Ângela Zanatta

Pós-doutorado

Formação complementar

Idiomas

Organização de eventos

Participação em eventos

Participação em bancas

Produções bibliográficas

• SIQUEIRA, L. ; RODRIGUES, F. V. F. ; Zanatta, Ângela ; GONCALVES, J. I. B. ; GHILARDI, I. M. ; ALCARÁ, ALLAN ; BECKER, N. B. ; PINZETTA, G. ; ZANIRATI, G. ; BECKER, B. M. A. ; ERWIG, H. ; COSTA, J. C. ; MARINOWIC, DANIEL . Evaluation of the effects of the Zika Virus-Immunoglobulin G + complex on murine microglial cells. Journal Of Neurovirology , v. 30, p. 477-488, 2024.

• MARINOWIC, DANIEL ; ZANIRATI, GABRIELE ; AZEVEDO, PAMELLA ; Zanatta, Ângela ; PLENTZ, ISMAEL ; ALCARÁ, ALLAN ; MORRONE, FERNANDA ; SCHEFFEL, THAMIRIS ; CAPPELLARI, ANGÉLICA ; ROEHE, PAULO ; VARELA, ANA PAULA ; MACHADO, DENISE ; VIOLA, FABIANA ; DA COSTA, JADERSON . Influence of Zika virus on the cytotoxicity, cell adhesion, apoptosis and inflammatory markers of glioblastoma cells. Oncology Letters , v. 27, p. 176, 2024.

• RIBEIRO, RAFAEL TEIXEIRA ; Seminotti, Bianca ; Zanatta, Ângela ; DE OLIVEIRA, FRANCINE HEHN ; Amaral, Alexandre Umpierrez ; LEIPNITZ, Guilhian ; WAJNER, Moacir . Neuronal Death, Glial Reactivity, Microglia Activation, Oxidative Stress and Bioenergetics Impairment Caused by Intracerebroventricular Administration of D-2-hydroxyglutaric Acid to Neonatal Rats. NEUROSCIENCE , v. 471, p. 115-132, 2021.

• Seminotti, Bianca ; ROGINSKI, ANA CRISTINA ; Zanatta, Ângela ; Amaral, Alexandre Umpierrez ; FERNANDES, THABATA ; SPANNENBERGER, KALEB PINTO ; DA SILVA, LUCAS HENRIQUE RODRIGUES ; RIBEIRO, RAFAEL TEIXEIRA ; LEIPNITZ, Guilhian ; WAJNER, Moacir . S-adenosylmethionine induces mitochondrial dysfunction, permeability transition pore opening and redox imbalance in subcellular preparations of rat liver. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES , v. 53, p. 525-539, 2021.

• Seminotti, Bianca ; Zanatta, Ângela ; RIBEIRO, RAFAEL TEIXEIRA ; DA ROSA, MATEUS STRUECKER ; WYSE, ANGELA T. S. ; LEIPNITZ, Guilhian ; WAJNER, Moacir . Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats. MOLECULAR NEUROBIOLOGY , v. 56, p. 2760-2773, 2019.

• ZANATTA, Â. ; CECATTO, CRISTIANE ; RIBEIRO, R. T. ; Amaral AU ; WYSE, A.T.S. ; LEIPNITZ, G. ; WAJNER, M . S-Adenosylmethionine Promotes Oxidative Stress and Decreases Na+, K+-ATPase Activity in Cerebral Cortex Supernatants of Adolescent Rats: Implications for the Pathogenesis of S-Adenosylhomocysteine Hydrolase Deficiency. MOLECULAR NEUROBIOLOGY , v. 55, p. 5868-5878, 2018.

• RIBEIRO, R. T. ; Zanatta, ÿngela ; Amaral AU ; Leipnitz G. ; OLIVEIRA, F. H. ; Seminotti B. ; WAJNER, M. . Experimental evidence that in vitro intracerebral administration of L-2-hydroxyglutaric acid to neonatal rats provokes disruption of redox status and histopatological abnormalities in the brain. NEUROTOXICITY RESEARCH , v. 33, p. 681-692, 2018.

• CECATTO, CRISTIANE ; Amaral, Alexandre Umpierrez ; DA SILVA, JANAÍNA CAMACHO ; WAJNER, ALESSANDRO ; DE OLIVEIRA VARGAS SCHIMIT, MARIANA ; DA SILVA, LUCAS HENRIQUE RODRIGUES ; WAJNER, SIMONE MAGAGNIN ; Zanatta, Ângela ; CASTILHO, ROGER FRIGÉRIO ; WAJNER, Moacir . Metabolite accumulation in VLCAD deficiency markedly disrupts mitochondrial bioenergetics and Ca homeostasis in the heart. FEBS Journal , v. 285, p. 1437-1455, 2018.

• ANDRADE, R. B. ; GEMELLI, T. ; ROJAS, D. B. ; KIM, T. D. H. ; ZANATTA, A. ; SCHMITZ, F. ; RODRIGUES, A. F. ; WYSE, A.T.S. ; WAJNER, Moacir ; Dutra Filho, Carlos S. ; WANNMACHER, C . Evaluation of oxidative stress and energy metabolism in cerebral cortex of rats subjected to sarcosine administration. Molecular Neurobiology , v. 54, p. 4496-4506, 2017.

• RODRIGUES, M. D. N. ; Seminotti, Bianca ; ZANATTA, A. ; GONCALVES, A. M. ; BELLAVER, B. ; Amaral AU ; QUINCOZES-SANTOS, A. ; GOODMAN, S. ; WOOTNER, M. ; DE SOUZA, DIOGO ONOFRE GOMES ; WAJNER, M . Higher Vulnerability of Menadione-Exposed Cortical Astrocytes of Glutaryl-CoA Dehydrogenase Deficient Mice to Oxidative Stress, Mitochondrial Dysfunction, and Cell Death: Implications for the Neurodegeneration in Glutaric Aciduria Type I.. Molecular Neurobiology , v. 54, p. 4795-4805, 2017.

• SILVA, J. C. ; Amaral AU ; CECATTO, CRISTIANE ; WAJNER, A. ; GODOY, K. S. ; RIBEIRO, R. T. ; GONCALVES, A. M. ; Zanatta, Ângela ; ROSA, M. S. ; LOUREIRO, S. O. ; Vargas, Carmen R. ; LEIPNITZ, G. ; SOUZA, D. G. ; WAJNER, M . α-Ketoadipic acid and α-aminoadipic acid cause disturbance of glutamatergic neurotransmission and induction of oxidative stress in vitro in brain of adolescent rats. NEUROTOXICITY RESEARCH , v. 32, p. 276-290, 2017.

• ANDRADE, VIVIAN STRASSBURGER ; ROJAS, DENISE BERTIN ; DE ANDRADE, RODRIGO BINKOWSKI ; KIM, TOMAS DUK HWA ; VIZUETE, ADRIANA FERNANDA ; Zanatta, Ângela ; WAJNER, Moacir ; GONÇALVES, CARLOS-ALBERTO SARAIVA ; WANNMACHER, CLOVIS MILTON DUVAL . A Possible Anti-Inflammatory Effect of Proline in the Brain Cortex and Cerebellum of Rats. MOLECULAR NEUROBIOLOGY , v. 55, p. 4068-4077, 2017.

• GEMELLI, T. ; ANDRADE, R. B. ; ROJAS, DENISE BERTIN ; Zanatta, Ângela ; SCHIRMBECK, G. ; FUNCHAL, C. ; Wajner, Moacir ; DUTRA-FILHO, C. S. ; WANNMACHER, CLOVIS MILTON DUVAL . Chronic Exposure to β-Alanine Generates Oxidative Stress and Alters Energy Metabolism in Cerebral Cortex and Cerebellum of Wistar Rats.. MOLECULAR NEUROBIOLOGY , v. 55, p. 5101-5110, 2017.

• Zanatta, ÿngela ; RODRIGUES, M. D. N. ; Amaral AU ; SOUZA, D. G. ; QUINCOZES-SANTOS, A. ; WAJNER, M . Ornithine and homocitrulline impair mitochondrial function, decrease antioxidant defenses and induce cell death in menadione-stressed rat cortical astrocytes: potential mechanisms of neurological dysfunction in HHH syndrome. Neurochemical Research , v. 41, p. 2190-2198, 2016.

• Zanatta, Ângela ; Viegas CM ; HICKMANN, F. H. ; MONTEIRO, W. O. ; SITTA, A. ; COELHO, D. M. ; Vargas, Carmen R. ; LEIPNITZ, G. ; WAJNER, M . Ornithine In Vivo Administration Disrupts Redox Homeostasis and Decreases Synaptic Na+, K+-ATPase Activity in Cerebellum of Adolescent Rats: Implications for the Pathogenesis of Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) Syndrome. Cellular and Molecular Neurobiology , v. 35, p. 797-806, 2015.

• Fernandes CG ; PIEROZAN, P. ; SOARES, G. M. ; FERREIRA, F. ; Zanatta, Ângela ; Amaral, Alexandre Umpierrez ; Borges, CG ; WAJNER, Moacir ; PESSOA-PUREUR, R. . NMDA receptors and oxidative stress induced by the major metabolites accumulating in HMG lyase deficiency mediate hypophosphorylation of cytoskeletal proteins in brain from adolescent rats: potential mechanisms contributing to the neuropathology of this disease. Neurotoxicity Research , v. 28, p. 239-252, 2015.

• BORGES, C.G. ; CANANI, C.R. ; FERNANDES, C.G. ; ZANATTA, Â. ; SEMINOTTI, B. ; RIBEIRO, C.A.J. ; LEIPNITZ, G. ; VARGAS, C.R. ; WAJNER, M. . Reactive nitrogen species mediate oxidative stress and astrogliosis provoked by in vivo administration of phytanic acid in cerebellum of adolescent rats: A potential contributing pathomechanism of cerebellar injury in peroxisomal disorders. Neuroscience , v. 304, p. 122-132, 2015.

• Busanello, Estela Natacha Brandt ; Lobato, Vannessa Araujo ; Zanatta, Ângela ; Borges, CG ; Tonin, Anelise Miotti ; VIEGAS, Carolina Maso ; MANFREDINI, V. ; RIBEIRO, C. A. J. ; Vargas, Carmen R. ; SOUZA, D. O. G. ; Wajner, Moacir . Pristanic Acid Provokes Lipid, Protein, and DNA Oxidative Damage and Reduces the Antioxidant Defenses in Cerebellum of Young Rats. Cerebellum (London. Print) , v. 13, p. 751-759, 2014.

• VIEGAS, C. M. ; ZANATTA, Â. ; Grings, M. ; HICKMANN, F. H. ; MONTEIRO, W. O. ; SOARES, L. E. ; SITTA, Â. ; LEIPNITZ, G. ; DE OLIVEIRA, F. H. ; WAJNER, M. . Disruption of redox homeostasis and brain damage caused in vivo by methylmalonic acid and ammonia in cerebral cortex and striatum of developing rats. Free Radical Research , v. 48, p. 659-669, 2014.

• Busanello, Estela Natacha Brandt ; LOBATO, VANNESSA GONÇALVES ARAUJO ; Zanatta, Ângela ; VIEGAS, Carolina Maso ; RIBEIRO, CÉSAR AUGUSTO JOÃO ; WAJNER, Moacir . Disruption of oxidative phosphorylation and synaptic Na+, K+-ATPase activity by pristanic acid in cerebellum of young rats. Life Sciences (1973) , v. 94, p. 67-73, 2014.

• Busanello EN ; Amaral AU ; TONIN, A. M. ; ZANATTA, A. ; Viegas CM ; Vargas, Carmen Regla ; Wajner, Moacir . Disruption of Mitochondrial Homeostasis by Phytanic Acid in Cerebellum of Young Rats. Cerebellum (London. Print) , v. 12, p. 362-369, 2013.

• Moura, AP ; Grings, Mateus ; PARMEGGIANI, B. S. ; MARCOWICH, G. ; Tonin, Anelise M. ; VIEGAS, Carolina Maso ; Zanatta, Ângela ; RIBEIRO, CÉSAR AUGUSTO JOÃO ; Wajner, Moacir ; Leipnitz, Guilhian . Glycine Intracerebroventricular Administration Disrupts Mitochondrial Energy Homeostasis in Cerebral Cortex and Striatum of Young Rats. Neurotoxicity Research , v. 24, p. 502-511, 2013.

• Zanatta, Ângela ; VIEGAS, Carolina Maso ; Tonin, Anelise Miotti ; Busanello, Estela Natacha Brandt ; Grings, Mateus ; Moura, Alana Pimentel ; LEIPNITZ, Guilhian ; Wajner, Moacir . Disturbance of redox homeostasis by ornithine and homocitrulline in rat cerebellum: A possible mechanism of cerebellar dysfunction in HHH syndrome. Life Sciences (1973) , v. 93, p. 161-168, 2013.

• Moura, Alana Pimentel ; Ribeiro, César Augusto João ; Zanatta, ÿngela ; Busanello, Estela Natacha Brandt ; Tonin, Anelise Miotti ; Wajner, Moacir . 3-Methylcrotonylglycine Disrupts Mitochondrial Energy Homeostasis and Inhibits Synaptic Na+,K+-ATPase Activity in Brain of Young Rats. Cellular and Molecular Neurobiology , v. 32, p. 297-307, 2012.

• Grings, Mateus ; Tonin, Anelise Miotti ; Knebel, Lisiane Aurélio ; Zanatta, ÿngela ; Moura, Alana Pimentel ; Filho, Carlos Severo Dutra ; Wajner, Moacir ; Leipnitz, Guilhian . Phytanic acid disturbs mitochondrial homeostasis in heart of young rats: a possible pathomechanism of cardiomyopathy in Refsum disease. Molecular and Cellular Biochemistry , v. 366, p. 335-343, 2012.

• TONIN, A. M. ; GRINGS, M. ; KNEBEL, L. A. ; ZANATTA, A. ; MOURA, A. P. ; RIBEIRO, C. A. J. ; LEIPNITZ, G. ; WAJNER, M . Disruption of redox homeostasis in cerebral cortex of developing rats by acylcarnitines accumulating in medium-chain acyl-CoA dehydrogenase deficiency.. International Journal of Developmental Neuroscience , v. 30, p. 383-390, 2012.

• Knebel, LA ; Zanatta, Ângela ; TONIN, A. M. ; Grings, M ; ALVORCEM, L. M. ; Wajner, Moacir ; Leipnitz G. . 2-Methylbutyrylglycine induces lipid oxidative damage and decreases the antioxidant defenses in rat brain. Brain Research , v. 1478, p. 74-82, 2012.

• Amaral, Alexandre Umpierrez ; Seminotti B. ; Ceccatto, C ; Fernandes CG ; Busanello EN ; ZANATTA, A. ; KIST, L. W. ; BOGO, M. R. ; SOUZA, D. G. ; WOOTNER, M. ; GOODMAN, S. ; KOELLER, D. M. ; WAJNER, M. . Reduction of Na+, K+-ATPase activity and expression in cerebral cortex of glutaryl-CoA dehydrogenase deficient mice: A possible mechanism for brain injury in glutaric aciduria type I. Molecular Genetics and Metabolism (Print) , v. 34, p. 34-44, 2012.

• ZANATTA, A. ; TONIN, Anelise ; PIMENTEL, A. M. ; Tonin, Anelise M. ; KNEBEL, L. A. ; Grings, M. ; Lobato, V. A ; RIBEIRO, César Augusto João ; DUTRAFILHO, Carlos Severo ; LEIPNITZ, Guilhian ; WAJNER, Moacir . Neurochemical Evidence that the Metabolites Accumulating in 3-Methylcrotonyl-CoA Carboxylase Deficiency Induce Oxidative Damage in Cerebral Cortex of Young Rats. Cellular and Molecular Neurobiology , p. 11, 2012.

• VIEGAS, Carolina Maso ; Busanello, Estela Natacha Brandt ; Tonin, Anelise Miotti ; Grings, Mateus ; Moura, Alana Pimentel ; Ritter, Luciana ; ZANATTA, A. ; Knebel, Lisiane Aurélio ; Lobato, Vannessa Araujo ; Pettenuzzo, Letícia Ferreira ; Vargas, Carmen Regla ; Leipnitz, Guilhian ; Wajner, Moacir . Chronic postnatal ornithine administration to rats provokes learning deficit in the open field task. Metabolic Brain Disease , v. 27, p. 1-486, 2012.

• VIEGAS, Carolina Maso ; Tonin, Anelise Miotti ; ZANATTA, A. ; Seminotti, Bianca ; Busanello, Estela Natacha Brandt ; Fernandes, Carolina Gonçalves ; Moura, AP ; Leipnitz, Guilhian ; Wajner, Moacir . Impairment of brain redox homeostasis caused by the major metabolites accumulating in hyperornithinemia¿hyperammonemia¿homocitrullinuria syndrome in vivo. Metabolic Brain Disease , v. 28, p. 1-530, 2012.

• Busanello, Estela Natacha Brandt ; ZANATTA, A. ; Tonin, Anelise Miotti ; VIEGAS, Carolina Maso ; Vargas, Carmen Regla ; Leipnitz, Guilhian ; RIBEIRO, CÉSAR AUGUSTO JOÃO ; Wajner, Moacir . Marked inhibition of Na+, K+ - ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease. Journal of Bioenergetics and Biomembranes , v. 1, p. 1, 2012.

• Amaral, Alexandre Umpierrez ; CECATTO, CRISTIANE ; Seminotti, Bianca ; Zanatta, Ângela ; Fernandes, Carolina Gonçalves ; Busanello, Estela Natacha Brandt ; BRAGA, LUISA MACEDO ; RIBEIRO, CÉSAR AUGUSTO JOÃO ; DE SOUZA, DIOGO ONOFRE GOMES ; WOONTNER, MICHAEL ; KOELLER, DAVID M. ; GOODMAN, STEPHEN ; WAJNER, Moacir . Marked reduction of Na+, K+-ATPase and creatine kinase activities induced by acute lysine administration in glutaryl-CoA dehydrogenase deficient mice. Molecular Genetics and Metabolism (Print) , v. 107, p. 81-86, 2012.

• Leipnitz, Guilhian ; Amaral, Alexandre Umpierrez ; Fernandes, Carolina Gonçalves ; Seminotti, Bianca ; Zanatta, Ângela ; Knebel, Lisiane Aurélio ; Vargas, Carmen Regla ; Wajner, Moacir . Pristanic acid promotes oxidative stress in brain cortex of young rats: A possible pathophysiological mechanism for brain damage in peroxisomal disorders. Brain Research , v. 1382, p. 259-265, 2011.

• Fernandes, Carolina G. ; Leipnitz, Guilhian ; Seminotti, Bianca ; Amaral, Alexandre U. ; ZANATTA, A. ; Vargas, Carmen R. ; Dutra Filho, Carlos S. ; Wajner, Moacir . Experimental Evidence that Phenylalanine Provokes Oxidative Stress in Hippocampus and Cerebral Cortex of Developing Rats. Cellular and Molecular Neurobiology , v. 30, p. 317-326, 2010.

• Busanello EN ; Moura, AP ; Viegas CM ; ZANATTA, A. ; da Costa Ferreira G ; SCHUCK, P. F. ; WAJNER, M. . Neurochemical evidence that glycine induces bioenergetical dysfunction. Neurochemistry International , v. 56, p. 948-954, 2010.

• TONIN, A. M. ; da Costa Ferreira G ; Grings, M ; Viegas CM ; Busanello EN ; Amaral AU ; ZANATTA, A. ; SCHUCK, P. F. ; WAJNER, M. . Disturbance of mitochondrial energy homeostasis caused by the metabolites accumulating in LCHAD and MTP deficiencies in rat brain. Life Sciences (1973) , v. 86, p. 825-831, 2010.

• Leipnitz, Guilhian ; Amaral, Alexandre U. ; ZANATTA, A. ; Seminotti, Bianca ; Fernandes, Carolina G. ; Knebel, Lisiane A. ; Vargas, Carmen R. ; Wajner, Moacir . Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats. Life Sciences (1973) , v. 87, p. 275-280, 2010.

• Seminotti, Bianca ; Fernandes, Carolina Gonçalves ; Leipnitz, Guilhian ; Amaral, Alexandre Umpierrez ; Zanatta, Ângela ; Wajner, Moacir . Neurochemical Evidence that Lysine Inhibits Synaptic Na+,K+-ATPase Activity and Provokes Oxidative Damage in Striatum of Young Rats In vivo. Neurochemical Research , p. 205-214, 2010.

• TONIN, A. M. ; da Costa Ferreira G ; SCHUCK, P. F. ; Viegas CM ; ZANATTA, A. ; Leipnitz G. ; Seminotti B. ; WANNMACHER, C. M. ; WAJNER, M. . Inhibition of creatine kinase activity by lysine in rat cerebral cortex. Metabolic Brain Disease , v. 24, p. 349-360, 2009.

• dos Santos EF ; Busanello EN ; Miglioranza A ; ZANATTA, A. ; Barchak AG ; Vargas CR ; Saute J ; Rosa C ; Carrion MJ ; Camargo D ; Dalben D ; da Costa J ; de Sousa Miguel SR ; de Mello Rieder SR ; WAJNER, M. . Evidence that folic acid deficiency is a major determinant of hyperhomocysteinemia in Parkinson´s disease. Metabolic Brain Disease , v. 24, p. 257-269, 2009.

• Leipnitz G. ; Seminotti B. ; Fernandes CG ; Amaral AU ; Beskow AP ; da Silva LB ; ZANATTA, A. ; Ribeiro CAJ ; Vargas CR ; WAJNER, M. . Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver. International Journal of Developmental Neuroscience , v. 27, p. 351-356, 2009.

• ZANATTA, A. ; SCHUCK, P. F. ; Viegas CM ; Knebel, LA ; Busanello EN ; Moura, AP ; WAJNER, M. . In vitro evidence that d-serine disturbs the citric acid cycle through inhibition of citrate synthase activity in rat cerebral cortex. Brain Research , v. 1298, p. 186-193, 2009.

• Amaral AU ; Leipnitz G. ; Fernandes CG ; Seminotti B. ; ZANATTA, A. ; Viegas CM ; DUTRA-FILHO, C. S. ; WAJNER, M. . Evidence that the major metabolites accumulating in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome induce oxidative stress in brain of young rats. International Journal of Developmental Neuroscience , v. 27, p. 635-641, 2009.

• Viegas CM ; ZANATTA, A. ; Knebel, LA ; SCHUCK, P. F. ; TONIN, A. M. ; da Costa Ferreira G ; Amaral AU ; DUTRA-FILHO, C. S. ; WANNMACHER, C. M. ; WAJNER, M. . Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats. Brain Research , v. 1291, p. 102-112, 2009.

• SCHUCK, P. F. ; da Costa Ferreira G ; TONIN, A. M. ; Viegas CM ; Busanello EN ; Moura, AP ; ZANATTA, A. ; Klamt, F ; WAJNER, M. . Evidence that the major metabolites accumulating in medium-chain acyl-CoA dehydrogenase deficiency disturb mitochondrial energy homeostasis in rat brain. Brain Research , v. 1296, p. 117-126, 2009.

• VIEGAS, C. M. ; FERREIRA, G. C. ; SCHUCK, P. F. ; TONIN, A. M. ; ZANATTA, A. ; WYSE, A.T.S. ; DUTRA-FILHO, C. S. ; WANNMACHER, C. M. ; WAJNER, M. . Evidence that 3-hydroxyisobutyric acid inhibits key enzymes of energy metabolism in cerebral cortex of young rats. International Journal of Developmental Neuroscience , v. 26, p. 293-299, 2008.

• Amaral AU ; LEIPNITZ, G. ; FERNANDES, C.G. ; SEMINOTTI, B. ; ZANATTA, Â. ; da Silva LB ; DUTRA-FILHO, C. S. ; WAJNER, M . Homocitruline and ornitihine induce oxidative stress in rat brain. In: VI Meeting of SFRBM - South America Group, 2009, Santiago. Free Radicals and Antioxidants in Chile, 2009. v. 1. p. 63-63.

• FERREIRA, G. C. ; SCHUCK, P ; TONIN, A. M. ; VIEGAS, C. M. ; Busanello, Estela Natacha Brandt ; ZANATTA, Â. ; WAJNER, M . Evidenche that octanoic and decanoic acids affect mitochondrial homeostasis in rat brain. In: IV Neurotoxicity Meeting, 2009, Arica. IV Neurotoxicity Meeting ? Neurochemicals mechanisms for neurodegenerative disorders, 2009. v. 1. p. 108-108.

• ZANATTA, Â. ; Viegas CM ; TONIN, A. M. ; Knebel, LA ; WYSE, ANGELA T. S. ; WAJNER, M . Bioenergetics is disturbed by homocitrulline and ornithine in cerebral cortex of young rats. In: I Congresso IBRO/LARC de Neurociências, 2008, Búzios. I Congresso IBRO/LARC de Neurociências - Programa, 2008. v. 1. p. 73-73.

• GRINGS, M. ; da Silva LB ; LEIPNITZ, G. ; SEMINOTTI, B. ; Fernandes, Carolina G. ; Beskow AP ; Amaral, Alexandre U. ; ZANATTA, Â. ; Vargas, Carmen R. ; WAJNER, M . D-serine provokes lipid and protein oxidative damage and reduces the antioxidant defenses in rat brain. In: I Congresso IBRO/LARC de Neurociências, 2008, Búzios. I Congresso IBRO/LARC de Neurociências - Programa, 2008. v. 1. p. 73-73.

• TONIN, A ; SCHUCK, P ; FERREIRA, G. C. ; Viegas CM ; ZANATTA, Â. ; SEMINOTTI, B. ; Grings, Mateus ; WANNMACHER, C ; DUTRAFILHO, C ; WAJNER, M . Inhibition of brain creatine kinase activity caused by lysine is prevented by reduced glutathione. In: I Congresso IBRO/LARC de Neurociências, 2008, Búzios. I Congresso IBRO/LARC de Neurociências - Programa, 2008. v. 1. p. 74-74.

• WAJNER, M ; ZANATTA, Â. ; Vargas, Carmen Regla ; de Mello Rieder SR . Folic acid deficiency is an important determinant of hyperhomocisteinemia in Parkinson's disease. In: 37th Meeting of SBBq, 2008, Águas de Lindoia. 37th Meeting of SBBq - Programa, 2008. v. 1. p. 41-41.

• SCHUCK, P ; Ceolato, PC ; da Costa Ferreira G ; TONIN, A. M. ; ZANATTA, Â. ; LATINI, A. ; WAJNER, M . Evidence that 4-cis-decenoic acid induces oxidative stress in brain of young rats. In: V Meeting of SFRBM - South America Group, 2007, Monteviodeo. Free Radicals in Montevideo, 2007. v. 1. p. 97-97.

• SILVA, J. C. ; Amaral, Alexandre U. ; CECATTO, CRISTIANE ; WAJNER, A. ; GODOY, K. S. ; RIBEIRO, R. T. ; SILVA, L. H. R. ; ZANATTA, Â. ; ROSA, M. S. ; LOUREIRO, S. O. ; Vargas, Carmen Regla ; LEIPNITZ, G. ; SOUZA, D. O. G. ; WAJNER, M . Experimental Evidence That - Ketoadipic and -Aminoadipic Acids Provoke Marked Oxidative Damage and Reduces the Antioxidant Defenses in Rat Brain. In: 13th International Congress of Inborn Errors of Metabolism, 2017, Rio de Janeiro. Journal of Inborn Errors of Metabolism and Screening, 2017. v. 5. p. 187-187.

• Zanatta, Ângela ; PLENTZ, I. ; MAJOLO, F. ; ZANIRATI, G. ; MARINOWIC, D. R. ; XAVIER, F. A. C. ; GHILARDI, I. M. ; MACHADO, D. C. ; COSTA, J. C. . IN VITRO ANALYSIS OF THE DAMAGE RISK OF ANTIBODY-VIRUS COMPLEX TO NEURO DEVELOPMENT USING INDUCED PLURIPOTENT-STEM CELLS (IPSC). In: ABTCEL - X Congress, 2018, São Paulo. ABTCEL, 2018.

• RIBEIRO, C.A.J. ; Zanatta, Ângela ; Amaral, Alexandre U. ; SEMINOTTI, B. ; LEIPNITZ, G. ; WAJNER, M . Effects on redox homeostasis and histopathology provoked by intracerebral administration of D-2-HG in neonatal rats. In: SSIEM 2018, 2018, Atenas. Journal of Inherited Metabolic Disease, 2018. v. 41. p. S129-S129.

• Seminotti, Bianca ; ZANATTA, Â. ; RIBEIRO, R. T. ; WYSE, ANGELA T. S. ; BR, N. ; LEIPNITZ, G. ; WAJNER, M . Redox homeostasis disruption and microglia activation are triggered by S-adenosyl methionine administration in rat brain. In: SSIEM 2019, 2018, Atenas. Journal of Inherited Metabolic Disease, 2018. v. 41. p. S26-S26.

• ZANATTA, Â. ; SEMINOTTI, B. ; Ceccatto, C ; RIBEIRO, R. T. ; WAJNER, ALESSANDRO ; SPANNENBERGER, K. P. ; SILVA, L. H. R. ; WYSE, ANGELA T. S. ; WAJNER, M . S-Adenosyl methionine disturbs redox and mitochondrial homeostasis in the liver of young rats. In: SSIEM 2019, 2018, Atenas. Journal of Inherited Metabolic Disease, 2018. v. 41. p. S26-S26.

• RIBEIRO, R. T. ; ZANATTA, Â. ; Amaral, Alexandre U. ; LEIPNITZ, G. ; SEMINOTTI, B. ; WAJNER, M . L-2-hydroxyglutaric acid provokes disruption on redox status and histopathological abnormalities in brain of neonatal rats. In: SSIEM 2018, 2018, Atenas. Journal of Inherited Metabolic Disease, 2018. v. 41. p. S28-S28.

• SILVA, J. C. ; Amaral, Alexandre U. ; Ceccatto, C ; WAJNER, A. ; GODOY, K. S. ; RIBEIRO, R. T. ; ZANATTA, Â. ; ROSA, M. S. ; LOUREIRO, S. O. ; Vargas, Carmen Regla ; Leipnitz, Guilhian ; SOUZA, D. G. ; WAJNER, M . Disruption of Redox Homeostasis Caused by α-Ketoadipic and α-Aminoadipic acids in Rat Brain. In: 46th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq), 2017, Águas de Lindoia. Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq), 2017.

• GODOY, K. S. ; Borges, CG ; CANANI, C.R. ; Fernandes, Carolina Gonçalves ; ZANATTA, A. ; RIBEIRO, C.A.J. ; Leipnitz, Guilhian ; Vargas, Carmen R. ; WAJNER, M . In vivo adminitration of phytanic acid in cerebellum of adolescent rats provokes oxidative stress and astrogliosis. In: 23rd Congress of the International Union for Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq), 2015, Foz do Iguaçu. 23rd Congress of the International Union for Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq), 2015. p. 649.

• Zanatta, Ângela ; VIEGAS, Carolina Maso ; HICKMANN, F. H. ; Grings, Mateus ; Fernandes CG ; MONTEIRO, W. O. ; LEIPNITZ, Guilhian ; WAJNER, Moacir . Experimetal evidence that the metabolites accumulated in HHH-syndrome provokes impairment on redox homeostasis in cerebellum of young rats. In: SSIEM Annual Symposium, 2014, Innsbruck. Journal of Inherited Metabolic Disease, 2014. v. 37. p. S-83-S-83.

• ZANATTA, A. ; VIEGAS, Carolina Maso ; Busanello, Estela Natacha Brandt ; GRINGS, M. ; HICKMANN, F. H. ; MONTEIRO, W. O. ; COELHO, D. M. ; SITTA, A. ; Leipnitz, Guilhian ; Wajner, Moacir . Evidence that ornithine and homocitrulline disturb redox homeostasis in cerebellum of young rats in vivo. In: 12th International Congress of Inborn Errors of Metabolism, 2013, Barcelona. Journal of Inherited Metabolic Disease, 2013. v. 36. p. S140-S140.

• PIMENTEL, A. M. ; GRINGS, M. ; PARMEGGIANI, B. S. ; MARCOWICH, G. M. ; TONIN, A ; ZANATTA, A. ; VIEGAS, Carolina Maso ; BUMBEL, A. ; RIBEIRO, C. A. J. ; Wajner, Moacir ; Leipnitz, Guilhian . Mk-801 and antioxidants prevent glycine-induced bioenergetic dysfunction in rat brain: potential novel adjuvant therapies for nonketotic hyperglycemia. In: 12th International Congress of Inborn Errors of Metabolism, 2013, Barcelona. Journal of Inherited Metabolic Disease, 2013. v. 36. p. S153-S154.

• Amaral, Alexandre U. ; Ceccatto, C ; Seminotti, Bianca ; ZANATTA, A. ; Fernandes, Carolina G. ; Busanello, Estela Natacha Brandt ; KIST, L. W. ; BOGO, M. R. ; LEIPNITZ, G. ; SOUZA, D. O. G. ; WOOTNER, M. ; KOELLER, D. M. ; GOODMAN, S. ; WAJNER, M . Na+, K+ ATPase activity is reduced in cerebral cortex of glutaryl-CoA dehydrogenase deficient mice: a possible mechanism for brain injury in glutaric aciduria type I. In: 12th International Congress of Inborn Errors of Metabolism, 2013, Barcelona. Journal of Inherited Metabolic Disease, 2013. v. 36. p. S166-S166.

• VIEGAS, Carolina Maso ; ZANATTA, A. ; GRINGS, M. ; HICKMANN, F. H. ; MONTEIRO, W. O. ; SITTA, A. ; LEIPNITZ, G. ; WAJNER, M . Methylmalonic acid and ammonia act synergistically in vivo causing a redox imbalance in cerebral cortex and striatum of young rats. In: 12th International Congress of Inborn Errors of Metabolism, 2013, Barcelona. Journal of Inherited Metabolic Disease, 2013. v. 36. p. S166-S167.

• Busanello EN ; Lobato, Vannessa Araujo ; ZANATTA, A. ; VIEGAS, Carolina Maso ; RIBEIRO, C. A. J. ; Vargas, Carmen R. ; WAJNER, M . Mithocondrial oxidative phosphorylation and synaptic membrane Na+, K+-ATPase activity are strongly compromised by prystanic acid in cerebellum of rats. In: 12th International Congress of Inborn Errors of Metabolism, 2013, Barcelona. Journal of Inherited Metabolic Disease, 2013. v. 36. p. S242-S242.

• VIEGAS, Carolina Maso ; Tonin, Anelise Miotti ; Busanello, Estela Natacha Brandt ; Zanatta, Ângela ; Moura, Alana Pimentel ; AGOSTINI, C. ; Leipnitz, Guilhian ; Wajner, Moacir . The major metabolites accumulating in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome compromise brain redox homeostasi in vivo. In: Annual Symposium of the Society for the Study of Imborn Errors of Metabolism, 2012, Birmingham. Journal of Inheareted Metabolic Disease, 2012. v. 35. p. S48-S48.

• Zanatta, Ângela ; VIEGAS, Carolina Maso ; Tonin, Anelise Miotti ; Moura, Alana Pimentel ; Busanello, Estela Natacha Brandt ; Grings, Mateus ; Lobato, Vannessa Araujo ; Leipnitz, Guilhian ; Wajner, Moacir . Eidence that ornithine and homociruline provoke oxidative damage in cerebellum of young rats. In: Annual Symposium of the Society for the Study of Imborn Errors of Metabolism, 2012, Birmingham. Journal of Inheareted Metabolic Disease, 2012. v. 35. p. S24-S24.

• Moura, Alana Pimentel ; Grings, Mateus ; Tonin, Anelise Miotti ; Zanatta, Ângela ; PARMEGGIANI, B. S. ; ALVORCEM, L. M. ; FRITCH, L. ; RIBEIRO, CÉSAR AUGUSTO JOÃO ; Wajner, Moacir ; Leipnitz, Guilhian . Glycine intracerebroventricular administration compromises brain energy metabolism of young rats. In: Annual Symposium of the Society for the Study of Imborn Errors of Metabolism, 2012, Birmingham. Journal of Inheareted Metabolic Disease, 2012. v. 37. p. S24-S24.

• Amaral, Alexandre Umpierrez ; Ceccatto, C ; Seminotti, Bianca ; Zanatta, Ângela ; Fernandes, Carolina Gonçalves ; Busanello, Estela Natacha Brandt ; BRAGA, L. ; RIBEIRO, CÉSAR AUGUSTO JOÃO ; SOUZA, D. O. G. ; WOOTNER, M. ; KOELLER, D. M. ; GOODMAN, S. ; Wajner, Moacir . Experimental evidence that acute lysine administration provokes marked reduction of Na+,K+-ATPase and creatine kinase activities in glutaryl-CoA dehydrogenase deficient mice. In: Annual Symposium of the Society for the Study of Imborn Errors of Metabolism, 2012, Birmingham. Journal of Inheareted Metabolic Disease, 2012. v. 35. p. S59-S59.

• Moura, Alana Pimentel ; Lobato, Vannessa Araujo ; Zanatta, Ângela ; Busanello, Estela Natacha Brandt ; Grings, Mateus ; Tonin, Anelise Miotti ; RIBEIRO, CÉSAR AUGUSTO JOÃO ; Leipnitz, Guilhian ; Wajner, Moacir . Mitochondrial bioenergetics and cellular energy transfer are compromised by 3-methylcrotonylglycine in the heart of young rats. In: Annual Symposium of the Society for the Study of Imborn Errors of Metabolism, 2012, Birmingham. Journal of Inheareted Metabolic Disease, 2012. v. 35. p. S62-S62.

• Busanello, Estela Natacha Brandt ; Amaral, Alexandre Umpierrez ; Zanatta, Ângela ; Tonin, Anelise Miotti ; VIEGAS, Carolina Maso ; AGOSTINI, C. ; Leipnitz, Guilhian ; Wajner, Moacir . Disruption of bioenergetics homeostasis by phytanic acid in cerebellum of young rats. In: Annual Symposium of the Society for the Study of Imborn Errors of Metabolism, 2012, Birmingham. Journal of Inheareted Metabolic Disease, 2012. v. 35. p. S130-S130.

• Leipnitz, Guilhian ; Grings, Mateus ; Tonin, Anelise Miotti ; Zanatta, Ângela ; Knebel, Lisiane A. ; Moura, Alana Pimentel ; Wajner, Moacir . Mitochondrial function is disrupted by phytanic acid in rat heart. In: Annual Symposium of the Society for the Study of Imborn Errors of Metabolism, 2012, Birmingham. Journal of Inheareted Metabolic Disease, 2012. v. 35. p. S131-S131.

• Knebel, LA ; ZANATTA, A. ; Grings, M ; TONIN, A. M. ; Moura, AP ; ALVORCEM, L. M. ; WAJNER, M. ; Leipnitz G. . Induction of oxidative stress by 2-methybutyrylglycine in rat brain. In: SSIEM Annual Symposium 2011, 2011, Genebra. Journal of Inherited Metabolic Disease, 2011. v. 34. p. S141-S141.

• Moura, AP ; ZANATTA, A. ; TONIN, A. M. ; Busanello EN ; Grings, M ; Knebel, LA ; LOBATO, V. G. ; Leipnitz G. ; Ribeiro CAJ ; WAJNER, M. . 3-methylcotonyglycine induces lipid and protein damage in brain of young rats. In: SSIEM Annual Symposium 2011, 2011, Genebra. Journal of Inherited Metabolic Disease, 2011. v. 34. p. S143-S143.

• TONIN, A. M. ; Moura, AP ; ZANATTA, A. ; Busanello EN ; Grings, M ; HICKMANN, F. H. ; Ribeiro CAJ ; WAJNER, M. . Mitochondrial bioenergetics, cellular energy transfer and Na+,K+ ATPase activity are compromised by 3-methycrotonylglycine in brain of young rats. In: SSIEM Annual Symposium 2011, 2011, Genebra. Journal of Inherited Metabolic Disease, 2011. v. 34. p. S144-S144.

• Leipnitz G. ; Amaral AU ; Seminotti B. ; Fernandes CG ; Knebel, LA ; ZANATTA, A. ; Vargas CR ; WAJNER, M. . Evidence that pristanic acid induces lipid and protein oxidative damage and reduces non-enzymatic antioxidant defenses in rat brain. In: SSIEM Annual Symposium 2011, 2011, Genebra. Journal of Inherited Metabolic Disease, 2011. v. 34. p. S171-S171.

• Moura, AP ; ZANATTA, A. ; Busanello EN ; TONIN, A. M. ; Ribeiro CAJ ; WAJNER, M. . Evidence that 3-methylcrotonylglycine disrupts energy metabolism in the brain. In: XL Annual Meeting of SBBq, 2011, Foz do Iguaçu. XL Annual Meeting of SBBq, 2011. p. 91-91.

• HICKMANN, F. H. ; ZANATTA, A. ; Ribeiro CAJ ; WAJNER, M. . Evidence that neuroinflammation associated to high brain levels of isovaleric acid induce lipid oxidation and reduce creatine kinase activity in striatum of young rats. In: XL Annual Meeting of SBBq, 2011, Foz do Iguaçu. XL Annual Meeting of SBBq, 2011. p. 92-92.

• ZANATTA, A. ; Moura, AP ; TONIN, A. M. ; Busanello EN ; Grings, M ; Knebel, LA ; LOBATO, V. G. ; Ribeiro CAJ ; Leipnitz G. ; WAJNER, M. . Indução de dano oxidativo lipídico e proteico por 3-metilcrotonilglicina em córtex cerebral de ratos jovens. In: VIII Congreso Latinoamericano de Errores Innatos del Metabolismo Y Pesquisa Neonatal, 2011, Cusco. VIII Congreso Latinoamericano de Errores Innatos del Metabolismo Y Pesquisa Neonatal, 2011.

• Moura, AP ; ZANATTA, A. ; Busanello EN ; TONIN, A. M. ; Grings, M ; HICKMANN, F. H. ; Ribeiro CAJ ; WAJNER, M. . A 3-metilcrotonilglicina compromete o metabolismo energético cerebral de ratos jovens: um possível patomecanismo envolvido no dano cerebral na deficiência da 3-metilcrotonil-CoA carboxilase. In: VIII Congreso Latinoamericano de Errores Innatos del Metabolismo Y Pesquisa Neonatal, 2011, Cusco. VIII Congreso Latinoamericano de Errores Innatos del Metabolismo Y Pesquisa Neonatal, 2011.

• Leipnitz G. ; Seminotti B. ; Amaral AU ; Fernandes CG ; Knebel, LA ; ZANATTA, A. ; Vargas CR ; WAJNER, M. . Evidência neuroquímica de que estresse oxidativo induzido pelo ácido pristânico representa um mecanismo responsável pelo dano cerebral encontrado em doenças peroxissomais. In: VIII Congreso Latinoamericano de Errores Innatos del Metabolismo Y Pesquisa Neonatal, 2011, Cusco. VIII Congreso Latinoamericano de Errores Innatos del Metabolismo Y Pesquisa Neonatal, 2011.

• Seminotti B. ; Fernandes CG ; Amaral AU ; ZANATTA, A. ; Leipnitz G. ; DUTRA-FILHO, C. S. ; WAJNER, M. . Intrastriatal administration of lysine induces oxidative and bioenergetics damage in striatum of developing rats. In: SSIEM Annual Symposium 2010, 2010, Istanbul. Journal of Inherited Metabolic Disease, 2010. v. 33. p. 21-21.

• Amaral AU ; Leipnitz G. ; Fernandes CG ; Seminotti B. ; SCHUCK, P. F. ; ZANATTA, A. ; P, Eichler ; Ceccatto, C ; DUTRA-FILHO, C. S. ; WAJNER, M. . Neurochemical evidence that the major metabolites accumulating in maple syrup urine disease disturb mitochondrial bioenergetic in brain of young rats. In: SSIEM Annual Symposium 2010, 2010, Istanbul. Journal of Inherited Metabolic Disease, 2010. v. 33. p. 22-22.

• Fernandes CG ; Borges, CG ; Seminotti B. ; Amaral AU ; Leipnitz G. ; ZANATTA, A. ; WANNMACHER, C. M. ; WAJNER, M. . Neurochemical evidence that methylmalonic acid elicits lipid and protein oxidative damage in vitro and ex vivo in brain of young rats. In: SSIEM Annual Symposium 2010, 2010, Istanbul. Journal of Inherited Metabolic Disease, 2010. v. 33. p. 41-41.

• Leipnitz G. ; Amaral AU ; ZANATTA, A. ; Seminotti B. ; Fernandes CG ; Knebel, LA ; P, Eichler ; Vargas CR ; WAJNER, M. . Phytanic acid induces oxidative stress in cerebellum and cerebral cortex of young rats. In: SSIEM Annual Symposium 2010, 2010, Istanbul. Journal of Inherited Metabolic Disease, 2010. v. 33. p. 94-94.

• Amaral AU ; Leipnitz G. ; Fernandes CG ; Seminotti B. ; SCHUCK, P. F. ; ZANATTA, A. ; WAJNER, M. . alfa-ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain. In: XXXIX Annual Meeting of SBBq, 2010, Foz do Iguaçu. XXXIX Annual Meeting of SBBq, 2010. p. 41-41.

• Seminotti B. ; TONIN, A. M. ; Fernandes CG ; Amaral AU ; ZANATTA, A. ; Leipnitz G. ; WAJNER, M. . Oxidative damage and disturbance of brain bioenergetics acaused by lysine. In: XXXIX Annual Meeting of SBBq, 2010, Foz do Iguaçu. XXXIX Annual Meeting of SBBq, 2010. p. 45-45.

• Leipnitz G. ; Busanello EN ; Viegas CM ; ZANATTA, A. ; Moura, AP ; Amaral AU ; SCHUCK, P. F. ; WAJNER, M. . Dual mechanism of brain damage induced by phytanic acid. In: XXXIX Annual Meeting of SBBq, 2010, Foz do Iguaçu. XXXIX Annual Meeting of SBBq, 2010. p. 45-45.

• Busanello EN ; Moura, AP ; ZANATTA, A. ; Viegas CM ; da Costa Ferreira G ; SCHUCK, P. F. ; WAJNER, M. . Experimental evidence that glycine impairs energy metabolism in the brain of young rats. In: XXXIX Annual Meeting of SBBq, 2010, Foz do Iguaçu. XXXIX Annual Meeting of SBBq, 2010. p. 121-121.

• Moura, AP ; Busanello EN ; ZANATTA, A. ; da Costa Ferreira G ; Gamallo, CG ; SCHUCK, P. F. ; WAJNER, M. . Evidence that glycine disrupts energy metabolism in the brain. In: 11th International Congress of Inborn Errors of Metabolism, 2009, San Diego. Molecular genetics and metabolism, 2009. v. 98.

• Fernandes CG ; da Silva LB ; Amaral AU ; Seminotti B. ; Leipnitz G. ; ZANATTA, A. ; SCHUCK, P. F. ; DUTRA-FILHO, C. S. ; WAJNER, M. . Evidence that phenylalanine induces oxidative stress in hippocampus and cerebral cortex from young rats. In: 11th International Congress of Inborn Errors of Metabolism, 2009, San Diego. Molecular genetics and metabolism, 2009. v. 98.

• Amaral AU ; Viegas CM ; Seminotti B. ; Fernandes CG ; ZANATTA, A. ; Leipnitz G. ; Knebel, LA ; WAJNER, M. . Evidence that major metabolites accumulating in HHH syndrome induce oxidative stress in brain. In: 11th International Congress of Inborn Errors of Metabolism, 2009, San Diego. Molecular genetics and metabolism, 2009. v. 98.

• da Costa Ferreira G ; SCHUCK, P. F. ; TONIN, A. M. ; Viegas CM ; Busanello EN ; Moura, AP ; ZANATTA, A. ; Ritter, L ; WAJNER, M. . Octanoic acid neurotoxicity: implications for MCAD deficiency neuropathology. In: 11th International Congress oof Inborn Errors of Metabolism, 2009, San Diego. Molecular genetics and metabolism, 2009. v. 98.

• Seminotti B. ; da Silva LB ; Leipnitz G. ; Fernandes CG ; Amaral AU ; ZANATTA, A. ; DUTRA-FILHO, C. S. ; WAJNER, M. . D-serine induces oxidative stress in cerebral cortex from young rats. In: 11th International Congress of Inborn Errors of Metabolism, 2009, San Diego. Molecular genetics and metabolism, 2009. v. 98.

• Leipnitz G. ; Seminotti B. ; Fernandes CG ; Beskow AP ; Amaral AU ; da Silva LB ; ZANATTA, A. ; WAJNER, M. . Brain is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-metilglutaric aciduria as compared to the liver. In: 7th International and Latin American congress Inborn Errors of Metabolism and Neonatal Screening, 2009, Cancún. Revista de Investigación Clínica, 2009. v. 61. p. 39-40.

• da Silva LB ; Leipnitz G. ; Seminotti B. ; Fernandes CG ; Beskow AP ; Amaral AU ; ZANATTA, A. ; DUTRA-FILHO, C. S. ; WAJNER, M. . D-serine provokes lipid and protein oxidative damage and reduces the antioxidant defenses in brain of young rats. In: 7th International and Latin American congress Inborn Errors of Metabolism and Neonatal Screening, 2009, Cancún. Revista de Investigación Clínica, 2009. v. 61. p. 72-72.

• da Costa Ferreira G ; SCHUCK, P. F. ; TONIN, A. M. ; Busanello EN ; Viegas CM ; ZANATTA, A. ; WAJNER, M. . Evidence that the major metabolites accumulating in MCAD deficiency disturb mithocondrial homeostasis in rat brain. In: 7th International and Latin American congress Inborn Errors of Metabolism and Neonatal Screening, 2009, Cancún. Revista de Investigación Clínica, 2009. v. 61. p. 72-73.

• VIEGAS, Carolina Maso ; Tonin, Anelise Miotti ; ZANATTA, Â. ; KNEBEL, L. A. ; SCHUCK, P ; da Costa Ferreira G ; WAJNER, M . Evidence that homocitruline and ornithine compromises bioenergetics in cerebral cortex of young rats. In: IV Neurotoxicity Meeting, 2009, Arica. IV Neurotoxicity Meeting - Neurochemicals mechanisms for neurodegenerative disorders, 2009. v. 1. p. 102-102.

• VIEGAS, Carolina Maso ; ZANATTA, Â. ; Tonin, Anelise Miotti ; Knebel, Lisiane A. ; SCHUCK, P. F. ; da Costa Ferreira G ; POTTER, W. ; WAJNER, M . Homocotrulline and ornithine provokes mitochondrial dysfunction in brain of young rats.. In: 7th International and Latin American congress Inborn Errors of Metabolism and Neonatal Screening, 2009, Cancún. Revista de Investigación Clínica, 2009. v. 61. p. 48-48.

• Viegas CM ; TONIN, A ; ZANATTA, A. ; Knebel, LA ; WYSE, A.T.S. ; WAJNER, M. . Evidence that homocitrulline and ornithine compromise bioenergetics in cerebral cortex of young rats. In: SSIEM 2008, 2008, Lisboa. Journal of Inherited Metabolic Disease, 2008. v. 31.

• Leipnitz G. ; Seminotti B. ; Fernandes CG ; Ribeiro CAJ ; Amaral AU ; Beskow AP ; da Silva LB ; ZANATTA, A. ; DUTRA-FILHO, C. S. ; WAJNER, M. . Greater vulnerability of brain to oxidative damage induced by the metaolites accumulating in 3-hydroxy-3-methylglutaric aciduria compared to the liver. In: SSIEM 2008, 2008, Lisboa. Journal of Inherited Metabolic Disease, 2008. v. 31.

• Amaral AU ; Leipnitz G. ; Ribeiro CAJ ; Seminotti B. ; Fernandes CG ; Beskow AP ; Knebel, LA ; ZANATTA, A. ; Grings, M ; DUTRA-FILHO, C. S. ; WAJNER, M. . a-Ketoisocaproic acid compromises cellular respiration in rat brain. In: SSIEM 2008, 2008, Lisboa. Journal of Inherited Metabolic Disease, 2008. v. 31.

• VIEGAS, C. M. ; FERREIRA, G. C. ; SCHUCK, P. F. ; TONIN, A. M. ; ZANATTA, Â. ; Wajner, Moacir . Evidence that 3-hydroxyisobutiric acid inhibits key enzymes of energy metabolism in cerebral cortex of young rats. In: 37th Meeting of SBBq, 2008, Águas de Lindóia. 37th Meeting of SBBq - Programa, 2008. v. 1. p. 114-114.

• ZANATTA, Â. ; TONIN, A. M. ; SCHUCK, P. F. ; VIEGAS, C. M. ; Ceolato, PC ; DUTRA FILHO, C. S. ; WANNMACHER, CLOVIS MILTON DUVAL ; WAJNER, M . In vitro effects of lysine on various parameters of energy metabolism in cerebral cortex of young rats. In: 37th Meeting of SBBq, 2008, Águas de Lindóia. 37th Meeting of SBBq - Programa, 2008. v. 1. p. 115-115.

• Lopes, FM ; Ceolato, PC ; da Costa Ferreira G ; ZANATTA, A. ; SCHUCK, P. F. ; WAJNER, M. . Evidência de que o ácido cis-4-decanóico provoca estresse oxidativo em cérebro de ratos jovens. In: 27ª Semana Científica do Hospital de Clínicas de Porto Alegre, 2007, Porto Alegre. Revista HCPA, 2007. v. 27.

• Viegas CM ; da Costa Ferreira G ; SCHUCK, P. F. ; TONIN, A. M. ; Ceolato, PC ; ZANATTA, A. ; WYSE, A.T.S. ; DUTRA-FILHO, C. S. ; WANNMACHER, C. M. ; WAJNER, M. . 3-Hydroxyusobutiric acid impairs energy metabolism in cerebral cortex of young rats. In: SSIEM 2007 Annual Symposium, 2007, Hamburg. Journal of Inherited Metabolic Disease, 2007. v. 30.

• SCHUCK, P. F. ; Ceolato, PC ; FERREIRA, G. C. ; Tonin, Anelise Miotti ; ZANATTA, Â. ; Lopes, FM ; LATINI, A. ; WYSE, ANGELA T. S. ; WAJNER, M . Evidence that cis-4-decenoic acid alters oxidative phosporylation and elicits oxidative stress in the rat brain: relevance for MCAD deficiency. In: VI Congreso Latiniamericano de Errores Innatos del Metabolismo y Pesquisa Neonatal, 2007, Punta del Este. Acta Bioquimica Clinica Latinoamericana, 2007. v. 1. p. 61-61.

• VIEGAS, Carolina Maso ; FERREIRA, G. C. ; SCHUCK, P ; TONIN, A. M. ; Ceolato, PC ; ZANATTA, Â. ; SEMINOTTI, B. ; DUTRA-FILHO, C. S. ; WANNMACHER, CLOVIS MILTON DUVAL ; WAJNER, M . Evidence that 3-hydroxybutiric acid impairs energy metabolism in the brain of young rats. In: VI Congreso Latinoamericano de Errores Inaatos del Metabolismo y Pesquisa Neonatal, 2007, Punta del Este. Acta Bioquimica Clinica Latinoamericana, 2007. v. 1. p. 105-105.

• SIQUEIRA, L. S. ; ZANATTA, A. ; ZANIRATI, G. ; RODRIGUES, F. V. F. ; GRAHL, M. ; SILVA, A. P. B. ; PINZETTA, G. ; BECKER, N. B. ; VARELA, A. P. M. ; ROEHE, P. M. ; MACHADO, D. C. ; COSTA, J. C. ; MARINOWIC, D. R. . Effects of Zika Virus on microglia cell line after exposure with IgG isolated from serum of infected pregnant women. 2020. (Apresentação de Trabalho/Congresso).

• RODRIGUES, F. V. F. ; MARINOWIC, D. R. ; ZANIRATI, G. ; SANTOS, K. S. ; BASSO, N. R. S. ; Zanatta, Ângela ; AZEVEDO, P. N. ; COSTA, J. C. . Preparação de modelo estrutural e funcional de hipocampo em biomaterial impresso 3D. 2019. (Apresentação de Trabalho/Congresso).

• ZANATTA, A. ; MARINOWIC, D. R. ; VIOLA, F. S. ; ZANIRATI, G. ; AZEVEDO, P. N. ; PLENTZ, I. ; CAPPELLARI, A. R. ; MORRONE, F. B. ; VARELA, A. P. M. ; ROEHE, P. M. ; MACHADO, D. C. ; COSTA, J. C. . Zika virus alters cellular and immunological parameters in glioblastoma cell line. 2019. (Apresentação de Trabalho/Congresso).

• MARINOWIC, D. R. ; Zanatta, Ângela ; VIOLA, F. S. ; ZANIRATI, G. ; AZEVEDO, P. N. ; PLENTZ, I. ; CAPPELLARI, A. R. ; MORRONE, F. B. ; VARELA, A. P. M. ; ROEHE, P. M. ; MACHADO, D. C. ; COSTA, J. C. . Influence of Zika virus on potential of cell migration and cell adhesion in human glioblastoma cells. 2019. (Apresentação de Trabalho/Congresso).

• PLENTZ, I. ; AZEVEDO, P. N. ; Zanatta, Ângela ; XAVIER, F. A. C. ; RODRIGUES, F. V. F. ; ZANIRATI, G. ; MARINOWIC, D. R. ; COSTA, J. C. . In vitro analysis of the risk of Zika antibody-virus complex damage in neural progenitor cells of neonatal rats. 2019. (Apresentação de Trabalho/Congresso).

• Zanatta, Ângela ; VENDRUSCULO, F. M. . Workshop: Organização do tempo. 2019. (Apresentação de Trabalho/Outra).

• Zanatta, Ângela . Bioquímica em Neurociências. 2019. (Apresentação de Trabalho/Outra).

• ZANATTA, Â. . Estresse oxidativo: Perspectivas atuais na fisiopatologia de doenças. 2016. (Apresentação de Trabalho/Seminário).

• ZANATTA, Â. . Estresse oxidativo: Perspectivas atuais na fisiopatologia de doenças. 2016. (Apresentação de Trabalho/Seminário).

• ZANATTA, A. ; Moura, AP ; Viegas CM ; Busanello EN ; Knebel, LA ; SCHUCK, P. F. ; WAJNER, M. . Evidências in vitro que a D-serina compromete o ciclo do ácido cítrico em córtex cerebral de ratos jovens. 2009. (Apresentação de Trabalho/Comunicação).

• Knebel, LA ; TONIN, A. M. ; ZANATTA, A. ; Viegas CM ; da Costa Ferreira G ; SCHUCK, P. F. ; WAJNER, M. . Inibição do metabolismo energético causada pelos metabólitos acumulados na sídrome HHH. 2009. (Apresentação de Trabalho/Comunicação).

• Gamallo, CG ; Amaral AU ; ZANATTA, A. ; Seminotti B. ; Fernandes CG ; Leipnitz G. ; WAJNER, M. . Evidência de que a fenilalanina provoca dano oxidativo em hipocampo e córtex cerebral de ratos jovens. 2009. (Apresentação de Trabalho/Comunicação).

• Ritter, L ; Moura, AP ; TONIN, A. M. ; ZANATTA, A. ; Viegas CM ; Busanello EN ; da Costa Ferreira G ; SCHUCK, P. F. ; WAJNER, M. . Evidência de que o ácido octanóico provoca disfunção mitocondrial em cérebro de ratos jovens. 2009. (Apresentação de Trabalho/Comunicação).

• Moura, AP ; ZANATTA, A. ; Gamallo, CG ; Viegas CM ; Busanello EN ; Knebel, LA ; SCHUCK, P. F. ; WAJNER, M. . Efeitos da glicina sobre o metabolismo energético em cérebro de ratos jovens. 2009. (Apresentação de Trabalho/Comunicação).

• Grings, M ; da Silva LB ; Leipnitz G. ; Seminotti B. ; Fernandes CG ; Beskow AP ; Amaral AU ; ZANATTA, A. ; DUTRA-FILHO, C. S. ; WAJNER, M. . D-serina induz dano oxidativo a lipídeos e proteinas e reduz as defesas antioxidantes em córtex cerebral de ratos jovens. 2008. (Apresentação de Trabalho/Comunicação).

• ZANATTA, A. ; Viegas CM ; TONIN, A. M. ; Knebel, LA ; Grings, M ; WAJNER, M. . A homocitrulina e a ornitina aletram o metabolismo energético em cótex cerebral de ratos jovens. 2008. (Apresentação de Trabalho/Comunicação).

• Ceolato, PC ; Lopes, FM ; da Costa Ferreira G ; ZANATTA, A. ; SCHUCK, P. F. ; WAJNER, M. . O ácido cis-4-decenóico induz estresse oxidativo em córtex cerebral de ratos jovens. 2007. (Apresentação de Trabalho/Comunicação).

• ZANATTA, A. ; Viegas CM ; TONIN, A. M. ; da Costa Ferreira G ; SCHUCK, P. F. ; WYSE, A.T.S. ; DUTRA-FILHO, C. S. ; WANNMACHER, C. M. ; WAJNER, M. . Evidências de que o ácido 3-hidroxiisobutírico afeta alguns parâmetros do metabolismo energético. 2007. (Apresentação de Trabalho/Comunicação).

• TONIN, A. M. ; da Costa Ferreira G ; SCHUCK, P. F. ; Viegas CM ; ZANATTA, A. ; Ceolato, PC ; DUTRA-FILHO, C. S. ; WANNMACHER, C. M. ; WAJNER, M. . Efeitos in vitro da lisina sobre vários parâmetros do metabolismo energético em córtex cerebral de ratos jovens. 2007. (Apresentação de Trabalho/Comunicação).

Outras produções

Projetos de pesquisa

• 2019 - Atual

  Avaliação da Migração e Neurodiferenciação de células-tronco pluripotentes induzidas (IPSCs) de pacientes com epilepsia refratária e displasia cortical, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Ângela Zanatta - Integrante / Daniel Rodrigo Marinowic - Coordenador.

• 2019 - Atual

  VALIAÇÃO DA DEPRESSÃO EM PACIENTES COM EPILEPSIA DO LOBO TEMPORAL: ASPECTOS SINTOMATOLÓGICOS, IMUNOHISTOLÓGICOS E MOLECULARES, Situação: Em andamento; Natureza: Pesquisa. , Integrantes: Ângela Zanatta - Integrante / Gabriele Zanirati - Integrante / Daniel Rodrigo Marinowic - Integrante / Jaderson Costa da Costa - Coordenador.

• 2014 - 2016

  Efeitos da adminitração do ácido fitânico sobre a homeostase redox em cerebelo de ratos jovens, Projeto certificado pelo(a) coordenador(a) Moacir Wajner em 07/10/2015., Descrição: O ácido fitânico (Fit) é um ácido graxo saturado de cadeia ramificada que se acumula em diversas doenças peroxissomais, como na síndrome de Zellweger (SZ) e particularmente na doença de Refsum (DR). Essas desordens podem ocorrer devido a defeitos na biogênese do peroxissomo ou em alguma proteína envolvida na β ou α-oxidação de ácidos graxos. Os pacientes afetados geralmente apresentam disfunções neurológicas, incluindo anormalidades cerebelares. Considerando que a patogênese das alterações cerebelares nas doenças onde o Fit se acumula ainda é pouco conhecida, o presente trabalho se propõe a investigar os efeitos ex vivo de injeção intracerebelar aguda do ácido Fit sobre a homeostase redox em cerebelo de ratos jovens.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Ângela Zanatta - Integrante / Borges, Clarissa Günther - Integrante / Fernandes, Carolina Gonçalves - Integrante / Fernanda Hermmes Hickmann - Integrante / Moacir Wajner - Coordenador / CANANI, C.R. - Integrante / Glberto Machado Soares - Integrante.

• 2014 - 2016

  Efeitos do ácido metilcítrico sobre a homeostase energética em cérebro e fígado de ratos jovens, Projeto certificado pelo(a) coordenador(a) Moacir Wajner em 07/10/2015., Descrição: O presente trabalho visa investigar a influência in vitro do ácido metilcítrico sobre parâmetros de metabolismo energético na presença ou ausência de Ca2+ exógeno em preparações mitocondriais ou fatias de cérebro e fígado de ratos jovens com o intuito de melhor compreender a fisiopatologia das acidemias metilmalônica e propiônica. A avaliação dos parâmetros feita na presença de Ca2+ exógeno adicionado ao meio de incubação objetiva verificar a capacidade de tamponamento desse íon por mitocôndrias de ratos jovens submetidos aos vários tratamentos que, quando não ocorre, se reflete no comprometimento da homeostase mitocondrial.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Ângela Zanatta - Integrante / Alexandre Umpierrez Amaral - Integrante / Cecatto, C - Integrante / Fernanda Hermmes Hickmann - Integrante / Moacir Wajner - Coordenador / Luiza de Freitas Lima Flores - Integrante.

• 2013 - 2017

  ESTUDO DOS EFEITOS DOS ÁCIDOS GRAXOS ACUMULADOS NAS DEFICIÊNCIAS DA DESIDROGENASE DE ACILAS-COA HIDROXILADAS DE CADEIA LONGA E DA PROTEÍNA TRIFUNCIONAL MITOCONDRIAL SOBRE A HOMEOSTASE MITOCONDRIAL ENERGÉTICA E REDOX EM FÍGADO E MÚSCULO ESQUELÉTICO DE RATO, Projeto certificado pelo(a) coordenador(a) Moacir Wajner em 07/10/2015., Descrição: As deficiências da desidrogenase de acilas-CoA de cadeia longa hidroxilada (LCHAD) e da proteína trifuncional mitocondrial (TFP) são defeitos da β-oxidação de ácidos graxos cujos pacientes afetados apresentam acúmulo de 3-hidroxiácidos de cadeia longa, como os ácidos 3-hidroxidodecanóico (3HDA), 3-hidroxitetradecanóico (3HTA) e 3-hidroxipalmítico (3HPA) em tecidos e líquidos biológicos. Os principais achados clínicos incluem disfunção hepática, cardiomiopatia e miopatia, além de alterações neurológicas, especialmente quando o paciente apresenta crises de descompensação metabólica. Considerando que a fisiopatologia dessas doenças ainda não está bem estabelecida e que estudos prévios indicam toxicidade dos ácidos graxos acumulados nessas doenças, o presente trabalho se propõe a investigar os efeitos in vitro dos ácidos 3HDA, 3HTA e 3HPA sobre parâmetros de metabolismo energético e estresse oxidativo em fígado e músculo de ratos jovens.. , Situação: Concluído; Natureza: Pesquisa. , Integrantes: Ângela Zanatta - Integrante / WAJNER, M - Coordenador / Luciana Ritter - Integrante / Fernanda Hermmes Hickmann - Integrante / Tonin, Anelise Miotti - Integrante / Carolina Maso Viegas - Integrante / Wagner de Oliveira Monteiro - Integrante / Daniele Kleemann - Integrante.

Prêmios