julio cesar fernandes

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Produções bibliográficas

• JIANG, JUN ; C FERNANDES, JULIO . A lateral approach defect closure technique with deep fascia flap for valgus knee TKA. Journal of Orthopaedic Surgery and Research , v. 10, p. 173, 2015.

• LAFLAMME, G-YVES ; BELZILE, ETIENNE L. ; FERNANDES, JULIO C. ; VENDITTOLI, PASCAL A. ; HÉBERT-DAVIES, JONAH . Periprosthetic Fractures of the Acetabulum During Cup Insertion: Posterior Column Stability is Crucial. The Journal of Arthroplasty , v. 30, p. 265-269, 2015.

• SENAY, A. ; DELISLE, J. ; RAYNAULD, J. P. ; MORIN, S. N. ; FERNANDES, J. C. . Agreement between physicians? and nurses? clinical decisions for the management of the fracture liaison service (4iFLS): the Lucky Bone- program. Osteoporosis International (Internet) , v. 1, p. 1-8, 2015.

• ABID, ALEXANDRE ; THAKARE, DHAWAL ; PEREIRA, DANIEL ; RAJAGOPAL, PRABU ; FERNANDES, JULIO ; BÉLANGER, PIERRE . Guided wave velocity sensitivity to bone mechanical property evolution in cortical-marrow and cortical-trabecular phantoms. The Journal of the Acoustical Society of America , v. 138, p. 1799-1799, 2015.

• MONGKHON, JOHN-MAX ; THACH, MARYANE ; SHI, QIN ; FERNANDES, JULIO C. ; FAHMI, HASSAN ; BENDERDOUR, MOHAMED . Sorbitol-modified hyaluronic acid reduces oxidative stress, apoptosis and mediators of inflammation and catabolism in human osteoarthritic chondrocytes. Inflammation Research (Printed ed.) , v. 63, p. 691-701, 2014.

• SHI, QIN ; ABUSARAH, JAMILAH ; ZAOUTER, CHARLOTTE ; MOLDOVAN, FLORINA ; FERNANDES, JULIO C. ; FAHMI, HASSAN ; BENDERDOUR, MOHAMED . New Evidence Implicating 4-Hydroxynonenal in the Pathogenesis of Osteoarthritis In Vivo. ARTHRITIS RHEUMATOL , v. 66, p. 2461-2471, 2014.

• TIERA, MARCIO ; SHI, QIN ; BARBOSA, HELLEN ; FERNANDES, JULIO . Polymeric Systems as Nanodevices for siRNA Delivery. Current Gene Therapy , v. 13, p. 358-369, 2013.

• SHI, QIN ; ABUSARAH, JAMILAH ; BAROUDI, GHAYATH ; FERNANDES, JULIO C ; FAHMI, HASSAN ; BENDERDOUR, MOHAMED . Response to 'Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis' - authors' reply. Arthritis Research & Therapy (Print) , v. 15, p. 406, 2013.

• DE PAULA PANSANI OLIVEIRA, FRANCIELE ; PICOLA, ISADORA PFEIFER DALLA ; SHI, QIN ; BARBOSA, HELLEN FRANCIANE GONÇALVES ; DE OLIVEIRA TIERA, VERA APARECIDA ; FERNANDES, JÚLIO CESAR ; TIERA, MARCIO JOSÉ . Synthesis and evaluation of diethylethylamine-chitosan for gene delivery: composition effects on the transfection efficiency. Nanotechnology (Bristol. Print) , v. 24, p. 055101, 2013.

• SHI, QIN ; FERNANDES, JULIO ; QIU ; ZHANG ; DAI ; BENDERDOUR, MOHAMED ; WINNIK, FRANCOISE . Linear polyethylenimine produced by partial acid hydrolysis of poly(2-ethyl-2-oxazoline) for DNA and siRNA delivery in vitro. International Journal of Nanomedicine (Online) , v. 8, p. 4091, 2013.

• LI, J ; ZHANG, N ; HUANG, X ; XU, J ; FERNANDES, J C ; DAI, K ; ZHANG, X . Dexamethasone shifts bone marrow stromal cells from osteoblasts to adipocytes by C/EBPalpha promoter methylation. Cell Death & Disease , v. 4, p. e832, 2013.

• DESMEULES, FRANÇOIS ; TOLIOPOULOS, PANAGIOTA ; ROY, JEAN-SÉBASTIEN ; WOODHOUSE, LINDA ; LACELLE, MARC ; LEROUX, MANON ; GIRARD, STEVEN ; FELDMAN, DEBBIE E ; FERNANDES, JULIO C . Validation of an advanced practice physiotherapy model of care in an orthopaedic outpatient clinic. BMC Musculoskeletal Disorders (Online) , v. 14, p. 162, 2013.

• TONG, HAIJUN ; WANG ; SHI, QIN ; FERNANDES, JULIO C ; DAI ; TANG, GUPING ; ZHANG ; HUANG . Polyethylenimine600-β-cyclodextrin: a promising nanopolymer for nonviral gene delivery of primary mesenchymal stem cells. International Journal of Nanomedicine (Online) , v. 8, p. 1935, 2013.

• SHI, QIN ; ABUSARAH, JAMILAH ; BAROUDI, GHAYATH ; FERNANDES, JULIO C ; FAHMI, HASSAN ; BENDERDOUR, MOHAMED . Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis. Arthritis Research & Therapy (Print) , v. 14, p. R223, 2012.

• SHI, QIN ; FERNANDES, JULIO ; WINNIK, FRANCOISE ; BENDERDOUR, MOHAMED ; ZHANG ; QIU ; DAI . Low molecular weight chitosan conjugated with folate for siRNA delivery in vitro: optimization studies. International Journal of Nanomedicine (Online) , v. 7, p. 5833, 2012.

• BENTZ, MIREILLE ; ZAOUTER, CHARLOTTE ; SHI, QIN ; FAHMI, HASSAN ; MOLDOVAN, FLORINA ; FERNANDES, JULIO C. ; BENDERDOUR, MOHAMED . Inhibition of inducible nitric oxide synthase prevents lipid peroxidation in osteoarthritic chondrocytes. Journal of Cellular Biochemistry (Print) , v. 113, p. 2256-2267, 2012.

• XIANG, SHENGNAN ; TONG, HAIJUN ; SHI, QIN ; FERNANDES, JULIO C. ; JIN, TUO ; DAI, KERONG ; ZHANG, XIAOLING . Uptake mechanisms of non-viral gene delivery. Journal of Controlled Release , v. 158, p. 371-378, 2012.

• JREYSSATY, CHRISTIAN ; SHI, QIN ; WANG, HUIJIE ; QIU, XINGPING ; WINNIK, FRANÇOISE M. ; ZHANG, XIAOLING ; DAI, KERONG ; BENDERDOUR, MOHAMED ; FERNANDES, JULIO C. . Efficient Nonviral Gene Therapy Using Folate-Targeted Chitosan-DNA Nanoparticles. ISRN Pharmaceutics , v. 2012, p. 1-9, 2012.

• BENDERDOUR, MOHAMED ; FAHMI, HASSAN ; BEAUDET, FRANÇOIS ; FERNANDES, JULIO C. ; SHI, QIN . Nuclear receptor retinoid-related orphan receptor α1 modulates the metabolic activity of human osteoblasts. Journal of Cellular Biochemistry (Print) , v. 112, p. 2160-2169, 2011.

• J. TIERA, MARCIO ; SHI, QIN ; M. WINNIK, FRANCOISE ; C. FERNANDES, JULIO . Polycation-Based Gene Therapy: Current Knowledge and New Perspectives. Current Gene Therapy , v. 11, p. 288-306, 2011.

• DAVIES, JONAH HEBERT ; LAFLAMME, G. YVES ; DELISLE, JOSEE ; FERNANDES, JULIO . Trabecular Metal Used for Major Bone Loss in Acetabular Hip Revision. The Journal of Arthroplasty , v. 26, p. 1245-1250, 2011.

• SHI, QIN ; WANG, HUIJIE ; TRAN, COVI ; QIU, XINGPING ; WINNIK, FRANÇOISE M. ; ZHANG, XIAOLING ; DAI, KERONG ; BENDERDOUR, MOHAMED ; FERNANDES, JULIO C. . Hydrodynamic Delivery of Chitosan-Folate-DNA Nanoparticles in Rats with Adjuvant-Induced Arthritis. Journal of Biomedicine and Biotechnology (Print) , v. 2011, p. 1-9, 2011.

• VAILLANCOURT, FRANCE ; SILVA, PATRICK ; SHI, QIN ; FAHMI, HASSAN ; FERNANDES, JULIO C. ; BENDERDOUR, MOHAMED . Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis. Journal of Cellular Biochemistry (Print) , v. 112, p. 107-117, 2011.

• SHI, QIN ; ZHANG, XIAO-LING ; DAI, KE-RONG ; BENDERDOUR, MOHAMED ; FERNANDES, JULIO C . siRNA therapy for cancer and non-lethal diseases such as arthritis and osteoporosis. Expert Opinion on Biological Therapy , v. 11, p. 5-16, 2011.

• LABBE, DAVID R. ; DE GUISE, JACQUES A. ; MEZGHANI, NEILA ; GODBOUT, VÉRONIQUE ; GRIMARD, GUY ; BAILLARGEON, DAVID ; LAVIGNE, PATRICK ; FERNANDES, JULIO ; RANGER, PIERRE ; HAGEMEISTER, NICOLA . Objective grading of the pivot shift phenomenon using a support vector machine approach. Journal of Biomechanics , v. 44, p. 1-5, 2011.

• LABBE, DAVID R. ; DE GUISE, JACQUES A. ; GODBOUT, VÉRONIQUE ; GRIMARD, GUY ; BAILLARGEON, DAVID ; LAVIGNE, PATRICK ; FERNANDES, JULIO ; MASSÉ, VINCENT ; RANGER, PIERRE ; HAGEMEISTER, NICOLA . Accounting for velocity of the pivot shift test manoeuvre decreases kinematic variability. Knee (Oxford) , v. 18, p. 88-93, 2011.

• EL-BIKAI, RANA ; WELMAN, MÉLANIE ; MARGARON, YORAN ; CÔTÉ, JEAN-FRANÇOIS ; MACQUEEN, LUKE ; BUSCHMANN, MICHAEL D ; FAHMI, HASSAN ; SHI, QIN ; MAGHNI, KARIM ; FERNANDES, JULIO C ; BENDERDOUR, MOHAMED . Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis. Arthritis Research & Therapy (Print) , v. 12, p. R201, 2010.

• LABBE, DAVID R. ; DE GUISE, JACQUES A ; MEZGHANI, NEILA ; GODBOUT, VÉRONIQUE ; GRIMARD, GUY ; BAILLARGEON, DAVID ; LAVIGNE, PATRICK ; FERNANDES, JULIO ; RANGER, PIERRE ; HAGEMEISTER, NICOLA . Feature selection using a principal component analysis of the kinematics of the pivot shift phenomenon. Journal of Biomechanics , v. 43, p. 3080-3084, 2010.

• KISS, MARC-OLIVIER ; HAGEMEISTER, NICOLA ; LEVASSEUR, ANNIE ; FERNANDES, JULIO ; LUSSIER, BERTRAND ; PETIT, YVAN . A low-cost thermoelectrically cooled tissue clamp for in vitro cyclic loading and load-to-failure testing of muscles and tendons. Medical Engineering & Physics , v. 31, p. 1182-1186, 2009.

• TONG, HAIJUN ; SHI, QIN ; FERNANDES, JULIO ; LIU, LI ; DAI, KERONG ; ZHANG, XIAOLING . Progress and Prospects of Chitosan and Its Derivatives as Non-Viral Gene Vectors in Gene Therapy. Current Gene Therapy , v. 9, p. 495-502, 2009.

• BLOUIN, J. ; DRAGOMIR, A. ; FREDETTE, M. ; STE-MARIE, L.-G. ; FERNANDES, J. C. ; PERREAULT, S. . Comparison of direct health care costs related to the pharmacological treatment of osteoporosis and to the management of osteoporotic fractures among compliant and noncompliant users of alendronate and risedronate: a population-based study. Osteoporosis International , v. 20, p. 1571-1581, 2009.

• BRUNET-MAHEU, J.-M. ; FERNANDES, J. C. ; DE LACERDA, C. A. ; SHI, Q. ; BENDERDOUR, M. ; LAVIGNE, P. . Pluronic F-127 as a Cell Carrier for Bone Tissue Engineering. Journal of Biomaterials Applications , v. 24, p. 275-287, 2009.

• CASÉ, ANA HELENA ; PICOLA, ISADORA PFEIFER DALLA ; ZANIQUELLI, MARIA ELISABETE DARBELLO ; FERNANDES, JÚLIO CESAR ; TABOGA, SEBASTIÃO ROBERTO ; WINNIK, FRANÇOISE M. ; TIERA, MARCIO JOSÉ . Physicochemical characterization of nanoparticles formed between DNA and phosphorylcholine substituted chitosans. Journal of Colloid and Interface Science (Print) , v. 336, p. 125-133, 2009.

• ZHANG, XIAOLING ; TANG, TINGTING ; SHI, QIN ; FERNANDES, JULIO C. ; DAI, KERONG . The immunologic properties of undifferentiated and osteogenic differentiated mouse mesenchymal stem cells and its potential application in bone regeneration. Immunobiology (Jena. 1979) , v. 214, p. 179-186, 2009.

• DAI, KE-RONG ; ZHANG, XIAO-LING ; SHI, QIN ; FERNANDES, JULIO C . Gene therapy of arthritis and orthopaedic disorders: current experimental approaches in China and in Canada. Expert Opinion on Biological Therapy , v. 8, p. 1337-1346, 2008.

• BLOUIN, JULIE ; DRAGOMIR, ALICE ; MORIDE, YOLA ; STE-MARIE, LOUIS-GEORGES ; FERNANDES, JULIO CESAR ; PERREAULT, SYLVIE . Impact of noncompliance with alendronate and risedronate on the incidence of nonvertebral osteoporotic fractures in elderly women. British Journal of Clinical Pharmacology (Print) , v. 66, p. 117-127, 2008.

• FERNANDES, JULIO C ; WANG, HUIJIE ; JREYSSATY, CHRISTIAN ; BENDERDOUR, MOHAMED ; LAVIGNE, PATRICK ; QIU, XINGPIN ; WINNIK, FRANCOISE M ; ZHANG, XIAOLING ; DAI, KERONG ; SHI, QIN . Bone-protective Effects of Nonviral Gene Therapy With Folate-Chitosan DNA Nanoparticle Containing Interleukin-1 Receptor Antagonist Gene in Rats With Adjuvant-induced Arthritis. Molecular Therapy (Print) , v. 16, p. 1243-1251, 2008.

• VAILLANCOURT, FRANCE ; FAHMI, HASSAN ; SHI, QIN ; LAVIGNE, PATRICK ; RANGER, PIERRE ; FERNANDES, JULIO C ; BENDERDOUR, MOHAMED . 4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase. Arthritis Research & Therapy (Print) , v. 10, p. R107, 2008.

• FERNANDES, JULIO C. ; SHI, QIN ; BENDERDOUR, MOHAMED ; LAJEUNESSE, DANIEL ; LAVIGNE, PATRICK . An active role for soluble and membrane intercellular adhesion molecule-1 in osteoclast activity in vitro. Journal of Bone and Mineral Metabolism (English ed. Print) , v. 26, p. 543-550, 2008.

• PERREAULT, SYLVIE ; DRAGOMIR, ALICE ; BLAIS, LUCIE ; MORIDE, YOLA ; ROSSIGNOL, MICHEL ; STE-MARIE, LOUIS-GEORGES ; FERNANDÈS, JULIO CESAR . Population-based study of the effectiveness of bone-specific drugs in reducing the risk of osteoporotic fracture. Pharmacoepidemiology and Drug Safety , v. 17, p. 248-259, 2008.

• VAILLANCOURT, FRANCE ; MORQUETTE, BARBARA ; SHI, QIN ; FAHMI, HASSAN ; LAVIGNE, PATRICK ; DI BATTISTA, JOHN A. ; FERNANDES, JULIO C. ; BENDERDOUR, MOHAMED . Differential regulation of cyclooxygenase-2 and inducible nitric oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2/CREB-1 transactivation and concomitant inhibition of NF-κB signaling cascade. Journal of Cellular Biochemistry (Print) , v. 100, p. 1217-1231, 2007.

• BLOUIN, JULIE ; DRAGOMIR, ALICE ; STE-MARIE, LOUIS-GEORGES ; FERNANDES, JULIO CESAR ; PERREAULT, SYLVIE . Discontinuation of Antiresorptive Therapies: A Comparison between 1998-2001 and 2002-2004 among Osteoporotic Women. The Journal of Clinical Endocrinology and Metabolism , v. 92, p. 887-894, 2007.

• SHI, Q. ; BENDERDOUR, M. ; LAVIGNE, P. ; RANGER, P. ; FERNANDES, J.C. . Evidence for two distinct pathways in TNFα-induced membrane and soluble forms of ICAM-1 in human osteoblast-like cells isolated from osteoarthritic patients. Osteoarthritis and Cartilage , v. 15, p. 300-308, 2007.

• YOUSEFI, AZIZEH-MITRA ; GAUVIN, CHANTAL ; SUN, LOUISE ; DIRADDO, ROBERT W. ; FERNANDES, JULIO . Design and fabrication of 3D-plotted polymeric scaffolds in functional tissue engineering. Polymer Engineering and Science , v. 47, p. 608-618, 2007.

• TIERA, MARCIO J. ; QIU, XING-PING ; BECHAOUCH, SOFIANE ; SHI, QIN ; FERNANDES, JÚLIO C. ; WINNIK, FRANÇOISE M. . Synthesis and Characterization of Phosphorylcholine-Substituted Chitosans Soluble in Physiological pH Conditions. Biomacromolecules , v. 7, p. 3151-3156, 2006.

• MANSOURI, SANIA ; CUIE, YAN ; WINNIK, FRANCOISE ; SHI, QIN ; LAVIGNE, PATRICK ; BENDERDOUR, MOHAMED ; BEAUMONT, ERIC ; FERNANDES, JULIO C. . Characterization of folate-chitosan-DNA nanoparticles for gene therapy. Biomaterials (Guildford) , v. 27, p. 2060-2065, 2006.

• MASSICOTTE, FRÉDÉRIC ; FERNANDES, JULIO CESAR ; MARTEL-PELLETIER, JOHANNE ; PELLETIER, JEAN-PIERRE ; LAJEUNESSE, DANIEL . Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts. Bone (New York, N.Y.) , v. 38, p. 333-341, 2006.

• TIERA, MARCIO ; WINNIK, FRANCOISE ; FERNANDES, JULIO . Synthetic and Natural Polycations for Gene Therapy: State of the Art and New Perspectives. Current Gene Therapy , v. 6, p. 59-71, 2006.

• MORQUETTE, BARBARA ; SHI, QIN ; LAVIGNE, PATRICK ; RANGER, PIERRE ; FERNANDES, JULIO C. ; BENDERDOUR, MOHAMED . Production of lipid peroxidation products in osteoarthritic tissues: New evidence linking 4-hydroxynonenal to cartilage degradation. Arthritis and Rheumatism , v. 54, p. 271-281, 2006.

• SHI, QIN ; VAILLANCOURT, FRANCE ; CÔTÉ, VÉRONIQUE ; FAHMI, HASSAN ; LAVIGNE, PATRICK ; AFIF, HASSAN ; DI BATTISTA, JOHN A ; FERNANDES, JULIO C ; BENDERDOUR, MOHAMED . Alterations of metabolic activity in human osteoarthritic osteoblasts by lipid peroxidation end product 4-hydroxynonenal. Arthritis Research & Therapy (Print) , v. 8, p. R159, 2006.

• PERREAULT, SYLVIE ; DRAGOMIR, ALICE ; DESGAGNÉ, ALAIN ; BLAIS, LUCIE ; ROSSIGNOL, MICHEL ; BLOUIN, JULIE ; MORIDE, YOLA ; STE-MARIE, LOUIS-GEORGES ; FERNANDÈS, JULIO CESAR . Trends and determinants of antiresorptive drug use for osteoporosis among elderly women. Pharmacoepidemiology and Drug Safety , v. 14, p. 685-695, 2005.

• LAVIGNE, P ; BENDERDOUR, M ; LAJEUNESSE, D ; REBOUL, P ; SHI, Q ; PELLETIER, J ; MARTELPELLETIER, J ; FERNANDES, J . Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis. Osteoarthritis and Cartilage , v. 13, p. 310-317, 2005.

• LAVIGNE, PATRICK ; BENDERDOUR, MOHAMED ; SHI, QIN ; LAJEUNESSE, DANIEL ; FERNANDES, JULIO C . Involvement of ICAM-1 in bone metabolism: a potential target in the treatment of bone diseases?. Expert Opinion on Biological Therapy , v. 5, p. 313-320, 2005.

• MANACU, CHRISTINA ; MARTEL-PELLETIER, JOHANNE ; ROY-BEAUDRY, MARJOLAINE ; PELLETIER, JEAN-PIERRE ; FERNANDES, JULIO C ; SHIPKOLYE, FAZOOL S ; MITROVIC, DRAGOSLAV R ; MOLDOVAN, FLORINA . Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production. Arthritis Research & Therapy , v. 7, p. R324, 2005.

• LAVIGNE, PATRICK ; BENDERDOUR, MOHAMED ; LAJEUNESSE, DANIEL ; SHI, QIN ; FERNANDES, JULIO C . Expression of ICAM-1 by osteoblasts in healthy individuals and in patients suffering from osteoarthritis and osteoporosis. Bone (New York, N.Y.) , v. 35, p. 463-470, 2004.

• LAVIGNE, PATRICK ; SHI, QIN ; LAJEUNESSE, DANIEL ; DEHNADE, FARAMAZE ; FERNANDES, JULIO C . Metabolic activity of osteoblasts retrieved from osteoarthritic patients after stimulation with mediators involved in periprosthetic loosening. Bone (New York, N.Y.) , v. 34, p. 478-486, 2004.

• MANSOURI, SANIA ; LAVIGNE, PATRICK ; CORSI, KARIN ; BENDERDOUR, MOHAMED ; BEAUMONT, ERIC ; FERNANDES, JULIO C . Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy. European Journal of Pharmaceutics and Biopharmaceutics , v. 57, p. 1-8, 2004.

• PELLETIER, JEAN-PIERRE ; FERNANDES, JULIO C. ; BRUNET, JULIE ; MOLDOVAN, FLORINA ; SCHRIER, DENIS ; FLORY, CRAIG ; MARTEL-PELLETIER, JOHANNE . In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes. Arthritis and Rheumatism , v. 48, p. 1582-1593, 2003.

• CORSI, KARIN ; CHELLAT, FATIHA ; YAHIA, L'HOCINE ; FERNANDES, JULIO C. . Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles. Biomaterials (Guildford) , v. 24, p. 1255-1264, 2003.

• LAVIGNE, P. ; SHI, Q. ; JOLICOEUR, F.C. ; PELLETIER, J.-P. ; MARTEL-PELLETIER, J. ; FERNANDES, J.C. . Modulation of IL-1β, IL-6, TNF-α and PGE2 by pharmacological agents in explants of membranes from failed total hip replacement. Osteoarthritis and Cartilage , v. 10, p. 898-904, 2002.

• SHI, Q ; LAJEUNESSE, D ; REBOUL, P ; MARTELPELLETIER, J ; PELLETIER, JEAN-PIERRE ; DEHNADE, F. ; FERNANDES, J C . Metabolic activity of osteoblasts from periprosthetic trabecular bone in failed total hip arthroplasties and osteoarthritis as markers of osteolysis and loosening.. The Journal of Rheumatology (Online) , v. 29, p. 1437, 2002.

• FERNANDES, J C ; MARTEL-PELLETIER, JOHANNE ; PELLETIER, JEAN-PIERRE . The role of cytokines in osteoarthritis pathophysiology. Biorheology (Oxford) , v. 39, p. 237, 2002.

• PELLETIER, JEAN-PIERRE ; FERNANDES, J. C. ; JOVANOVIC, D. V. ; REBOUL, P ; MARTELPELLETIER, J . Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase.. The Journal of Rheumatology Supplement , v. 28, p. 2509, 2001.

• JOVANOVIC, DRAGAN V. ; FERNANDES, JULIO C. ; MARTEL-PELLETIER, JOHANNE ; JOLICOEUR, FRAN'OIS-CYRIL ; REBOUL, PASCAL ; LAUFER, STEFAN ; TRIES, SUSANNE ; PELLETIER, JEAN-PIERRE . In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: Suppression of collagenase 1 and interleukin-1? synthesis. Arthritis and Rheumatism , v. 44, p. 2320-2330, 2001.

• HILAL, GEORGE ; MASSICOTTE, FRÉDÉRIC ; MARTEL-PELLETIER, JOHANNE ; FERNANDES, JULIO C. ; PELLETIER, JEAN-PIERRE ; LAJEUNESSE, DANIEL . Endogenous Prostaglandin E2 and Insulin-like Growth Factor 1 Can Modulate the Levels of Parathyroid Hormone Receptor in Human Osteoarthritic Osteoblasts. Journal of Bone and Mineral Research , v. 16, p. 713-721, 2001.

• PELLETIER, JEAN-PIERRE ; LAJEUNESSE, D ; REBOUL, P ; MINEAU, F. ; FERNANDES, J. C. ; SABOURET, P. ; MARTELPELLETIER, J . Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.. The Journal of Rheumatology Supplement , v. 28, p. 814, 2001.

• FERNANDES, JULIO C. ; MARTEL-PELLETIER, JOHANNE ; PELLETIER, JEAN-PIERRE . Gene Therapy for Osteoarthritis. Clinical Orthopaedics and Related Research , v. 379, p. S262-S272, 2000.

• PELLETIER, JEAN'PIERRE ; JOVANOVIC, DRAGAN V. ; LASCAU'COMAN, VIORICA ; FERNANDES, JULIO C. ; MANNING, PAMELA T. ; CONNOR, JANE R. ; CURRIE, MARK G. ; MARTEL'PELLETIER, JOHANNE . Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: Possible link with the reduction in chondrocyte apoptosis and caspase 3 level. Arthritis and Rheumatism , v. 43, p. 1290-1299, 2000.

• PELLETIER, JEAN-PIERRE ; LAJEUNESSE, D ; JOVANOVIC, D. V. ; LASCAU-COMAN, V. ; JOLICOEUR, F. C. ; HILAL, G. ; FERNANDES, J. C. ; MARTELPELLETIER, J . Carprofen simultaneously reduces progression of morphological changes in cartilage and subchondral bone in experimental dog osteoarthritis. The Journal of Rheumatology Supplement , v. 27, p. 2893, 2000.

• PELLETIER, JEAN-PIERRE ; CHOQUETTE, DENIS ; HARAOUI, BOULOS ; RAYNAULD, JEAN-PIERRE ; RICH, ÉRIC ; FERNANDES, JULIO C. ; MARTEL-PELLETIER, JOHANNE . Pharmacologic therapy of osteoarthritis. Current Rheumatology Reports (Print) , v. 1, p. 54-58, 1999.

• PELLETIER, JEAN-PIERRE ; LASCAU-COMAN, V. ; JOVANOVIC, D. V. ; FERNANDES, J. C. ; MANNING, P. ; CONNOR, J. R. ; CURRIE, M. G. ; MARTELPELLETIER, J . Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. The Journal of Rheumatology Supplement , v. 26, p. 2002, 1999.

• LEDUC, S. ; YAHIA, L. ; BOUDREAULT, F. ; FERNANDES, J. C. ; DUVAL, N. . Mechanical evaluation of a ligament fixation system for ACL reconstruction at the tibia in a canine cadaver model. Annales de Chirurgie (Cessou em 2006) , v. 53, p. 735, 1999.

• PELLETIER, JEAN-PIERRE ; MINEAU, F. ; FERNANDES, J. C. ; DUVAL, N. ; MARTELPELLETIER, J . Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes.. The Journal of Rheumatology Supplement , v. 25, p. 2417, 1998.

• FERNANDES, J. C. ; MARTELPELLETIER, J ; LASCAU-COMAN, V. ; MOLDOVAN, FLORINA ; JOVANOVIC, D. V. ; RAYNAULD, J. P. ; PELLETIER, JEAN-PIERRE . Collagenase-1 and collagenase-3 synthesis in normal and early experimental osteoarthritic canine cartilage: an immunohistochemical study. The Journal of Rheumatology Supplement , v. 25, p. 1585, 1998.

• PELLETIER, JEAN-PIERRE ; JOVANOVIC, DRAGAN ; FERNANDES, JULIO C. ; MANNING, PAMELA ; CONNOR, JANE R. ; CURRIE, MARK G. ; DI BATTISTA, JOHN A. ; MARTEL-PELLETIER, JOHANNE . Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. Arthritis and Rheumatism , v. 41, p. 1275-1286, 1998.

• FERNANDES, J. C. ; MARTELPELLETIER, J ; JOVANOVIC, D. V. ; TARDIF, G. ; DI BATTISTA, JOHN A ; LASCAU-COMAN, V. ; OTTERNESS, I. G. ; PELLETIER, JEAN-PIERRE . The effects of tenidap on canine experimental osteoarthritis: II. Study of the expression of collagenase-1 and interleukin 1beta by in situ hybridization. The Journal of Rheumatology Supplement , v. 25, p. 951, 1998.

• FERNANDES, J. C. ; JOVANOVIC, D. V. ; DEHNADE, F. ; MARTELPELLETIER, J ; PELLETIER, JEAN-PIERRE . Resection of the anterior cruciate ligament of the knee using arthroscopy induces arthrosis in dogs. Validity of the Pond-Nuki model. Annales de Chirurgie (Cessou em 2006) , v. 52, p. 768, 1998.

• PELLETIER, JEAN-PIERRE ; CARON, JOHN P. ; EVANS, CHRISTOPHER ; ROBBINS, PAUL D. ; GEORGESCU, HELGA I. ; JOVANOVIC, DRAGAN ; FERNANDES, JULIO C. ; MARTEL-PELLETIER, JOHANNE . In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy. Arthritis and Rheumatism , v. 40, p. 1012-1019, 1997.

• JOVANOVIC, D. V. ; CARON, J. P. ; MARTELPELLETIER, J ; FERNANDES, J. C. ; RICKETTS, T. ; PELLETIER, JEAN-PIERRE . The therapeutic effects of tenidap in canine experimental osteoarthritis: relationship with biochemical markers. The Journal of Rheumatology Supplement , v. 24, p. 916, 1997.

• FERNANDES, JULIO C. ; CARON, JOHN P. ; MARTEL-PELLETIER, JOHANNE ; JOVANOVIC, DRAGAN ; MINEAU, FRANÇOIS ; TARDIF, GINETTE ; OTTERNESS, IVAN G. ; PELLETIER, JEAN-PIERRE . Effects of tenidap on the progression of osteoarthritic lesions in a canine experimental model. Suppression of metalloprotease and interleukin-1 activity. Arthritis and Rheumatism , v. 40, p. 284-294, 1997.

• CARON, JOHN P. ; FERNANDES, JULIO C. ; MARTEL-PELLETIER, JOHANNE ; TARDIF, GINETTE ; MINEAU, FRANÇOIS ; GENG, CHANGSHAN ; PELLETIER, JEAN-PIERRE . Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression. Arthritis and Rheumatism , v. 39, p. 1535-1544, 1996.

• MARTELPELLETIER, J ; MINEAU, F. ; TARDIF, G. ; FERNANDES, J. C. ; RANGER, P. ; LOOSE, L. ; PELLETIER, JEAN-PIERRE . Tenidap reduces the level of interleukin 1 receptors and collagenase expression in human arthritic synovial fibroblasts. The Journal of Rheumatology Supplement , v. 23, p. 24, 1996.

• FERNANDES, JULIO C. ; MARTEL-PELLETIER, JOHANNE ; OTTERNESS, IVAN G. ; LOPEZ-ANAYA, ARTURO ; MINEAU, FRANÇOIS ; TARDIF, GINETTE ; PELLETIER, JEAN-PIERRE . Effects of tenidap on canine experimental osteoarthritis i. morphologic and metalloprotease analysis. Arthritis and Rheumatism , v. 38, p. 1290-1303, 1995.

• SHI, QIN ; J., Marcio ; ZHANG, XIAOLING ; DAI, KERONG ; BENDERDOUR, MOHAMED ; C., Julio . Chitosan-DNA/siRNA Nanoparticles for Gene Therapy. Non-Viral Gene Therapy. 1ed.: InTech, 2011, v. , p. 457-.

• FERNANDES, J.C. ; TIERA, M. J. ; WINNIK, FRANCOISE . DNA-Chitosan nanoparticles for gene therapy: current knowledge and future trends. Biological and pharmaceutical nanomaterials. 1ed.: , 2006, v. 2, p. 68-.

• LEVASSEUR, A. ; PETIT, Y. ; DANSEREAU, M. ; FERNANDES, J. C. . Strength evaluation of a variable diameter acetabular trial implant under realistic loading conditions. In: 2011 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011, Boston. 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011. p. 7433.

• LEVASSEUR, A ; PETIT, Y ; DANSEREAU, M ; FERNANDES, J C . Finite element analysis of an acetabular trial implant. In: 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010), 2010, Buenos Aires. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology, 2010. p. 3930.

• RONDON, E. ; SHI, Q ; PICOLA, I. P. D. ; BENDERDOUR, M. ; TIERA, M. J. ; FERNANDES, J.C. . Folate-Chitosan-DNA/siRNA nanoparticle biodistribution in vivo.. In: The American Orthopaedic Association/Canadian Orthopaedic Association Combined Meeting (AOA/COA), 2014, Montreal. AOA/COA, 2014.

• MONGKHON, JOHN-MAX ; THACH, MARYANE ; SHI, Q. ; FERNANDES, J.C. ; FAHMI, H. ; BENDERDOUR, M. . Sorbitol-modified Hyaluronic acid reduces oxidative stress, apoptosis and mediators of inflammation and catabolism in human osteoarthritic chondrocytes.. In: The American Orthopaedic Association/Canadian Orthopaedic Association Combined Meeting (AOA/COA), 2014, Montreal. AOA/COA, 2014.

• MONGKHON, JOHN-MAX ; THACH, MARYANE ; SHI, Q ; FERNANDES, J.C. ; FAHMI, H. ; BENDERDOUR, M. . Sorbitol-modified Hyaluronic acid reduces oxidative stress, apoptosis and mediators of inflammation and catabolism in human osteoarthritic chondrocytes.. In: Osteoarthritis Research Society International (OARSI), 2014. OARSI, 2014.

• ABUSARAH, JAMILAH ; SHI, Q ; FAHMI, H. ; FERNANDES, J.C. ; BENDERDOUR, M. . The role of Nrf2 transcription factor in osteoarthritis.. In: Osteoarthritis Research Society International (OARSI), 2014. OARSI, 2014.

• SHI, Q. ; PICOLA, I. P. D. ; RONDON, E. ; SOUZA, B. C. ; BENDERDOUR, M. ; TIERA, M. J. ; FERNANDES, J.C. . Folate-Chitosan/siRNA Nanoparticle-mediated TNF-alpha knockdown for Anti-inflammatory Treatment in a Murine TiterMax Gold (adjuvant)/Collagen typeII (antigen)-Induced Arthritis Model.. In: The American Orthopaedic Association/Canadian Orthopaedic Association Combined Meeting (AOA/COA), 2014, Montreal. AOA/COA, 2014.

• ABUSARAH, JAMILAH ; FAHMI, H. ; SHI, Q ; FERNANDES, J.C. ; BENDERDOUR, M. . Nrf2 transcription factor inhibits interleukin-1 beta-induced catabolic and inflammatory responses in human osteoarthritic chonbdrocytes. In: Meeting of European League Against Rheumatism, 2013, Madrid. EULAR, 2013.

• GAGNON, G. ; FAHMI, H. ; SHI, Q ; FERNANDES, J.C. ; BENDERDOUR, M. . Resolvin D1 attenuates the production of catabolic and pro-inflammatory mediators in human osteoarthritic chonbdrocytes.. In: 13e Journée de la recherche de l'hôpital du Sacré-Coeur de Montréal, 2013, Montreal. Journée de la recherche HSCM, 2013.

• ABUSARAH, JAMILAH ; FAHMI, H. ; SHI, Q ; FERNANDES, J.C. ; BENDERDOUR, M. . Nrf2 transcription factor inhibits interleukin-1 beta-induced catabolic and inflammatory responses in human osteoarthritic chonbdrocytes. In: Journée de la Recherche du POES, 2013, Montreal. PROGRAMME D'ORTHOPÉDIE ÉDOUARD-SAMSON, 2013.

• THACH, MARYANE ; MONGKHON, JOHN-MAX ; FAHMI, H. ; SHI, Q ; FERNANDES, J.C. ; BENDERDOUR, M. . Synolis-VA reduces oxidative stress, metalloproteinase-13 and cycooxygenase-2 in human osteoarthritic chondrocytes. In: 33e Journée de la Recherche du POES, 2013, Montreal. PROGRAMME D'ORTHOPÉDIE ÉDOUARD-SAMSON, 2013.

• ABUSARAH, JAMILAH ; FAHMI, H. ; SHI, Q ; FERNANDES, J.C. ; BENDERDOUR, M. . Nrf2 transcription factor inhibits interleukin-1 beta-induced catabolic and inflammatory responses in human osteoarthritic chonbdrocytes. In: 13e Journée de la recherche de l'hôpital du Sacré-Coeur de Montréal, 2013, Montreal. Journée de la recherche HSCM, 2013.

• PERREAULT, S. ; FERNANDES, J.C. ; DELISLE, JOSEE ; BEAUBOIS, C. ; BEAUMONT, P. ; BENOIT, B. ; GAGNON, S. ; JODOIN, A. ; LAFLAMME, G. YVES ; LEDUC, S. ; MACTHIONG, J. M. ; MALO, M. ; MAURAIS, G. ; PARENT, S. ; RANGER, P. ; TROYANOV, Y. . Osteoporosis: Preliminary results of treatment adherence during a systematic follow-up of fragility fractures. In: 15th Annual European Congress., 2012, Berlim. 15th Annual European Congress., 2012.

• FERNANDES, J.C. ; DELISLE, JOSEE ; PERREAULT, S. ; BEAUBOIS, C. ; BEAUMONT, P. ; BENOIT, B. ; GAGNON, S. ; JODOIN, A. ; LAFLAMME, G. YVES ; LEDUC, S. ; MACTHIONG, J. M. ; MALO, M. ; MAURAIS, G. ; NGUYEN, H. ; PARENT, S. ; ROULEAU, D. ; RANGER, P. ; RAYNAULD, J. P. . Suivi systématique des fractures de fragilité : Résultats préliminaires d?une approche multidisciplinaire. In: 87e réunion annuelle de la Société française de Chirurgie orthopédique et traumatologique (SOFCOT), 2012. SOFCOT, 2012.

• FERNANDES, J.C. ; DELISLE, JOSEE ; PERREAULT, S. ; BEAUMONT, P. ; GAGNON, S. ; GIROUX, M. ; JODOIN, A. ; LAFLAMME, G. YVES ; LEDUC, S. ; MACTHIONG, J. M. ; MALO, M. ; MAURAIS, G. ; NGUYEN, H. ; PARENT, S. ; ROULEAU, D. ; RANGER, P. ; RAYNAULD, J. P. . Suivi systématique des fractures de fragilité : Résultats préliminaires d?une approche multidisciplinaire.. In: Congrès Annuel de l?Ordre des Infirmières, 2012. Congrès Annuel de l?Ordre des Infirmières, 2012.

• FERNANDES, J.C. ; DELISLE, JOSEE ; BEAUBOIS, C. ; BEAUMONT, P. ; BENOIT, B. ; GAGNON, S. ; JODOIN, A. ; LAFLAMME, G. YVES ; LEDUC, S. ; MACTHIONG, J. M. ; MALO, M. ; MAURAIS, G. ; PARENT, S. ; RANGER, P. ; TROYANOV, Y. ; PERREAULT, S. . Multidisciplinary Approach and Systematic Follow-up of Fragility Fracture: Preliminary. In: 1st Fragility Fracture Network Global Congress, 2012, Berlin. 1st Fragility Fracture Network Global Congress, 2012.

• FERNANDES, J.C. ; DELISLE, JOSEE ; BEAUBOIS, C. ; BEAUMONT, P. ; BENOIT, B. ; GAGNON, S. ; JODOIN, A. ; LAFLAMME, G. YVES ; LEDUC, S. ; MACTHIONG, J. M. ; MALO, M. ; MAURAIS, G. ; PARENT, S. ; RANGER, P. ; TROYANOV, Y. ; PERREAULT, S. . Osteoporosis: Preliminary results of treatment adherence during a systematic follow-up of fragility fractures. In: International Conference on Pharmacoepidemiology and therapeutic risk management (IPSE), 2012, Barcelona. International Conference on Pharmacoepidemiology and therapeutic risk management (IPSE), 2012.

• FERNANDES, J.C. ; QIU, XINGPING ; WINNIK, F. M. ; BENDERDOUR, M. ; ZHANG, X. ; DAI, K. ; SHI, Q . Linear Polyethylenimine Prepared by Partial Acid Hydrolysis of Poly(2-ethyl-2- oxazoline) for DNA and siRNA Nanoparticle Delivery in vitro. In: International Conference on Nanoscience + Technology, 2012, Paris. International Conference on Nanoscience + Technology, 2012.

• FERNANDES, J.C. ; DELISLE, JOSEE ; BEAUBOIS, C. ; BEAUMONT, P. ; BENOIT, B. ; GAGNON, S. ; JODOIN, A. ; LAFLAMME, G. YVES ; LEDUC, S. ; MACTHIONG, J. M. ; MALO, M. ; MAURAIS, G. ; PARENT, S. ; RANGER, P. ; TROYANOV, Y. ; PERREAULT, S. . Systematic Follow-up of Osteoporotic Fracture: Preliminary Results of a Multidisciplinary Approach. In: COA/CORS Annual Meeting, 2012, Ottawa. COA/CORS Annual Meeting, 2012.

• FERNANDES, J.C. ; DELISLE, JOSEE ; PERREAULT, S. ; BEAUMONT, P. ; GAGNON, S. ; GIROUX, M. ; JODOIN, A. ; LAFLAMME, G. YVES ; LEDUC, S. ; MACTHIONG, J. M. ; MALO, M. ; MAURAIS, G. ; NGUYEN, H. ; PARENT, S. ; ROULEAU, D. ; RANGER, P. ; RAYNAULD, J. P. . Suivi systématique des fractures de fragilité : Résultats préliminaires d?une approche multidisciplinaire. In: Journée scientifique du programme Orthopédique Édouard Samson, 2012, Montreal. programme Orthopédique Édouard Samson, 2012.

• SHI, Q ; FAHMI, H. ; FERNANDES, J.C. ; BENDERDOUR, M. . New evidence linking the in vivo implication of 4-HNE in osteoarthritis pathogenesis. In: Meeting of European League Against Rheumatism (EULAR), 2012, Berlin. EULAR, 2012.

• PERREAULT, S. ; FERNANDES, J.C. ; DELISLE, JOSEE ; BEAUBOIS, C. ; BEAUMONT, P. ; BENOIT, B. ; GAGNON, S. ; JODOIN, A. ; LAFLAMME, G. YVES ; LEDUC, S. ; MACTHIONG, J. M. ; MALO, M. ; MAURAIS, G. ; PARENT, S. ; RANGER, P. ; TROYANOV, Y. . Systematic Follow-up of Fragility Fractures : Preliminary Results of treatment adherence. In: Canadian Association for Population Therapeutics (CAPT) 2012 Annual Conference, 2012, Montreal. CAPT 2012 Annual Conference, 2012.

• SHI, Q ; FAHMI, H. ; FERNANDES, J.C. ; BENDERDOUR, M. . NEW EVIDENCE LINKING THE IN VIVO IMPLICATION OF 4-HYDROXYNONENAL IN THE OSTEOARTHRITIS PATHOGENESIS. In: Meeting of Osteoarthritis Research Society International (OARSI), 2012, Barcelona. Meeting of Osteoarthritis Research Society International (OARSI) 2012, 2012.

• BENTZ, MIREILLE ; ZAOUTER, CHARLOTTE ; OSMAN, M. ; SHI, Q ; FAHMI, H. ; FERNANDES, J.C. ; MOLDOVAN, FLORINA ; BENDERDOUR, M. . SELECTIVE INHIBITION OF INDUCIBLE NITRIC OXIDE SYNTHASE PREVENTS LIPID PEROXIDATION IN CARTILAGE FROM PATIENTS WITH OSTEOARTHRITIS. In: 42nd laurentian conference of rheumatology, 2011, Fairmont Tremblant. Programme, 2011.

• BENTZ, MIREILLE ; ZAOUTER, CHARLOTTE ; OSMAN, M. ; SHI, Q ; FAHMI, H. ; FERNANDES, J.C. ; MOLDOVAN, FLORINA ; BENDERDOUR, M. . SELECTIVE INHIBITION OF INDUCIBLE NITRIC OXIDE SYNTHASE PREVENTS LIPID PEROXIDATION IN CARTILAGE FROM PATIENTS WITH OSTEOARTHRITIS.. In: Meeting of OsteoArthritis Research Society International (OARSI), 2011, San Diego. Meeting of OsteoArthritis Research Society International (OARSI) 2011, 2011.

• FERNANDES, J.C. ; DELISLE, JOSEE ; TROYANOV, Y. ; PERREAULT, S. . Systematic Follow up of osteoporotic fracture: Preliminary results of a Multidisciplinary Approach. In: Canadian Orthopaedic Association, Annual Meeting 2011, 2011. Canadian Orthopaedic Association, Annual Meeting 2011, 2011.

• FARHADNIA, P. ; FERNANDES, J.C. ; OLIVEIRA, E. . Knee articular cartilage repair using a microfracture, minced cartilage autograft and polymeric scaffold combined technique: Preliminary data of a prospective cohort observational study. In: Canadian Orthopaedic Association, Annual Meeting 2011, 2011. Canadian Orthopaedic Association, Annual Meeting 2011, 2011.

• FERNANDES, J.C. ; DELISLE, JOSEE ; TROYANOV, Y. ; PERREAULT, S. . Systematic Follow up of osteoporotic fracture: Preliminary results of a Multidisciplinary Approach. In: 31e Journée de la recherche du POES, 2011. PROGRAMME D'ORTHOPÉDIE ÉDOUARD-SAMSON 2011, 2011.

• OSMAN, M. ; BENTZ, MIREILLE ; FAHMI, H. ; SHI, Q ; FERNANDES, J.C. ; BENDERDOUR, M. . La modification de la matrice extracellulaire par le 4-hydroxynonénal induit des changements morphologiques et fonctionnels des ostéoblastes arthrosiques.. In: 11e Journée de la recherche de l'hôpital du Sacré-Coeur de Montréa, 2011, Montreal. Journée de la recherche HSCM 2011, 2011.

• OSMAN, M. ; BENTZ, MIREILLE ; FAHMI, H. ; SHI, Q ; FERNANDES, J.C. ; BENDERDOUR, M. . La perturbation de l?interaction entre les ostéoblastes et les complexes 4-hydroxynonénal-collagène.. In: 31e Journée de la recherche du POES 2011, 2011, Montreal. PROGRAMME D'ORTHOPÉDIE ÉDOUARD-SAMSON 2011, 2011.

• FERNANDES, J.C. ; DELISLE, JOSEE ; TROYANOV, Y. ; PERREAULT, S. . Systematic Follow up of osteoporotic fracture: Preliminary results of a Multidisciplinary Approach.. In: European Congress on Osteoporosis and Osteoarthritis, 2011, Valencia. European Congress on Osteoporosis and Osteoarthritis 2011, 2011.

• BENTZ, MIREILLE ; ZAOUTER, CHARLOTTE ; OSMAN, M. ; SHI, Q ; FAHMI, H. ; FERNANDES, J.C. ; MOLDOVAN, FLORINA ; BENDERDOUR, M. . L?inhibition selective de l?oxyde nitrique synthétase inducible inhibe la péroxydation lipidique chez les patients souffrant de l?ostéoarthrose. In: 11e Journée de la recherche de l'hôpital du Sacré-Coeur de Montréal, 2011, Montreal. Journée de la recherche HSCM 2011, 2011.

• FERNANDES, J.C. ; JREYSSATY, CHRISTIAN ; BENDERDOUR, M. ; LAVIGNE, P ; QIU, XINGPIN ; WINNIK, F. M. ; ZHANG, XIAO-LING ; DAI, K. ; SHI, Q . Linear Polyethylenimine Prepared by Partial Acid Hydrolysis of Poly (2-ethyl-2-oxazoline) for DNA and siRNA Delivery in Vitro. In: 13th Annual Meeting of American society of gene therapy, 2010, Washington. 13th Annual Meeting of American society of gene therapy, 2010.

• EL-BIKAI, RANA ; SHI, Q ; FERNANDES, J.C. ; BENDERDOUR, M . L?INTERACTION CELLULE-MATRICE EXTRACELLULAIRE MODIFIÉE PAR LE 4-HYDROXYNONÉNAL INDUIT DES CHANGEMENTS PHÉNOTYPIQUES ET FONCTIONNELS AU NIVEAU DES CHONDROCYTES ET DES OSTÉOBLASTES. In: Journée de la Recherche Gabriel Plaa, 2009, Montreal. Journée de la recherche Gabriel Plaa 2009.

• EL-BIKAI, RANA ; CHEN, S. H. ; SHI, Q ; FERNANDES, J.C. ; BENDERDOUR, M . Interaction between articular chondrocytes and 4-hydroxynonenal-modified type II collagen modulates cell adhesion and function. In: 29e Journée de la recherche du POES, 2009, Montreal. PROGRAMME D'ORTHOPÉDIE ÉDOUARD-SAMSON, 2009.

• FERNANDES, J.C. ; JREYSSATY, CHRISTIAN ; BENDERDOUR, M. ; LAVIGNE, P ; QIU, XINGPIN ; WINNIK, F. M. ; ZHANG, X ; DAI, K ; SHI, Q . Characterization of Low Molecular Weight Folate Conjugated Chitosan as Polymeric Nanocarriers for siRNA Delivery.. In: American Society of Gene Therapy (ASGT) 12th Annual Meeting, 2009, San Diego. American Society of Gene Therapy (ASGT) 12th Annual Meeting, 2009.

• JREYSSATY, CHRISTIAN ; SHI, Q ; LAVIGNE, P ; BENDERDOUR, M. ; WINNIK, F. M. ; DAI, K. ; FERNANDES, J.C. . Chitosan-PEG-FA-DNA Nanoparticules for Non-Viral Gene Therapy and Expression of the IL1- Ra Gene in an Experimental Model of Rheumatoid Arthritis. In: American Society of Gene Therapy (ASGT) 12th Annual Meeting, 2009, San Diego. American Society of Gene Therapy (ASGT) 12th Annual Meeting, 2009.

• CHEN, S. H. ; SHI, Q ; LAVIGNE, P ; FERNANDES, J.C. ; BENDERDOUR, M. . ROLE OF 4-HYDROXYNONENAL IN PROSTAGLANDIN E2 SYNTHASE AND 5-LIPOXYGENASE REGULATION IN OSTEOARTHRITC CHONDROCYTES. In: 29e Journée de la recherche du POES, 2009, Montreal. PROGRAMME D'ORTHOPÉDIE ÉDOUARD-SAMSON 2009, 2009.

• VAILLANCOURT, FRANCE ; FAHMI, H. ; SHI, Q ; LAVIGNE, P ; FERNANDES, J.C. ; MOLDOVAN, FLORINA ; BENDERDOUR, M. . 4-HYDROXYNONENAL INDUCES APOPTOSIS IN HUMAN OSTEOARTHRITIC CHONDROCYTES: THE PROTECTIVE ROLE OF GLUTATHIONE-S-TRANSFERASE. In: The European League Against Rheumatism (EULAR), 2008, Paris. EULAR, 2008.

Projetos de pesquisa

• 2015 - Atual

  Aptâmeros anti-RANK-L asssociados a nanovetores para utilização em terapias celulares sitio-dirigidas, Projeto certificado pela empresa DNAPTA Biotecnologia em 10/10/2014., Descrição: Desenvolvimento de nanovetores para terapia biológica da osteoporose.. , Situação: Desativado; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Mestrado acadêmico: (1) / Doutorado: (1) . , Integrantes: Julio Cesar Fernandes - Coordenador / Marcio José Tiera - Integrante / Paulo Peitl - Integrante., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.

• 2014 - Atual

  A prevalência de hipersensibilidade de metal em pacientes de artroplastia total de joelho primária. Correlação com os resultados clínicos., Descrição: Estudo de população a risco de reaçao aos metais presentes nos implantes ortopédicos.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Especialização: (1) / Mestrado acadêmico: (1) . , Integrantes: Julio Cesar Fernandes - Coordenador / Mohamed Benderdour - Integrante / Benoit Benoit - Integrante / Hai Nguyen - Integrante / Mario Giroux - Integrante / Pierre Ranger - Integrante / Georges-Yves Laflamme - Integrante / Michel Malo - Integrante., Financiador(es): Smith & Nephew Inc. (Mtl, Canada) - Auxílio financeiro.

• 2014 - Atual

  O acompanhamento sistemático sobre a profilaxia da TVP após um THR ou TKR, Descrição: Registro pos-operatorio de pacientes submetidos a cirurgia de quadril ou joelho. Resultado da profilaxia e frequência de trombo-embolia venosa.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador / Benoit Benoit - Integrante / Hai Nguyen - Integrante / Mario Giroux - Integrante / Michael Malo - Integrante / Pierre Beaumont - Integrante / Pierre Ranger - Integrante / Yves Laflamme - Integrante., Financiador(es): Sanofi-Aventis (Canadá) - Auxílio financeiro.

• 2014 - Atual

  Aptâmeros anti-rank-l associados a nanovetores para utilização de terapias celulares sítio-dirigidas, Descrição: O projeto tem como objetivo principal o desenvolvimento de nanodispositivos bi-funcionais cujos alvos são as formas solúveis e membranares do ligante do receptor ativador do fator nuclear kappa B (RANKL). A proposta envolve uma tecnologia inovadora, que conjuga aptameros altamente específicos para bloquear RANKL, e direcionar os nanovetores da terapia gênica não viral para a liberação de RNA de interferência. A terapia terá como alvo o silenciamento da via metabólica de produção de TNF-α utilizando nanopartículas preparadas com derivados de quitosana. A proposta de utilização de derivados de quitosana está baseada em nossos estudos prévios, nos quais nanopartículas mediaram eficiências de transfecção muito significativas, comparáveis ao lipídeo comercial lipofectamina, com um índice de citotoxicidade muito baixo. Além disso, são propostas novas sínteses visando aumentar a biocompatibilidade das nanopartículas bem como a bioresposta no meio intracelular para disparar a liberação do RNA de interferência, buscando-se assim, altas eficiências de transfecção, e um controle eficaz de doenças. O esquema descritivo da proposta é apresentado na Figura 1, e compreendem etapas de síntese da proteína recombinante RANKL, seleção dos aptameros, preparação dos polímeros e das nanopartículas, estudos in vitro como norteadores dos estudos in vivo, estes últimos serão realizados utilizando-se como modelos a artrite reumatóide e a osteoporose secundaria da própria artrite reumatoide.. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (0) / Especialização: (0) / Mestrado acadêmico: (0) / Mestrado profissional: (0) / Doutorado: (0) . , Integrantes: Julio Cesar Fernandes - Integrante / Marcio José Tiera - Integrante / Paulo Peitl - Coordenador., Financiador(es): Fundação de Amparo à Pesquisa do Estado de São Paulo - Auxílio financeiro.

• 2013 - Atual

  Estudo da função de 4-hidroxinonenal na osteoartrite, Descrição: DESCRIÇÃO. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador / Mohamed Benderdour - Integrante / Hassan Fahmi - Integrante / Lekha Sleno - Integrante / Bertrand Lussier - Integrante / Piotr Zimniak - Integrante., Financiador(es): Canadian Institute for Health Research - Auxílio financeiro.

• 2013 - Atual

  Terapia gênica e nanotecnologia, Descrição: DESCRIÇÃO. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador / Qin Shi - Integrante / Mohamed Benderdour - Integrante., Financiador(es): Chaire de recherche en orthopédie de l'HSCM à l'UdeM - Auxílio financeiro.

• 2011 - 2014

  Prevenção sistemática de fraturas frágeis. Acompanhamento de dez anos de estudo, Descrição: DESCRIÇÃO. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador., Financiador(es): Eli Lilly Canada Inc. - Auxílio financeiro.

• 2010 - 2013

  Nanovetores de polímeros catiônicos para transporte de DNA e siRNA em tratamentos experimentais de artirte e fratura de ossos, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador / Qin Shi - Integrante / Mohamed Benderdour - Integrante / Shengrong Guo - Integrante / Li liu - Integrante / Tingting Tang - Integrante / Françoise Martine Winnik - Integrante / Xiaoling Zhang - Integrante., Financiador(es): Canadian institutes of health research - Auxílio financeiro.

• 2009 - 2014

  Implementação de uma profilaxia sistemática da TVP depois de um THR / TKR, Descrição: DESCRIÇÃO. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador., Financiador(es): Sanofi-Aventis (Canadá) - Auxílio financeiro / Boehringer Ingelheim Pharma GmbH & Co. KG - Auxílio financeiro.

• 2009 - 2011

  Terapia gênica direcionada por folato usando nanovetores poliméricos catiônicos e DNA plamídial minicircular em tratamento experimental de atrite, Descrição: DESCRIÇÃO. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador / Qin Shi - Integrante / Mohamed Benderdour - Integrante / Shengrong Guo - Integrante / Li liu - Integrante / Tingting Tang - Integrante / Françoise Martine Winnik - Integrante / Xiaoling Zhang - Integrante., Financiador(es): Canadian institutes of health research - Auxílio financeiro.

• 2009 - 2010

  Alésoir acétabulaire à diamètre variable, Descrição: L'objectif de cette recherche est d'optimiser et vérifier l'efficacité de coupe et d'utilisation de l'instrument proposé. Pour ce faire, le concept sera d'abord raffiné et des prototypes fonctionnels seront fabriqués. Ces prototypes de l'alésoir acétabulaire seront utilisés pour comparer sa performance à celle d'un l'alésoir hémisphérique couramment utilisé en salle d'opération.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (0) / Especialização: (0) / Mestrado acadêmico: (2) / Mestrado profissional: (0) / Doutorado: (0) . , Integrantes: Julio Cesar Fernandes - Integrante / PETIT, Y - Coordenador / Victor Songmene - Integrante., Financiador(es): Natural Sciences and Engineering Research Council of Canada - Auxílio financeiro.

• 2009 - 2010

  Aplicação da terapia gênica utilizando nanovetores poliméricos catiônicos e plasmídeos minicirculares de DNA em atrite experimental, Descrição: DESCRIÇÃO. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador., Financiador(es): Fonds de la recherche en santé du québec - Auxílio financeiro.

• 2008 - 2009

  Nanopartículas polímericas para terapia gênica em artrite experimental, Descrição: DESCRIÇÃO. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador / Qin Shi - Integrante / Kerong Dai - Integrante., Financiador(es): Fonds de la recherche en santé du québec - Auxílio financeiro.

• 2008 - 2009

  Nanovetores poliméricos para terapia gênica, Descrição: DESCRIÇÃO. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador / Qin Shi - Integrante / Kerong Dai - Integrante., Financiador(es): Université de Montreal - Auxílio financeiro.

• 2007 - 2010

  Desenvolvimento de tecnologias biomédicas para diagnóstico quantitativo de pivot shift, Descrição: DESCRIÇÃO. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Coordenador / Nicola Hagemeister - Integrante., Financiador(es): Natural Sciences and Engineering Research Council of Canada - Auxílio financeiro.

• 2005 - 2008

  Efeitos de aldeídos em respostas inflamatórias e catabólicas em cartilagem osteoartrítica, Descrição: DESCRIÇÃO. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Julio Cesar Fernandes - Integrante / Mohamed Benderdour - Coordenador., Financiador(es): Canadian institutes of health research - Auxílio financeiro.

Projetos de desenvolvimento

• 2009 - 2012

  Universal reamer for total hip arthroplasty., Descrição: Design de instrumentação cirúrgica para a artroplastia total do quadril.. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Técnico de nível médio: (1) Mestrado acadêmico: (2) . , Integrantes: Julio Cesar Fernandes - Coordenador / PETIT, Y. - Integrante., Financiador(es): Canadian Institute for Health Research - Auxílio financeiro / Fonds de recherche en sciences naturelles et le génie - Bolsa., Número de produções C, T & A: 2

• 2009 - 2012

  Universal reamer for total hip arthroplasty., Descrição: Design de instrumentação cirúrgica para a artroplastia total do quadril.. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Técnico de nível médio: (1) Mestrado acadêmico: (2) . , Integrantes: Julio Cesar Fernandes - Coordenador / PETIT, Y. - Integrante., Financiador(es): Canadian Institute for Health Research - Auxílio financeiro / Fonds de recherche en sciences naturelles et le génie - Bolsa., Número de produções C, T & A: 2

• 2009 - 2012

  Universal reamer for total hip arthroplasty., Descrição: Design de instrumentação cirúrgica para a artroplastia total do quadril.. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Técnico de nível médio: (1) Mestrado acadêmico: (2) . , Integrantes: Julio Cesar Fernandes - Coordenador / PETIT, Y. - Integrante., Financiador(es): Canadian Institute for Health Research - Auxílio financeiro / Fonds de recherche en sciences naturelles et le génie - Bolsa., Número de produções C, T & A: 2

• 2009 - 2012

  Universal reamer for total hip arthroplasty., Descrição: Design de instrumentação cirúrgica para a artroplastia total do quadril.. , Situação: Concluído; Natureza: Desenvolvimento. , Alunos envolvidos: Técnico de nível médio: (1) Mestrado acadêmico: (2) . , Integrantes: Julio Cesar Fernandes - Coordenador / PETIT, Y. - Integrante., Financiador(es): Fonds de recherche en sciences naturelles et le génie - Bolsa / Canadian Institute for Health Research - Auxílio financeiro., Número de produções C, T & A: 2