Cristiano Schaffer Aguzzoli

Pós-doutorado

Formação complementar

Idiomas

Áreas de atuação

Organização de eventos

Participação em eventos

Participação em bancas

Produções bibliográficas

• DA ROS, LUCAS U ; BORELLI, WYLLIANS VENDRAMINI ; AGUZZOLI, CRISTIANO SCHAFFER ; DE BASTIANI, MARCO ANTÔNIO ; SCHILLING, LUCAS PORCELLO ; SANTAMARIA-GARCIA, HERNANDO ; PASCOAL, THARICK A ; ROSA-NETO, PEDRO ; SOUZA, DIOGO O ; DA COSTA, JADERSON COSTA ; IBAÑEZ, AGUSTIN ; SUEMOTO, CLAUDIA KIMIE ; ZIMMER, EDUARDO R . Social and health disparities associated with healthy brain ageing in Brazil and in other Latin American countries. Lancet Global Health , v. 13, p. e277-e284, 2025.

• BORELLI, WYLLIANS VENDRAMINI ; FERREIRA, PAMELA C. L. ; BRUM, WAGNER S. ; FERRARI-SOUZA, JOÃO PEDRO ; CARELLO-COLLAR, GIOVANNA ; HOLZ, MAILA ; TIZELI, VICTORIA ; STRELOW, MATHEUS ZSCHORNACK ; FORMOSO, CAROLINA ; CHAVES, MARCIA LORENA FAGUNDES ; ROCHA, ANDREIA ; AGUZZOLI, CRISTIANO SCHAFFER ; ROHDEN, FRANCIELI ; SOUZA, DÉBORA G. ; SCHUMACHER SCHUH, ARTUR FRANCISCO ; POVALA, GUILHERME ; BELLAVER, BRUNA ; ROSA-NETO, PEDRO ; CASTILHOS, RAPHAEL MACHADO ; PASCOAL, THARICK A. ; et.al . Diagnostic performance of Alzheimer?s disease blood and CSF biomarkers in a Brazilian cohort with low educational attainment. MOLECULAR PSYCHIATRY , v. 1, p. 1, 2025.

• LEFFA, DOUGLAS T. ; POVALA, GUILHERME ; BELLAVER, BRUNA ; FERRARI'SOUZA, JOÃO PEDRO ; FERREIRA, PAMELA C. L. ; LUSSIER, FIROZA Z. ; SCHAFFER AGUZZOLI, CRISTIANO ; SOARES, CAROLINA ; ZALZALE, HUSSEIN ; ROHDEN, FRANCIELI ; BAUER'NEGRINI, GUILHERME ; ABBAS, SARAH ; SCHNEIDER, MAITÊ ; THERRIAULT, JOSEPH ; LOPEZ, OSCAR L. ; VILLEMAGNE, VICTOR L. ; KLUNK, WILLIAM E. ; TUDORASCU, DANA L. ; COHEN, ANN D. ; ROSA'NETO, PEDRO ; et.al . Impact of the polygenic risk scores for attention-deficit/hyperactivity disorder in Alzheimer's disease. Alzheimers & Dementia , v. 21, p. 1, 2025.

• SOARES, CAROLINA ; BELLAVER, BRUNA ; FERREIRA, PAMELA C. L. ; POVALA, GUILHERME ; SCHAFFER AGUZZOLI, CRISTIANO ; FERRARI-SOUZA, JOÃO PEDRO ; ZALZALE, HUSSEIN ; LUSSIER, FIROZA Z. ; ROHDEN, FRANCIELI ; ABBAS, SARAH ; BAUER-NEGRINI, GUILHERME ; TEIXEIRA LEFFA, DOUGLAS ; BENEDET, ANDRÉA LESSA ; LANGHOUGH, REBECCA ; BETTHAUSER, TOBEY J. ; CHRISTIAN, BRADLEY T. ; WILSON, RACHAEL E. ; L. TUDORASCU, DANA ; ROSA-NETO, PEDRO ; KARIKARI, THOMAS K. ; et.al . CSF total tau as a proxy of synaptic degeneration. Nature Communications , v. 16, p. 1, 2025.

• FERRARI-SOUZA, JOÃO PEDRO ; POVALA, GUILHERME ; RAHMOUNI, NESRINE ; BELLAVER, BRUNA ; FERREIRA, PAMELA C. L. ; DE BASTIANI, MARCO ANTÔNIO ; LEFFA, DOUGLAS T. ; LUSSIER, FIROZA Z. ; Aguzzoli, Cristiano S. ; BRUM, WAGNER S. ; CARELLO-COLLAR, GIOVANNA ; BORELLI, WYLLIANS V. ; THERRIAULT, JOSEPH ; MACEDO, ARTHUR C. ; SERVAES, STIJN ; STEVENSON, JENNA ; POLA, ILARIA ; GAUTHIER, SERGE ; SOUZA, DIOGO O. ; SCHILLING, LUCAS PORCELLO ; et.al . Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer?s disease. NATURE NEUROSCIENCE , v. 1, p. 1, 2025.

• ABBAS, SARAH ; FERREIRA, PAMELA C. L ; BELLAVER, BRUNA ; POVALA, GUILHERME ; ROHDEN, FRANCIELI ; AGUZZOLI, CRISTIANO SCHAFFER ; ZALZALE, HUSSEIN ; FERRARI-SOUZA, JOÃO PEDRO ; LEFFA, DOUGLAS T. ; LUSSIER, FIROZA Z. ; SOARES, CAROLINA ; BAUER-NEGRINI, GUILHERME ; OLIVEIRA-JUNIOR, MARKLEY SILVA ; RODRIGUES, MATHEUS SCARPATTO ; SAHA, PAMPA ; RUPPERT, EMMA ; MEDEIROS, MARINA SCOP ; TISSOT, CÉCILE ; THERRIAULT, JOSEPH ; RAHMOUNI, NESRINE ; et.al . Utility of plasma GFAP as a secondary endpoint for clinical trials in Alzheimer?s disease. JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE , v. 1, p. 100205, 2025.

• POVALA, GUILHERME ; BELLAVER, BRUNA ; BASTIANI, MARCO ANTÔNIO DE ; FERRARI'SOUZA, JOÃO PEDRO ; Aguzzoli, Cristiano S. ; LEFFA, DOUGLAS T. ; FERREIRA, PAMELA C. L. ; LUSSIER, FIROZA Z. ; ROCHA, ANDREIA ; ZALZALE, HUSSEIN ; SOARES, CAROLINA ; BAUER'NEGRINI, GUILHERME ; THERRIAULT, JOSEPH ; RAHMOUNI, NESRINE ; STEVENSON, JENNA ; SERVAES, STIJN ; TISSOT, CÉCILE ; ZATT, BRUNO ; KARIKARI, THOMAS K. ; IKONOMOVIC, MILOS D. ; et.al . Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration. Alzheimers & Dementia , v. 21, p. 1, 2025.

• ROHDEN, FRANCIELI ; FERREIRA, PAMELA C. L. ; BELLAVER, BRUNA ; FERRARI-SOUZA, JOÃO PEDRO ; Aguzzoli, Cristiano S. ; SOARES, CAROLINA ; ABBAS, SARAH ; ZALZALE, HUSSEIN ; POVALA, GUILHERME ; LUSSIER, FIROZA Z. ; LEFFA, DOUGLAS T. ; BAUER-NEGRINI, GUILHERME ; RAHMOUNI, NESRINE ; TISSOT, CÉCILE ; THERRIAULT, JOSEPH ; SERVAES, STIJN ; STEVENSON, JENNA ; BENEDET, ANDREA L. ; ASHTON, NICHOLAS J. ; KARIKARI, THOMAS K. ; et.al . Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer?s disease. Nature Communications , v. 16, p. 1, 2025.

• PASCOAL, THARICK A. ; Aguzzoli, Cristiano S. ; LUSSIER, FIROZA Z. ; CRIVELLI, LUCÍA ; SUEMOTO, CLAUDIA K. ; FORTEA, JUAN ; ROSA-NETO, PEDRO ; ZIMMER, EDUARDO R. ; FERREIRA, PAMELA C.L. ; BELLAVER, BRUNA . Insights into the use of biomarkers in clinical trials in Alzheimer's disease. EBIOMEDICINE , v. 108, p. 105322, 2024.

• SCHAFFER AGUZZOLI, CRISTIANO ; FERREIRA, PÂMELA C. L. ; POVALA, GUILHERME ; FERRARI-SOUZA, JOÃO PEDRO ; BELLAVER, BRUNA ; SOARES KATZ, CAROLINA ; ZALZALE, HUSSEIN ; LUSSIER, FIROZA Z. ; ROHDEN, FRANCIELI ; ABBAS, SARAH ; LEFFA, DOUGLAS T. ; SCOP MEDEIROS, MARINA ; THERRIAULT, JOSEPH ; BENEDET, ANDRÉA L. ; TISSOT, CÉCILE ; SERVAES, STIJN ; RAHMOUNI, NESRINE ; CASSA MACEDO, ARTHUR ; BEZGIN, GLEB ; KANG, MIN SU ; et.al . Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease. JAMA NETWORK OPEN , v. 6, p. e2345175, 2023.

• Fitri, FI ; Lage, C ; MOLLAYEVA, T. ; SANTAMARIA-GARCIA, H. ; CHAN, M. ; COMINETTI, M. ; DARIA, T. ; FALLON, G. ; GATELY, D. ; GICHU, M. ; ZUNIGA, R. G. ; HADAD, R. ; HILL-JARRETT, T. ; OKELLY, M. ; MARTINEZ, L. ; MODJAJI, P. ; NGCOBO, N. ; NOWAK, R. ; OGBUAGU, C. ; AGUZZOLI, C. S. ; et.al . Empathy as a crucial skill in disrupting disparities in global brain health. Frontiers in Neurology , v. 14, p. 1, 2023.

• AGUZZOLI, CRISTIANO SCHAFFER ; BATTISTA, PETRONILLA ; HADAD, RAFI ; FERREIRA FELLONI BORGES, YURI ; SCHILLING, LUCAS PORCELLO ; MILLER, BRUCE L . Very early-onset behavioral variant frontotemporal dementia in a patient with a variant of uncertain significance of a FUS gene mutation. NEUROCASE , v. 28, p. 403-409, 2022.

• AGUZZOLI, C. S. ; MONTEIRO, R. ; SCHILLING, L. P. . SÍNDROME ATÁXICA CEREBELAR: RELATO DE CASO E BREVE REVISÃO DA LITERATURA. Revista Científica do Hospital de Aeronáutica de Canoas , v. 1, p. 32, 2021.

• DE OLIVEIRA ROSA, VIRGINIA ; ROSA FRANCO, ALEXANDRE ; ABRAHÃO SALUM JÚNIOR, GIOVANNI ; MOREIRA-MAIA, CARLOS RENATO ; WAGNER, FLÁVIA ; SIMIONI, ANDRÉ ; DE FRAGA BASSOTTO, CAROLINE ; R. MORITZ, GUILHERME ; SCHAFFER AGUZZOLI, CRISTIANO ; BUCHWEITZ, AUGUSTO ; SCHMITZ, MARCELO ; RUBIA, KATYA ; PAIM ROHDE, LUIS AUGUSTO . Effects of computerized cognitive training as add-on treatment to stimulants in ADHD: a pilot fMRI study. Brain Imaging and Behavior , v. 3, p. 1-13, 2019.

• BUCHWEITZ, AUGUSTO ; COSTA, ADRIANA CORRÊA ; TOAZZA, RUDINEIA ; DE MORAES, ANA BASSÔA ; CARA, VALENTINA METSAVAHT ; ESPER, NATHÁLIA BIANCHINI ; AGUZZOLI, CRISTIANO ; GREGOLIM, BRUNA ; DRESCH, LUIZ FERNANDO ; SOLDATELLI, MATHEUS DORIGATTI ; DA COSTA, JADERSON COSTA ; PORTUGUEZ, MIRNA WETTERS ; FRANCO, ALEXANDRE ROSA . Decoupling of the Occipitotemporal Cortex and the Brain?s Default-Mode Network in Dyslexia and a Role for the Cingulate Cortex in Good Readers: A Brain Imaging Study of Brazilian Children. DEVELOPMENTAL NEUROPSYCHOLOGY , v. 347, p. 1-12, 2018.

• TOAZZA, RUDINEIA ; FRANCO, ALEXANDRE ROSA ; BUCHWEITZ, AUGUSTO ; MOLLE, ROBERTA DALLE ; RODRIGUES, DANITSA MARCOS ; REIS, ROBERTA SENA ; MUCELLINI, AMANDA BRONDANI ; ESPER, NATHALIA BIANCHINI ; AGUZZOLI, CRISTIANO ; SILVEIRA, PATRÍCIA PELUFO ; SALUM, GIOVANNI ABRAHÃO ; MANFRO, GISELE GUS . Amygdala-based intrinsic functional connectivity and anxiety disorders in adolescents and young adults. PSYCHIATRY RESEARCH-NEUROIMAGING , v. 257, p. 11-16, 2016.

• SOLDATELLI, M. D. ; AGUZZOLI, C. S. ; BORELLI, W. V. ; MARRONE, L. C. P. . Acidente Vascular Cerebral Isquêmico. Acta Médica (Porto Alegre) , v. 1, p. 1-5, 2016.

• BORELLI, W. V. ; AGUZZOLI, C. S. ; SOLDATELLI, M. D. ; SCHILLING, L. P. . Estado Confusional Agudo. ACTA MÉDICA (PORTO ALEGRE) , v. 1, p. 23-27, 2016.

• FIGUEIREDO, LUCIANA S. ; DORNELLES, ARETHUZA S. ; PETRY, FERNANDA S. ; FALAVIGNA, LUCIO ; DARGÉL, VINICIUS A. ; KÖBE, LUIZA M. ; AGUZZOLI, CRISTIANO ; ROESLER, RAFAEL ; SCHRÖDER, NADJA . Two waves of proteasome-dependent protein degradation in the hippocampus are required for recognition memory consolidation. NEUROBIOLOGY OF LEARNING AND MEMORY , v. 120, p. 1-6, 2015.

• LAVICH, I.C. ; DE FREITAS, B.S. ; KIST, L.W. ; FALAVIGNA, L. ; DARGÉL, V.A. ; KÖBE, L.M. ; AGUZZOLI, C. ; PIFFERO, B. ; FLORIAN, P.Z. ; BOGO, M.R. ; DE LIMA, M.N.M. ; SCHRÖDER, N. . Sulforaphane rescues memory dysfunction and synaptic and mitochondrial alterations induced by brain iron accumulation. Neuroscience , v. 301, p. 542-552, 2015.

• AGUZZOLI, C. S. ; BORELLI, W. V. ; SCOP MEDEIROS, MARINA ; SCHILLING, LUCAS P. . Neuropsicologia do Envelhecimento (capítulo Demências potencialmente reversíveis). 1. ed. São Paulo: Ampla, 2023. v. 1.

• FLEITH, L. V. ; GONCALVES, L. I. ; SCHAFFER AGUZZOLI, CRISTIANO ; BELLORA, R. M. ; SCHILLING, L. P. . Manual de internação psiquiátrica (capítulo Demências). 1. ed. São Paulo: Editora Manole; 1ª edição (16 abril 2021), 2021. v. 1. 440p .

• TERRA, N.L ; NETO, A.C ; PORTUGUEZ, MIRNA WETTERS ; CRIPPA, A. ; SCHAFFER AGUZZOLI, CRISTIANO . Geriatria e gerontologia clínica. 1. ed. Porto Alegre: EDIPUCRS, 2020. v. 1. 796p .

• AGUZZOLI, C. S. ; COSTA, D. . Manifestações neuropsiquiátricas na Doença de Alzheimer: Intervenções farmacológicas e não farmacológicas. BrainTV magazine, p. 18 - 21, 01 nov. 2024.

• SCHAFFER AGUZZOLI, CRISTIANO ; SCHILLING, L. P. . Empatia: Redes Neurais e Comportamentos Sociais. BrainTV magazine, Porto Alegre, p. 20 - 25, 01 mar. 2022.

• AGUZZOLI, C. S. ; MILLER, B. L. . Valuable initiatives to understand and address stigma in rarer forms of dementia. World Alzheimer Report 2024.

• AGUZZOLI, CRISTIANO SCHAFFER . Microglial activation is closely associated with neuropsychiatric symptoms across the Alzheimer?s disease continuum. In: Reunião de Pesquisadores em Doença de Alzheimer e Desordens Relacionadas, 2024. XIV RPDA. p. 1.

• AGUZZOLI, C. S. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; KLUNK, W. E. ; VILLEMAGNE, V. L. ; GAUTHIER, S. ; ASHTON, N. J. ; SCHILLING, L. P. ; KARIKARI, T. K. ; BLENNOW, K. ; ZETTERBERG, H. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. . Microglial Activation Contributes to Neuropsychiatric Dysfunction in Alzheimer?s Disease. In: Alzheimer's Association International Conference Imaging Consortium, 2023, Amsterdam. Alzheimers Dement. 2023, 2023.

• AGUZZOLI, C. S. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; KLUNK, W. E. ; VILLEMAGNE, V. L. ; GAUTHIER, S. ; ASHTON, N. J. ; SOUZA, D. O. ; SCHILLING, L. P. ; KARIKARI, T. K. ; BLENNOW, K. ; ZETTERBERG, H. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. . Microglial Activation Contributes to Neuropsychiatric Dysfunction in Alzheimer?s Disease. In: Alzheimer's Association International Conference, 2023, Amsterdam. Alzheimers Dement. 2023, 2023.

• AGUZZOLI, C. S. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; KLUNK, W. E. ; VILLEMAGNE, V. L. ; GAUTHIER, S. ; SCHILLING, L. P. ; KARIKARI, T. K. ; ASHTON, N. J. ; ZETTERBERG, H. ; BLENNOW, K. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. . Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer?s Disease. In: Alzheimer's Association International Conference, 2023, Amsterdam. Alzheimers Dement. 2023, 2023.

• ABBAS, S. ; BELLAVER, B. ; AGUZZOLI, C. S. ; KARIKARI, T. K. ; ASHTON, N. J. ; BENEDET, A. L. ; ZETTERBERG, H. ; BLENNOW, K. ; ROSA-NETO, P. ; PASCOAL, T. A. . Sex impacts the association of plasma Glial Fibrillary Acidic Protein with neurodegeneration in Alzheimer?s disease. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• NEGRINI, G. B. ; POVALA, G. ; LUSSIER, F. L. ; FERREIRA, P. C. L. ; AGUZZOLI, C. S. ; THERRIAULT, J. ; TISSOT, C. ; GAUTHIER, S. ; KARIKARI, T. K. ; ROSA-NETO, P. ; PASCOAL, T. A. . Employing transfer learning to optimize deep learning models for Alzheimer?s disease classification using two tau PET tracers. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• BELLAVER, B. ; POVALA, G. ; FERREIRA, P. C. L. ; AGUZZOLI, C. S. ; ASHTON, N. J. ; THERRIAULT, J. ; TISSOT, C. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; VILLEMAGNE, V. L. ; KLUNK, W. E. ; COHEN, A. ; GAUTHIER, S. ; ZIMMER, E. R. ; ZETTERBERG, H. ; BLENNOW, K. ; KARIKARI, T. K. ; ROSA-NETO, P. ; PASCOAL, T. A. . Astrocyte reactivity potentiates longitudinal tau tangle accumulation in cognitively unimpaired individuals. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• BELLAVER, B. ; POVALA, G. ; LUSSIER, F. L. ; AGUZZOLI, C. S. ; BENEDET, A. L. ; ASHTON, N. J. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; VILLEMAGNE, V. L. ; KLUNK, W. E. ; COHEN, A. ; GAUTHIER, S. ; ZIMMER, E. R. ; ZETTERBERG, H. ; BLENNOW, K. ; KARIKARI, T. K. ; ROSA-NETO, P. ; PASCOAL, T. A. . Sex modulates the role of astrocyte reactivity in preclinical Alzheimer?s disease. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• BELLAVER, B. ; POVALA, G. ; FERREIRA, P. C. L. ; AGUZZOLI, C. S. ; ASHTON, N. J. ; TISSOT, C. ; THERRIAULT, J. ; RAHMOUNI, N. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; VILLEMAGNE, VICTOR L. ; KLUNK, W. E. ; COHEN, A. ; GAUTHIER, S. ; ZIMMER, E. R. ; ZETTERBERG, H. ; BLENNOW, K. ; KARIKARI, T. K. ; ROSA-NETO, P. ; PASCOAL, T. A. ; et.al . Sex modulates the role of astrocyte reactivity in preclinical Alzheimer?s disease. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• FERRARI-SOUZA, J. P. ; BELLAVER, B. ; FERREIRA, P. C. L. ; BENEDET, A. L. ; AGUZZOLI, C. S. ; SOUZA, D. O. ; GAUTHIER, S. ; SCHILLING, L. P. ; KARIKARI, T. K. ; ASHTON, N. J. ; ZETTERBERG, H. ; BLENNOW, K. ; ROSA-NETO, P. ; PASCOAL, T. A. ; ZIMMER, E. R. . Association of reactive astrogliosis and microglial activation with tau pathology in Alzheimer?s disease. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• FERRARI-SOUZA, J. P. ; BELLAVER, B. ; FERREIRA, P. C. L. ; POVALA, G. ; LUSSIER, F. L. ; LEFFA, D. T. ; THERRIAULT, J. ; TISSOT, C. ; AGUZZOLI, C. S. ; SOUZA, D. O. ; GAUTHIER, S. ; SCHILLING, L. P. ; KARIKARI, T. K. ; ASHTON, N. J. ; ZETTERBERG, H. ; BLENNOW, K. ; ROSA-NETO, P. ; PASCOAL, T. A. ; ZIMMER, E. R. . Association of reactive astrogliosis and microglial activation with tau pathology in Alzheimer?s disease. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• FERRARI-SOUZA, J. P. ; FERREIRA, P. C. L. ; BELLAVER, B. ; POVALA, G. ; AGUZZOLI, C. S. ; COHEN, A. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; KLUNK, W. E. ; VILLEMAGNE, V. L. ; SOUZA, D. O. ; SCHILLING, L. P. ; KARIKARI, T. K. ; GAUTHIER, S. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. . Potential utility of using both APOEε4 and Aβ positivity to enrich clinical trials of tau-targeting therapies. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• FERRARI-SOUZA, J. P. ; FERREIRA, P. C. L. ; BELLAVER, B. ; POVALA, G. ; AGUZZOLI, C. S. ; COHEN, A. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; KLUNK, W. E. ; VILLEMAGNE, V. L. ; SOUZA, D. O. ; SCHILLING, L. P. ; KARIKARI, T. K. ; GAUTHIER, S. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. . Potential utility of using both APOEε4 and Aβ positivity to enrich clinical trials of tau-targeting therapies. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• FERREIRA, P. C. L. ; BELLAVER, B. ; POVALA, G. ; LUSSIER, F. L. ; AGUZZOLI, C. S. ; TISSOT, C. ; LOPEZ, O. L. ; VILLEMAGNE, V. L. ; COHEN, A. ; TUDORASCU, D. L. ; GAUTHIER, S. ; ZIMMER, E. R. ; KARIKARI, T. K. ; ASHTON, N. J. ; ZETTERBERG, H. ; BLENNOW, KAJ ; ROSA-NETO, P. ; PASCOAL, T. A. . Plasma p-tau and brain-derived total tau biomarkers predict longitudinal changes in Aβ, tau, and cognition across the AD continuum. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• FERREIRA, P. C. L. ; BELLAVER, B. ; POVALA, G. ; THERRIAULT, J. ; TISSOT, C. ; AGUZZOLI, C. S. ; TUDORASCU, D. L. ; KLUNK, W. E. ; VILLEMAGNE, V. L. ; COHEN, A. ; GAUTHIER, S. ; ZIMMER, E. R. ; ASHTON, N. J. ; ZETTERBERG, H. ; BLENNOW, K. ; KARIKARI, T. K. ; ROSA-NETO, P. ; PASCOAL, T. A. . Plasma p-tau231 and p-tau217 provides information on tau tangle deposition in symptomatic Alzheimer?s disease individuals. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• FERREIRA, P. C. L. ; BELLAVER, B. ; POVALA, G. ; THERRIAULT, J. ; TISSOT, C. ; FERRARI-SOUZA, J. P. ; BENEDET, A. L. ; AGUZZOLI, C. S. ; TUDORASCU, D. L. ; KLUNK, W. E. ; VILLEMAGNE, V. L. ; COHEN, A. ; GAUTHIER, S. ; ASHTON, N. J. ; ZIMMER, E. R. ; ZETTERBERG, H. ; BLENNOW, K. ; KARIKARI, T. K. ; ROSA-NETO, P. ; PASCOAL, T. A. ; et.al . Plasma p-tau231 and p-tau217 provides information on tau tangle deposition in symptomatic Alzheimer?s disease individuals. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• LEFFA, D. T. ; POVALA, G. ; BELLAVER, B. ; LUSSIER, F. L. ; FERRARI-SOUZA, J. P. ; AGUZZOLI, C. S. ; LOPEZ, O. L. ; VILLEMAGNE, V. L. ; COHEN, A. ; KLUNK, W. E. ; ZIMMER, E. R. ; KARIKARI, T. K. ; ROSA-NETO, P. ; PAIM ROHDE, LUIS AUGUSTO ; PASCOAL, T. A. . Increased Genetic Risk for ADHD Potentiates Cognitive Impairment and Brain Hypometabolism in Alzheimer?sDisease Patients. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• POVALA, G. ; BELLAVER, B. ; LUSSIER, F. L. ; FERREIRA, P. C. L. ; FERRARI-SOUZA, J. P. ; LEFFA, D. T. ; AGUZZOLI, C. S. ; COHEN, A. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; KLUNK, W. E. ; VILLEMAGNE, V. L. ; KARIKARI, T. K. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. . Microglial activation interacts with amyloid-β to drive longitudinal tau tangle accumulation and cognitive decline. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• POVALA, G. ; BELLAVER, B. ; LEFFA, D. T. ; FERREIRA, P. C. L. ; FERRARI-SOUZA, J. P. ; Aguzzoli, Cristiano S. ; LUSSIER, F. L. ; COHEN, A. ; VILLEMAGNE, V. L. ; KARIKARI, T. K. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; KLUNK, W. E. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. . Microglial activation interacts with amyloid-β to drive longitudinal tau tangle accumulation and cognitive decline. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• ROHDEN, F. ; FERREIRA, P. C. L. ; BELLAVER, B. ; AGUZZOLI, C. S. ; POVALA, G. ; LUSSIER, F. L. ; COHEN, A. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; KARIKARI, T. K. ; VILLEMAGNE, V. L. ; ZETTERBERG, H. ; BLENNOW, K. ; SOUZA, D. O. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. . Astrocyte reactivity is associated with synaptic dysfunction across the aging and Alzheimer?s disease spectrum, whereas microglial reactivity is specifically associated with synaptic dysfunction related to cognitive impairment. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• ROHDEN, F. ; FERREIRA, P. C. L. ; BELLAVER, B. ; AGUZZOLI, C. S. ; SOARES, C. ; POVALA, G. ; COHEN, A. ; LOPEZ, O. L. ; ASHTON, N. J. ; VILLEMAGNE, V. L. ; KARIKARI, T. K. ; TUDORASCU, D. L. ; ZETTERBERG, H. ; BLENNOW, K. ; SOUZA, D. O. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. . Astrocyte reactivity is associated with synaptic dysfunction across the aging and Alzheimer?s disease spectrum, whereas microglial reactivity is specifically associated with synaptic dysfunction related to cognitive impairment. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• ROHDEN, F. ; BELLAVER, B. ; FERREIRA, P. C. L. ; AGUZZOLI, C. S. ; POVALA, G. ; LUSSIER, F. L. ; FERRARI-SOUZA, J. P. ; COHEN, A. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; KARIKARI, T. K. ; ASHTON, N. J. ; VILLEMAGNE, V. L. ; KLUNK, W. E. ; ZETTERBERG, H. ; BLENNOW, K. ; SOUZA, D. O. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. ; et.al . Synapse dysfunction and astrocyte reactivity are associated independently of amyloid-β and tau pathologies. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• ROHDEN, F. ; FERREIRA, P. C. L. ; BELLAVER, B. ; AGUZZOLI, C. S. ; FERRARI-SOUZA, J. P. ; THERRIAULT, J. ; COHEN, A. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; ASHTON, N. J. ; KARIKARI, T. K. ; KLUNK, W. E. ; ZETTERBERG, H. ; BLENNOW, K. ; SOUZA, D. O. ; ZIMMER, E. R. ; ROSA-NETO, P. ; PASCOAL, T. A. . Synapse dysfunction and astrocyte reactivity are associated independently of amyloid-β and tau pathologies. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• SOARES, C. ; BELLAVER, B. ; FERREIRA, P. C. L. ; POVALA, G. ; AGUZZOLI, C. S. ; COHEN, A. ; LOPEZ, O. L. ; VILLEMAGNE, V. L. ; KLUNK, W. E. ; GAUTHIER, S. ; SOUZA, D. O. ; KARIKARI, T. K. ; ASHTON, N. J. ; ZETTERBERG, H. ; BLENNOW, K. ; ROSA-NETO, P. ; ZIMMER, E. R. ; PASCOAL, T. A. . CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• SOARES, C. ; BELLAVER, B. ; FERREIRA, P. C. L. ; AGUZZOLI, C. S. ; FERRARI-SOUZA, J. P. ; COHEN, A. ; LOPEZ, O. L. ; VILLEMAGNE, V. L. ; TUDORASCU, D. L. ; KLUNK, W. E. ; KARIKARI, T. K. ; SOUZA, D. O. ; ASHTON, N. J. ; GAUTHIER, S. ; BLENNOW, K. ; ROSA-NETO, P. ; ZIMMER, E. R. ; PASCOAL, T. A. . CSF total tau is more closely associated with synaptic dysfunction than overt neurodegeneration. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• SOARES, C. ; BELLAVER, B. ; FERREIRA, P. C. L. ; AGUZZOLI, C. S. ; FERRARI-SOUZA, J. P. ; COHEN, A. ; TUDORASCU, D. L. ; KLUNK, W. E. ; VILLEMAGNE, V. L. ; ASHTON, N. J. ; GAUTHIER, S. ; ZETTERBERG, H. ; SOUZA, D. O. ; BLENNOW, K. ; ROSA-NETO, P. ; ZIMMER, E. R. ; PASCOAL, T. A. . Synaptic dysfunction in the presence of tau tangles is not a strong predictor of atrophy. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• SOARES, C. ; BELLAVER, B. ; FERREIRA, P. C. L. ; AGUZZOLI, C. S. ; FERRARI-SOUZA, J. P. ; COHEN, A. ; LOPEZ, O. L. ; TUDORASCU, D. L. ; KLUNK, W. E. ; ASHTON, N. J. ; SOUZA, D. O. ; GAUTHIER, S. ; ZETTERBERG, H. ; BLENNOW, K. ; KARIKARI, T. K. ; ROSA-NETO, P. ; ZIMMER, E. R. ; PASCOAL, T. A. . Synaptic dysfunction, Tau pathology and Neurodegeneration. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• ZALZALE, H. ; POVALA, G. ; FERREIRA, P. C. L. ; BELLAVER, B. ; FERRARI-SOUZA, J. P. ; SOARES, C. ; Aguzzoli, Cristiano S. ; ASHTON, N. J. ; BENEDET, A. L. ; BLENNOW, K. ; ZETTERBERG, H. ; KARIKARI, T. K. ; ROSA-NETO, P. ; PASCOAL, T. A. . Amyloid and Tau Predominance Subtyping Identifies CI Patients With Different Clinical Phenotypes. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• ZALZALE, H. ; POVALA, G. ; FERREIRA, P. C. L. ; BELLAVER, B. ; FERRARI-SOUZA, J. P. ; SOARES, C. ; AGUZZOLI, C. S. ; BENEDET, A. L. ; ASHTON, N. J. ; BLENNOW, K. ; ZETTERBERG, H. ; KARIKARI, T. K. ; ROSA-NETO, P. ; PASCOAL, T. A. . Amyloid and Tau Predominance Subtyping Identifies CI Patients With Different Clinical Phenotypes. In: AAIC, 2023. Alzheimer?s Dement. 2023.

• AGUZZOLI, C. S. ; FERREIRA, P. C. L. ; POVALA, G. ; SOARES KATZ, CAROLINA ; FERRARI-SOUZA, J. P. ; BELLAVER, B. ; ZALZALE, H. ; LUSSIER, F. L. ; ROHDEN, F. ; ABBAS, S. ; LEFFA, DOUGLAS T. ; THERRIAULT, J. ; BENEDET, A. L. ; TISSOT, C. ; SERVAES, S. ; MACEDO, A. C. ; RAHMOUNI, N. ; LOPEZ, OSCAR L. ; TUDORASCU, D. L. ; KLUNK, W. E. ; et.al . Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer?s Disease. In: Alzheimer's Association International Conference, 2023, Amsterdam. Alzheimers Dement. 2023, 2023.

• LAZZARETTI, F. ; FELICIO, A. O. ; PATATT, J. ; AGUZZOLI, C. S. ; SCHILLING, LUCAS P. . Modifiable dementia risk factors in a memory outpatient clinic in Brazil. In: Alzheimer's Association International Conference, 2024, Philadelphia. Alzheimer?s Dement. 2024;20(Suppl. 7):e092894..

• BORELLI, W. V. ; ROS, L. U. ; AGUZZOLI, C. S. ; BASTIANI, M. A. ; SUEMOTO, C. K. ; ZIMMER, EDUARDO R . Modifiable and non-modifiable disparity-related predictors of cognitive scores in a population-based cohort: the ELSI-Brazil. In: AAIC, 2024. Alzheimer?s Dement. 2024;20(Suppl. 7):e092264..

• DA ROS, LUCAS U ; BORELLI, W. V. ; BASTIANI, M. A. ; AGUZZOLI, C. S. ; SCHILLING, LUCAS P. ; SANTAMARIA-GARCIA, H. A. ; PASCOAL, THARICK A. ; ROSA-NETO, PEDRO ; COSTA, J. C. ; IBANEZ, A. ; SUEMOTO, CLAUDIA K. ; ZIMMER, EDUARDO R . Socioeconomic and health-related disparities associated with healthy brain aging in Latin American countries. In: AAIC, 2024. Alzheimer?s Dement. 2024;20(Suppl. 7):e093131..

• ZALZALE, HUSSEIN ; FERREIRA, PAMELA C. L. ; LEMAIRE, P. ; SCOP MEDEIROS, MARINA ; SOARES, CAROLINA ; BELLAVER, BRUNA ; BAUER'NEGRINI, GUILHERME ; LUSSIER, FIROZA Z. ; POVALA, GUILHERME ; FERRARI'SOUZA, JOÃO PEDRO ; ABBAS, SARAH ; AGUZZOLI, C. S. ; RODRIGUES, M. S. ; ROHDEN, FRANCIELI ; AMARAL, L. ; LEFFA, DOUGLAS T. ; OLIVEIRA JR, M. ; TUDORASCU, DANA L. ; TISSOT, CÉCILE ; RAHMOUNI, N. ; et.al . Robust Symptomatic Subtypes of Typical Alzheimer?s Disease Characterized by Differential Neuropathological Patterns and Functional Decline. In: AAIC, 2024. NEUROPSYCHIATRY AND BEHAVIORAL NEUROLOGY.

• AGUZZOLI, C. S. ; POVALA, GUILHERME ; FERREIRA, PAMELA C. L. ; LUSSIER, FIROZA Z. ; BAUER'NEGRINI, GUILHERME ; AMARAL, L. ; SOARES, CAROLINA ; FERRARI'SOUZA, JOÃO PEDRO ; ZALZALE, HUSSEIN ; BELLAVER, BRUNA ; ROHDEN, FRANCIELI ; ABBAS, SARAH ; LEFFA, DOUGLAS T. ; SCHILLING, LUCAS P. ; ZIMMER, EDUARDO R ; TUDORASCU, DANA L. ; PASCUAL, B. ; GORDON, B. A. ; LOWE, V. J. ; OH, H. ; et.al . Tau exacerbates the development of distinct neuropsychiatric symptoms in late braak stage ? the head study. In: AAIC, 2024. NEUROPSYCHIATRY AND BEHAVIORAL NEUROLOGY.

• FELIX, C. ; FERREIRA, PAMELA C. L. ; KOLLASSERRY, F. J. ; SNITZ, B. E. ; REBOK, G. ; TUDORASCU, DANA L. ; RODRIGUES, M. S. ; OLIVEIRA JR, M. ; POVALA, GUILHERME ; LEMAIRE, P. ; BAUER'NEGRINI, GUILHERME ; SCOP MEDEIROS, MARINA ; ABBAS, SARAH ; SOARES, CAROLINA ; AGUZZOLI, C. S. ; BELLAVER, BRUNA ; LUSSIER, FIROZA Z. ; AMARAL, L. ; PASCUAL, B. ; GORDON, B. A. ; et.al . CU PET Aβ and Tau Positive Individuals Show Impairment in MoCA Delayed Recall. In: AAIC, 2024. NEUROIMAGING.

• SCOP MEDEIROS, MARINA ; FERREIRA, PAMELA C. L. ; BELLAVER, BRUNA ; BAUER'NEGRINI, GUILHERME ; POVALA, GUILHERME ; AGUZZOLI, C. S. ; SOARES, CAROLINA ; ZALZALE, HUSSEIN ; OLIVEIRA JR, M. ; RODRIGUES, M. S. ; ABBAS, SARAH ; AMARAL, L. ; FELIX, C. ; RUPPERT, E. P. ; SAHA, P. ; FINE, D. J. ; CEHULA, J. ; BLOOMQUIST, M. ; LUSSIER, FIROZA Z. ; THERRIAULT, JOSEPH ; et.al . Performance of an AI-based prediction model versus stratified thresholds using plasma biomarkers for biological staging of AD. In: AAIC, 2024. BIOMARKERS (NON-NEUROIMAGING), 2024.

• FERRARI'SOUZA, JOÃO PEDRO ; POVALA, GUILHERME ; BELLAVER, BRUNA ; FERREIRA, PÂMELA C. L. ; LUSSIER, FIROZA Z. ; LEFFA, DOUGLAS T. ; AGUZZOLI, C. S. ; SOARES, CAROLINA ; CARELLO-COLLAR, G. ; BORELLI, WYLLIANS VENDRAMINI ; THERRIAULT, JOSEPH ; RAHMOUNI, N. ; MACEDO, A. C. ; SERVAES, STIJN ; STEVENSON, J. ; GAUTHIER, SERGE ; SOUZA, DIOGO ; SCHILLING, LUCAS P. ; LOURENCO, M. V. ; TUDORASCU, DANA L. ; et.al . Microglial activation impacts amyloid-β effects on reactive astrogliosis. In: AAIC, 2024. BIOMARKERS (NON-NEUROIMAGING).

• FERREIRA, PÂMELA C. L. ; BELLAVER, BRUNA ; POVALA, GUILHERME ; AGUZZOLI, C. S. ; FERRARI'SOUZA, JOÃO PEDRO ; LEFFA, DOUGLAS T. ; LUSSIER, FIROZA Z. ; SCOP MEDEIROS, MARINA ; ZALZALE, HUSSEIN ; SOARES, CAROLINA ; ROHDEN, FRANCIELI ; ABBAS, SARAH ; BAUER'NEGRINI, GUILHERME ; KARIM, H. T. ; HONG, C. H. ; ROH, H. W. ; TUDORASCU, DANA L. ; KARIKARI, THOMAS K. ; SNITZ, B. E. ; SON, S. J. ; et.al . Utility of plasma p-tau217 as a secondary outcome for clinical trials across AD continuum. In: AAIC, 2024. BIOMARKERS (NON-NEUROIMAGING).

• MACEDO, A. C. ; THERRIAULT, JOSEPH ; RAHMOUNI, N. ; SERVAES, STIJN ; WANG, Y. ; TISSOT, CÉCILE ; LUSSIER, FIROZA Z. ; ARIAS, J. F. ; SOCUALAYA, K. M. Q. ; HOSSEINI, S. A. ; FERREIRA, PAMELA C. L. ; BELLAVER, BRUNA ; FERRARI'SOUZA, JOÃO PEDRO ; AGUZZOLI, C. S. ; POVALA, GUILHERME ; PASCUAL, B. ; GORDON, B. A. ; LOWE, V. J. ; OH, H. ; SOLEIMANI-MEIGOONI, D. N. ; et.al . Comparison of tau-PET tracers for in vivo Braak staging: the HEAD Study. In: AAIC, 2024. Biomarkers.

• PEIXOTO, C. ; OLIVEIRA, J. ; ZAIDEN, I. ; AGUZZOLI, C. ; MIRO, H. ; BRUCKI, S. . Feasibility, Safety and Adherence of a Remote Physical and Cognitive Exercises Protocol for Elders. In: XIII RPDA - Reunião de Pesquisadores em Doença de Alzheimer e Desordens Relacionadas, 2021. Dementia & Neuropsychologia. São Paulo: Dementia & Neuropsychologia, 2021. v. 15.

• ESPER, NATHALIA BIANCHINI ; AGUZZOLI, C. S. ; SOLDATELLI, MATHEUS DORIGATTI ; XAVIER, L. L. ; PORTUGUEZ, MIRNA WETTERS ; ROSA FRANCO, ALEXANDRE ; BUCHWEITZ, AUGUSTO . FUNCTIONAL AND STRUCTURAL STUDY OF BRAIN INDICES OF READING IMPAIRMENT: A COMPARISON OF SCHOOLS AND READING CLINIC PARTICIPANTS. In: World Congress on Brain, Behavior and Emotions 2016, 2016, Buenos Aires. Revista Eletrônica do World Congress on Brain, Behavior and Emotions 2016, 2016.

• AGUZZOLI, C. S. ; SOLDATELLI, MATHEUS DORIGATTI ; XAVIER, L. L. ; ESPER, NATHÁLIA BIANCHINI ; PORTUGUEZ, MIRNA WETTERS ; ROSA FRANCO, ALEXANDRE ; BUCHWEITZ, AUGUSTO . Good X Poor Readers: A Resting-State Cluster Analysis Of The DMN (poster presentation at World Congress on Brain, Behavior and Emotions, Buenos Aires). In: World Congress on Brain, Behavior and Emotions 2016, 2016, Buenos Aires. Revista Eletrônica do World Congress on Brain, Behavior and Emotions 2016, 2016.

• XAVIER, L. L. ; AGUZZOLI, C. S. ; SOLDATELLI, MATHEUS DORIGATTI ; ROSA FRANCO, ALEXANDRE ; MENEGUZZI, F. ; BUCHWEITZ, AUGUSTO . Classifying Brain States During Cognitive Tasks: A Functional Magnetic Ressonance Study in Children at Reading acquisition Stage (oral presentation at BRAIN, Buenos Aires 2016). In: World Congress on Brain, Behavior and Emotions 2016, 2016, Buenos Aires. Revista Eletrônica do World Congress on Brain, Behavior and Emotions 2016, 2016.

• SOLDATELLI, MATHEUS DORIGATTI ; AGUZZOLI, C. S. ; XAVIER, L. L. ; CARA, VALENTINA METSAVAHT ; COSTA, ADRIANA CORRÊA ; PORTUGUEZ, MIRNA WETTERS ; ROSA FRANCO, ALEXANDRE ; BUCHWEITZ, AUGUSTO . Neural Correlates Of Dyslexia And Poor Reading: AN FMRI STUDY ON EARLY NEURAL INDICES FOR READING DISABILITY AND DIFFICULTY (poster presentation at BRAIN BEHAVIOR AND EMOTION, Buenos Aires, 2016). In: World Congress on Brain, Behavior and Emotions 2016, 2016, Buenos Aires. Revista Eletrônica do World Congress on Brain, Behavior and Emotions 2016, 2016.

• AGUZZOLI, C. S. ; BUCHWEITZ, A. . Correlatos Neurais Dos Transtornos De Aprendizagem: Um Estudo De fMRI SObre As Bases Anatomo-Funcionais Da Dislexia Em Crianças (oral presentation at XVI Salão de Iniciação Científica da PUCRS, Porto Alegre, 2015). In: Anais do XVI Salão de Iniciação Científica, 2015, Porto Alegre. Anais do XVI Salão de Iniciação Científica. Porto Alegre: © EDIPUCRS, 2015, 2015.

• AGUZZOLI, C. S. ; BUCHWEITZ, A. . As Bases Neurais De Crianças Com Dislexia. In: XV Salão Iniciação Científica da PUCRS, 2014, Porto Alegre. Anais do XIV Salão de Iniciação Científica. Porto Alegre: © EDIPUCRS, 2014, 2014.

• AGUZZOLI, C. S. ; BUCHWEITZ, AUGUSTO . As Bases Neurais da Compreensão de Bons e Maus Leitores. In: XIV Salão de Iniciação Científica da PUCRS, 2013, Porto Alegre. Anais do XIV Salão de Iniciação Científica. Porto Alegre: © EDIPUCRS, 2014, 2013. v. XIV.

• AGUZZOLI, C. S. . Perspectivas terapêuticas nas demências. 2025. (Apresentação de Trabalho/Conferência ou palestra).

• AGUZZOLI, C. S. . Inscer Centro de Taupatias: Pesquisa Clínica e Aplicação Clínica. 2025. (Apresentação de Trabalho/Conferência ou palestra).

• AGUZZOLI, C. S. . GBHI pilot project: impacto dos projetos-piloto na comunidade brasileira.. 2025. (Apresentação de Trabalho/Conferência ou palestra).

• AGUZZOLI, C. S. ; PASCOAL, T. A. . Tau exacerbates the development of distinct neuropsychiatric symptoms in late Braak Stage - The Head Study. 2024. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. ; PASCOAL, T. A. . Tau Exacerbates the Development of Distinct Neuropsychiatric Symptoms in Late Braak Stage ? The HEAD Study. 2024. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. ; PASCOAL, T. A. . TAU EXACERBATES THE DEVELOPMENT OF DISTINCT NEUROPSYCHIATRIC SYMPTOMS IN LATE BRAAK STAGE ? THE HEAD STUDY. 2024. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. . Valor do Pet amiloide na tomada de decisão clínica. 2024. (Apresentação de Trabalho/Conferência ou palestra).

• AGUZZOLI, C. S. . MESA REDONDA-19 Hot Topics 03: Na Doença Alzheimer. 2024. (Apresentação de Trabalho/Conferência ou palestra).

• AGUZZOLI, C. S. . MESA REDONDA-18 Desafios no atendimento à pessoa idosa: Demência de Parkinson X Corpos de Lewy. 2024. (Apresentação de Trabalho/Conferência ou palestra).

• AGUZZOLI, C. S. . MESA 6 - NEUROLOGIA - DISTÚRBIOS COGNITIVOS - O diagnóstico diferencial entre demência e doença psiquiátrica. 2024. (Apresentação de Trabalho/Conferência ou palestra).

• AGUZZOLI, C. S. ; COSTA, J. C. . aß-pet Substantiates Clinical Decision-making In Real-life Clinical Settings In Brazil. 2024. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. . New Horizons in Dementia Diagnosis: A LMIC Perspective. 2024. (Apresentação de Trabalho/Conferência ou palestra).

• AGUZZOLI, C. S. . Fisiopatologia de sintomas neuropsiquiátricos da Doença de Alzheimer. 2024. (Apresentação de Trabalho/Conferência ou palestra).

• AGUZZOLI, C. S. ; FERREIRA, P. C. L. ; POVALA, G. ; FERRARI-SOUZA, J. P. ; BELLAVER, B. ; SOARES, C. ; ZALZALE, H. ; LUSSIER, F. L. ; ROHDEN, F. ; ABBAS, S. ; LEFFA, D. T. ; THERRIAULT, J. ; BENEDET, A. L. ; TISSOT, C. ; SERVAES, S. ; RAHMOUNI, N. ; MACEDO, A. C. ; BEZGIN, G. ; KANG, M. S. ; STEVENSON, J. ; et.al . Microglial Activation Independently Contributes to Neuropsychiatric Dysfunction in Alzheimer's Disease (oral presentation at ADPD, Gothenburg). 2023. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. ; FERREIRA, P. C. L. ; POVALA, G. ; FERRARI-SOUZA, J. P. ; BELLAVER, B. ; SOARES, C. ; ZALZALE, H. ; LUSSIER, F. L. ; ROHDEN, F. ; ABBAS, S. ; LEFFA, D. T. ; THERRIAULT, J. ; BENEDET, A. L. ; TISSOT, C. ; SERVAES, S. ; RAHMOUNI, N. ; MACEDO, A. C. ; BEZGIN, G. ; KANG, M. S. ; STEVENSON, J. ; et.al . Neuropsychiatric Symptoms are Closely Related to Microglial Activation Across the Aging and Alzheimer's Disease Continuum (poster at GBHI Conference, Mexico). 2023. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. ; FERREIRA, P. C. L. ; POVALA, G. ; FERRARI-SOUZA, J. P. ; BELLAVER, B. ; SOARES, C. ; ZALZALE, H. ; LUSSIER, F. L. ; ROHDEN, F. ; ABBAS, S. ; LEFFA, D. T. ; THERRIAULT, J. ; BENEDET, A. L. ; TISSOT, C. ; SERVAES, S. ; RAHMOUNI, N. ; MACEDO, A. C. ; BEZGIN, G. ; KANG, M. S. ; STEVENSON, J. ; et.al . Microglial Activation Associates with Neuropsychiatric Symptoms in Alzheimer's Disease (oral presentation at AAIC-SS, Mexico). 2023. (Apresentação de Trabalho/Congresso).

• SCHAFFER AGUZZOLI, CRISTIANO ; FERREIRA, P. C. L. ; POVALA, G. ; FERRARI-SOUZA, J. P. ; BELLAVER, B. ; SOARES, C. ; ZALZALE, H. ; LUSSIER, F. L. ; ROHDEN, F. ; ABBAS, S. ; LEFFA, D. T. ; THERRIAULT, J. ; BENEDET, A. L. ; TISSOT, C. ; SERVAES, S. ; RAHMOUNI, N. ; MACEDO, A. C. ; BEZGIN, G. ; KANG, M. S. ; STEVENSON, J. ; et.al . Microglial Activation Contributes to Neuropsychiatric Dysfunction in Alzheimer?s Disease (oral presentation at AAIC, Amsterdam). 2023. (Apresentação de Trabalho/Congresso).

• SCHAFFER AGUZZOLI, CRISTIANO ; FERREIRA, P. C. L. ; POVALA, G. ; FERRARI-SOUZA, J. P. ; BELLAVER, B. ; SOARES, C. ; ZALZALE, H. ; LUSSIER, F. L. ; ROHDEN, F. ; ABBAS, S. ; LEFFA, D. T. ; THERRIAULT, J. ; BENEDET, A. L. ; TISSOT, C. ; SERVAES, S. ; RAHMOUNI, N. ; MACEDO, A. C. ; BEZGIN, G. ; KANG, M. S. ; STEVENSON, J. ; et.al . Microglial activation contributes to neuropsychiatric dysfunction in Alzheimer?s disease (poster at Alzheimer's Imaging Consortium Preconference, Amsterdam). 2023. (Apresentação de Trabalho/Congresso).

• SCHAFFER AGUZZOLI, CRISTIANO ; FERREIRA, P. C. L. ; POVALA, G. ; FERRARI-SOUZA, J. P. ; BELLAVER, B. ; SOARES, C. ; ZALZALE, H. ; LUSSIER, F. L. ; ROHDEN, F. ; ABBAS, S. ; LEFFA, D. T. ; THERRIAULT, J. ; BENEDET, A. L. ; TISSOT, C. ; SERVAES, S. ; RAHMOUNI, N. ; MACEDO, A. C. ; BEZGIN, G. ; KANG, M. S. ; STEVENSON, J. ; et.al . Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer's Disease (poster presentation at Alzheimer's Imaging Consortium Preconference, Amsterdam). 2023. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. ; FERREIRA, P. C. L. ; POVALA, G. ; FERRARI-SOUZA, J. P. ; BELLAVER, B. ; SOARES, C. ; ZALZALE, H. ; LUSSIER, F. L. ; ROHDEN, F. ; ABBAS, S. ; LEFFA, D. T. ; THERRIAULT, J. ; BENEDET, A. L. ; TISSOT, C. ; SERVAES, S. ; RAHMOUNI, N. ; MACEDO, A. C. ; BEZGIN, G. ; KANG, M. S. ; STEVENSON, J. ; et.al . Neuroinflammation Exacerbates Irritability and Agitation in Alzheimer's Disease (poster presentation at AAIC, Amsterdam). 2023. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. ; FERREIRA, P. C. L. ; POVALA, G. ; FERRARI-SOUZA, J. P. ; BELLAVER, B. ; SOARES, C. ; ZALZALE, H. ; LUSSIER, F. L. ; ROHDEN, F. ; ABBAS, S. ; LEFFA, D. T. ; THERRIAULT, J. ; BENEDET, A. L. ; TISSOT, C. ; SERVAES, S. ; RAHMOUNI, N. ; MACEDO, A. C. ; BEZGIN, G. ; KANG, M. S. ; STEVENSON, J. ; et.al . Neuropsychiatric Symptoms are Closely Related to Microglial Activation Across the Aging and Alzheimer's Disease Continuum (poster at AAIC-SS, Mexico). 2023. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. ; ZIMMER, E. R. ; FERREIRA, PÂMELA C. L. ; FERRARI-SOUZA, JOÃO PEDRO ; SCHILLING, L. P. ; VALCOUR, VICTOR ; ZETTERBERG, HENRIK ; MILLER, B. L. ; ROSA-NETO, PEDRO ; PASCOAL, T. A. . MICROGLIAL ACTIVATION IS CLOSELY ASSOCIATED WITH NEUROPSYCHIATRIC SYMPTOMS ACROSS THE ALZHEIMER?S DISEASE CONTINUUM (oral presentation, RPDA, Recife, Brasil, 2023). 2023. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. . Sintomas Neuropsiquiátricos nas demências. 2023. (Apresentação de Trabalho/Conferência ou palestra).

• AGUZZOLI, C. S. ; BORELLI, W. V. ; MATUSHITA, C. ; COSTA, D. ; MARRONI, S. ; PORTUGUEZ, MIRNA WETTERS ; COSTA, J. C. ; SCHILLING, L. P. . PET-Amyloid Imaging: A Transversal Study (oral presentation at NEURODC, Campinas). 2019. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. ; SOLDATELLI, M. D. ; XAVIER, L. L. ; ESPER, N. B. ; PORTUGUEZ, D. M. W. ; FRANCO, A. R. ; BUCHWEITZ, A. . Good X Poor Readers: A Resting-State Cluster Analysis Of The DMN (poster presentation at World Congress on Brain, Behavior and Emotions, Buenos Aires). 2016. (Apresentação de Trabalho/Congresso).

• XAVIER, L. L. ; HEINSFELD, A. S. ; AGUZZOLI, C. S. ; SOLDATELLI, M. D. ; MENEGUZZI, F. ; BUCHWEITZ, A. . Classifying Brain States During Cognitive Tasks: A Functional Magnetic Ressonance Study in Children at Reading acquisition Stage (oral presentation at BRAIN, Buenos Aires 2016). 2016. (Apresentação de Trabalho/Congresso).

• ESPER, N. B. ; AGUZZOLI, C. S. ; SOLDATELLI, M. D. ; XAVIER, L. L. ; PORTUGUEZ, D. M. W. ; FRANCO, A. R. ; BUCHWEITZ, A. . FUNCTIONAL AND STRUCTURAL STUDY OF BRAIN INDICES OF READING IMPAIRMENT: A COMPARISON OF SCHOOLS AND READING CLINIC PARTICIPANTS (poster presentation at BRAIN BEHAVIOR AND EMOTION, Buenos Aires, 2016). 2016. (Apresentação de Trabalho/Congresso).

• SOLDATELLI, M. D. ; AGUZZOLI, C. S. ; ESPER, N. B. ; XAVIER, L. L. ; CARA, V. M. ; COSTA, A. C. ; PORTUGUEZ, D. M. W. ; FRANCO, A. R. ; BUCHWEITZ, A. . Neural Correlates Of Dyslexia And Poor Reading: AN FMRI STUDY ON EARLY NEURAL INDICES FOR READING DISABILITY AND DIFFICULTY (poster presentation at BRAIN BEHAVIOR AND EMOTION, Buenos Aires, 2016). 2016. (Apresentação de Trabalho/Congresso).

• SOLDATELLI, MATHEUS DORIGATTI ; AGUZZOLI, C. S. ; ESPER, NATHALIA BIANCHINI ; OLIVEIRA ; JACQUES, G. ; FLORIAN, L. Z. ; COSTA, ADRIANA CORRÊA ; PORTUGUEZ, MIRNA WETTERS ; ROSA FRANCO, ALEXANDRE ; BUCHWEITZ, AUGUSTO . Um Papel para o Córtex Cingulado na Dislexia: Investigação das Bases Neurais em Estudos de Neuroimagem Funcional (poster presentation). 2016. (Apresentação de Trabalho/Seminário).

• AGUZZOLI, C. S. ; CARA, V. M. ; XAVIER, L. L. ; COSTA, A. C. ; PORTUGUEZ, D. M. W. ; BUCHWEITZ, A. . An fMRI Study Of Children Diagnosed With Activation As A Marker Of Word-Reading Dyslexia: Increased Right-Hemisphere Difficulty (oral presentation at the World Congress on Brain, Behavior and Emotions, Porto Alegre). 2015. (Apresentação de Trabalho/Congresso).

• BUCHWEITZ, A. ; COSTA, A. C. ; TOAZZA, RUDINEIA ; BASSOA, A. ; AGUZZOLI, C. S. ; PEIXOTO, G. ; CARA, V. M. ; PORTUGUEZ, D. M. W. ; FRANCO, A. R. . Reading disorder in the brain: a functional and structural study of brain indices of dyslexia (poster presentation at 21st Annual Meeting of the Organization for Human Brain Mapping, Honolulu). 2015. (Apresentação de Trabalho/Congresso).

• BUCHWEITZ, A. ; AGUZZOLI, C. S. ; CARA, V. M. ; XAVIER, L. L. ; BRITO, G. C. ; COSTA, A. C. ; TOAZZA, RUDINEIA ; FRANCO, A. R. . Neural Correlates Of Dyslexia And Poor Reading: A Multicenter Study On Early Neural Indices Of Reading Disability And Difficulty (poster presentation at IBRO, Rio de Janeiro). 2015. (Apresentação de Trabalho/Congresso).

• AGUZZOLI, C. S. ; BUCHWEITZ, A. . Correlatos Neurais Dos Transtornos De Aprendizagem: Um Estudo De fMRI SObre As Bases Anatomo-Funcionais Da Dislexia Em Crianças (oral presentation at XVI Salão de Iniciação Científica da PUCRS, Porto Alegre). 2015. (Apresentação de Trabalho/Seminário).

• AGUZZOLI, C. S. ; BUCHWEITZ, A. . As Bases Neurais De Crianças Com Dislexia (oral presentation at XV Salão de Iniciação Científica da PUCRS, Porto Alegre). 2014. (Apresentação de Trabalho/Seminário).

• AGUZZOLI, C. S. ; CARA, V. M. . Evidências de lateralização da linguagem topográfica motora no córtex cerebral de paciente com dissecção de artéria basilar. 2014. (Apresentação de Trabalho/Simpósio).

• PORTAL, B. C. D. A. ; AGUZZOLI, C. S. ; CARA, VALENTINA METSAVAHT ; BUCHWEITZ, AUGUSTO . Evidências da lateralização da linguagem em estudos de neuroimagem (Projeto ELLI). 2014. (Apresentação de Trabalho/Seminário).

• AGUZZOLI, C. S. ; CARA, VALENTINA METSAVAHT ; PORTUGUEZ, D. M. W. . As Bases Neurais da Compreensão de Bons e Maus Leitores (oral presentation at XIV Salão de Iniciação Científica da PUCRS, Porto Alegre). 2013. (Apresentação de Trabalho/Seminário).

Outras produções

Projetos de pesquisa

• 2024 - Atual

  Clinical Performance of ADRD Biomarkers for Early Detection and Treatment in Diverse Populations, Descrição: Research conducted in state-of-the-art cohorts has highlighted the potential of blood-based tests for amyloid-beta (A#946;) and phosphorylated tau (p-tau) to transform the care landscape for patients with Alzheimer's disease (AD). Although these studies showed concordance with CSF/PET AD pathology, their retrospective nature and isolation from clinical decision-making precluded generalizing their results to clinical settings. A recent study in Sweden demonstrated, for the first time, agreement between blood tests and CSF results in a large, real-world prospective cohort1. However, the generalizability of this study and other ongoing clinical implementation efforts is very limited as they focus exclusively on white Caucasians in resource-rich settings. Compelling evidence suggests that the performance of AD blood tests may vary significantly across diverse backgrounds2. Additionally, this study used AD blood tests from a single company, relying on expensive mass spectrometry techniques that demand advanced technical expertise, currently available only in one facility. This sharply contrasts with desirable low-cost blood tests, which use simple, scalable methods that can be widely distributed from diverse sources. Furthermore, validating blood-aided AD diagnosis exclusively in Europe/North America disregards cultural, economic, and environmental variabilities, potentially perpetuating inequity in AD diagnosis in years to come. Leveraging complementary multidisciplinary expertise from past and ongoing collaborative dementia research and care in global settings, the overarching goal of the present study is to evaluate the impact and accuracy of blood-aided AD diagnosis in geographically, culturally, and ethnically diverse real-world clinical populations. This proposal closely aligns with NIA Health Disparities Framework and directly responds to PAR-23-258, Clinical Validation of Biomarkers for AD. We will study 1,200 cognitively impaired patients (60 mild cognitive impairment and 40 mild dementia) with suspected AD, distributed equally across North America (USA), South America (Brazil), Africa (Kenya), and Asia (South Korea, Singapore). Licensed physicians, while providing secondary dementia care in these health systems, will initially evaluate patients through (i) clinical assessment and structural MRI without AD markers and (ii) then with the additional knowledge of AD blood markers. We will use plasma A#946;42/40 and p-tau217 assays validated for clinical use from multiple companies. Additionally, all participants will undergo confirmatory A#946; PET at baseline and additional clinical assessments and blood draws at 1-year and 2-year follow-ups.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Cristiano Schaffer Aguzzoli - Integrante / Pamela C. Lukasewicz Ferreira - Integrante / Bruna Bellaver - Integrante / Tharick Ali Pascoal - Coordenador.

• 2024 - Atual

  Centro Temático em Taupatias, Descrição: As taupatias englobam um conjunto diversificado de doenças neurodegenerativas, todas marcadaspelo acúmulo anormal da proteína tau no cérebro. Essas condições, incluindo a doença deAlzheimer, a demência frontotemporal, a paralisia supranuclear progressiva e a degeneraçãocorticobasal, compartilham a característica central da formação de agregados insolúveis de tau.Esse acúmulo desencadeia uma deterioração progressiva das funções cognitivas e motoras,tornando a compreensão dessas doenças fundamental para o desenvolvimento de estratégiaseficazes de diagnóstico e tratamento. Neste contexto, de forma inédita, este projeto pioneiro visa estabelecer o Centro Temático em Taupatias (CTT), o primeiro centro especializado no Brasil dedicado à pesquisa translacional das taupatias. O CTT se propõe a conduzir estudos abrangentes desde a pesquisa de laboratório até aaplicação clínica, representando um avanço significativo na compreensão e no tratamento dasdemências no país. Uma etapa crucial será a produção local dos primeiros radiofármacos de tau, [18F]MK-6240 e[18F]PI-2620 no Centro de Produção de Radiofármacos (CPR) do Instituto do Cérebro (InsCer) doRio Grande do Sul. Esses radiofármacos serão utilizados em estudos clínicos abrangentesconduzidos no Centro de Pesquisa e Investigação Clínica (Cepic) e no Centro de ImagemMolecular (CIM) do InsCer, juntamente com avaliações clínicas e neuropsicológicas.Paralelamente, no Centro de Pesquisa Pré-Clínica (CPPC) do InsCer, serão identificados novosbiomarcadores sanguíneos para taupatias, enquanto novos radiotraçadores serão desenvolvidospara ampliar as opções de diagnóstico. A participação ativa no estudo global americano HEAD (Longitudinal multicenter head-to-head harmonization of tau PET tracers), financiado pelo National Institutes of Health (NIH), permitindo a padronização e certificação Internacional de radiofármacos para tau, e a colaboração nacional einternacional serão fundamentais para garantir a relevância e a qualidade dos resultados obtidospelo CTT. Além disso, a coleta de dados resultante dessas atividades subsidiará a implementação de umprotocolo de diagnóstico precoce de taupatias via biomarcadores sanguíneos de tau no Sistema Único de Saúde (SUS), contribuindo para melhorar o acesso ao diagnóstico e tratamento dessascondições em todo o país. O projeto também visa contribuir para a formação de recursos humanosna área, capacitando mestres, doutores e profissionais da saúde.Por fim, os radiofármacos de tau produzidos poderão ser distribuídos para hospitais, centros depesquisa e empresas interessadas, seguindo o modelo bem-sucedido atualmente utilizado noInsCer com o [18F]FBB, um radiofármaco de beta-amiloide, utilizado para o diagnóstico da doençade Alzheimer. Assim, o CTT tem o potencial de impactar positivamente a saúde pública, a pesquisaneurocientífica e a indústria nacional de saúde.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Cristiano Schaffer Aguzzoli - Integrante / Jaderson Costa da Costa - Coordenador / Lucas Porcello Schilling - Integrante / Eduardo R. Zimmer - Integrante / Thamiris B Scheffel - Integrante.

• 2024 - Atual

  MUSIC AD: Multidimensional Underrepresented South Initiative Collaboration for Alzheimer's and Dementia, Descrição: Background: Current standards of brain health and dementia come from high-income populations,unrepresentative of most individuals with dementia globally. There is an essential lack of evidence regardingunderrepresented populations with dementia, which is a significant gap in the current knowledge ofneurodegenerative and neuroprotective traits. The most significant increase in the future prevalence ofdementia is expected to occur in the Global South. Latino, Afro-American, and Asian populations togetherrepresent significant minority groups in the US with a higher risk of dementia and are often underserved. Suchpopulations are characterized by socioeconomic status (SES) disparities and other more extended negativesocial determinants of health (SDH). Recent brain age models leverage the impact of environment x biologicalinteractions. A deeper understanding of how varying SDH/SES and biomarker burden influence acceleratingaging and brain clocks in dementia is unknown. These disparities can accelerate brain aging, inducing a largerchronological age gap (CAG- the difference between the estimated brain age and the chronological age).Moreover, current models of brain health and dementia fail to provide adequate characterization of diverse,underrepresented populations. Plasma biomarkers represent a unique opportunity to develop affordable andscalable approaches to assess the risk of development and progression of dementia. Still, these are notvalidated in the Global South. Genetics, admixtures, whole-body health and cardiometabolic conditions,exposome, and SES/SDH are all critical drivers of heterogeneity that can impact blood biomarkers. Theseinfluences involve dementia-related/unrelated pathological changes, external mediators, and risk factors.Mapping and quantifying aspects of brain health and dementia in underserved regions is a paramountchallenge, and addressing it is essential to change the face of dementia worldwide.Long-term aim: Validate and measure the diagnostic and prognostic performance of blood biomarkersof Alzheimer's disease (AD) continuum in underrepresented populations in the Global South, includingLatin American, African, Asian, and Oceanian countries. We will perform a cross-sectional study of 9,760individuals, 8,800 healthy individuals, 960 AD patients (8 countries), and 10 of subjects assessed with PET.We will also follow up with those healthy individuals to evaluate changes in cognition and functionality,including conversion to subjective complaint (SC), mild cognitive impairment (MCI), and AD dementia (seemethods).. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Cristiano Schaffer Aguzzoli - Coordenador / Eduardo R. Zimmer - Integrante / Bruce L. Miller - Integrante / Tharick Ali Pascoal - Integrante / Agustin Ibanez - Integrante.

• 2023 - Atual

  ASSOCIATION BETWEEN HIPPOCAMPAL VOLUME AND VISUAL CLASSIFICATION OF HIPPOCAMPAL ATROPHY: AN MRI STUDY, Descrição: Hippocampus has a key role in the memory and cognitive functions and its volume tends to shrink during aging and with more severity in neurodegenerative [1]. The hippocampal atrophy can be assessed visualy (MTA score) or by quantitative volumetry, and its highly applied in order to differentiate normal and pathological aging, as Alzheimer's disease (AD)The objective of this research was to perform a comparison between the values of automatic hippocampal volumetry and the MTA score, in order to analyze possible variations through a correlation curve and their impacts on quantitative and qualitative measures.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Cristiano Schaffer Aguzzoli - Integrante / Lucas Porcello Schilling - Coordenador / fabricio Nery garrafiel - Integrante.

• 2023 - Atual

  USE OF THE CENTILOID SCALE IN PET IMAGES WITH [18F] FLORBETABEN IN THE EVALUATION OF PATIENTS WITH SUSPECTED ALZHEIMER'S DISEASE, Descrição: The aim of this study is to evaluate the distribution of centiloid scale (CL) values in Positron Emission Tomography (PET) images using [18F]Florbetaben (FBB) tracer in individuals with clinically suspected Alzheimer's disease (AD). The CL has been validated for FBB in previous studies [1]. We conducted a retrospective study including 13 PET images with FBB tracer and their respective MRI scans. PET and MRI data were corregistered and normalized with the PNEURO tool from PMOD software v.4.0. The CL results showed high variability, ranging from 11.4 to 79.9 (mean 50.6 17.8). We observed a continuous spectrum of CL values within the study population. Moreover, we identified only 15 of individuals having moderate amyloid density.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Cristiano Schaffer Aguzzoli - Integrante / Lucas Porcello Schilling - Coordenador / Rosa Maria alves da silva - Integrante.

• 2023 - Atual

  Alzheimers disease physiopathology in a Brazilian psychiatric ward, Descrição: This study aims to assess the frequency and clinical impact of Alzheimers disease (AD) clinical syndromes and plasma biomarkers in patients hospitalized in a Brazilian psychiatric ward for 2 years. AD is strongly associated with neuropsychiatric symptoms (NPS) (such as depression, anxiety, irritability) during prodromal and clinical stages of typical and atypical presentations, often leading to psychiatric misdiagnosis and hospitalization in the psychiatric ward. Moreover, nonamnestic presentations of AD can mimic specific NDD syndromes with prominent changes in social cognition and perception, such as behavioral variant frontotemporal dementia (bvFTD) and dementia with Lewy bodies (DLB), which are also often misinterpreted as primary psychiatric disorders. Interestingly, AD has been shown to be the main or a contributing underlying pathology in bvFTD, corticobasal syndrome (CBS), DLB, and nonfluent variant PPA (nfvPPA) syndromes in clinicopathological studies. This proposal seeks to develop a methodology that will allow in-depth neurological phenotyping of the population of patients admitted to the psychiatric ward of São Lucas Hospital in Porto Alegre, Brazil. We propose to screen all patients over 45 years of age for AD clinical syndromes and for NDD that can mimic these phenotypes (bvFTD, DLB, nfvPPA, CBS). In each of these groups, we will have the novel opportunity to screen for the presence of AD neuropathology using novel plasma-based biomarkers. This study also aims to determine whether plasma biomarkers are associated with clinical outcomes. We will collect blood at the time of admission, evaluate functional status and clinical diagnosis of AD, bvFTD, DLB, PPA, or CBS during hospitalization, and evaluate cognitive performance when neuropsychiatric stability criteria are met. Exclusion criteria include inability to collect blood and blood abnormalities. Blood samples will be sent and analyzed in the University of Pittsburgh using cutting-edge single molecule array (SIMOA) technology. This will be the first study to assess the frequency and clinical outcome of AD in psychiatric settings in Brazil, which may improve decision-making by showing unprecedented data on clinical outcome, AD frequency, and potential misdiagnosis in a psychiatric ward. In the medium term, this pilot will substantiate further grant funding that aim to investigate the impact of plasma AD biomarkers in decision-making and clinical outcomes in a more representative population.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Cristiano Schaffer Aguzzoli - Coordenador / MILLER, BRUCE L - Integrante / ZIMMER, EDUARDO R. - Integrante / SCHILLING, LUCAS P. - Integrante / PASCOAL, THARICK A. - Integrante.

• 2023 - Atual

  Glial Reactivity Marker Predictive Value on Neuropsychiatric Symptoms in AD, Descrição: Neuropsychiatric symptoms (NPS) are commonly encountered in people living with Alzheimers disease (AD): more than 80 of patients with dementia will develop at least one NPS with severe clinical implications. These symptoms are associated with higher mortality and hospitalization rates, poorer quality of life, and increased caregiver distress. Although NPS are clinically well characterized, the underlying physiopathology remains elusive. Recent studies and preliminary data from our group showing an association between glial markers (microglial activation and astrocyte reactivity) and NPS, support a key role of neuroinflammation in the development of these symptoms. However, these results were obtained using a small sample size and they lack longitudinal data. Thus, this proposal aims to investigate the association between glial markers and NPS in a larger longitudinal cohort. Specific aims: Aim 1: To evaluate the cross-sectional association between NPS and plasma glial markers in cognitively unimpaired, mild cognitive impairment, and AD dementia individuals. The hypothesis is that NPS associates with glial markers independently of levels of amyloid (A) and tau. Aim 2: To evaluate whether baseline plasma glial markers predict longitudinal deterioration of NPS. We hypothesize, based on our preliminary data, that baseline glial markers will predict the worsening of distinct NPS, such as irritability and agitation, above and beyond A and tau levels. Exploratory Aim 3: To compare the magnitude of effect of glial reactivity, A and tau biomarkers in predicting the development of distinct NPS. We hypothesize that glial markers will predict worsening of irritability; A will predict worsening of depression and anxiety, and tau will predict worsening of hallucinations and delusions. Experimental design and methods: This study will leverage data from the Longitudinal multicenter head-to-head harmonization of tau PET tracers (HEAD Study, R01AG073267, PI: Pascoal), which includes 620 individuals across the AD spectrum with A PET, blood biomarkers, clinical and MRI assessments, as well as tau PET at baseline and 18 months (currently enrolling). Microglial reactivity measured by plasma sTREM2, YKL-40, and MCP-1 and astrocyte reactivity measured by plasma GFAP and S100B will be used as proxy measures of neuroinflammation in the brain. NPS will be assessed with the Neuropsychiatry Inventory Questionnaire (NPI-Q). The association between NPS and glial markers will be evaluated using censored linear regression models. Longitudinal linear models will be used to assess whether baseline glial markers predict the worsening of distinct NPS over time. The contribution of each NPI-Q domain to the results will be assessed using a leave-one-out approach. Relevance: This study will shed light on the role of glial reactivity in the NPS of patients with AD, and has the potential to improve care and substantiate drug development targeting glial cells.. , Situação: Desativado; Natureza: Pesquisa. , Integrantes: Cristiano Schaffer Aguzzoli - Coordenador / Lucas Porcello Schilling - Integrante / Tharick Ali Pascoal - Integrante.

• 2021 - Atual

  Longitudinal multicenter head-to-head harmonization of tau PET tracers (HEAD Study), Descrição: The overarching goal of this longitudinal, multi-site, observational, non-randomized study is to assess head-to-head tau PET scans using [18F]Flortaucipir and [18F]MK-6240 tracers collected at baseline and approximately 18-month follow-up to: (1) standardize their analysis, allowing datasets to be combined; (2) compare their rates of longitudinal deposition to elucidate their advantages and limitations for research, trials, and practice; and (3) produce a benchmark dataset to be used by the scientific community to develop methods for PET quantification and harmonization.The overall purpose of this study is to compare cross-sectional and longitudinal tau measures obtained with the two most widely used tau PET tracers, [18F]Flortaucipir and [18F]MK6240, head-to-head in the same volunteers to elucidate the advantages and caveats of their use in research cohorts, clinical trials, and clinical practice. To accomplish this, we will strive to enroll 620 subjects across 8 sites over the course of the five-year study, with the possibility of a 1 year no-cost extension if necessary. Two sets of tau tracers, [18F]Flortaucipir and [18F]MK-6240, will be acquired in the same subjects at baseline and at approximately 18-month follow-up. These individuals will also undergo magnetic resonance imaging, amyloid-#946; (A#946;) PET, cognitive and health testing, and blood biomarker assessment at each time point.Approximately 40 young controls, 280 cognitively unimpaired elderly individuals, 200 individuals with mild cognitive impairment, 100 individuals with Alzheimers disease dementia anticipated total of 620 subjects.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Cristiano Schaffer Aguzzoli - Integrante / Tharick Ali Pascoal - Coordenador / Suzanne L. Baker - Integrante.

• 2013 - 2015

  Avaliação de Crianças em Risco de Transtorno de Aprendizagem - ACERTA, Descrição: Trabalha na produção de testes cognitivos para o exame de ressonância magnética funcional (fMRI) que são realizados nos participantes do projeto ACERTA; na análise de dados dos testes cognitivos; na análise de imagens; e na revisão da literatura pertinente.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) . , Integrantes: Cristiano Schaffer Aguzzoli - Integrante / Dra. Mirna Wetters Portuguez - Integrante / Augusto Buchweitz - Coordenador / Alexandre Rosa Franco - Integrante., Financiador(es): Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Bolsa.

• 2012 - 2013

  Estudo Longitudinal de Leitura na Infancia (ELLI) - Bolsa I.C. BPA/PUCRS, Descrição: Trabalhou na produção de testes cognitivos para o exame de ressonância funcional (fMRI) para o projeto ELLI - Estudo Longitudinal de Leitura na Infância.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) . , Integrantes: Cristiano Schaffer Aguzzoli - Integrante / Dra. Mirna Wetters Portuguez - Coordenador., Financiador(es): Pontifícia Universidade Católica do Rio Grande do Sul - Bolsa.

Prêmios