Marco Aurelio de Paula Brotto

Pós-doutorado

Idiomas

Orientou

Produções bibliográficas

• MONTE, FELIPE ; AWAD, KAMAL R. ; AHUJA, NEELAM ; KIM, HARRY ; ASWATH, PRANESH ; Brotto, Marco ; VARANASI, VENU G . Amorphous Silicon Oxynitrophosphide Coated Implants Boost Angiogenic Activity of Endothelial Cells. TISSUE ENGINEERING. PART A , v. 31, p. PubMed PMID: 31, 2019.

• MAUREL, DELPHINE B. ; MATSUMOTO, TSUTOMU ; VALLEJO, JULIAN A. ; JOHNSON, MARK L. ; DALLAS, SARAH L. ; KITASE, YUKIKO ; Brotto, Marco ; WACKER, MICHAEL J. ; HARRIS, MARIE A. ; HARRIS, STEPHEN E. ; BONEWALD, LYNDA F. . Characterization of a novel murine Sost ERT2 Cre model targeting osteocytes. Bone Research , v. 7, p. 6, 2019.

• KING, GREGORY W. ; ABREU, EDUARDO L. ; KELLY, PATRICIA J. ; Brotto, Marco . Neural control of postural sway: Relationship to strength measures in young and elderly adults. EXPERIMENTAL GERONTOLOGY , v. 118, p. 39-44, 2019.

• GATCHEL, ROBERT ; BEVERS, KELLEY ; LICCIARDONE, JOHN ; SU, JIANZHONG ; DU, YING ; Brotto, Marco . Transitioning from Acute to Chronic Pain: An Examination of Different Trajectories of Low-Back Pain. Healthcare , v. 6, p. 48, 2018.

• SUTARIYA, VIJAYKUMAR ; TUR, JARED ; KELLY, SHANNON ; HALASZ, KATHLEEN ; CHAPALAMADUGU, KALYAN C. ; NIMBALKAR, ROHINI ; PATHAK, YASHWANT V. ; WEIGEL, ROBERT ; DAVIAU, TODD ; WEBB, TRAVIS ; CACACE, JANICE ; Brotto, Marco ; TIPPARAJU, SRINIVAS M. . Nanodrug delivery platform for glucocorticoid use in skeletal muscle injury. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY , v. 96, p. 681-689, 2018.

• CHAPALAMADUGU, K. C. ; TUR, J. ; BADOLE, S. L. ; KUKREJA, R. C. ; Brotto, M. ; TIPPARAJU, S. M. . Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation. Acta Physiologica , v. 224, p. e13083, 2018.

• AVIN, KEITH G. ; VALLEJO, JULIAN A. ; CHEN, NEAL X. ; WANG, KUN ; TOUCHBERRY, CHAD D. ; Brotto, Marco ; DALLAS, SARAH L. ; MOE, SHARON M. ; WACKER, MICHAEL J. . Fibroblast growth factor 23 does not directly influence skeletal muscle cell proliferation and differentiation or ex vivo muscle contractility. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM , v. 315, p. E594-E604, 2018.

• KITASE, YUKIKO ; VALLEJO, JULIAN A. ; GUTHEIL, WILLIAM ; VEMULA, HARIKA ; JÄHN, KATHARINA ; YI, JIANXUN ; Zhou, Jingsong ; Brotto, Marco ; BONEWALD, LYNDA F. . β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor. Cell Reports , v. 22, p. 1531-1544, 2018.

• WARD, LEANNE M. ; KINNETT, KATHI ; BONEWALD, LYNDA ; ADACHI, JONATHAN D. ; BACHRACH, LAURA ; BELLIDO, TERESITA ; Brotto, Marco ; BONEWALD, LYNDA ; DONOVAN, JOANNE ; HOFFMAN, ERIC ; KINNETT, KATHI ; LEONARD, MARY ; MCMILLAN, HUGH ; NOVOTNY, SUSAN ; RAFAEL-FORTNEY, JILL ; RAUCH, FRANK ; WARD, LEANNE ; WARDEN, STUART . Proceedings of a Parent Project Muscular Dystrophy Bone Health Workshop. NEUROMUSCULAR DISORDERS , v. 28, p. 64-76, 2018.

• HUANG, JIAN ; Romero-Suarez, Sandra ; LARA, NURIA ; Mo, ChengLin ; KAJA, SIMON ; Brotto, Leticia ; DALLAS, SARAH L ; JOHNSON, MARK L ; JÄHN, KATHARINA ; BONEWALD, LYNDA F ; Brotto, Marco . Crosstalk Between MLO-Y4 Osteocytes and C2C12 Muscle Cells Is Mediated by the Wnt/β-Catenin Pathway. JBMR Plus , v. 1, p. 86-100, 2017.

• WANG, ZHIYING ; BIAN, LIANGQIAO ; Mo, ChengLin ; KUKULA, MACIEJ ; SCHUG, KEVIN A. ; Brotto, Marco . Targeted quantification of lipid mediators in skeletal muscles using restricted access media-based trap-and-elute liquid chromatography-mass spectrometry. ANALYTICA CHIMICA ACTA , v. 984, p. 151-161, 2017.

• BHAN, ARUNODAY ; DEB, PAROMITA ; SHIHABEDDIN, NADINE ; ANSARI, KHAIRUL I. ; Brotto, Marco ; MANDAL, SUBHRANGSU S. . Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia. GENE , v. 629, p. 16-28, 2017.

• WACKER, MICHAEL J. ; TOUCHBERRY, CHAD D. ; SILSWAL, NEERUPMA ; Brotto, Leticia ; ELMORE, CHRIS J. ; BONEWALD, LYNDA F. ; ANDRESEN, JON ; Brotto, Marco . Skeletal Muscle, but not Cardiovascular Function, Is Altered in a Mouse Model of Autosomal Recessive Hypophosphatemic Rickets. Frontiers in Physiology , v. 7, p. PubMed PMID: 31, 2016.

• VALLEJO, JULIAN ; SPENCE, MADOKA ; CHENG, AN-LIN ; Brotto, Leticia ; EDENS, NEILE K. ; GARVEY, SEAN M. ; Brotto, Marco . Cellular and Physiological Effects of Dietary Supplementation with β-Hydroxy-β-Methylbutyrate (HMB) and β-Alanine in Late Middle-Aged Mice. PLoS One , v. 11, p. e0150066, 2016.

• KING, GREGORY W. ; ABREU, EDUARDO L. ; CHENG, AN-LIN ; CHERTOFF, KEYNA K. ; Brotto, Leticia ; KELLY, PATRICIA J. ; Brotto, Marco . A multimodal assessment of balance in elderly and young adults. Oncotarget , v. 7, p. PubMed PMID: 31, 2016.

• GORSKI, JEFF P. ; HUFFMAN, NICHOLE T. ; VALLEJO, JULIAN ; Brotto, Leticia ; CHITTUR, SRIDAR V. ; BREGGIA, ANNE ; STERN, AMBER ; HUANG, JIAN ; Mo, ChengLin ; SEIDAH, NABIL G. ; BONEWALD, LYNDA ; Brotto, Marco . Deletion of ( , , ) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age. JOURNAL OF BIOLOGICAL CHEMISTRY , v. 291, p. 4308-4322, 2016.

• Brotto, Marco ; BONEWALD, LYNDA . Bone and muscle: Interactions beyond mechanical. BONE , v. 80, p. 109-114, 2015.

• Mo, ChengLin ; ZHAO, RUONAN ; VALLEJO, JULIAN ; IGWE, ORISA ; BONEWALD, LYNDA ; WETMORE, LORI ; Brotto, Marco . Prostaglandin E promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation. CELL CYCLE , v. 14, p. 1507-1516, 2015.

• LLANQUE, SARAH M. ; ENRIQUEZ, MAITHE ; CHENG, AN-LIN ; DOTY, LEILANI ; Brotto, Marco A. ; KELLY, PATRICIA J. ; NIEDENS, MICHELLE ; CASERTA, MICHAEL S. ; SAVAGE, LYNETTE M. . The Family Series Workshop. American Journal of Alzheimers Disease and Other Dementias , v. 30, p. 573-583, 2015.

• GARIMELLA, RAMA ; WASHINGTON, LAURIE ; Isaacson, Janalee ; VALLEJO, JULIAN ; SPENCE, MADOKA ; TAWFIK, OSSAMA ; ROWE, PETER ; Brotto, Marco ; PEREZ, RAYMOND . Extracellular Membrane Vesicles Derived from 143B Osteosarcoma Cells Contain Pro-Osteoclastogenic Cargo: A Novel Communication Mechanism in Osteosarcoma Bone Microenvironment. Translational Oncology , v. 7, p. 331-340, 2014.

• MUKAI, TOMOYUKI ; ISHIDA, SHU ; ISHIKAWA, REMI ; YOSHITAKA, TERUHITO ; KITTAKA, MIZUHO ; GALLANT, RICHARD ; LIN, YI-LING ; ROTTAPEL, ROBERT ; Brotto, Marco ; REICHENBERGER, ERNST J ; UEKI, YASUYOSHI . SH3BP2 Cherubism Mutation Potentiates TNF-α-Induced Osteoclastogenesis via NFATc1 and TNF-α-Mediated Inflammatory Bone Loss. JOURNAL OF BONE AND MINERAL RESEARCH , v. 29, p. 2618-2635, 2014.

• SMITH, JOAN R. ; MCGRATH, JACQUELINE ; Brotto, Marco ; INDER, TERRIE . A Randomized-Controlled Trial Pilot Study Examining the Neurodevelopmental Effects of a 5-Week M Technique Intervention on Very Preterm Infants. Advances in Neonatal Care , v. 14, p. 187-200, 2014.

• CHOU, WEI-CHUN ; CHENG, AN-LIN ; Brotto, Marco ; CHUANG, CHUN-YU . Visual gene-network analysis reveals the cancer gene co-expression in human endometrial cancer. BMC GENOMICS , v. 15, p. 300, 2014.

• HUANG, JIAN ; HSU, YI-HSIANG ; Mo, ChengLin ; Abreu, Eduardo ; KIEL, DOUGLAS P ; BONEWALD, LYNDA F ; Brotto, Marco ; KARASIK, DAVID . Is a Potential Pleiotropic Gene for Osteoporosis and Sarcopenia Acting Through the Modulation of the NF-κB Signaling Pathway. JOURNAL OF BONE AND MINERAL RESEARCH , v. 29, p. 1531-1540, 2014.

• Brotto, Marco ; JOHNSON, MARK L. . Endocrine Crosstalk Between Muscle and Bone. Current Osteoporosis Reports , v. 12, p. 135-141, 2014.

• MANRING, HEATHER ; Abreu, Eduardo ; Brotto, Leticia ; Weisleder, Noah ; Brotto, Marco . Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases. Frontiers in Physiology , v. 5, p. PubMed PMID: 31, 2014.

• ABREU, EDUARDO L. ; CHENG, AN-LIN ; KELLY, PATRICIA J. ; CHERTOFF, KEYNA ; Brotto, Leticia ; GRIFFITH, ELIZABETH ; KINDER, GLENDA ; URIDGE, TINA ; ZACHOW, ROB ; Brotto, Marco . Skeletal Muscle Troponin as a Novel Biomarker to Enhance Assessment of the Impact of Strength Training on Fall Prevention in the Older Adults. NURSING RESEARCH , v. 63, p. 75-82, 2014.

• BALL, STEPHEN ; GAMMON, ROBIN ; KELLY, PATRICIA J. ; CHENG, AN-LIN ; CHERTOFF, KEYNA ; KAUME, LYDIA ; ABREU, EDUARDO L. ; Brotto, Marco . Outcomes of Stay Strong, Stay Healthy in Community Settings. JOURNAL OF AGING AND HEALTH , v. 25, p. 1388-1397, 2013.

• CESAR PAULILLO, LUIS ; Mo, ChengLin ; Isaacson, Janalee ; Lessa, Luciene ; Lopes, Edjacy ; Romero-Suarez, Sandra ; Brotto, Leticia ; Abreu, Eduardo ; GUTHEIL, WILLIAM ; Brotto, Marco . Jatropha curcas: From Biodiesel Generation to Medicinal Applications. Recent Patents on Biotechnology , v. 6, p. 192-199, 2012.

• PAULILLO, L. C. M. S. ; ANDRADE JUNIOR, S. J. ; GESTEIRA, A. S. ; Marco Aurélio de Paula Brotto ; GOES-NETO, A. . 'Generation of a cDNA library reveals the presence of a Ty-1/copia transposon in Phellinus rimosus (Hymenochaetaceae, Basidiomycota)'. Journal of Yeast and Fungal Research , v. 3, p. 18-24, 2012.

• PAULILLO, LUIS CESAR MAFFEI SARTINI ; MAGNO SEBBENN, ALEXANDRE ; DE CARVALHO DERBYSHIRE, MARIA TEREZA VITRAL ; GÓES-NETO, ARISTÓTELES ; de Paula Brotto, Marco Aurélio ; FIGUEIRA, ANTONIO . EVALUATION OF IN VITRO AND IN VIVO EFFECTS OF SEMIPURIFIED PROTEINASE INHIBITORS FROM THEOBROMA SEEDS ON MIDGUT PROTEASE ACTIVITY OF LEPIDOPTERAN PEST INSECTS. Archives of Insect Biochemistry and Physiology , v. -, p. -, 2012.

• Silswal, N. ; Parelkar, N. K. ; Wacker, M. J. ; Brotto, M. ; Andresen, J. . Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction. American Journal of Physiology. Heart and Circulatory Physiology , v. 300, p. H2016-H2026, 2011.

• Brotto, Marco ; Brotto, Leticia ; Jin, J.-P. ; Nosek, Thomas M. ; Romani, Andrea . Temporal Adaptive Changes in Contractility and Fatigability of Diaphragm Muscles from Streptozotocin-Diabetic Rats. Journal of Biomedicine and Biotechnology , v. 2010, p. 1-9, 2010.

• Zhao, X. ; Yamazaki, D. ; Park, K. H. ; Komazaki, S. ; Tjondrokoesoemo, A. ; Nishi, M. ; Lin, P. ; Hirata, Y. ; Brotto, M. ; Takeshima, H. ; Ma, J. . Ca2+ Overload and Sarcoplasmic Reticulum Instability in tric-a Null Skeletal Muscle. The Journal of Biological Chemistry (Print) , v. 285, p. 37370-37376, 2010.

• 2009 Kosloski, L. M. ; Gilbert, W. J. R. ; Touchberry, C. D. ; Moore, D. S. ; Kelly, J. K. ; Brotto, M. ; Orr, J. A. . Inhibition of Thromboxane A2-Induced Arrhythmias and Intracellular Calcium Changes in Cardiac Myocytes by Blockade of the Inositol Trisphosphate Pathway. The Journal of Pharmacology and Experimental Therapeutics (Print) , v. 331, p. 917-924, 2009.

• Brotto, Marco ; Shen, Jinhua ; Yu, Wen-Mei ; Scherman, Joseph A. ; Guo, Caiying ; Stoddard, Christopher ; Nosek, Thomas M. ; Valdivia, Héctor H. ; Qu, Cheng-Kui . Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis. Nature Cell Biology , v. 11, p. 769-776, 2009.

• Cai, Chuanxi ; Masumiya, Haruko ; Weisleder, Noah ; Matsuda, Noriyuki ; Nishi, Miyuki ; Hwang, Moonsun ; Ko, Jae-Kyun ; Lin, Peihui ; Thornton, Angela ; Zhao, Xiaoli ; Pan, Zui ; Komazaki, Shinji ; Brotto, Marco ; Takeshima, Hiroshi ; Ma, Jianjie . MG53 nucleates assembly of cell membrane repair machinery. Nature Cell Biology , v. 11, p. 56-64, 2008.

• Zhao, Xiaoli ; Weisleder, Noah ; Thornton, Angela ; Oppong, Yaa ; Campbell, Rachel ; Ma, Jianjie ; Brotto, Marco . Compromised store-operated Ca 2 entry in aged skeletal muscle. Aging Cell , v. 7, p. 561-568, 2008.

• Zhao, X. ; Weisleder, N. ; Han, X. ; Pan, Z. ; Parness, J. ; Brotto, M. ; Ma, J. . Azumolene Inhibits a Component of Store-operated Calcium Entry Coupled to the Skeletal Muscle Ryanodine Receptor. The Journal of Biological Chemistry (Print) , v. 281, p. 33477-33486, 2006.

• Weisleder, N. ; BROTTO, M . Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release. The Journal of Cell Biology , v. 174, p. 639-645, 2006.

• HIRATA, Y ; BROTTO, M ; WEISLEDER, N ; CHU, Y ; LIN, P ; ZHAO, X ; THORNTON, A ; KOMAZAKI, S ; TAKESHIMA, H ; MA, J ; BROTTO, M . Uncoupling Store-Operated Ca2+ Entry and Altered Ca2+ Release from Sarcoplasmic Reticulum through Silencing of Junctophilin Genes. Biophysical Journal (Print) , v. 90, p. 4418-4427, 2006.

• Brotto, M. A. ; BROTTO, M . Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility. American Journal of Physiology. Cell Physiology , v. 290, p. C567-C576, 2005.

• Wang, Xu ; Weisleder, Noah ; Collet, Claude ; Zhou, Jingsong ; Chu, Yi ; Hirata, Yutaka ; Zhao, Xiaoli ; Pan, Zui ; Brotto, Marco ; Cheng, Heping ; Ma, Jianjie . Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle. Nature Cell Biology , v. 7, p. 525-530, 2005.

• BROTTO, M. A. P. . Functional and biochemical modifications in skeletal muscles from malarial mice. Experimental Physiology , v. 90, p. 417-425, 2005.

• Zhao, X. ; BROTTO, M . Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice. Physiological Genomics (Print) , v. 23, p. 72-78, 2005.

• BROTTO, Marco A P ; NAGARAJ, Ramakrishnan Y ; BROTTO, Leticia S ; Takeshima, Hiroshi ; Ma, Jianjie ; NOSEK, Thomas M ; BROTTO, M . Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null mice. Cell Research , v. 14, p. 373-378, 2004.

• NOSEK, T ; BROTTO, M ; JIN, J ; BROTTO, M . Troponin T isoforms alter the tolerance of transgenic mouse cardiac muscle to acidosis. Archives of Biochemistry and Biophysics (Print) , v. 430, p. 178-184, 2004.

• Abe, K ; Brotto, M. . A novel stop codon mutation in the PMP22 gene associated with a variable phenotype. Neuromuscular Disorders , v. 14, p. 313-320, 2004.

• de Paula Brotto, M. A. ; BROTTO, M . Temporal Effects of Stress by Immobilization and Sensitivity of the Isolated Rat Pacemaker to Isoproterenol: Roles of Corticosterone, Neuronal Uptake, and  -Adrenergic Homogeneity. The Journal of Pharmacology and Experimental Therapeutics (Print) , v. 306, p. 1152-1158, 2003.

• Jin, J.-P. ; BROTTO, M . Truncation by Glu180 Nonsense Mutation Results in Complete Loss of Slow Skeletal Muscle Troponin T in a Lethal Nemaline Myopathy. The Journal of Biological Chemistry (Print) , v. 278, p. 26159-26165, 2003.

• de Paula Brotto, Marco ; Van Leyen, Sheila ; Brotto, Leticia ; Jin, Jian-Ping ; Nosek, Christopher ; Nosek, Thomas ; BROTTO, M . Hypoxia/fatigue-induced degradation of troponin I and troponin C: new insights into physiologic muscle fatigue. Pfluegers Archiv , v. 442, p. 738-744, 2001.

• Conway, S ; BROTTO, M . Neural Crest is Involved in Development of Abnormal Myocardial Function. Journal of Molecular and Cellular Cardiology , v. 29, p. 2675-2685, 1997.

• MAUGHAN, D ; MOLLOY, J ; BROTTO, M ; GODT, R ; BROTTO, M . Approximating the isometric force-calcium relation of intact frog muscle using skinned fibers. Biophysical Journal (Print) , v. 69, p. 1484-1490, 1995.

• BROTTO, M. A. P. ; FOGA'A, R. T. H. ; CREAZZO, T. L. ; GODT, R. E. ; NOSEK, T. M. . The effect of 2,3-butanedione 2-monoxime (BDM) on ventricular trabeculae from the avian heart. Journal of Muscle Research and Cell Motility , v. 16, p. 1-10, 1995.

• BROTTO, M ; BURCH, J. ; CREAZZO, T. . The Excitation-Contraction Coupling in Cardiac Dysmorphogenesis.. In: Lippincott-Raven Publishers. (Org.). The Developing Heart. Philadelphia: Lippincott-Raven, 1997, v. , p. 313-324.

• Brotto, Leticia ; Paulillo, Luis ; Lopes, Edjacy ; Mo, ChengLin ; Isaacson, Janalee ; Carneiro, Pedro ; Lessa, Luciene ; Romero-Suarez, Sandra ; Abreu, Eduardo ; Brotto, Marco A. . PinhãO-Manso: A Native Jatropha Curcas from Brazil Protects Muscle Cells from Ethanol Toxicity and Improves Muscle Function. In: 55th International Biophysical Society Meeting in Baltimore Maryland-USA, 2011, 2011, Baltimore Maryland-USA. Biophysical Journal. Baltimore Maryland-USA: Biophysical Journal, 2011. v. 100. p. 288-288.

Projetos de pesquisa

• 2019 - Atual

  Preserving mitochondria function for alleviating ALS Progression, Descrição: The goal of this proposal is to investigate to study how changes in specific substrate availability in skeletal muscle contribute to diabetic related injury, and to test new strategies to prevent and treat muscle injury induced by diabetic muscle disorder.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marco Aurelio de Paula Brotto - Coordenador.

• 2019 - Atual

  Preserving mitochondria function for alleviating ALS Progression, Descrição: The goal of this proposal is to investigate the role of ROS on the progression of ALS and more specifically how the leaky gut observed on ALS affects muscle function via ROS and lipid signaling.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marco Aurelio de Paula Brotto - Coordenador.

• 2018 - Atual

  Osteocyte Regulation of Bone/Muscle with Age, Descrição: The goal of this program project grant is to investigate the biochemical signaling mechanisms regulating specific factors that influence the health and function of each tissue vice-versa during aging using cell and via the Wnt/-catenin pathway during aging.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marco Aurelio de Paula Brotto - Coordenador.

• 2018 - Atual

  Regulation of Store-Operated Calcium Entry during Muscle Aging, Descrição: The Brotto Lab will be in charge of conducting all studies at carrying out the specific aims related to testing the function of MG29 mutants and overexpressing constructs as well as the manipulations to reduce the levels of MG29.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marco Aurelio de Paula Brotto - Coordenador.

• 2018 - Atual

  Loss of Numb in Muscle Dysfunction in Aging, Descrição: The goal of this proposal is to investigate the role of the Numb gene/protein in EC muscle aging through its effects on regulation of the EC coupling process.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marco Aurelio de Paula Brotto - Coordenador.

• 2016 - Atual

  Targeting Sympathetic Overactivity in CKD Patients: Mechanisms & Novel Therapies, Descrição: The goal of this study is to determine the specific mechanisms leading to hyperactivity of the sympathetic system in CKD patients. Due to the participation of the musculoskeletal system and potential new biomarkers, I am contributing as a Co-Investigator as well as my laboratory.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marco Aurelio de Paula Brotto - Coordenador.

• 2012 - 2015

  Dale & Dorothy Thompson Endowment Fund, Situação: Concluído; Natureza: Pesquisa. , Integrantes: Marco Aurelio de Paula Brotto - Coordenador., Financiador(es): Dale & Dorothy Thompson Endowment Fund - Auxílio financeiro.

• 2012 - Atual

  NIH- National Institute on Aging P01, Descrição: Osteocyte Regulation of Bone/ Muscle with Age. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marco Aurelio de Paula Brotto - Coordenador / L Bonewald - Integrante / S Dallas - Integrante / M Johnson - Integrante., Financiador(es): National Institutes of Health - Auxílio financeiro.

• 2011 - 2014

  Investigação dos efeitos e mecanismos de ação dos extratos de plantas nativas do NE Brasileiro, em modelos mamíferos visando o desenvolvimento de novos fármacos para tratamento de miopatias cardíacas e musculares alcoólicas e outras formas de intoxicação, Descrição: Preedy e colaboradores calcularam que miopatia alcoólica é a mais prevalente forma de doença muscular no mundo ocorrendo em mais de 50% daqueles que abusam do álcool mesmo que moderadamente. O etanol e seu principal subproduto, o acetil aldeído são inibidores potentes da síntese protéica muscular, e tanto proteínas contráteis como não contráteis são danificadas pelo álcool. Estes efeitos são causados por uso agudo e crônico que também causam redução da atividade do RNA muscular por mecanismos que envolvem o aumento das atividades da RNAse. Pesquisas recentes no Brasil indicam que o problema não é diferente no nosso país, e que de fato esse está se tornando um problema seríssimo para a saúde e economia . É possível que o extrato de pinhão-manso interaja com proteínas relacionadas ao processo agudo de reparo muscular, como por exemplo a proteína MG53 , e acelere o processo agudo de reparo (patching)? Esta, e outras perguntas de fundamental importância fisiológica serão respondidas ao realizarmos este projeto.. , Situação: Concluído; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (2) / Mestrado profissional: (1) . , Integrantes: Marco Aurelio de Paula Brotto - Integrante / Marco Aurélio de Paula Brotto - Coordenador / Luis Cesar Maffei Sartini Paulillo - Integrante., Financiador(es): Conselho Nacional de Desenvolvimento Científico e Tecnológico - Auxílio financeiro.

• 2010 - Atual

  National Institute of Health, NIAMS R01AR-0027581-A1 (Ueki, Yasu), Descrição: Molecular Mechanisms of Cherubism. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marco Aurelio de Paula Brotto - Coordenador., Financiador(es): National Institutes of Health - Auxílio financeiro.

• 2009 - 2012

  Bone-Muscle Crosstalk, Descrição: NIH Funded Grant. , Situação: Em andamento; Natureza: Pesquisa. , Alunos envolvidos: Graduação: (1) / Mestrado acadêmico: (2) / Doutorado: (2) . , Integrantes: Marco Aurelio de Paula Brotto - Coordenador.

• 2000 - Atual

  Store-operated calcium entry in muscle health, aging and fatigue, Descrição: During aging skeletal muscles become weaker and hundreds of millions of individuals become afflicted by a condition named sarcopenia. While some of the changes that take place in aged skeletal muscles are directly related to muscle atrophy, changes in contractile apparatus function cannot fully explain the decrease in the specific force during aging. Our recent studies revealed that muscle aging is associated with compromised store-operated calcium entry (SOCE, see figure below), the elemental process for refilling of the intracellular calcium stores in skeletal muscles and the majority of cells studied to date. As calcium (Ca) entry is chronically reduced in aged muscle fibers, Ca storage in the muscles decrease making less Ca available for each contraction-relaxation cycle, leading to reduced contractile force and fatigue. Thus, my lab was among the first to demonstrate that effective SOCE is essential for normal muscle contractility. Our research involves the use of genetically modified mouse models, molecular-genetic manipulations, muscle contractility studies, calcium imaging and a number of biochemical and biophysical approaches. We always combine in vitro with in vivo approaches to create a broader understanding of physiological phenomena. A number of our studies are now being expanded to humans? patients with different muscle diseases.. , Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Marco Aurelio de Paula Brotto - Coordenador.