. In: Global Academic Program, 2015, Houston. GAP, 2015.
RAMOS, M. C. ; CURY, F. P. ; SILVA, I. R. ; SCAPULATEMPO, C. ; Marques, M. M. C. M. ; SILVEIRA, H. C. S. . Evaluation of genotoxicity in construction workers exposed to occupational and environmental agents. In: IV Symposium on Translational Oncology of the Barretos Cancer Hospital, 2014, Barretos. IV Symposium on Translational Oncology, 2014. v. 2.
RAMOS, M. C. ; CURY, F. P. ; SILVA, I. R. ; SCAPULATEMPO, C. ; Marques, M. M. C. M. ; SILVEIRA, H. C. S. . Assessment of micronuclei in construction workers exposed to occupational and environmental agents. In: Environmental Mutagenesis and Genomics Society 45th Annual Meeting, 2014, Orlando. Environmental Mutagenesis and Genomics Society 45th Annual Meeting, 2014.
CURY, F. P. ; RAMOS, M. C. ; SILVEIRA, H. C. S. . Assessment of micronuclei frequency in civil construction workers. In: III International Symposium on Translational Oncology, 2013, Barretos. III International Symposium on Translational Oncology, 2013.
CURY, F. P. ; RAMOS, M. C. ; SILVEIRA, H. C. S. . Assessment of micronuclei frequency in civil construction workers.. In: 59 Congresso Brasileiro de Genética., 2013, Aguas de Lindóia. 59 Congresso Brasileiro de Genética., 2013.
CURY, F. P. ; RAMOS, M. C. ; SCAPULATEMPO, C. ; SILVEIRA, H. C. S. . Assessment of micronuclei frequency in civil construction workers. In: V Encontro Científico do Hospital de Câncer de Barretos., 2013. V Encontro Científico do Hospital de Câncer de Barretos., 2013.
RAMOS, M. C. ; CURY, F. P. ; SCAPULATEMPO, C. ; SILVEIRA, H. C. S. . Análise comparativa para seleção de Micronúcleos em células esfoliadas da mucosa bucal preparados por citologia de base liquida.. In: V Encontro Científico do Hospital de Câncer de Barretos., 2013, Barretos. V Encontro Científico do Hospital de Câncer de Barretos., 2013.
CURY, F. P. ; CARRIJO-Schimdt, M. ; VILLEGAS, C. ; SEIDEL, E. H. ; SALDIVA, P.H. ; SILVEIRA, H. C. S. . Assessing the genotoxicity of urban air quality in Barretos during the sugarcane burning using tradescantia micronucleus (TRAD-MCN) bioassay. In: Congresso Brasileiro de Genética, 2012, Foz do Iguaçu. Congresso Brasileiro de Genetica MU049, 2012.
SILVEIRA, H. C. S. ; SCHMDIT-CARRIJO, M. S. ; SEIDEL, E. H. ; SCAPULATEMPO, C. ; LONGHATO, A. ; CARVALHO, A. L. ; REIS, R. M. ; SALDIVA, P.H. . Evaluation of genotoxic effects of sugarcane workers using micronucleus assay. In: 58 Congresso Brasileiro de Genética, 2012, Foz do Iguaçu. 58 Congresso Brasileiro de Genética MU055, 2012.
SILVEIRA, H. C. S. ; SCHMDIT-CARRIJO, M. S. ; SEIDEL, E. H. ; SCAPULATEMPO, C. ; LONGHATO, A. ; CARVALHO, A. L. ; REIS, R. M. ; SALDIVA, P.H. . Evaluation of genotoxic effects of sugarcane workers using micronucleus assay. In: IV Encontro Cientifico do Hospital de câncer de Barretos, 2012, Barretos. IV Encontro Cientifico do Hospital de Câncer, 2012.
CURY, F. P. ; SCHMDIT-CARRIJO, M. S. ; VILLEGAS, C. ; SEIDEL, E. H. ; SALDIVA, P.H. ; Silveira, H.C.S. . Assessing the genotoxicity of urban air quality in Barretos during the sugarcane burning using Tradescantia pallida micronucleus (TRAD-MCN) bioassay. In: IV Encontro Cientifico do Hospital de câncer de Barretos, 2012, Barretos. IV Encontro Cientifico do Hospital de Câncer, 2012.
Marino, AL ; MACEDO, T. ; LONGHATO, A. ; KERR, L. M. ; VIEIRA, R. A. C. ; EVANGELISTA, A. F. ; SILVEIRA, H. C. S. ; Marques, MMC . Differential expression profile of microRNAs during human breast cancer progression. In: 58 Congresso Brasileiro de Genética, 2012, Foz do Iguaçú. 58 Congresso Brasileiro de Genética, 2012. v. 58.
Marino, AL ; MACEDO, T. ; LONGHATO, A. ; VIEIRA, R. A. C. ; EVANGELISTA, A. F. ; SILVEIRA, H. C. S. ; Marques, MMC . Avaliação do perfil de expressão diferencial de microRNAs durante a progressão do câncer de mama. In: II Congresso Franco-Brasileiro de Oncologia, 2012, Rio de Janeiro. VII Congresso Franco-Brasileiro de Oncologia, 2012.
Marino, AL ; MACEDO, T. ; LONGHATO, A. ; Peres, Nalu T.A. ; EVANGELISTA, A. F. ; VIEIRA, R. A. C. ; SILVEIRA, H. C. S. . Differential expression profile of paraffin embedded microRNAs during human breast cancer progression. In: Cell Symposia: Hallmarks of cancer, 2012, São Francisco. Hallmarks of cancer, 2012.
Marino, AL ; MACEDO, T. ; LONGHATO, A. ; VIEIRA, R. A. C. ; EVANGELISTA, A. F. ; SILVEIRA, H. C. S. ; Marques, MMC . Analysis of microRNA expression using tissues frozen and formallin-fixed paraffin embedded from breast cancer samples. In: International Symposium, 2012, São Paulo. International Symposium, 2012.
Marino, AL ; QUEIROZ JUNIOR, A. F. ; KERR, L. M. ; VIEIRA, R. A. C. ; EVANGELISTA, A. F. ; Silveira, H.C.S. ; Marques, MMC . Analysis of MicroRNA expression comparing matched frozen and formalin-fixed paraffin-embedded from breast cancer samples.. In: 57° Congresso Brasileiro de Genética, 2011, Águas de Lindóia. 57° Congresso Brasileiro de Genética, 2011.
Peres NT ; CAZZANIGA, R. ; EVANGELISTA, A. F. ; SILVEIRA, H. C. S. ; Marques, MMC ; PASSOS, GAS ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Trichophyton rubrum gene expression regulation during development in keratin. In: 26 Fungal Genetics Conference, 2011, Asilomar, CA. 26 Fungal Genetics Conference, 2011. p. 166.
CAZZANIGA, R. ; SILVEIRA, H. C. S. ; Marques, MMC ; EVANGELISTA, A. F. ; PASSOS, GAS ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Trichophyton rubrum gene expression kinetics during growth on keratin as the sole nutrient source.. In: 10th European Conference on Fungal Genetics, 2010, Amsterdam. 10th European Conference on Fungal Genetics, 2010. p. 76.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; CAZZANIGA, R. ; Marques, MMC ; EVANGELISTA, A. F. ; PASSOS, GAS ; Sanches PR ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Análise das Interações Transcricionais no dermatófito Trichophyton rubrum em resposta ao pH ambiente durante o processo de degradação de queratina. In: 56* Congresso Brasileiro de Genética, 2010, Guarujá. 56* Congresso Brasileiro de Genética, 2010.
R, C. ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras D ; Sanches PR ; Mazucato, M ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Identification of Trichophyton rubrum expressed genes involved in pH modulation. In: 25th Fungal Genetics Conference at Asilomar, 2009, Montrrey, CA - USA. 25th Fungal Genetics Conference at Asilomar, 2009.
SILVEIRA, H. C. S. ; SEGATO, F. ; PRADE, R. A. ; CAZZANIGA, R. ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Silenciamento de RNA como ferramenta para exploração da função de genes no dermatófito Trichophyton rubrum.. In: 55 Congresso Brasileiro de Genética, 2009, Aguas de Lindóia. 55 Congresso Brasileiro de Genética, 2009.
Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; LEAL, J. ; Peres NT ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Regulation of Neurospora crassa MAP Kinase genes in response to exogenous phosphate levels. In: 9th European Conference on Fungal Genetics, 2008, Edinburgh. 9th European Conference on Fungal Genetics, 2008.
Peres NT ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; MARTINEZ-ROSSI, N. M. ; PRADE, R. A. . Antifungal Targeting of Signaling in dermatophytes Trichophyton rubrum. In: XXIV Fungal Genetics Conference, 2007, Asilomar. XXIV Fungal Genetics Conference, 2007. p. 513.
SILVA, E. M. ; FREITAS, J. S. ; LEAL, J. ; SQUINA, F. M. ; Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Sanches PR ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Identification of genes up regulated in the palA1 mutant strain of Aspergillus nidulans.. In: XXIV Fungal Genetics Conference, 2007, Asilomar, USA. XXIV Fungal Genetics Conference, 2007. p. 316.
Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Identification of genes up- and down-regulated in the nuc-2A mutant strain of Neurospora crassa.. In: XXIV Fungal Genetics Conference, 2007, Asilomar, USA. XXIV Fungal Genetics Conference, 2007.
Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Gene regulation in the nuc-2 mutant strain of Neurospora crassa grown under phosphate starvation. In: XXXVI Reunião Anual da SBBq e 10th IUBMB Conference, 2007, Salvador. XXXVI Reunião Anual da SBBq e 10th IUBMB Conference, 2007.
SILVA, E. M. ; FREITAS, J. S. ; Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; LEAL, J. ; SQUINA, F. M. ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Supression subtractive hybridization analyses identified gene up-regulated in the palA1 mutant strain of Aspergillus nidulans. In: XXXVI Reunião Anual da SBBq e 10th IUBMB Conference, 2007, Salvador. XXXVI Reunião Anual da SBBq e 10th IUBMB Conference, 2007.
LEAL, J. ; SQUINA, F. M. ; FREITAS, J. S. ; SILVA, E. M. ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras D ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Identification of new Neurospora crassa genes under regulation of the transcription factor nuc-1 in response to Pi starvation. In: XXXVI Reunião Anual da SBBq e 10th IUBMB Conference, 2007, Salvador. XXXVI Reunião Anual da SBBq e 10th IUBMB Conference, 2007.
FREITAS, J. S. ; SILVA, E. M. ; LEAL, J. ; SQUINA, F. M. ; Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Suppression subtractive analyses revealed genes down-regulated in the palA1 mutant strain of Aspergillus nidulans grown in acid pH. In: XXXVI Reunião Anual da SBBq e 10th IUBMB Conference, 2007, Salvador. XXXVI Reunião Anual da SBBq e 10th IUBMB Conference, 2007.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras D ; Sanches PR ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Identificação de genes possivelmente expressos nos passos iniciais da infecção do dermatófito Trichophyton rubrum e suas relações com a via de sinalização do pH extracelular. In: 53 Congresso Brasileiro de Genética, 2007, Aguas de Lindoia. 53 Congresso Brasileiro de Genética, 2007.
Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; MARTINEZ-ROSSI, N. M. ; ROSSI, Antonio . Identification of differentially expressed genes in the nuc-2 mutant strain of Neurospora crassa. In: 8th European Conference on Fungal Genetics, 2006, Viena - Austria. 8th European Conference on Fungal Genetics, 2006.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; FERREIRA-NOZAWA, M. S. ; Ono CJ ; Gras D ; ROSSI, Antonio ; MARTINEZ-ROSSI, N. M. . Full virulence of the dermatophyte Trichophyton rubrum is dependent on transcription factor PacC.. In: 8th Conference on Fungal Genetics, 2006, Viena. 8th Conference on Fungal Genetics, 2006.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras D ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . The sensing of acid pH by the dermatophyte Trichophyton rubrum correlates with its infecting capacity. In: XXXV Reunião Anual da SBBq, 2006, Aguas de Lindóia. XXXV Reunião Anual da SBBq, 2006.
FREITAS, J. S. ; SILVA, E. M. ; LEAL, J. ; SQUINA, F. M. ; Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Sanches PR ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Expressão diferencial de genes em Aspergillus nidulans em resposta ao pH ambiente. In: 52 Congresso Brasileiro de Genética, 2006, Foz do Iguaçu. 52 Congresso Brasileiro de Genética, 2006.
COELHO, L. M. ; SEGATO, F. ; Paião, FG ; Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; MARTINEZ-ROSSI, N. M. . Genes diferencialmente expressos em Trichophyton rubrum na presença do antifúngico itraconazol. In: 52 Congresso Brasileiro de Genética, 2006, Foz do Iguaçu. 52 Congresso Brasileiro de Genética, 2006.
SILVA, E. M. ; FREITAS, J. S. ; LEAL, J. ; SQUINA, F. M. ; Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Sanches PR ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Identificação de genes diferencialmente expressos no mutante palA1 de Aspergillus nidulans através de uma biblioteca de subtração de cDNA.. In: 52 Congresso Brasileiro de Genética, 2006, Foz do Iguaçu. 52 Congresso Brasileiro de Genética, 2006.
LEAL, J. ; SQUINA, F. M. ; SILVA, E. M. ; FREITAS, J. S. ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras D ; Sanches PR ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Regulação da expressão gênica no fungo Neurospora crassa em resposta ao nível de fosfato sob controle do gene nuc-1. In: 52 Congresso Brasileiro de Genética, 2006, Foz do Iguaçu. 52 Congresso Brasileiro de Genética, 2006.
Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Sanches PR ; CRESCENCIO-SOUZA, A. C. ; MARTINEZ-ROSSI, N. M. ; ROSSI, A. . Identificação de genes regulados positivamente pela proteína NUC-2 do fungo Neurospora crassa.. In: 52 Congresso Brasileiro de Genética, 2006, Foz do Iguaçu. 52 Congresso Brasileiro de Genética, 2006.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras D ; Peres NT ; AQUINO-FERREIRA, R. ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . A Capacidade de infecção do dermatófito Trichophyton rubrum é correlacionada com a sinalização do pH extracelular.. In: 52 Congresso Brasileiro de Genética, 2006, Foz do Iguaçu. 52 Congresso Brasileiro de Genética, 2006.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; FERREIRA-NOZAWA, M. S. ; ROSSI, Antonio ; MARTINEZ-ROSSI, N. M. . Identification of genes differentially expressed in response to acidicinduction in Trichophyton rubrum. In: 23rd Fungal Genetics Conference at Asilomar, 2005, Asilomar. 23rd Fungal Genetics Conference at Asilomar, 2005.
Maranhão, FCA ; Paião, FG ; Peres NT ; Santos JRC ; Gras D ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; MARTINEZ-ROSSI, N. M. . ANÁLISE DA EXPRESSÃO GÊNICA NO DERMATÓFITO TRICHOPHYTON RUBRUM CULTIVADO EM. In: XXIII Congresso Brasileiro de Microbiologia, 2005, Santos. XXIII Congresso Brasileiro de Microbiologia, 2005. v. 475-1.
ANDRADE, A. S. ; Paião, FG ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Fachin AL ; MARTINEZ-ROSSI, N. M. . EXPRESSÃO DIFERENCIAL DE GENES NO DERMATÓFITO Trichophyton rubrum EM RESPOSTA A TERBINAFINA.. In: 51 Congresso Brasileiro de Genética, 2005, Aguas de Lindóia. 51 Congresso Brasileiro de Genética, 2005.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; FERREIRA-NOZAWA, M. S. ; Sanches PR ; ROSSI, Antonio ; MARTINEZ-ROSSI, N. M. . O FATOR DE TRANSCRIÇÃO PacC MEDIA A PATOGENICIDADE E A EXPRESSÃO DE GENES EM pH ÁCIDO NO DERMATÓFITO Trichophyton rubrum. In: 51 Congresso Brasileiro de Genética, 2005, Aguas de Lindóia. 51 Congresso Brasileiro de Genética, 2005.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Ferreira-NOZAWA, M. S. ; NOZAWA, S. R. ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . EFEITO DO pH AMBIENTE NA EXPRESSÃO DIFERENCIAL DE GENES NO DERMATÓFITO Trichophyton rubrum. In: 50 Congreso Nacional de Genética da Sociedade Brasileira de Genética, 2004, Florianópolis, 2004.
ANDRADE, A. S. ; SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; FERREIRA-NOZAWA, M. S. ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Análise da expressão gênica diferencial no dermatófito Trichophyton rubrum utilizando a metodologia de differencial display. In: Simpósio Internacional de Iniciação Científica da Universidade de São Paulo - SIICUSP, 2004, Ribeirão Preto. Simpósio Internacional de Iniciação Científica da Universidade de São Paulo - SIICUSP, 2004.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Sommer, C. A. ; HENRIQUE-SILVA, F. . DSCR1, a calcineurin interacting protein, also interacts with two other proteins APLP1 (amyloid precursor-like protein 1) and UXT (ubiquitously expressed transcript). In: XXXII Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq, 2003, Caxambú- MG. XXXII Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular - SBBq, 2003. v. 32.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Nozawa, S. R. ; MARTINEZ-ROSSI, N. M. . Análise de genes diferencialmente expressos no dermatófito Trichophyton rubrum, em condição de estresse com cloranfenicol utilizando DDRT-PCR. In: 49 Congresso Nacional de Genética da Sociedade Brasileira de Genética, 2003, Águas de Lindoia. 49 Congresso Nacional de Genética da Sociedade Brasileira de Genética, 2003.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Cassago, A ; Soares-Costa, A ; Sommer, C. A. ; HENRIQUE-SILVA, F. ; PANEPUCCI, R. A. ; Malago, W. . Sage Transcriptome Profiling of Human Leucocytes from 28 Years Old Down Syndrome Individual. In: XXXI Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular, 2002, Caxambú. In Anais da XXXI Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular, 2002. v. 31.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Cassago, A ; Soares-Costa, A ; Sommer, C. A. ; PANEPUCCI, R. A. ; Malago, W. ; HENRIQUE-SILVA, F. . Human leukocyte transcriptome profile of a down syndrome patient. In: 48 Congresso Nacional de Genética da Sociedade Brasileira de Genética, 2002, Águas de Lyndoia. In: 48 Congresso Nacional de Genética da Sociedade Brasileira de Genética, 2002. v. 48.
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; PANEPUCCI, R. A. ; HENRIQUE-SILVA, F. . Down Syndrome Candidate Region Gene A interacts with a Phosphatase Protein including many cellular processes. In: XXX Reunião Anual da Sociedade Brasileira de Bioquímica e Biologia Molecular, 2001, Caxambú. XXX Reunião Anual Programa e Resumos, 2001. v. 30.
Silveira, H.C.S. . Saude e Meio Ambiente. 2019. (Apresentação de Trabalho/Conferência ou palestra).
Silveira, H.C.S. . Contribuição da Biologia Molecular na investigação da exposição a agentes cancerígenos ocupacionais/ambientais. 2017. (Apresentação de Trabalho/Conferência ou palestra).
Silveira, H.C.S. . Fatores Ambientais e Ocupacionais do Câncer. 2017. (Apresentação de Trabalho/Conferência ou palestra).
Silveira, H.C.S. . Avaliação de risco e conscientização do câncer ocupacional em trabalhadores rurais na região de Barretos. 2017. (Apresentação de Trabalho/Conferência ou palestra).
Silveira, H.C.S. . O mundo do trabalho e suas consequências na vida e na saúde das mulheres e dos homens: fatores de risco, prevenção de câncer ocupacional e ambiental. 2017. (Apresentação de Trabalho/Conferência ou palestra).
Silveira, H.C.S. . Meio Ambiente e Estudos Moleculares. 2017. (Apresentação de Trabalho/Conferência ou palestra).
Silveira, H.C.S. . Avaliação de risco e conscientização do câncer ocupacional em trabalhadores rurais na região de Barretos. 2017. (Apresentação de Trabalho/Conferência ou palestra).
Silveira, H.C.S. . Brócolis: Mecanismos, Alvos celulares e ação antitumoral. 2017. (Apresentação de Trabalho/Conferência ou palestra).
Silveira, H.C.S. . Meio Ambiente e Câncer Ocupacional. 2017. (Apresentação de Trabalho/Conferência ou palestra).
SILVEIRA, H. C. S. . Rapid DNA methylation changes in cosntruction workers. 2016. (Apresentação de Trabalho/Congresso).
SILVEIRA, H. C. S. . Interações Genéticas e Ambiente. 2016. (Apresentação de Trabalho/Conferência ou palestra).
SILVEIRA, H. C. S. . Meio Ambiente e Câncer. 2016. (Apresentação de Trabalho/Conferência ou palestra).
SILVEIRA, H. C. S. . Emissions generated with sugarcane burning promote genotoxicity in rural workers. 2015. (Apresentação de Trabalho/Conferência ou palestra).
Silveira, H.C.S. . Risk assessment on occupationally exposed populations. 2013. (Apresentação de Trabalho/Simpósio).
SILVEIRA, H. C. S. . Fatores Ambientais e suas implicações no desenvolvimento de câncer. 2013. (Apresentação de Trabalho/Simpósio).
SILVEIRA, H. C. S. . Moderador. III International Symposium on Translacional Oncology. 2013. (Apresentação de Trabalho/Outra).
SILVEIRA, H. C. S. . Análise da queima da palha da cana-de-açúcar e suas relações com a mutagênese humana. 2012. (Apresentação de Trabalho/Conferência ou palestra).
SILVEIRA, H. C. S. . Trabalho, meio ambiente, saúde e o câncer. 2012. (Apresentação de Trabalho/Conferência ou palestra).
SILVEIRA, H. C. S. . Meio Ambiente e suas relações com o câncer. 2012. (Apresentação de Trabalho/Conferência ou palestra).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; CAZZANIGA, R. ; Marques, MMC ; EVANGELISTA, A. F. ; Sanches PR ; PASSOS, GAS ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Análise das Interações transcricionais no dermatófito Trichophyton rubrum em resposta ao pH ambiente durante o processo de degradação de queratina. 2010. (Apresentação de Trabalho/Congresso).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; R, C. ; Sanches PR ; PASSOS, GAS ; Marques, MMC ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Trichophyton rubrum gene expression profile during the process of keratin degradation. 2009. (Apresentação de Trabalho/Congresso).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras D ; Sanches PR ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Transcription factor PacC also has metabolic functions specific to acid pH sensing by the dermatophyte Trichophyton rubrum. 2008. (Apresentação de Trabalho/Congresso).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras D ; Sanches PR ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Identificação de genes possivelmente expressos nos passos iniciais da infecção do dermatófito Trichophyton rubrum e suas relações com a via de sinalização do pH extracelular. 2007. (Apresentação de Trabalho/Congresso).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; Gras D ; Ono CJ ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Full virulence of the dermatophyte Trichophyton rubrum is dependent on transcription factor PacC.. 2006. (Apresentação de Trabalho/Congresso).
Outras produções
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Consultoria realizada no Laboratório de Estudos em Meio Ambiente da Universidade Católica do Salvador em Técnicas de Biologia Molecular e Expressão Gênica. 2005.
Peres NT ; Sanches PR ; Falcão, Juliana P ; SILVEIRA, H. C. S. ; Paião, Fernanda G ; Maranhão, Fernanda CA ; Gras D ; SEGATO, F. ; CAZZANIGA, R. ; MAZZUCATO, ; Cursino-Santos, Jeny R ; Aquino-Ferreira, Roseli ; ROSSI, A. ; MARTINEZ-ROSSI, N. M. . Genbank - número de acesso: FE524602 a FE527336. 2008.
Silveira, H.C.S. . Papo com o Jardim. 2017.
Silveira, H.C.S. . Estudo analisa relação entre agrotóxicos e câncer. 2017. (Programa de rádio ou TV/Entrevista).
Silveira, H.C.S. . I Concurso de Redação. 2013. (Programa de rádio ou TV/Entrevista).
SILVEIRA, H. C. S. ; REIS, R. M. . Site Centro de Pesquisa em Oncologia Molecular. 2015. (Site).
FRANSCISCO, L. V. ; VICENTE, J. T. S. ; DAMASCENO, L. S. P. ; SILVA, R. N. ; CANGANI, T. M. ; FERNANDES, V. ; SILVEIRA, H. C. S. . Identificação dos Agrotóxicos Associados ao Desenvolvimento de Linfoma Não-Hodgkin. 2020. (Monitoria- Programa de Aperfeiçoamento de Ensino).
DAMASCENO, T. M. A. ; ANJOS, B. F. ; JAUDY, T. A. R. ; ALE, A. B. ; LOTUFO, M. N. ; SILVEIRA, H. C. S. ; FERNANDES, V. . Normas de Orientação aos Pacientes para Armazenagem e Conservação de Imunobiológicos. 2020. (Monitoria- Programa de Aperfeiçoamento de Ensino).
SILVEIRA, H. C. S. . Meio Ambiente e Saúde. 2013. (Curso de curta duração ministrado/Extensão).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Curso intitulado Genômica Funcional em Fungos. 2009. .
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Curso intitulado Genômica Funcional em Fungos. 2009. (Curso de curta duração ministrado/Extensão).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Monitoria - Disciplina Introdução a Bioinformática (Curso de Informática Biomédica - Universidade de São Paulo). 2006. (Monitoria- Programa de Aperfeiçoamento de Ensino).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Expressão Diferencial de Genes e Análise dos Dados por Bioinformática - Curso de Verão em Genética 2004. 2004. (Curso de curta duração ministrado/Extensão).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; POLIZELI, M. L. T. M. . Monitoria - Disciplina de Biologia Celular (5920108). 2004. (monitoria).
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. ; HENRIQUE-SILVA, F. . Monitoria - Disciplina GEV-110 Tópicos em Genética e Evolução 2: Amplificação, Clonagem e Sequenciamento de DNA - Uma Abordagem Experimental.. 2001. (monitoria).
Silveira, H.C.S. ; SARAIVA, J. M. D. ; BERNARDO, C. R. ; CAMPANELLI, I. . Cuidados na Aplicação dos Agrotóxicos. 2017. Vídeo.
SILVEIRA, H. C. S. . Meio Ambiente, Trabalho, Agrotóxicos e Câncer. 2012 (Palestra) .
Silveira, H.C.S. . Análise da queima da palha de cana-de-açucar e suas relações com a mutagênese humana.. 2011 (Palestra) .
SILVEIRA, H. C. S. . Meio Ambiente e o potencial risco de câncer. 2011 (Palestra) .
SILVEIRA, H. C. S. . Biomonitoramento e o potencial risco de câncer. 2011 (Palestra) .
SILVEIRA, H. C. S. . Genomica Funcional em Fungos. 2010 (Palestra) .
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Conferencista III Semana Nacional de Ciência e Tecnologia. 2006 (Palestra) .
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Análise dos Dados por Bioinformática. 2005 (Aula teorica ministrada) .
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Aplicação das ferramentas e utilização dos softwares de Bioinformática. 2004 (Aula teorica ministrada) .
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Contatos com o sequenciador de DNA e primeiras análises com as sequências geradas. 2004 (Aula teorica ministrada) .
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Do sequenciamento dos genes ao Transcriptoma e Proteoma e a importância da Bioinformática nesses estudos.. 2004 (Aula teorica ministrada) .
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Clonagem dos produtos de PCR originadas no DDRT- PCR. 2004 (Aula teorica - prática ministrada) .
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . Conhecimentos na Área de Biomedicina. 2003 (Aula ministrada) .
SILVEIRA, H. C. S. ou Santejo-Silveira, H.C. . SUGARCANE EST GENOME PROJECT SUCEST-Fapesp. 2000 (pesquisa e desenvolvimento) .
2019 - Atual
Avaliação da expressão de biomarcadores em indivíduos expostos a agrotóxicos: uma abordagem exposômica, Descrição: O aumento da contaminação ambiental em grande parte está relacionado com as atividades antrópicas. Uma importante fonte desta contaminação é a agricultura. A quantidade de agrotóxicos utilizados nesta produção tem aumentado devido à maior demanda de alimentos decorrente do crescimento populacional. Os resíduos destes produtos contaminam o solo, ar e a água e, com isso, apresentam risco direto e/ ou indireto a saúde humana e ambiental. A exposição aguda e crônica aos agrotóxicos está relacionada com diversos efeitos negativos à saúde humana, dentre eles, o aumento de risco de cânceres, como o Linfoma não-Hodgkin. Apesar das diferentes vias de exposição, a população mais susceptível aos efeitos dos pesticidas, são os indivíduos ocupacionalmente expostos a eles. Diante disso, este estudo tem como objetivos: 1) analisar a concentração de agrotóxicos na urina de indivíduos sem câncer expostos e não expostos aos agrotóxicos; 2) avaliar a instabilidade genômica em indivíduos sem câncer expostos e não expostos; e 3) determinar o perfil de expressão de microRNAs em pacientes com Linfoma não-Hodgkin e indivíduos sem câncer expostos e não expostos a agrotóxicos. Os microRNAs apontados como biomarcadores tanto nos indivíduos saudáveis quanto nos pacientes, serão validados por meio da tecnologia de PCR digital. Este projeto conta com a colaboração internacional do Dr. Bernardo Lemos da Harvard T.H. Chan School of Public Health.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Henrique César Santejo Silveira - Coordenador / Marcia M. C. Marques Silveira - Integrante / Luiza Veiga Francisco - Integrante / Bernardo Lemos - Integrante., Financiador(es): Ministério da Saúde - Auxílio financeiro.Número de orientações: 1
2019 - Atual
Cancer e trabalhadores rurais: um estudo de coorte, Descrição: Esta é uma iniciativa entre o Hospital de Câncer de Barretos e o Departamento de Vigilância em Saúde Ambiental e Saúde do Trabalhador ? DSAST, Ministério da Saúde onde ambas as Instituições desenvolverão um projeto com os objetivos integrados à Política Nacional de Saúde do Trabalhador e da Trabalhadora. Considerando que atualmente o Brasil é líder mundial no consumo de agrotóxicos e que os impactos à saúde humana devido à exposição ocupacional e ambiental em grupos de trabalhadores rurais atingidos ainda é pouco conhecido; o projeto visa analisar e avaliar a relação entre câncer ocupacional e exposição aos fatores do ambiente de trabalho, que possam estar correlacionados à incidência do câncer ou mesmo ao desfecho câncer. Estudos epidemiológicos têm revelado importantes associações entre o uso de agrotóxicos e o acometimento de câncer nas populações expostas. Além disso, estes compostos podem induzir danos no genoma humano. Sendo assim, o objetivo deste projeto é realizar estudo de coorte com trabalhadores das regiões de abrangência de 2 CERESTs do Estado de São Paulo, quanto à exposição a agrotóxicos e a ocorrência de câncer. Para isto, nesta proposta realizaremos uma coorte prospectiva com cerca de 2131 trabalhadores que serão classificados quanto ao seu grau de exposição a agrotóxicos, de forma ambiental e ocupacional. Além disso, serão utilizados biomarcadores genéticos para avaliação molecular a fim de identificar indivíduos com potencial risco ao câncer. Considerando o desenho epidemiológico deste estudo e a realização da análise da interação entre a composição genética dos indivíduos, seu histórico de exposição ambiental e a susceptibilidade ao câncer pode-se dizer que este estudo tende a contribuir com uma área bastante promissora e desafiadora que é o exposoma. Este projeto coordenado pelo Dr. Henrique Silveira está associado ao Consórcio Internacional (AGRICOH) sediado pela IARC.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Henrique César Santejo Silveira - Coordenador / Marques, - Integrante / Adriane Feijó Evangelista - Integrante / Isabela Campanelli dos Santos - Integrante / REIS, RUI M. - Integrante / Fabiana Vazquez - Integrante / Alvaro Jose dos Santos-Neto - Integrante / Carlos Eduardo Paiva - Integrante / Bianca Sakamoto Ribeiro Paiva - Integrante / Ana Carolina Carvalho - Integrante / Daniela Buosi Rohfls - Integrante / Raphael Guimarães - Integrante / Karla Baêta - Integrante / Renan Duarte dos Santos Saraiva - Integrante / Thenile Carmo - Integrante / Jackline Leita Pereira Pavin - Integrante / Luiza Veiga Franscisco - Integrante., Financiador(es): Ministério da Saúde - Auxílio financeiro.
2019 - Atual
Avaliação do comprimento dos telômeros como biomarcador para indivíduos ocupacionalmente expostos aos agrotóxicos, Descrição: Nos últimos cinquenta anos, a agricultura sofreu uma profunda mudança com o crescimento massivo do uso de agrotóxicos para melhorar a produção e proteção da colheita, assim como a qualidade e preservação do alimento. O Brasil é um dos maiores consumidores de agrotóxicos do mundo. Com o aumento da utilização de agrotóxicos nos últimos anos no país, aumenta também o risco de exposição de trabalhadores como também da população através da contaminação do meio ambiente, da água e alimentos. Devido à sua toxicidade intrínseca, esses agrotóxicos podem causar alguns efeitos deletérios como, alergias; distúrbios gastrintestinais, respiratórios, endócrinos, reprodutivos e neurológicos; e também o câncer. Sendo assim, o objetivo desse projeto é analisar o comprimento dos telômeros como potencial biomarcador para associação da potencial influência da exposição aos agrotóxicos no risco de desenvolvimento de câncer em indivíduos expostos aos agrotóxicos e comparado com um grupo não exposto. Trata-se de um estudo observacional transversal que analisará grupos de indivíduos expostos e não expostos que serão recrutados nos municípios que compõem a DRS-Barretos. Serão analisados 400 participantes na faixa etária de 21 a 65 anos, divididos em quatro grupos; Grupo 1: Indivíduos não expostos aos agrotóxicos, Grupo 2: Indivíduos expostos aos agrotóxicos, Grupo 3: Pacientes com câncer e que tiveram exposição aos agrotóxicos durante a vida ocupacional (expostos), Grupo 4: Pacientes com câncer que não tiveram exposição (não exposto) aos agrotóxicos. Esse estudo visa fundamentar a importância da utilização de biomarcadores como os telômeros para a avaliação da instabilidade genômica em relação a exposição aos agrotóxicos e o risco de desenvolvimento de câncer. Este projeto conta com a colaboração da Dr. Juliana da Silva ULBRA - Universidade Luterana do Brasil e da Dr. Vivian Kahl Unidade de Regulação do Comprimento dos Telômeros, Westmead ? Australia.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (2) . , Integrantes: Henrique César Santejo Silveira - Coordenador / André Lengert - Integrante / Isabela Campanelli dos Santos - Integrante / Juliana da Silva - Integrante / Vivian Kahl - Integrante., Financiador(es): Ministerio Publico do Trabalho - Auxílio financeiro., Número de produções C, T & A: 1
2016 - Atual
AVALIAÇÃO DA PRESENÇA DE ANTINEOPLÁSICOS E SEUS METABÓLITOS EM EFLUENTES NO MUNICÍPIO DE BARRETOS, SP, E SUAS INTERAÇÕES ECOLÓGICAS E GENOTÓXICAS, Descrição: Com o crescente aumento dos casos de câncer no Brasil e no mundo, há, também uma maior demanda no consumo de drogas antineoplásicas administradas na quimioterapia, uma terapia citotóxica que mata ou inibe o crescimento de células cancerosas. As drogas antineoplásicas causam danos ao DNA ou cessam a replicação dos cromossomos. Estudos em diversos países têm demonstrado que as drogas antineoplásicas, devido às suas características recalcitrantes, estão presentes em efluentes hospitalares e persistem mesmo após passarem por tratamento em estações de tratamento de esgoto (ETE?s), além de demonstrarem potencial citotóxico e genotóxico. No Brasil, as pesquisas são incipientes em relação a presença de drogas em efluentes hospitalares e municipais. Diante disso, no presente estudo, será quantificada a presença dos antineoplásicos mais consumidos no Hospital de Câncer de Barretos (HCB) bem como no Sistema Único de Saúde Brasileiro (SUS), sendo estes: 5-fluorouracil, gemcitabina, ciclofosfamida, e seus respectivos metabólitos alfa-fluoro-beta-alanina, 2-deoxy-2,2-difluorouridina e acroleína, no efluente do HCB e na entrada e saída dos efluentes da ETE IV do Município de Barretos, SP, por meio das ferramentas analíticas de cromatografia líquida acoplada a espectrofotometria (CLAE-UV/Vis) e/ou espectrometria de massas (EM/EM), seguido de análise de toxicidade aguda e risco ambiental de todos os compostos com zebrafish (Danio rerio). Para as drogas e metabólitos encontrados nas análises dos efluentes, as concentrações obtidas serão avaliadas de acordo com a citotoxicidade e a genotoxicidade em linhagem celular de fígado humano (HepG2) por meio de ensaio de MTS e pelos ensaios de micronúcleo e cometa, respectivamente.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Doutorado: (1) . , Integrantes: Henrique César Santejo Silveira - Coordenador / Rui Manuel Reis - Integrante / Sergio Vicente Serrano - Integrante / Mariana de Oliveira Klein - Integrante., Financiador(es): Ministerio Publico do Trabalho - Auxílio financeiro., Número de produções C, T & A: 1
2015 - Atual
Avaliação de risco e conscientização do câncer ocupacional em trabalhadores rurais na região de Barretos, Descrição: Aproximadamente 80% dos casos de câncer estão relacionados a fatores ambientais. Muitas substâncias ou a mistura destas presentes no ambiente ocupacional e que levam ao aumento da incidência de neoplasias, são consideradas substâncias com um potencial cancerígeno. Em países em desenvolvimento, a crescente modernização da agricultura e o processo de urbanização, ocasionam impacto direto no meio ambiente, o que propicia o aumento da exposição das populações a substâncias tóxicas expostas em seu ambiente de trabalho, principalmente no meio rural, onde existe uma escassez de informação sobre os produtos químicos que os trabalhadores estão expostos, tais como, os agrotóxicos. Desde 2009, o Brasil atingiu a posição de líder mundial no consumo de agrotóxicos, e embora a venda de pesticidas, principalmente nos Estados Unidos, tenha a análise de sua carcinogenicidade avaliada pela Agência de Proteção Ambiental (Environmental Protection Agencys ? EPA), um número grande de pesticidas estão ligados com a causa de vários tipos de câncer segundo investigações epidemiológicas. Os riscos aumentados têm sido detectados para leucemias, sarcoma de Ewing, câncer de rim, linfoma não-Hodgkin, tumores cerebrais, entre outros. O impacto causado à saúde humana devido a essa exposição em grupos de trabalhadores e nas populações atingidas, ainda é pouco conhecida. Desta forma, é importante o desenvolvimento de tecnologias limpas e, por outro lado, é imprescindível a determinação competente do risco a saúde humana e fazer-se incorporar os prejuízos da mesma no processo de formulação de políticas públicas ambientais. O objetivo deste projeto é a avaliação e conscientização do câncer ocupacional em trabalhadores rurais na região de Barretos, para isso será realizado um programa educacional de prevenção ao câncer junto às comunidades participantes por meio de cursos e palestras, além de um vídeo educativo para os trabalhadores de esclarecimento do câncer ocupacional e a importância do uso de EPI na prevenção do câncer. Serão aplicados questionários, a fim de obter dados epidemiológicos. Por conseguinte, será realizada a análise in vitro da citotoxicidade e do perfil epigenético dos principais agrotóxicos utilizados na região de Barretos em linhagens celulares de pulmão. Serão selecionados indivíduos expostos e não expostos a agrotóxicos, na faixa etária de 21 a 65 anos. Os critérios de inclusão para o grupo de indivíduos expostos serão trabalhadores rurais com exposição aos agrotóxicos pelo menos por cinco anos e para o grupo de indivíduos não expostos, participantes sem histórico de contato com os agrotóxicos. Serão coletadas amostras de sangue total, urina e raspado bucal, para estudos moleculares futuros. As análises da avaliação da citoxicidade celular e a capacidade de migração e invasão das linhagens celulares de pulmão expostas aos agrotóxicos serão feitas in vitro. A avaliação da genotoxicidade será realizada por meio dos ensaios de micronúcleos e do Cometa em linhagens celulares. Além disso, será realizada e a análise de metilação do DNA que será obtida pela metodologia de Pirosequenciamento. A confecção de análise de dados será feita no software ? Statistical Package for the Social Science (SPSS) versão 21. Se os grupos forem distribuídos igualmente, será aplicado o Teste-T de Student. Caso apresentarem distribuição anormal será utilizado o teste de Man-Whitney. Para análise de variáveis categóricas será utilizado o teste qui-quadrado de Pearson ou teste exato de Fisher. Um valor de p <0,05 será considerado estatisticamente significante para as análises.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Especialização: (3) / Mestrado acadêmico: (2) . , Integrantes: Henrique César Santejo Silveira - Coordenador / REIS, RUI MANUEL - Integrante / Jose Humberto T. G. Fregnani - Integrante / Rhafaela Causin - Integrante / Cassia Bernardo - Integrante / Julia Duarte - Integrante / Ana Leticia Camargo - Integrante / Jefferson Tenesse da Silva Vicente - Integrante., Financiador(es): Organizacão Pan-Americana da Saude/Organizacão Mundial da Saude - Auxílio financeiro., Número de produções C, T & A: 10
2014 - Atual
Perfil de metilação de genes em lesões precursoras do câncer do colo do útero, Descrição: Há inúmeras e bem documentadas evidências na literatura que demonstram que a citologia cervical é limitada como método isolado para o rastreamento do câncer do colo do útero. Por isso, há necessidade da incorporação de testes moleculares que melhorem a acurácia de detecção de lesões precursoras, como parece ser a avaliação das alterações epigenéticas. A análise da metilação de genes permitiria a ampliação do arsenal de testes diagnósticos para o rastreamento da neoplasia intraepitelial cervical (NIC). OBJETIVOS: 1) Avaliar e comparar o perfil de metilação de 15 genes do hospedeiro e 3 do HPV16 em amostras de citologia cervical de mulheres sem e com NIC; 2) Comparar as acurácias dos métodos moleculares (metilação e pesquisa do HPV) para diagnosticar NIC2 e NIC3. MATERIAIS E MÉTODOS: Serão incluídas 350 amostras armazenadas de citologia cervical de mulheres submetidas previamente à colposcopia no Hospital de Câncer de Barretos. Os casos terão a seguinte distribuição: colo do útero sem NIC (n=150), NIC1 (n=100), NIC2 (50) e NIC3 (50). As citologias cervicais fornecerão alíquotas para as análises moleculares. O teste do HPV será realizado no aparelho Cobas X480? (Roche Molecular Systems, EUA). A análise de metilação será realizada em um painel com 15 genes do hospedeiro (HIC1, APC, CADM1, CDH, DAPK1, TERT, JAM3, EPB41L3, C130RF18, MAL, hsa-miR-124-2, SOX1, PAX1, LMX1A e NKX6-1) e 3 genes do HPV16 (L1, L2 e E2/E4 do HPV16) por Real Time PCR (Quantitative Methylation Specific PCR - QMSP). A frequência de metilação de cada gene será comparada entre os grupos ( NIC1 vs. NIC2/NIC3) por meio do teste exato de Fisher. As acurácias de cada um dos testes moleculares (de metilação e de pesquisa do HPV) serão mensuradas e comparadas entre si por meio da sensibilidade, especificidade, valores preditivos (positivo e negativo) e área sob a curva ROC. RESULTADOS ESPERADOS E APLICAÇÕES: Alguns dos genes metilados estudados (ou a combinação deles) poderão ser utilizados como biomarcadores de lesões precursoras do câncer do colo do útero em amostras de citologia cervical preservadas em base líquida. Se estes biomarcadores mostrarem-se tão (ou mais) acurados que a pesquisa molecular do HPV, eles poderão representar uma nova forma de diagnosticar precocemente as lesões precursoras do câncer do colo do útero.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Mestrado acadêmico: (1) . , Integrantes: Henrique César Santejo Silveira - Integrante / Rhafaela Causin - Integrante / Jose Humberto T.G. Fregnani - Coordenador / Caroline Domingues Rogeri - Integrante., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro., Número de produções C, T & A: 2
2014 - Atual
Avaliação da exposição a agentes carcinogênicos ambientais e ocupacionais em trabalhadores da construção civil, Descrição: O setor da construção civil possui grande representatividade na economia brasileira e grande importância social, tendo em vista que só no estado de São Paulo o número de empresas ativas em 2009 foi de 10.543, com 606.060 pessoas ocupadas. Os trabalhadores, como os peões de obra, possuem longas jornadas de trabalho e estão expostos a diversos fatores ambientais e ocupacionais que podem levar ao desenvolvimento de doenças, como o câncer. Estima-se que cerca de 2% a 8% dos cânceres em todo o mundo ocorram por consequência da exposição ocupacional a substâncias carcinogênicas, sendo que o mais comum é o câncer de pulmão, que é responsável por 70% dos casos. A exposição destes trabalhadores a materiais contendo amianto, sílica e metais, além da exposição à radiação solar, são fatores capazes de interferir na estabilidade do genoma humano, provocando quebras no DNA, que podem causar alterações gênicas importantes no funcionamento normal do ciclo e na sobrevivência celular. Sendo assim, este projeto visa avaliar os danos genotóxicos e o potencial risco de câncer em trabalhadores expostos. Para isto, serão determinadas as frequências de micronúcleos em linfócitos do sangue e células da mucosa bucal dos trabalhadores da construção e comparadas a um grupo controle. Também serão dosados os metais do sangue dos grupos teste (trabalhadores da construção civil) e controle pela técnica de espectrometria de massas com fonte de plasma indutivamente acoplado (ICP-MS) e será realizada uma caracterização ambiental do material particulado que estes trabalhadores estão expostos no ambiente de trabalho. Além disso, será avaliado o perfil de metilação do DNA dos genes APC, RASSF1A, p16, p53, MGMT, MLH1 e das sequencias repetitivas ALU e LINE-1 utilizando a metodologia de pirosequenciamento, nos leucócitos do sangue dos trabalhadores em diferentes dias de trabalho e também comparado ao grupo controle. Estas análises podem elucidar mecanismos envolvidos no impacto da exposição aos agentes carcinogênicos ambientais. Cursos e palestras contribuirão com a prevenção de câncer junto à comunidade participante.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (1) . , Integrantes: Henrique César Santejo Silveira - Coordenador / Andre Lopes Carvalho - Integrante / REIS, RUI MANUEL - Integrante / SALDIVA, PAULO HILÁRIO - Integrante / Marcia M. C. Marques Silveira - Integrante / Fernando Barbosa JR - Integrante / Perola de Castro Vasconcellos - Integrante / Isana Rodrigues Silva - Integrante., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro., Número de produções C, T & A: 5
2013 - Atual
Perfil Mutacional de Melanomas - Consorcio Internacional ICGC, Descrição: O aumento da ocorrência de doenças como câncer em países em desenvolvimento é uma preocupação a nível governamental. Os trabalhos de prevenção ao câncer e de uma melhor compreensão da heterogeneidade molecular da doença são imprescindíveis para a mudança de políticas publicas eficientes que amenizam os gastos futuros em saúde. Atualmente, um dos tipos de câncer que apresenta crescente incidência e elevada letalidade são os melanomas, a forma mais agressiva do câncer de pele. Estima-se que no Brasil cerca de 6.000 casos novos e 1.300 mortes decorrentes do melanoma ocorram por ano. Por outro lado, este tipo de câncer se detectado nos estádios iniciais pode apresentar um bom prognóstico. Recentemente, houve grandes avanços moleculares, como a identificação de mutações associadas à resposta a novas terapias-alvo (como o BRAF), gerando a necessidade de determinação das características moleculares de cada paciente. Além disso, foi demonstrado que os padrões de mutações genéticas e alterações no número de cópias de DNA diferem significativamente entre os diferentes subtipos clinico-patológicos de melanoma. Dessa forma, a rápida geração de informações genéticas pode levar à identificação rápida e eficiente de padrões mutacionais em uma população, levando ao entendimento e desenvolvimento de modelos de vias biológicas que podem dirigir novas terapias alvo especificas. Além disso, o estabelecimento de um catalogo das alterações genéticas que ocorrem em melanomas poderá revelar novos biomarcadores de risco, diagnostico, prognostico e terapêuticos que poderão auxiliar a abordagem clinica destes pacientes, especialmente na população brasileira na qual esses dados são extremamente incipientes. Sendo assim, em vista do exposto, este projeto tem como meta o sequenciamento completo de uma coleção de tumores e seu tecido normal de portadores de melanoma, criando desta forma o perfil mutacional somático e germinativo de melanomas que acometem pacientes brasileiros. Além disso, serão correlacionados os eventos e alterações moleculares identificadas nas análises de genômica com os fatores epidemiológicos, clínicos e patológicos identificados nos pacientes. Assim, visamos auxiliar no diagnóstico precoce, no prognóstico e terapêutica desta neoplasia contribuindo com políticas de tratamento e de ações preventivas contra o câncer.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Henrique César Santejo Silveira - Integrante / Andre Lopes Carvalho - Integrante / Rui Manuel Reis - Integrante / Vinicius Vasquez - Coordenador / Guilherme Oliveira - Integrante., Financiador(es): Fundação Pio XII - Hospital de Câncer de Barretos, HCB - Auxílio financeiro.
2012 - Atual
Avaliação de danos genotóxicos em trabalhadores da construção civil expostos a agentes carcinogênicos ambientais e ocupacionais., Descrição: O setor da construção civil possui grande representatividade na economia brasileira e grande importância social, tendo em vista que só no estado de São Paulo o número de empresas ativas em 2009 foi de 10.543, com 606.060 pessoas ocupadas. Os trabalhadores, como os peões de obra, possuem longas jornadas de trabalho e estão expostos a diversos fatores ambientais e ocupacionais que podem levar aodesenvolvimento de doenças, como o câncer. Estima-se que de 2% a 8% dos cânceres em todo o mundo são em consequência da exposição ocupacional a substâncias carcinogênicas, sendo que o mais comum é o câncer de pulmão, que é responsável por 70% dos casos. A exposição destes trabalhadores a materiais contendo amianto, sílica e metais, além da exposição à radiação solar, são fatores capazes de interferir na estabilidade do genoma humano, provocando quebras no DNA, que podem causar alterações gênicas importantes no funcionamento normal do ciclo e na sobrevivência celular. Sendo assim, este projeto visa avaliar os danos genotóxicos e o potencial risco de câncer em trabalhadores expostos. Para isto, serão determinadas as frequências de micronúcleos em linfócitos do sangue e células da mucosa bucal dos trabalhadores da construção e comparadas a um grupo controle. Também serão dosados os metais do sangue dos grupos teste (trabalhadores da construção civil) e controle pela técnica de espectrometria de massas com fonte de plasma indutivamente acoplado (ICP-MS). Além disso, serão determinados os níveis de metilação do DNA na região promotora de genes supressores tumorais por pirosequenciamento.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Mestrado acadêmico: (1) . , Integrantes: Henrique César Santejo Silveira - Coordenador / Paulo Saldiva - Integrante / Andre Lopes Carvalho - Integrante., Financiador(es): Fundação Pio XII - Outra.
2011 - Atual
Análise da poluição do ar gerada pela queima da palha da cana-de-açúcar e suas relações com a mutagênese humana., Descrição: O uso de fontes renováveis de energia é uma ferramenta importante para sustentabilidade, o menor risco ao meio ambiente e a saúde humana. Os biocombustíveis são fontes alternativas e necessárias nos países em desenvolvimento, que contam com a expansão da frota automotiva, industrial e tecnológica. O etanol brasileiro, graças ao cultivo da cana-de-açucar, consolidou o país como um dos líderes mundiais na produção de biocombustíveis. O estado de São de Paulo é o maior produtor desta cultura e na colheita de cana é comum a queima da palha por motivos de produtividade e precauções com o trabalhador rural. Por outro lado, a queima de biomassa é uma das principais fontes para os gases tóxicos que comprometem a qualidade do ar. Diversos produtos genotóxicos são gerados durante esse processo e apresentam efeitos sobre a saúde humana, que são correlacionados com o aumento de doenças respiratórias, cardiovasculares e câncer na população exposta. Sendo assim, este projeto visa avaliar a qualidade do ar em regiões canavieiras do interior do Estado de São Paulo e relacioná-las com a incidência de câncer. Para isto, serão utilizadas plantas de Tradescantia pallida e as correlações das frequências de micronúcleos detectadas, para o biomonitoramento. O local escolhido será a região de Barretos que conta com plantações de cana ao seu redor e que há uma década contava somente com a criação de gado para produção de carne. Também serão coletados sangue periférico de moradores das zonas rurais (cortadores de cana) e da cidade de Barretos e correlacioná-los com a região de maior ou menor incidência de poluentes do ar. Além disso, a inclusão de estudantes e professores do ensino médio na manutenção das plantas possibilitará discussões sobre a qualidade do ar e a importância do meio ambiente, contribuindo para educação ambiental da população local.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Henrique César Santejo Silveira - Coordenador / Paulo Saldiva - Integrante., Financiador(es): Fundação Pio XII - Cooperação / Fundação de Amparo à Pesquisa do Estado de São Paulo - Bolsa.
2010 - Atual
Instituto Nacional de Análise Integrada do Risco Ambiental - INAIRA (INCT), Descrição: O desenvolvimento do Brasil, com o aumento do parque industrial, o crescimento da frota leve e pesada e a expansão da fronteira produtiva, levou a desafios para a determinação dos impactos da poluição à saúde humana. De um lado, temos a introdução de novos combustíveis, cujo potencial de interferir com os níveis de poluição (para mais ou para menos) ainda não foi determinado. Por outro lado, a expansão das fontes levou problemas de poluição atmosférica a áreas desprovidas de capacidade de monitoramento e gestão do risco. A velocidade da transição energética e da expansão das áreas potencialmente afetadas pela poluição fazem surgir a necessidade de que estudos de risco sejam implementados rapidamente.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Henrique César Santejo Silveira - Integrante / Paulo Saldiva - Coordenador / Thaís Mauad - Integrante., Financiador(es): Conselho Nacional de Desenvolvimento Científico e Tecnológico - Auxílio financeiro / Fundação de Amparo à Pesquisa do Estado de São Paulo - Bolsa.
2009 - 2013
Genômica funcional e comparativa em fungos (Projeto Temático), Descrição: Nossa proposta é analisar transcricionalmente T. rubrum durante sua interação com células da epiderme humana e outras moléculas presentes no ambiente hospedeiro; aprofundar o conhecimento dos mecanismos moleculares envolvidos no sensoriamento pelo pH ambiente e o seu papel na patogenicidade fúngica; identificar novos mecanismos moleculares envolvidos na resistência e na adaptação a inibidores fúngicos e consequentemente contribuir para o controle da infecção fúngica.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Henrique César Santejo Silveira - Integrante / Antônio Rossi - Integrante / Nilce M Martinez Rossi - Coordenador., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
2003 - 2009
Genética Molecular e Genômica funcional de fungos (Projeto Temático), Descrição: O projeto tem como objetivo ampliar nossa linha de pesquisa na tentativa de elucidar as vias metabólicas ou processos celulares que permitem aos fungos sobreviverem em condições adversas. Além disto, pretendemos identificar genes que estejam envolvidos na patogenicidade e portanto possam se tornar alvos para o desenvolvimento de novas drogas antifúngicas. Para isto serão utilizados preferencialmente o fungo modelo Aspergillus nidulans e o dermatófito Trichophyton rubrum. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Henrique César Santejo Silveira - Integrante / Antônio Rossi - Integrante / Nilce M Martinez Rossi - Coordenador., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.
Prêmios
2019
1 colocado na apresentação oral para aluna de mestrado Isabela Campanelli dos Santos. I Simpósio de RedCap, Hospital de Câncer de Barretos.
2018
1 colocado na categoria Doutorado apresentado pela aluna Mariana de Oliveira Klein no IX Encontro Cientifico do Hospital de Câncer de Barretos, Instituto de Ensino e Pesquisa do Hospital de Câncer de Barretos.
2017
2 colocado prêmio pôster pelo trabalho Utilização de mídia digital para conscientização e prevenção de câncer em trabalhadores rurais no II Encontro de Educação do Hospital de Câncer de Barretos, Hospital de Câncer de Barretos.
2017
1 colocado pelo trabalho Methylation profile of tumor supressor genes as biomarker of cervical high-grade lesions apresentado no VI Simpósio Internacional de Oncologia Translacional e Pesquisa Clinica, Hospital de Câncer de Barretos.
2014
2 Colocado no premio painel para a aluna Manoela Aguena Ramos no IV International Symposium on Translacional Oncology, Hospital de Câncer de Barretos.
2013
Mensão honrosa a aluna Fernada Cury no I Encontro de Jovens Talentos do Hospital de Câncer de Barretos, Hospital de Câncer de Barretos.
2012
Menção honrosa prêmio iniciação cienifica apres. oral para a aluna Fernada Cury no 58 Congresso Brasileiro de Genética, Sociedade Brasileira de Genética.
2012
Menção honrosa pelo trabalho apresentado na categoria postêr do IV Encontro cientifico do Hospital de Câncer de Barretos, Hospital de Câncer de Barretos.
2011
menção honrosa no Prêmio Amigo do Meio Ambiente, Secretária da Saúde do Estado de São Paulo.
2010
Menção honrosa 56* Congresso Brasileiro de Genética, Sociedade Brasileira de Genética.
2009
Seleção do trabalho "Avaliação da expressão gênica do dermatófito Trichophyton rubrum durante o cultivo em queratina como única fonte de nutriente" para apresentação oral., 25* Congresso Brasileiro de Microbiologia.
2006
Prêmio concedido pela Sociedade Brasileira de Genética de melhor trabalho por mim apresentado, na área de Genética de Microrganismos durante o 52 Congresso Brasileiro de Genética em 2006., Sociedade Brasileira de Genética.
2006
Distinção de trabalho pela, Sociedade Brasileira de Bioquímica e Biologia Molecular.
2005
Andrade, A.S, Paião, FG, Silveira, HC, Fachin, AL, Martinez-Rossi, NM. Análise da Expressão Diferencial de Genes do Mutante AtrD de T. rubrum Em Resposta ao Antifúngico Terbinafina, menção honrosa no, 51* Congresso Brasileiro de Genética, Sociedade Brasileira de Genética.
2005
Andrade, A.S, Silveira, HC, Paião, FG, Fachin, AL, Martinez-Rossi, NM. Perfil de expressão gênica das linhagens selvagem e mutante atrD-inativado do fungo patogênico T. rubrum expostas a terbinafina, menção honrosa, 13° Simpósio Internacional de Iniciação Cientifica - USP.
Histórico profissional
Endereço profissional
Fundação Pio XII - Hospital de Câncer de Barretos, HCB, Centro de Pesquisa em Oncologia Molecular. , Rua Antenor Duarte Vilela - de 1301/1302 ao fim, Doutor Paulo Prata, 14784400 - Barretos, SP - Brasil, Telefone: (17) 33216600, Ramal: 7057
Experiência profissional
2012 - 2012
Harvard School Of Public HealthVínculo: Professor vistante, Enquadramento Funcional: pesquisador visitante, Regime: Dedicação exclusiva.
2012 - Atual
Fundação Pio XIIVínculo: Celetista, Enquadramento Funcional: pesquisador, Carga horária: 44
2010 - 2011
Faculdade de Medicina (FM-USP)Vínculo: Pós-doc, Enquadramento Funcional: pesquisador, Carga horária: 40, Regime: Dedicação exclusiva.
2019 - Atual
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: Membro da Comissão de Ética Animal CEUA CPOM, Carga horária: 2
2018 - Atual
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: Presidente da Comissão de Biossegurança, Carga horária: 2
2014 - Atual
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: Membro do Comitê de Ética em Pesquisa, Carga horária: 2
2011 - Atual
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: docente da disciplina - Biologia Molecular I
2011 - Atual
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: docente da disciplina - Biologia Molecular II
2011 - Atual
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Celetista formal, Enquadramento Funcional: Pesquisador em Biologia Humana I, Carga horária: 44
2010 - Atual
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: Docente Pós-Graduação, Carga horária: 0
2018 - 2019
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: Coordenador da Residencia em Biomedicina, Carga horária: 2
2017 - 2018
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: Vice-coordenador da Residencia em Biomedicina, Carga horária: 2
2017 - 2018
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: Membro da Comissão de Ética Animal CEUA IRCAD, Carga horária: 2
2012 - 2017
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: Vice-coordenador Comissão de Biossegurança, Carga horária: 2
2011 - 2015
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Colaborador, Enquadramento Funcional: Comissão de Gestão Ambiental - Integrante
2012 - 2012
Fundação Pio XII - Hospital de Câncer de Barretos, HCBVínculo: Celetista, Enquadramento Funcional: Docente Responsável da, Carga horária: 8
Outras informações:
Disciplina de Fatores Ambientais e suas implicações na carcinogênese.
Atividades
Pesquisa e desenvolvimento, Centro de Pesquisa em Oncologia Molecular.,Linhas de pesquisa
2009 - 2009
Oklahoma State UniversityVínculo: Pesquisador visitante, Enquadramento Funcional: Colaboração em Projeto de Pesquisa, Carga horária: 40, Regime: Dedicação exclusiva.
2009 - 2013
Faculdade de Medicina deRibeirão PretoVínculo: Professor da Pós-Graduação, Enquadramento Funcional: Responsável (Docente) da disciplina (RGM5897)
Outras informações:
Responsável (Docente) da disciplina (RGM5897) Genômica Funcional Aplicada à Micologia, destinada aos alunos de Pós-Graduação, ministrada no Departamento de Genética da Faculdade de Medicina de Ribeirão Preto ? USP.
2003 - 2007
Faculdade de Medicina deRibeirão PretoVínculo: Pós-graduando, Enquadramento Funcional: doutorando, Regime: Dedicação exclusiva.
1999 - 1999
Faculdade de Medicina deRibeirão PretoVínculo: Estagiario, Enquadramento Funcional: estagiário, Carga horária: 60
1998 - 1998
Faculdade de Medicina deRibeirão PretoVínculo: Estagiario, Enquadramento Funcional: , Carga horária: 60
Outras informações:
Estágio voluntário - Laboratório Central de Patologia Clínica
Atividades
Estágios , Departamento de Genética.,Estágio realizado, Laboratório de Genética Molecular.
Estágios , Hospital das Clínicas de Ribeirão Preto.,Estágio realizado, Laboratório Central de Patologia Clínica.
2019 - Atual
Universidade de CuiabáVínculo: Colaborador, Enquadramento Funcional: Membro da Comissão de Pós-Graduação CPG
2016 - Atual
Universidade de CuiabáVínculo: , Enquadramento Funcional: Professor mestrado em Ambiente e Saúde, Carga horária: 20
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